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Ricardo C.T. Aguiar,
Assistant Professor (Primary appointment in Dept. of Medicine); M.D.,Federal University of Paraiba, Brazil, 1987; Ph.D., Univ. of Sao Paulo, Brazil, 1994 Telephone: (210) 567-4860 E-mail: aguiarr@uthscsa.edu Molecular pathogenesis of hematological malignancies: basis for the rational design of targeted therapeutics; Intersection of the cAMP signals with survival pathways in normal and malignant B-lymphocytes. |
Lyu
MA, Cheung LH, Hittelman WN, Marks JW, Aguiar RC, Rosenblum MG.
The rGel/BLyS fusion toxin specifically targets malignant B cells expressing
the BLyS receptors BAFF-R, TACI, and BCMA.
Mol Cancer Ther. 2007 Feb;6(2):460-70. Epub 2007 Jan 31.
PMID: 17267661
Chen
L, Juszczynski P, Takeyama K, Aguiar RC, Shipp MA.
Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates
SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation.
Blood. 2006 Nov 15;108(10):3428-33. Epub 2006 Aug 3.
PMID: 16888096
Juszczynski
P, Kutok JL, Li C, Mitra J, Aguiar RC, Shipp MA.
BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional
promoter and are overexpressed in diffuse large B-cell lymphomas with a
prominent inflammatory infiltrate.
Mol Cell Biol. 2006 Jul;26(14):5348-59.
PMID: 16809771
Aguiar
RC, Takeyama K, He C, Kreinbrink K, Shipp MA.
B-aggressive lymphoma family proteins have unique domains that modulate
transcription and exhibit poly(ADP-ribose) polymerase activity.
J Biol Chem. 2005 Oct 7;280(40):33756-65. Epub 2005 Aug 1.
PMID: 16061477
Monti
S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, Wu B, Pasqualucci
L, Neuberg D, Aguiar RC, Dal Cin P, Ladd C, Pinkus GS, Salles G, Harris
NL, Dalla-Favera R, Habermann TM, Aster JC, Golub TR, Shipp MA.
Molecular profiling of diffuse large B-cell lymphoma identifies robust
subtypes including one characterized by host inflammatory response.
Blood. 2005 Mar 1;105(5):1851-61. Epub 2004 Nov 18.
PMID: 15550490 [PubMed - indexed for MEDLINE]
Smith
PG, Wang F, Wilkinson KN, Savage KJ, Klein U, Neuberg DS, Bollag G, Shipp
MA, Aguiar RC.
The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent
apoptosis in diffuse large B-cell lymphoma.
Blood. 2005 Jan 1;105(1):308-16. Epub 2004 Aug 26.
PMID: 15331441 [PubMed - indexed for MEDLINE]
Savage
KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L, Kurtin P, Dal
Cin P, Ladd C, Feuerhake F, Aguiar RC, Li S, Salles G, Berger F, Jing W,
Pinkus GS, Habermann T, Dalla-Favera R, Harris NL, Aster JC, Golub TR,
Shipp MA.
The molecular signature of mediastinal large B-cell lymphoma differs
from that of other diffuse large B-cell lymphomas and shares features with
classical Hodgkin lymphoma.
Blood. 2003 Dec 1;102(12):3871-9. Epub 2003 Aug 21.
PMID: 12933571 [PubMed - indexed for MEDLINE]
Wilkinson
K, Velloso ER, Lopes LF, Lee C, Aster JC, Shipp MA, Aguiar RC.
Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated
with eosinophilia: involvement of PDGFRB and response to imatinib.
Blood. 2003 Dec 1;102(12):4187-90. Epub 2003 Aug 7.
PMID: 12907457 [PubMed - indexed for MEDLINE]
Takeyama
K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA.
The BAL-binding protein BBAP and related Deltex family members exhibit
ubiquitin-protein isopeptide ligase activity.
J Biol Chem. 2003 Jun 13;278(24):21930-7. Epub 2003 Apr 1.
PMID: 12670957 [PubMed - indexed for MEDLINE]
Olipitz
W, Hopfinger G, Aguiar RC, Gunsilius E, Girschikofsky M, Bodner C, Hiden
K, Linkesch W, Hoefler G, Sill H.
Defective DNA-mismatch repair: a potential mediator of leukemogenic
susceptibility in therapy-related myelodysplasia and leukemia.
