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Eugenio Cersosimo, Associate
Professor; M.D., Univ. Federal Fluminense, Rio de Janeiro, 1974; Ph.D.,
Vanderbilt, 1984.
Telephone: (210) 358-7200 E-mail:
cersosimo@uthscsa.edu
My research is primarily clinical
and focuses on: i) Glucose Homeostasis and Lipid Metabolism, ii) Insulin
Resistance and Vascular Dysfunction and iii) Diabetes and Cardio-Renal
Complications. The following are the techniques used: Euglycemic, hypoglycemic
and hyperglycemic hyperinsulinemic clamps, transcutaneous skeletal muscle
biopsy with frozen samples for micro-array analyses of insulin signaling
and related pathways, primary cell cultures of skeletal muscle and vascular
smooth muscle cells. In addition, vascular noninvasive studies and
dynamic testing with plethysmography and ultrasonography, continuous glucose
monitoring, intensive insulin therapy and radioisotope dilution technique
are some of the methods employed in our Clinical Research Center. |
Miyazaki
Y, Cersosimo E, Triplitt C, Defronzo RA.
Rosiglitazone decreases albuminuria in type 2 diabetic patients.
Kidney Int. 2007 Dec;72(11):1367-1373. Epub 2007 Sep 5.
PMID: 17805239
Fernandez
M, Triplitt C, Wajcberg E, Sriwijilkamol AA, Musi N, Cusi K, Defronzo R,
Cersosimo E.
Addition of Pioglitazone and Ramipril to Intensive Insulin Therapy
in Type 2 Diabetic Patients Improves Vascular Dysfunction by Different
Mechanisms.
Diabetes Care. 2007 Oct 1; [Epub ahead of print]
PMID: 17909084
Berria
R, Glass L, Mahankali A, Miyazaki Y, Monroy A, De Filippis E, Cusi K, Cersosimo
E, Defronzo RA, Gastaldelli A.
Reduction in hematocrit and hemoglobin following pioglitazone treatment
is not hemodilutional in Type II diabetes mellitus.
Clin Pharmacol Ther. 2007 Sep;82(3):275-81. Epub 2007 Mar 14.
PMID: 17361126
Gastaldelli
A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi
AM, Cersosimo E, Ferrannini E, Defronzo RA.
Relationship between hepatic/visceral fat and hepatic insulin resistance
in nondiabetic and type 2 diabetic subjects.
Gastroenterology. 2007 Aug;133(2):496-506. Epub 2007 May 1.
PMID: 17681171
Cusi
K, Kashyap S, Gastaldelli A, Bajaj M, Cersosimo E.
Effects on insulin secretion and insulin action of a 48-h reduction
of plasma free fatty acids with acipimox in nondiabetic subjects genetically
predisposed to type 2 diabetes.
Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1775-81. Epub
2007 Feb 13.
PMID: 17299078
Wajcberg
E, Sriwijitkamol A, Musi N, DeFronzo RA, Cersosimo E.
Relationship between vascular reactivity and lipids in Mexican-Americans
with type 2 diabetes treated with pioglitazone.
J Clin Endocrinol Metab. 2007 Apr;92(4):1256-62. Epub 2007 Jan
23.
PMID: 17244785
Sriwijitkamol
A, Coletta DK, Wajcberg E, Balbontin GB, Reyna SM, Barrientes J, Eagan
PA, Jenkinson CP, Cersosimo E, DeFronzo RA, Sakamoto K, Musi N.
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects
with type 2 diabetes: a time-course and dose-response study.
Diabetes. 2007 Mar;56(3):836-48.
PMID: 17327455
Wajcberg
E, Thoppil N, Patel S, Fernandez M, Hale D, DeFronzo R, Cersosimo E.
Comprehensive assessment of postischemic vascular reactivity in Hispanic
children and adults with and without diabetes mellitus.
Pediatr Diabetes. 2006 Dec;7(6):329-35.
PMID: 17212600
Triplitt
C, Glass L, Miyazaki Y, Wajcberg E, Gastaldelli A, De Filippis E, Cersosimo
E, DeFronzo RA.
Comparison of glargine insulin versus rosiglitazone addition in poorly
controlled type 2 diabetic patients on metformin plus sulfonylurea.
