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Martin L. Adamo,
Professor and Director M.D./Phd. Program; Ph.D., University of Houston, 1986. Telephone: (210) 567-3742 E-mail: adamo@uthscsa.edu My lab studies the mechanisms
of physiological and pathophysiological
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Adamo
ML, Ma X, Ackert-Bicknell CL, Donahue LR, Beamer WG, Rosen CJ.
Genetic increase in serum insulin-like growth factor-I (IGF-I) in C3H/HeJ
compared with C57BL/6J mice is associated with increased transcription
from the IGF-I exon 2 promoter.
Endocrinology. 2006 Jun;147(6):2944-55. Epub 2006 Mar 9.
PMID: 16527837
Delahunty
KM, Shultz KL, Gronowicz GA, Koczon-Jaremko B, Adamo ML, Horton LG, Lorenzo
J, Donahue LR, Ackert-Bicknell C, Kream BE, Beamer WG, Rosen CJ.
Congenic mice provide in vivo evidence for a genetic locus that modulates
serum insulin-like growth factor-I and bone acquisition.
Endocrinology. 2006 Aug;147(8):3915-23. Epub 2006 May 4.
PMID: 16675518
Adamo
ML, Farrar RP.
Resistance training, and IGF involvement in the maintenance of muscle
mass during the aging process.
Ageing Res Rev. 2006 Aug;5(3):310-31. Epub 2006 Sep 1. Review.
PMID: 16949353
Lecka-Czernik
B, Ackert-Bicknell C, Adamo ML, Marmolejos V, Churchill GA, Shockley KR,
Reid IR, Grey A, Rosen CJ.
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma)
by rosiglitazone suppresses components of the insulin-like growth factor
regulatory system in vitro and in vivo.
Endocrinology. 2007 Feb;148(2):903-11. Epub 2006 Nov 22.
PMID: 17122083
Kritsch
KR, Murali S, Adamo ML, Clayton MK, Ney DM.
Hypoenergetic high-carbohydrate or high-fat parenteral nutrition induces
a similar metabolic response with differential effects on hepatic IGF-I
mRNA in dexamethasone-treated rats.
J Nutr. 2005 Mar;135(3):479-85.
PMID: 15735081 [PubMed - indexed for MEDLINE]
Rosen
CJ, Ackert-Bicknell CL, Adamo ML, Shultz KL, Rubin J, Donahue LR, Horton
LG, Delahunty KM, Beamer WG, Sipos J, Clemmons D, Nelson T, Bouxsein ML,
Horowitz M.
Congenic mice with low serum IGF-I have increased body fat, reduced
bone mineral density, and an altered osteoblast differentiation program.
Bone. 2004 Nov;35(5):1046-58.
PMID: 15542029 [PubMed - in process]
Richardson
A, Liu F, Adamo ML, Van Remmen H, Nelson JF.
The role of insulin and insulin-like growth factor-I in mammalian ageing.
Best Pract Res Clin Endocrinol Metab. 2004 Sep;18(3):393-406.
Review.
PMID: 15261845 [PubMed - indexed for MEDLINE]
Chacko
MS, Ma X, Adamo ML.
Double-stranded ribonucleic acid decreases c6 rat glioma cell proliferation
in part by activating protein kinase R and decreasing insulin-like growth
factor I levels.
Endocrinology. 2002 Jun;143(6):2144-54.
PMID: 12021178 [PubMed - indexed for MEDLINE]
Bouxsein
ML, Rosen CJ, Turner CH, Ackert CL, Shultz KL, Donahue LR, Churchill G,
Adamo ML, Powell DR, Turner RT, Muller R, Beamer WG.
Generation of a new congenic mouse strain to test the relationships
among serum insulin-like growth factor I, bone mineral density, and skeletal
morphology in vivo.
J Bone Miner Res. 2002 Apr;17(4):570-9.
PMID: 11918215 [PubMed - indexed for MEDLINE]
Chacko
MS, Adamo ML.
Double-stranded RNA decreases IGF-I gene expression in a protein kinase
R-dependent, but type I interferon-independent, mechanism in C6 rat glioma
cells.
Endocrinology. 2002 Feb;143(2):525-34.
PMID: 11796507 [PubMed - indexed for MEDLINE]
Kritsch
KR, Murali S, Adamo ML, Ney DM.