Genes Chromosomes Cancer. 2002 Jun;34(2):243-8.
PMID: 11979558 [PubMed - indexed for MEDLINE]
Shipp
MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo
M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA,
Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR.
Diffuse large B-cell lymphoma outcome prediction by gene-expression
profiling and supervised machine learning.
Nat Med. 2002 Jan;8(1):68-74.
PMID: 11786909 [PubMed - indexed for MEDLINE]
Aguiar
RC, Dahia PL.
Identification and characterization of disease-related genes: focus
on endocrine neoplasias.
Front Horm Res. 2001;28:20-49. Review. No abstract available.
PMID: 11443852 [PubMed - indexed for MEDLINE]
Aguiar
RC, Cox G, Pomeroy SL, Dahia PL.
Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma
syndrome (PGL1), in pheochromocytomas.
J Clin Endocrinol Metab. 2001 Jun;86(6):2890-4.
PMID: 11397905 [PubMed - indexed for MEDLINE]
Aguiar
RC, Yakushijin Y, Kharbanda S, Salgia R, Fletcher JA, Shipp MA.
BAL is a novel risk-related gene in diffuse large B-cell lymphomas
that enhances cellular migration.
Blood. 2000 Dec 15;96(13):4328-34.
PMID: 11110709 [PubMed - indexed for MEDLINE]
Aguiar
RC, Yakushijin Y, Kharbanda S, Tiwari S, Freeman GJ, Shipp MA.
PTPROt: an alternatively spliced and developmentally regulated B-lymphoid
phosphatase that promotes G0/G1 arrest.
Blood. 1999 Oct 1;94(7):2403-13.
PMID: 10498613 [PubMed - indexed for MEDLINE]
Carapeti
M, Aguiar RC, Watmore AE, Goldman JM, Cross NC.
Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13).
Cancer Genet Cytogenet. 1999 Aug;113(1):70-2.
PMID: 10459350 [PubMed - indexed for MEDLINE]
Dahia
PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman
A, Stiles C, Eng C.
PTEN is inversely correlated with the cell survival factor Akt/PKB
and is inactivated via multiple mechanismsin haematological malignancies.
Hum Mol Genet. 1999 Feb;8(2):185-93.
PMID: 9931326 [PubMed - indexed for MEDLINE]
Carapeti
M, Aguiar RC, Chase A, Goldman JM, Cross NC.
Assignment of the steroid receptor coactivator-1 (SRC-1) gene to human
chromosome band 2p23.
Genomics. 1998 Sep 1;52(2):242-4. No abstract available.
PMID: 9782096 [PubMed - indexed for MEDLINE]
Carapeti
M, Aguiar RC, Sill H, Goldman JM, Cross NC.
Aberrant transcripts of the FHIT gene are expressed in normal and leukaemic
haemopoietic cells.
Br J Cancer. 1998 Sep;78(5):601-5.
PMID: 9744498 [PubMed - indexed for MEDLINE]
Reiter
A, Sohal J, Kulkarni S, Chase A, Macdonald DH, Aguiar RC, Goncalves C,
Hernandez JM, Jennings BA, Goldman JM, Cross NC.
Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1
in the t(8;13)(p11;q12) myeloproliferative syndrome.
Blood. 1998 Sep 1;92(5):1735-42.
PMID: 9716603 [PubMed - indexed for MEDLINE]
Aguiar
RC.
Therapy-related chronic myeloid leukemia: an epidemiological, clinical
and pathogenetic appraisal.
Leuk Lymphoma. 1998 Mar;29(1-2):17-26. Review. Erratum in: Leuk
Lymphoma 1998 Aug;30(5-6):665.
PMID: 9638972 [PubMed - indexed for MEDLINE]
Carapeti
M, Aguiar RC, Goldman JM, Cross NC.
A novel fusion between MOZ and the nuclear receptor coactivator TIF2
in acute myeloid leukemia.
Blood. 1998 May 1;91(9):3127-33.
PMID: 9558366 [PubMed - indexed for MEDLINE]
Dahia
PL, Aguiar RC, Honegger J, Fahlbush R, Jordan S, Lowe DG, Lu X, Clayton
RN, Besser GM, Grossman AB.
Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting
tumours.
Oncogene. 1998 Jan 8;16(1):69-76.
PMID: 9467944 [PubMed - indexed for MEDLINE]
Aguiar
RC, Chase A, Oscier DG, Carapeti M, Goldman JM, Cross NC.