Diabetes Care. 2006 Nov;29(11):2371-7.
PMID: 17065670
Cersosimo
E, DeFronzo RA.
Insulin resistance and endothelial dysfunction: the road map to cardiovascular
diseases.
Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):423-36. Review.
PMID: 16506274
Wajcberg
E, Miyazaki Y, Triplitt C, Cersosimo E, DeFronzo RA.
Dose-response effect of a single administration of oral hexyl-insulin
monoconjugate 2 in healthy nondiabetic subjects.
Diabetes Care. 2004 Dec;27(12):2868-73.
PMID: 15562199
Bajaj
M, Suraamornkul S, Piper P, Hardies LJ, Glass L, Cersosimo E, Pratipanawatr
T, Miyazaki Y, DeFronzo RA.
Decreased plasma adiponectin concentrations are closely related to
hepatic fat content and hepatic insulin resistance in pioglitazone-treated
type 2 diabetic patients.
J Clin Endocrinol Metab. 2004 Jan;89(1):200-6.
PMID: 14715850
Bajaj
M, Suraamornkul S, Pratipanawatr T, Hardies LJ, Pratipanawatr W, Glass
L, Cersosimo E, Miyazaki Y, DeFronzo RA.
Pioglitazone reduces hepatic fat content and augments splanchnic glucose
uptake in patients with type 2 diabetes.
Diabetes. 2003 Jun;52(6):1364-70.
PMID: 12765945
Cersosimo
E.
To pump or not to pump?
Diabetes Care. 2003 Mar;26(3):967;author reply 967-8. No abstract
available.
PMID: 12610089
Cersosimo
E, Garlick P, Ferretti J.
Abnormal glucose handling by the kidney in response to hypoglycemia
in type 1 diabetes.
Diabetes. 2001 Sep;50(9):2087-93.
PMID: 11522675
Cersosimo
E, Garlick P, Ferretti J.
Renal substrate metabolism and gluconeogenesis during hypoglycemia
in humans.
Diabetes. 2000 Jul;49(7):1186-93.
PMID: 10909977
Cersosimo
E, Garlick P, Ferretti J.
Regulation of splanchnic and renal substrate supply by insulin in humans.
Metabolism. 2000 May;49(5):676-83.
PMID: 10831183
Zaitseva
I, Ajmal M, Cersosimo E.
Application of high-performance liquid chromatography of plasma fatty
acids as their phenacyl esters to evaluate splanchnic and renal fatty acid
balance in vivo.
J Chromatogr B Biomed Sci Appl. 1999 Apr 30;727(1-2):15-22.
PMID: 10360418
Cersosimo
E, Garlick P, Ferretti J.
Renal glucose production during insulin-induced hypoglycemia in humans.
Diabetes. 1999 Feb;48(2):261-6.
PMID: 10334299
Cersosimo
E, Garlick P, Ferretti J.
Insulin regulation of renal glucose metabolism in humans.
Am J Physiol. 1999 Jan;276(1 Pt 1):E78-84.
PMID: 9886953
Cersosimo
E, Zaitseva IN, Ajmal M.
Effects of beta-adrenergic blockade on hepatic and renal glucose production
during hypoglycemia in conscious dogs.
Am J Physiol. 1998 Nov;275(5 Pt 1):E792-7.
PMID: 9814998
Cersosimo
E, Molina PE, Abumrad NN.
Renal lactate metabolism and gluconeogenesis during insulin-induced
hypoglycemia.
Diabetes. 1998 Jul;47(7):1101-6.
PMID: 9648834
Garlick
PJ, Cersosimo E.
Techniques for assessing protein and glucose kinetics.
Baillieres Clin Endocrinol Metab. 1997 Dec;11(4):629-44. Review.
PMID: 9589774
Cersosimo
E, Ajmal M, Naukam RJ, Molina PE, Abumrad NN.
Role of the kidney in plasma glucose regulation during hyperglycemia.
Am J Physiol. 1997 May;272(5 Pt 1):E756-61.
PMID: 9176172
Cersosimo
E, Molina PE, Abumrad NN.
Renal glucose production during insulin-induced hypoglycemia.
Diabetes. 1997 Apr;46(4):643-6. Erratum in: Diabetes 1997 Sep;46(9):1532.
PMID: 9075805