Dexamethasone decreases serum and liver IGF-I and maintains liver IGF-I
mRNA in parenterally fed rats.
Am J Physiol Regul Integr Comp Physiol. 2002 Feb;282(2):R528-36.
PMID: 11792663 [PubMed - indexed for MEDLINE]
Nair
PN, De Armond DT, Adamo ML, Strodel WE, Freeman JW.
Aberrant expression and activation of insulin-like growth factor-1
receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity
and stabilization of IGF-1R mRNA and contributes to growth factor independence
and increased survival of the pancreatic cancer cell line MIA PaCa-2.
Oncogene. 2001 Dec 13;20(57):8203-14.
PMID: 11781836 [PubMed - indexed for MEDLINE]
Wang
L, Ma X, Yeh LC, Adamo ML.
Differential regulation of IGF-binding protein gene expression by cAMP
in rat C6 glioma cells.
Endocrinology. 2001 Sep;142(9):3917-25.
PMID: 11517170 [PubMed - indexed for MEDLINE]
Wang
L, Liu F, Adamo ML.
Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol
3-kinase/Akt pathways by inhibiting Rap1.
J Biol Chem. 2001 Oct 5;276(40):37242-9. Epub 2001 Jul 30.
PMID: 11479306 [PubMed - indexed for MEDLINE]
Wang
L, Adamo ML.
Cyclic adenosine 3',5'-monophosphate inhibits insulin-like growth factor
I gene expression in rat glioma cell lines: evidence for regulation of
transcription and messenger ribonucleic acid stability.
Endocrinology. 2001 Jul;142(7):3041-50.
PMID: 11416026 [PubMed - indexed for MEDLINE]
Chacko
MS, Adamo ML.
Double-stranded ribonucleic acid decreases C6 rat glioma cell numbers:
effects on insulin-like growth factor I gene expression and action.
Endocrinology. 2000 Oct;141(10):3546-55.
PMID: 11014207 [PubMed - indexed for MEDLINE]
Peterson
CA, Gillingham MB, Mohapatra NK, Dahly EM, Adamo ML, Carey HV, Lund PK,
Ney DM.
Enterotrophic effect of insulin-like growth factor-I but not growth
hormone and localized expression of insulin-like growth factor-I, insulin-like
growth factor binding protein-3 and -5 mRNAs in jejunum of parenterally
fed rats.
JPEN J Parenter Enteral Nutr. 2000 Sep-Oct;24(5):288-95.
PMID: 11011784 [PubMed - indexed for MEDLINE]
Wang
L, Adamo ML.
Cell density influences insulin-like growth factor I gene expression
in a cell type-specific manner.
Endocrinology. 2000 Jul;141(7):2481-9.
PMID: 10875249 [PubMed - indexed for MEDLINE]
Wang
L, Yang H, Adamo ML.
Glucose starvation reduces IGF-I mRNA in tumor cells: evidence for
an effect on mRNA stability.
Biochem Biophys Res Commun. 2000 Mar 16;269(2):336-46.
PMID: 10708553 [PubMed - indexed for MEDLINE]
Wang
L, Wang X, Adamo ML.
Two putative GATA motifs in the proximal exon 1 promoter of the rat
insulin-like growth factor I gene regulate basal promoter activity.
Endocrinology. 2000 Mar;141(3):1118-26.
PMID: 10698188 [PubMed - indexed for MEDLINE]
Ney
DM, Huss DJ, Gillingham MB, Kritsch KR, Dahly EM, Talamantez JL, Adamo
ML.
Investigation of insulin-like growth factor (IGF)-I and insulin receptor
binding and expression in jejunum of parenterally fed rats treated with
IGF-I or growth hormone.
Endocrinology. 1999 Oct;140(10):4850-60.
PMID: 10499545 [PubMed - indexed for MEDLINE]
Benbassat
C, Shoba LN, Newman M, Adamo ML, Frank SJ, Lowe WL Jr.
Growth hormone-mediated regulation of insulin-like growth factor I
promoter activity in C6 glioma cells.
Endocrinology. 1999 Jul;140(7):3073-81.
PMID: 10385399 [PubMed - indexed for MEDLINE]
Yeh
LC, Adamo ML, Duan C, Lee JC.
