Jani R, Molina M, Matsuda M, Balas B, Chavez A, Defronzo RA, Abdul-Ghani M.
Decreased Non-Insulin Dependent Glucose Clearance Contributes to the Rise in FPG in the Non-Diabetic Range.
Diabetes Care. 2007 Nov 13; [Epub ahead of print]
PMID: 18000182

Kashyap SR, Lara A, Zhang R, Park YM, Defronzo RA.
Insulin Reduces Plasma Arginase Activity in Type 2 Diabetes Patients.
Diabetes Care. 2007 Oct 10; [Epub ahead of print]
PMID: 17928367

Miyazaki Y, Cersosimo E, Triplitt C, Defronzo RA.
Rosiglitazone decreases albuminuria in type 2 diabetic patients.
Kidney Int. 2007 Dec;72(11):1367-1373. Epub 2007 Sep 5.
PMID: 17805239

Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, Defronzo RA.
Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.
Gastroenterology. 2007 Aug;133(2):496-506. Epub 2007 May 1.
PMID: 17681171

Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, Li C, Deng C, Reyna S, Musi N, Dong LQ, DeFronzo RA, Liu F.
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.
Mol Cell Biol. 2007 Sep;27(18):6497-505. Epub 2007 Jul 9.
PMID: 17620412

Bajaj M, Suraamornkul S, Hardies LJ, Glass L, Musi N, DeFronzo RA.
Effects of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus.
Diabetologia. 2007 Aug;50(8):1723-31. Epub 2007 May 23.
PMID: 17520238

Kashyap SR, Defronzo RA.
The insulin resistance syndrome: physiological considerations.
Diab Vasc Dis Res. 2007 Mar;4(1):13-9. Review.
PMID: 17469039

Coletta DK, Schneider J, Stern MP, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP.
Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.
Obesity (Silver Spring). 2007 Apr;15(4):809-15.
PMID: 17426313

Hendee WR, Banovac F, Carson PL, DeFronzo RA, Eckelman WC, Fullerton GD, Larson SM, McLennan G, Welch MJ.
Biomedical imaging research opportunities workshop IV: a white paper.
Med Phys. 2007 Feb;34(2):673-9.
PMID: 17388185

Abdul-Ghani MA, Williams K, DeFronzo RA, Stern M.
What is the best predictor of future type 2 diabetes?
Diabetes Care. 2007 Jun;30(6):1544-8. Epub 2007 Mar 23.
PMID: 17384342

Berria R, Glass L, Mahankali A, Miyazaki Y, Monroy A, De Filippis E, Cusi K, Cersosimo E, Defronzo RA, Gastaldelli A.
Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus.
Clin Pharmacol Ther. 2007 Sep;82(3):275-81. Epub 2007 Mar 14.
PMID: 17361126

Sriwijitkamol A, Coletta DK, Wajcberg E, Balbontin GB, Reyna SM, Barrientes J, Eagan PA, Jenkinson CP, Cersosimo E, DeFronzo RA, Sakamoto K, Musi N.
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study.
Diabetes. 2007 Mar;56(3):836-48.
PMID: 17327455

Bajaj M, Medina-Navarro R, Suraamornkul S, Meyer C, DeFronzo RA, Mandarino LJ.
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration.
Diabetes. 2007 Mar;56(3):743-52.
PMID: 17327445

Abdul-Ghani M, DeFronzo RA.
Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion.
J Clin Endocrinol Metab. 2007 May;92(5):1778-84. Epub 2007 Feb 27.
PMID: 17327375

Nathan DM, Davidson MB, DeFronzo RA, Heine RJ, Henry RR, Pratley R, Zinman B; American Diabetes Association.
Impaired fasting glucose and impaired glucose tolerance: implications for care.
Diabetes Care. 2007 Mar;30(3):753-9. Review. No abstract available.
PMID: 17327355

