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Telephone: (210) 567-2720, FAX: (210)567-2709 , E-mail: asmis@uthscsa.edu.
Role of thiol oxidative stress in macrophage dysfunction associated with cardiovascular disease, inflammation and impaired wound healing.
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Reto Asmis,
Associate Professor, Director of Research Development, Office of the Dean, School of Allied Health; Ph.D., University of Fribourg, Switzerland, 1989.
Telephone: (210) 567-2720, FAX: (210)567-2709 , E-mail: asmis@uthscsa.edu. Role of thiol oxidative stress in macrophage dysfunction associated with cardiovascular disease, inflammation and impaired wound healing. |
Rutkute
K, Asmis RH, Nikolova-Karakashian MN.
Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the
role of oxidative stress in aging-associated inflammation.
J Lipid Res. 2007 Nov;48(11):2443-52. Epub 2007 Aug 10.
PMID: 17693623
Qiao
M, Kisgati M, Cholewa JM, Zhu W, Smart EJ, Sulistio MS, Asmis R.
Increased expression of glutathione reductase in macrophages decreases
atherosclerotic lesion formation in low-density lipoprotein receptor-deficient
mice.
Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1375-82. Epub
2007 Mar 15.
PMID: 17363688
Wang
Y, Qiao M, Mieyal JJ, Asmis LM, Asmis R.
Molecular mechanism of glutathione-mediated protection from oxidized
low-density lipoprotein-induced cell injury in human macrophages: role
of glutathione reductase and glutaredoxin.
Free Radic Biol Med. 2006 Sep 1;41(5):775-85. Epub 2006 Jun
3.
PMID: 16895798
Fanti
P, Asmis R, Stephenson TJ, Sawaya BP, Franke AA.
Positive effect of dietary soy in ESRD patients with systemic inflammation--correlation
between blood levels of the soy isoflavones and the acute-phase reactants.
Nephrol Dial Transplant. 2006 Aug;21(8):2239-46. Epub 2006 Jun
9.
PMID: 16766544
Asmis
R, Qiao M, Rossi RR, Cholewa J, Xu L, Asmis LM.
Adriamycin promotes macrophage dysfunction in mice.
Free Radic Biol Med. 2006 Jul 1;41(1):165-74. Epub 2006 Apr
18.
PMID: 16781464
Thompson
JS, Asmis R, Glass J, Liu H, Wilson C, Nelson B, Brown SA, Stromberg AJ.
P53 status influences regulation of HSPs and ribosomal proteins by
PDTC and radiation.
Biochem Biophys Res Commun. 2006 May 5;343(2):435-42. Epub 2006
Mar 9.
PMID: 16546138
Li
XA, Guo L, Asmis R, Nikolova-Karakashian M, Smart EJ.
Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and
endotoxin-induced death.
Circ Res. 2006 Apr 14;98(7):e60-5. Epub 2006 Mar 30.
PMID: 16574909
Asmis
R, Stevens J, Begley JG, Grimes B, Van Zant G, Fanti P.
The isoflavone genistein inhibits LPS-stimulated TNFalpha, but not
IL-6 expression in monocytes from hemodialysis patients and healthy subjects.
Clin Nephrol. 2006 Apr;65(4):267-75.
PMID: 16629226
Asmis
R, Wang Y, Xu L, Kisgati M, Begley JG, Mieyal JJ.
A novel thiol oxidation-based mechanism for adriamycin-induced cell
injury in human macrophages.
FASEB J. 2005 Nov;19(13):1866-8. Epub 2005 Sep 13.
PMID: 16160061
Asmis
R, Begley JG, Jelk J, Everson WV.
Lipoprotein aggregation protects human monocyte-derived macrophages
from OxLDL-induced cytotoxicity.
J Lipid Res. 2005 Jun;46(6):1124-32. Epub 2005 Mar 16.
PMID: 15772426
Li
XA, Guo L, Dressman JL, Asmis R, Smart EJ.
A novel ligand-independent apoptotic pathway induced by scavenger receptor
class B, type I and suppressed by endothelial nitric-oxide synthase and
high density lipoprotein.
J Biol Chem. 2005 May 13;280(19):19087-96. Epub 2005 Mar 4.
PMID: 15749707
Zhao
Z, de Beer MC, Cai L, Asmis R, de Beer FC, de Villiers WJ, van der Westhuyzen
DR.
Low-density lipoprotein from apolipoprotein E-deficient mice induces
macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent
manner.
Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):168-73. Epub 2004
Oct 28.
PMID: 15514202
Romerio
SC, Linder L, Nyfeler J, Wenk M, Litynsky P, Asmis R, Haefeli WE.
Acute hyperhomocysteinemia decreases NO bioavailability in healthy
adults.
Atherosclerosis. 2004 Oct;176(2):337-44.
PMID: 15380457
Asmis
R, Begley JG.