Osteogenic protein-1 regulates insulin-like growth factor-I (IGF-I),
IGF-II, and IGF-binding protein-5 (IGFBP-5) gene expression in fetal rat
calvaria cells by different mechanisms.
J Cell Physiol. 1998 Apr;175(1):78-88.
PMID: 9491783 [PubMed - indexed for MEDLINE]
Wang
X, Talamantez JL, Adamo ML.
A CACCC box in the proximal exon 2 promoter of the rat insulin-like
growth factor I gene is required for basal promoter activity.
Endocrinology. 1998 Mar;139(3):1054-66.
PMID: 9492038 [PubMed - indexed for MEDLINE]
Yang
H, Ney DM, Peterson CA, Lo HC, Carey HV, Adamo ML.
Stimulation of intestinal growth is associated with increased insulin-like
growth factor-binding protein 5 mRNA in the jejunal mucosa of insulin-like
growth factor-I-treated parenterally fed rats.
Proc Soc Exp Biol Med. 1997 Dec;216(3):438-45.
PMID: 9402151 [PubMed - indexed for MEDLINE]
Yeh
LC, Adamo ML, Olson MS, Lee JC.
Osteogenic protein-1 and insulin-like growth factor I synergistically
stimulate rat osteoblastic cell differentiation and proliferation.
Endocrinology. 1997 Oct;138(10):4181-90.
PMID: 9322928 [PubMed - indexed for MEDLINE]
Wang
X, Yang Y, Adamo ML.
Characterization of the rat insulin-like growth factor I gene promoters
and identification of a minimal exon 2 promoter.
Endocrinology. 1997 Apr;138(4):1528-36.
PMID: 9075712 [PubMed - indexed for MEDLINE]
Yeh
LC, Adamo ML, Kitten AM, Olson MS, Lee JC.
Osteogenic protein-1-mediated insulin-like growth factor gene expression
in primary cultures of rat osteoblastic cells.
Endocrinology. 1996 May;137(5):1921-31.
PMID: 8612532 [PubMed - indexed for MEDLINE]
Yang
H, Adamo ML, Koval AP, McGuinness MC, Ben-Hur H, Yang Y, LeRoith D, Roberts
CT Jr.
Alternative leader sequences in insulin-like growth factor I mRNAs
modulate translational efficiency and encode multiple signal peptides.
Mol Endocrinol. 1995 Oct;9(10):1380-95.
PMID: 8544846 [PubMed - indexed for MEDLINE]
Pash
JM, Delany AM, Adamo ML, Roberts CT Jr, LeRoith D, Canalis E.
Regulation of insulin-like growth factor I transcription by prostaglandin
E2 in osteoblast cells.
Endocrinology. 1995 Jan;136(1):33-8.
PMID: 7828549 [PubMed - indexed for MEDLINE]
Koval
A, Kulik V, Duguay S, Plisetskaya E, Adamo ML, Roberts CT Jr, Leroith D,
Kavsan V.
Characterization of a salmon insulin-like growth factor I promoter.
DNA Cell Biol. 1994 Oct;13(10):1057-62.
PMID: 7945938 [PubMed - indexed for MEDLINE]
Adamo
ML, Shemer J, Roberts CT Jr, LeRoith D.
Insulin and insulin-like growth factor-I induced phosphorylation in
neurally derived cells.
Ann N Y Acad Sci. 1993 Aug 27;692:113-25. Review. No abstract
available.
PMID: 7692785 [PubMed - indexed for MEDLINE]
LeRoith
D, Adamo ML, Shemer J, Lanau F, Shen-Orr Z, Yaron A, Roberts CT Jr, Clemmons
DR, Sheikh MS, Shao ZM, et al.
Retinoic acid inhibits growth of breast cancer cell lines: the role
of insulin-like growth factor binding proteins.
Growth Regul. 1993 Mar;3(1):78-80. No abstract available.
PMID: 7683539 [PubMed - indexed for MEDLINE]
Adamo
ML, Lanau F, Neuenschwander S, Werner H, LeRoith D, Roberts CT Jr.
Distinct promoters in the rat insulin-like growth factor-I (IGF-I)
gene are active in CHO cells.