Balas B, Baig MR, Watson C, Dunning BE, Ligueros-Saylan M, Wang Y, He YL, Darland C, Holst JJ, Deacon CF, Cusi K, Mari A, Foley JE, DeFronzo RA.
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.
J Clin Endocrinol Metab. 2007 Apr;92(4):1249-55. Epub 2007 Jan 23.
PMID: 17244786

Wajcberg E, Sriwijitkamol A, Musi N, DeFronzo RA, Cersosimo E.
Relationship between vascular reactivity and lipids in Mexican-Americans with type 2 diabetes treated with pioglitazone.
J Clin Endocrinol Metab. 2007 Apr;92(4):1256-62. Epub 2007 Jan 23.
PMID: 17244785

Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA.
Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test.
Diabetes Care. 2007 Jan;30(1):89-94.
PMID: 17192339

Jani R, Triplitt C, Reasner C, Defronzo RA.
First approved inhaled insulin therapy for diabetes mellitus.
Expert Opin Drug Deliv. 2007 Jan;4(1):63-76. Review. Erratum in: Expert Opin Drug Deliv. 2007 Mar;4(2):191.
PMID: 17184163

Mari A, Nielsen LL, Nanayakkara N, DeFronzo RA, Ferrannini E, Halseth A.
Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea.
Horm Metab Res. 2006 Dec;38(12):838-44.
PMID: 17163361

Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA.
Thiazolidinediones improve beta-cell function in type 2 diabetic patients.
Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E871-83. Epub 2006 Nov 14.
PMID: 17106061

Triplitt C, Glass L, Miyazaki Y, Wajcberg E, Gastaldelli A, De Filippis E, Cersosimo E, DeFronzo RA.
Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.
Diabetes Care. 2006 Nov;29(11):2371-7.
PMID: 17065670

Schimmack G, Defronzo RA, Musi N.
AMP-activated protein kinase: Role in metabolism and therapeutic implications.
Diabetes Obes Metab. 2006 Nov;8(6):591-602. Review.
PMID: 17026483

Gastaldelli A, Miyazaki Y, Mahankali A, Berria R, Pettiti M, Buzzigoli E, Ferrannini E, DeFronzo RA.
The effect of pioglitazone on the liver: role of adiponectin.
Diabetes Care. 2006 Oct;29(10):2275-81.
PMID: 17003306

Richardson DK, Schneider J, Fourcaudot MJ, Rodriguez LM, Arya R, Dyer TD, Almasy L, Blangero J, Stern MP, Defronzo RA, Duggirala R, Jenkinson CP.
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Diabetologia. 2006 Oct;49(10):2317-28. Epub 2006 Aug 29.
PMID: 16955209

Pendergrass M, Bertoldo A, Bonadonna R, Nucci G, Mandarino L, Cobelli C, Defronzo RA.
Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals.
Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E92-100. Epub 2006 Aug 8.
PMID: 16896161

Defronzo RA.
Is insulin resistance atherogenic? Possible mechanisms.
Atheroscler Suppl. 2006 Aug;7(4):11-5. Epub 2006 Jun 30. Review. No abstract available.
PMID: 16815101

Civitarese AE, Ukropcova B, Carling S, Hulver M, DeFronzo RA, Mandarino L, Ravussin E, Smith SR.
Role of adiponectin in human skeletal muscle bioenergetics.
Cell Metab. 2006 Jul;4(1):75-87.
PMID: 16814734

Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA.
Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study.
Diabetes. 2006 May;55(5):1430-5.
PMID: 16644701

Abdul-Ghani MA, Tripathy D, DeFronzo RA.
Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose.
Diabetes Care. 2006 May;29(5):1130-9. Review.
PMID: 16644654

Kendall DM, Rubin CJ, Mohideen P, Ledeine JM, Belder R, Gross J, Norwood P, O'Mahony M, Sall K, Sloan G, Roberts A, Fiedorek FT, DeFronzo RA.
Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study.
Diabetes Care. 2006 May;29(5):1016-23.
PMID: 16644631