Oxidized LDL promotes peroxide-mediated mitochondrial dysfunction and
cell death in human macrophages: a caspase-3-independent pathway.
Circ Res. 2003 Jan 10;92(1):e20-9.
PMID: 12522131
Hojo
Y, Saito Y, Tanimoto T, Hoefen RJ, Baines CP, Yamamoto K, Haendeler J,
Asmis R, Berk BC.
Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal
kinase activation via a glutathione reductase-mediated mechanism.
Circ Res. 2002 Oct 18;91(8):712-8.
PMID: 12386148
Bron
D, Asmis R.
Vitamin E and the prevention of atherosclerosis.
Int J Vitam Nutr Res. 2001 Jan;71(1):18-24. Review.
PMID: 11276917
Wintergerst
ES, Jelk J, Rahner C, Asmis R.
Apoptosis induced by oxidized low density lipoprotein in human monocyte-derived
macrophages involves CD36 and activation of caspase-3.
Eur J Biochem. 2000 Oct;267(19):6050-9.
PMID: 10998066
Asmis
R, Jelk J.
Vitamin E supplementation of human macrophages prevents neither foam
cell formation nor increased susceptibility of foam cells to lysis by oxidized
LDL.
Arterioscler Thromb Vasc Biol. 2000 Sep;20(9):2078-86.
PMID: 10978252
Asmis
R, Jelk J.
Large variations in human foam cell formation in individuals: a fully
autologous in vitro assay based on the quantitative analysis of cellular
neutral lipids.
Atherosclerosis. 2000 Feb;148(2):243-53.
PMID: 10657559
Heider
H, Verca SB, Rusconi S, Asmis R.
Comparison of lipid-mediated and adenoviral gene transfer in human
monocyte-derived macrophages and COS-7 cells.
Biotechniques. 2000 Feb;28(2):260-5, 268-70.
PMID: 10683735
Wintergerst
ES, Jelk J, Asmis R.
Differential expression of CD14, CD36 and the LDL receptor on human
monocyte-derived macrophages. A novel cell culture system to study macrophage
differentiation and heterogeneity.
Histochem Cell Biol. 1998 Sep;110(3):231-41.
PMID: 9749957
Asmis
R, Wintergerst ES.
Dehydroascorbic acid prevents apoptosis induced by oxidized low-density
lipoprotein in human monocyte-derived macrophages.
Eur J Biochem. 1998 Jul 1;255(1):147-55.
PMID: 9692913
Asmis
R.
Physical partitioning is the main mechanism of alpha-tocopherol and
cholesterol transfer between lipoproteins and P388D1 macrophage-like cells.
Eur J Biochem. 1997 Dec 1;250(2):600-7.
PMID: 9428715
Asmis
R, Buhler E, Jelk J, Gey KF.
Concurrent quantification of cellular cholesterol, cholesteryl esters
and triglycerides in small biological samples. Reevaluation of thin layer
chromatography using laser densitometry.
J Chromatogr B Biomed Sci Appl. 1997 Mar 28;691(1):59-66.
PMID: 9140758
Asmis
R, Llorente VC, Gey KF.
Prevention of cholesteryl ester accumulation in P388D1 macrophage-like
cells by increased cellular vitamin E depends on species of extracellular
cholesterol. Conventional heterologous non-human cell cultures are poor
models of human atherosclerotic foam cell formation.
Eur J Biochem. 1995 Oct 1;233(1):171-8.
PMID: 7588742
Asmis
R, Dennis EA.
Regulation of prostaglandin E2 production in P388D1 macrophage-like
cells.
Ann N Y Acad Sci. 1994 Nov 15;744:1-10. Review. No abstract
available.
PMID: 7825831
Asmis
R, Dennis EA.
PAF stimulates cAMP formation in P388D1 macrophage-like cells via the
formation and secretion of prostaglandin E2 in an autocrine fashion.
Biochim Biophys Acta. 1994 Nov 10;1224(2):295-301.
PMID: 7981245
Asmis
R, Randriamampita C, Tsien RY, Dennis EA.
Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling
in the stimulation by platelet-activating factor of prostaglandin E2 formation
in P388D1 macrophage-like cells.
Biochem J. 1994 Mar 15;298 Pt 3:543-51.
PMID: 8141766
Glaser
KB, Asmis R, Dennis EA.
PAF receptor mediated PGE2 production in LPS primed P388D1 macrophage-like
cells.
Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:249-55. No
abstract available.
PMID: 1847769
Glaser
KB, Asmis R, Dennis EA.
Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells
for enhanced arachidonic acid metabolism. Platelet-activating factor receptor
activation and regulation of phospholipase A2.
J Biol Chem. 1990 May 25;265(15):8658-64.
PMID: 2160463
Asmis
R, Jorg A.
Calcium-ionophore-induced formation of platelet-activating factor and
leukotrienes by horse eosinophils: a comparative study.
Eur J Biochem. 1990 Feb 14;187(3):475-80.
PMID: 2105886