Endocrinology. 1993 Feb;132(2):935-7. Erratum in: Endocrinology
1993 Aug;133(2):792.
PMID: 8425505 [PubMed - indexed for MEDLINE]
Adamo
ML, Neuenschwander S, LeRoith D, Roberts CT Jr.
Structure, expression, and regulation of the IGF-I gene.
Adv Exp Med Biol. 1993;343:1-11. Review. No abstract available.
PMID: 8184730 [PubMed - indexed for MEDLINE]
Shemer
J, Adamo ML, Roberts CT Jr, LeRoith D.
Tissue-specific transcription start site usage in the leader exons
of the rat insulin-like growth factor-I gene: evidence for differential
regulation in the developing kidney.
Endocrinology. 1992 Dec;131(6):2793-9.
PMID: 1446616 [PubMed - indexed for MEDLINE]
Adamo
ML, Shao ZM, Lanau F, Chen JC, Clemmons DR, Roberts CT Jr, LeRoith D, Fontana
JA.
Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of
IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and
protein secretion in a breast cancer cell line.
Endocrinology. 1992 Oct;131(4):1858-66.
PMID: 1382963 [PubMed - indexed for MEDLINE]
Adamo
ML, Hazelwood RL.
The effect of C-terminus and N-terminus iodination on avian pancreatic
polypeptide (APP) binding to its chicken brain receptor.
Neuropeptides. 1992 Apr;21(4):225-30.
PMID: 1518560 [PubMed - indexed for MEDLINE]
Adamo
ML, Ben-Hur H, Roberts CT Jr, LeRoith D.
Regulation of start site usage in the leader exons of the rat insulin-like
growth factor-I gene by development, fasting, and diabetes.
Mol Endocrinol. 1991 Nov;5(11):1677-86.
PMID: 1779970 [PubMed - indexed for MEDLINE]
Adamo
ML, Hazelwood RL.
Specific neuropeptide Y binding sites in chicken brain.
Am J Physiol. 1991 Jun;260(6 Pt 1):E839-45. Erratum in: Am J
Physiol 1992 Apr;262(4 Pt 1):E376. Am J Physiol 1992 Jun;262(6 Pt 3):section
E followi.
PMID: 1647670 [PubMed - indexed for MEDLINE]
Adamo
ML, Ben-Hur H, LeRoith D, Roberts CT Jr.
Transcription initiation in the two leader exons of the rat IGF-I gene
occurs from disperse versus localized sites.
Biochem Biophys Res Commun. 1991 Apr 30;176(2):887-93.
PMID: 2025299 [PubMed - indexed for MEDLINE]
Adamo
ML, Hazelwood RL.
Characterization of liver and cerebellar binding sites for avian pancreatic
polypeptide.
Endocrinology. 1990 Jan;126(1):434-40.
PMID: 2293998 [PubMed - indexed for MEDLINE]
Adamo
ML, Hazelwood RL.
Tissue distribution of avian pancreatic polypeptide-degrading activity.
Proc Soc Exp Biol Med. 1989 Sep;191(4):341-5.
PMID: 2672005 [PubMed - indexed for MEDLINE]
Ganeshan
K, Perlman MO, Perlman JM, Adamo ML, Hazelwood RL, Dyckes DF.
Recognition of neuropeptides FMRFamide and LPLRFamide by chicken cerebellum
avian pancreatic polypeptide binding sites.
Proc Soc Exp Biol Med. 1987 Sep;185(4):409-12.
PMID: 3615408 [PubMed - indexed for MEDLINE]
Perlman
MO, Perlman JM, Adamo ML, Hazelwood RL, Dyckes DF.
Binding of C-terminal segments of neuropeptide Y to chicken brain.
Int J Pept Protein Res. 1987 Aug;30(2):153-62.
PMID: 2824389 [PubMed - indexed for MEDLINE]
Adamo
ML, Hazelwood RL.
Cerebellar binding of avian pancreatic polypeptide.
Endocrinology. 1984 Mar;114(3):794-800.
PMID: 6321140 [PubMed - indexed for MEDLINE]
Adamo
ML, Dyckes DF, Hazelwood RL.
In vitro binding and degradation of avian pancreatic polypeptide by
chicken and rat tissues.
Endocrinology. 1983 Aug;113(2):508-16.
PMID: 6307642 [PubMed - indexed for MEDLINE]