Arya R, Demerath E, Jenkinson CP, Goring HH, Puppala S, Farook V, Fowler S, Schneider J, Granato R, Resendez RG, Dyer TD, Cole SA, Almasy L, Comuzzie AG, Siervogel RM, Bradshaw B, DeFronzo RA, MacCluer J, Stern MP, Towne B, Blangero J, Duggirala R.
A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies.
Hum Mol Genet. 2006 May 15;15(10):1569-79. Epub 2006 Apr 12.
PMID: 16611675

Cersosimo E, DeFronzo RA.
Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases.
Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):423-36. Review.
PMID: 16506274

Sriwijitkamol A, Christ-Roberts C, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ, Musi N.
Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training.
Diabetes. 2006 Mar;55(3):760-7.
PMID: 16505240

Gastaldelli A, Miyazaki Y, Pettiti M, Santini E, Ciociaro D, Defronzo RA, Ferrannini E.
The effect of rosiglitazone on the liver: decreased gluconeogenesis in patients with type 2 diabetes.
J Clin Endocrinol Metab. 2006 Mar;91(3):806-12. Epub 2005 Dec 13.
PMID: 16352689

Sriwijitkamol A, Ivy JL, Christ-Roberts C, DeFronzo RA, Mandarino LJ, Musi N.
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training.
Am J Physiol Endocrinol Metab. 2006 May;290(5):E925-32. Epub 2005 Dec 13.
PMID: 16352671

Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA.
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes. 2005 Nov;54(11):3148-53.
PMID: 16249438

Abdul-Ghani MA, DeFronzo RA.
To: Godsland IF, Jeffs JA, Johnston DG (2004) loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157-1166.
Diabetologia. 2005 Oct;48(10):2187-8; author reply 2189-90. Epub 2005 Aug 17. No abstract available.
PMID: 16132963

DeFronzo RA, Bergenstal RM, Cefalu WT, Pullman J, Lerman S, Bode BW, Phillips LS; Exubera Phase III Study Group.
Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial.
Diabetes Care. 2005 Aug;28(8):1922-8.
PMID: 16043733

DeFronzo RA.
Dysfunctional fat cells, lipotoxicity and type 2 diabetes.
Int J Clin Pract Suppl. 2004 Oct;(143):9-21. Review.
PMID: 16035392

Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, Defronzo RA, Cusi K.
Dose-response effect of elevated plasma free fatty acid on insulin signaling.
Diabetes. 2005 Jun;54(6):1640-8.
PMID: 15919784

DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD.
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.
Diabetes Care. 2005 May;28(5):1092-100.
PMID: 15855572

Stern SE, Williams K, Ferrannini E, DeFronzo RA, Bogardus C, Stern MP.
Identification of individuals with insulin resistance using routine clinical measurements.
Diabetes. 2005 Feb;54(2):333-9.
PMID: 15677489

Miranda PJ, DeFronzo RA, Califf RM, Guyton JR.
Metabolic syndrome: definition, pathophysiology, and mechanisms.
Am Heart J. 2005 Jan;149(1):33-45. No abstract available.
PMID: 15660032

Miranda PJ, DeFronzo RA, Califf RM, Guyton JR.
Metabolic syndrome: evaluation of pathological and therapeutic outcomes.
Am Heart J. 2005 Jan;149(1):20-32. No abstract available.
PMID: 15660031

Richardson DK, Kashyap S, Bajaj M, Cusi K, Mandarino SJ, Finlayson J, DeFronzo RA, Jenkinson CP, Mandarino LJ.
Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.
J Biol Chem. 2005 Mar 18;280(11):10290-7. Epub 2004 Dec 14.
PMID: 15598661

Wajcberg E, Miyazaki Y, Triplitt C, Cersosimo E, DeFronzo RA.
Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects.
Diabetes Care. 2004 Dec;27(12):2868-73.
PMID: 15562199