Characterization of a t(10;12)(q24;p13) in a case of CML in transformation.
Genes Chromosomes Cancer. 1997 Dec;20(4):408-11.
PMID: 9408758 [PubMed - indexed for MEDLINE]
Aguiar
RC, Chase A, Coulthard S, Macdonald DH, Carapeti M, Reiter A, Sohal J,
Lennard A, Goldman JM, Cross NC.
Abnormalities of chromosome band 8p11 in leukemia: two clinical syndromes
can be distinguished on the basis of MOZ involvement.
Blood. 1997 Oct 15;90(8):3130-5.
PMID: 9376594 [PubMed - indexed for MEDLINE]
Aguiar
RC, Sill H, Goldman JM, Cross NC.
The commonly deleted region at 9p21-22 in lymphoblastic leukemias spans
at least 400 kb and includes p16 but not p15 or the IFN gene cluster.
Leukemia. 1997 Feb;11(2):233-8.
PMID: 9009086 [PubMed - indexed for MEDLINE]
Aguiar
RC, Sohal J, van Rhee F, Carapeti M, Franklin IM, Goldstone AH, Goldman
JM, Cross NC.
TEL-AML1 fusion in acute lymphoblastic leukaemia of adults. M.R.C.
Adult Leukaemia Working Party.
Br J Haematol. 1996 Dec;95(4):673-7.
PMID: 8982044 [PubMed - indexed for MEDLINE]
Aguiar
RC, Sill H, Hochhaus A, Goldman JM, Cross NC.
Molecular investigation of secondary chronic myeloid leukemia.
Blood. 1996 Oct 1;88(7):2808-9. No abstract available.
PMID: 8839881 [PubMed - indexed for MEDLINE]
Aguiar
RC, Dahia PL, Sill H, Toledo SP, Goldman JM, Cross NC.
Deletion analysis of the p16 tumour suppressor gene in phaeochromocytomas.
Clin Endocrinol (Oxf). 1996 Jul;45(1):93-6.
PMID: 8796144 [PubMed - indexed for MEDLINE]
Sill
H, Aguiar RC, Schmidt H, Hochhaus A, Goldman JM, Cross NC.
Mutational analysis of the p15 and p16 genes in acute leukaemias.
Br J Haematol. 1996 Mar;92(3):681-3.
PMID: 8616035 [PubMed - indexed for MEDLINE]
Dahia
PL, Aguiar RC, Tsanaclis AM, Bendit I, Bydlowski SP, Abelin NM, Toledo
SP.
Molecular and immunohistochemical analysis of P53 in phaeochromocytoma.
Br J Cancer. 1995 Nov;72(5):1211-3.
PMID: 7577469 [PubMed - indexed for MEDLINE]
Aguiar
RC, Dahia PL, Bendit I, Beitler B, Dorlhiac P, Bydlowski S, Chamone D.
Further evidence for the lack of correlation between the breakpoint
site within M-BCR and CML prognosis and for the occasional involvement
of p53 in transformation.
Cancer Genet Cytogenet. 1995 Oct 15;84(2):105-12.
PMID: 8536222 [PubMed - indexed for MEDLINE]
Macdonald
D, Aguiar RC, Mason PJ, Goldman JM, Cross NC.
A new myeloproliferative disorder associated with chromosomal translocations
involving 8p11: a review.
Leukemia. 1995 Oct;9(10):1628-30. Review.
PMID: 7564500 [PubMed - indexed for MEDLINE]
Aguiar
RC, Macdonald D, Mason PJ, Cross NC, Goldman JM.
Myeloproliferative disorder associated with 8p11 translocations.
Blood. 1995 Jul 15;86(2):834-5. Review. No abstract available.
PMID: 7606017 [PubMed - indexed for MEDLINE]
Aguiar
RC, Beitler B, Dorlhiac-Llacer PE, Chamone DA.
Secondary chronic myelogenous leukemia: a diverse pathogenesis?
Acta Haematol. 1994;92(2):101-3. Review.
PMID: 7817701 [PubMed - indexed for MEDLINE]
Aguiar
RC, Pozzi DH, Chamone DA.
Granulocytic sarcoma of the ovary in a nonleukemic patient.
Haematologica. 1993 Jan-Feb;78(1):53-5.
PMID: 8491421 [PubMed - indexed for MEDLINE]