Kashyap SR, Roman LJ, Lamont J, Masters BS, Bajaj M, Suraamornkul S, Belfort R, Berria R, Kellogg DL Jr, Liu Y, DeFronzo RA.
Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.
J Clin Endocrinol Metab. 2005 Feb;90(2):1100-5. Epub 2004 Nov 23.
PMID: 15562034

Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA.
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.
J Clin Endocrinol Metab. 2005 Jan;90(1):493-500. Epub 2004 Oct 13.
PMID: 15483086

Bajaj M, Suraamornkul S, Kashyap S, Cusi K, Mandarino L, DeFronzo RA.
Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.
J Clin Endocrinol Metab. 2004 Sep;89(9):4649-55.
PMID: 15356076

Miyazaki Y, Mahankali A, Wajcberg E, Bajaj M, Mandarino LJ, DeFronzo RA.
Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients.
J Clin Endocrinol Metab. 2004 Sep;89(9):4312-9.
PMID: 15356026

DeFronzo RA.
Pathogenesis of type 2 diabetes mellitus.
Med Clin North Am. 2004 Jul;88(4):787-835, ix. Review.
PMID: 15308380

Gastaldelli A, Miyazaki Y, Pettiti M, Buzzigoli E, Mahankali S, Ferrannini E, DeFronzo RA.
Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis.
J Clin Endocrinol Metab. 2004 Aug;89(8):3914-21.
PMID: 15292327

Fanning EL, Selwyn BJ, Larme AC, DeFronzo RA.
Improving efficacy of diabetes management using treatment algorithms in a mainly Hispanic population.
Diabetes Care. 2004 Jul;27(7):1638-46.
PMID: 15220240

Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E.
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Diabetologia. 2004 May;47(5):816-20. Epub 2004 Apr 23.
PMID: 15105989

Bajaj M, Suraamornkul S, Hardies LJ, Pratipanawatr T, DeFronzo RA.
Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients.
Int J Obes Relat Metab Disord. 2004 Jun;28(6):783-9.
PMID: 15024400

Bays H, Mandarino L, DeFronzo RA.
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach.
J Clin Endocrinol Metab. 2004 Feb;89(2):463-78. Review. No abstract available.
PMID: 14764748

Bajaj M, Suraamornkul S, Piper P, Hardies LJ, Glass L, Cersosimo E, Pratipanawatr T, Miyazaki Y, DeFronzo RA.
Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients.
J Clin Endocrinol Metab. 2004 Jan;89(1):200-6.
PMID: 14715850

Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH, Steffes MW; American Diabetes Association.
Nephropathy in diabetes.
Diabetes Care. 2004 Jan;27 Suppl 1:S79-83. No abstract available.
PMID: 14693934

Adams JM 2nd, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, Sullards MC, Mandarino LJ.
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
Diabetes. 2004 Jan;53(1):25-31.
PMID: 14693694

Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA; San Antonio metabolism study.
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study.
Diabetologia. 2004 Jan;47(1):31-9. Epub 2003 Dec 10.
PMID: 14666364

Miyazaki Y, He H, Mandarino LJ, DeFronzo RA.
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.
Diabetes. 2003 Aug;52(8):1943-50.
PMID: 12882909

Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Pettiti M, Natali A, Mari A, DeFronzo RA.
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance.
Diabetologia. 2003 Sep;46(9):1211-9. Epub 2003 Jul 23.
PMID: 12879253

Ferrannini E, Gastaldelli A, Matsuda M, Miyazaki Y, Pettiti M, Glass L, DeFronzo RA.
Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis.
J Clin Endocrinol Metab. 2003 Jul;88(7):3251-7.
PMID: 12843172

Bajaj M, Defronzo RA.
Metabolic and molecular basis of insulin resistance.
J Nucl Cardiol. 2003 May-Jun;10(3):311-23. Review. No abstract available.
PMID: 12794631

Bajaj M, Suraamornkul S, Pratipanawatr T, Hardies LJ, Pratipanawatr W, Glass L, Cersosimo E, Miyazaki Y, DeFronzo RA.
Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes.
Diabetes. 2003 Jun;52(6):1364-70.
PMID: 12765945

Appel GB, Radhakrishnan J, Avram MM, DeFronzo RA, Escobar-Jimenez F, Campos MM, Burgess E, Hille DA, Dickson TZ, Shahinfar S, Brenner BM; RENAAL Study.
Analysis of metabolic parameters as predictors of risk in the RENAAL study.
Diabetes Care. 2003 May;26(5):1402-7.
PMID: 12716796

Duggirala R, Almasy L, Blangero J, Jenkinson CP, Arya R, DeFronzo RA, Stern MP, O'Connell P; American Diabetes Association GENNID Study Group.
Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q.
Genet Epidemiol. 2003 Apr;24(3):240-2. No abstract available.
PMID: 12652528

Miyazaki Y, Pipek R, Mandarino LJ, DeFronzo RA.
Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients.
Int J Obes Relat Metab Disord. 2003 Jan;27(1):88-94.
PMID: 12532159

Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH; American Diabetes Association.
Diabetic nephropathy.
Diabetes Care. 2003 Jan;26 Suppl 1:S94-8. No abstract available.
PMID: 12502629

Miyazaki Y, Glass L, Triplitt C, Wajcberg E, Mandarino LJ, DeFronzo RA.
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus.
Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1135-43.
PMID: 12424102

Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E, DeFronzo RA, Ferrannini E.
Metabolic effects of visceral fat accumulation in type 2 diabetes.
J Clin Endocrinol Metab. 2002 Nov;87(11):5098-103.
PMID: 12414878

Bajaj M, Pratipanawatr T, Berria R, Pratipanawatr W, Kashyap S, Cusi K, Mandarino L, DeFronzo RA.
Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes.
Diabetes. 2002 Oct;51(10):3043-8.
PMID: 12351445

Matsuda M, Defronzo RA, Glass L, Consoli A, Giordano M, Bressler P, Delprato S.
Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.
Metabolism. 2002 Sep;51(9):1111-9.
PMID: 12200754

Bajaj M, Berria R, Pratipanawatr T, Kashyap S, Pratipanawatr W, Belfort R, Cusi K, Mandarino L, DeFronzo RA.
Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans.
Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E346-52.
PMID: 12110541

Miyazaki Y, Mahankali A, Matsuda M, Mahankali S, Hardies J, Cusi K, Mandarino LJ, DeFronzo RA.
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.
J Clin Endocrinol Metab. 2002 Jun;87(6):2784-91.
PMID: 12050251

Lee NA, Matsuda M, Bressler P, Pratipanawatr T, Glass L, Mandarino LJ, DeFronzo RA.
Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects.
Diabetes Obes Metab. 2002 May;4(3):195-200.
PMID: 12047398

Pratipanawatr T, Pratipanawatr W, Rosen C, Berria R, Bajaj M, Cusi K, Mandarino L, Kashyap S, Belfort R, DeFronzo RA.
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects.
Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1360-8.
PMID: 12006367

Miyazaki Y, Matsuda M, DeFronzo RA.
Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes.
Diabetes Care. 2002 Mar;25(3):517-23.
PMID: 11874940

Pratipanawatr T, Cusi K, Ngo P, Pratipanawatr W, Mandarino LJ, DeFronzo RA.
Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes.
Diabetes. 2002 Feb;51(2):462-8.
PMID: 11812756

Miyazaki Y, Glass L, Triplitt C, Matsuda M, Cusi K, Mahankali A, Mahankali S, Mandarino LJ, DeFronzo RA.
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients.
Diabetologia. 2001 Dec;44(12):2210-9.
PMID: 11793023

Pratipanawatr W, Pratipanawatr T, Cusi K, Berria R, Adams JM, Jenkinson CP, Maezono K, DeFronzo RA, Mandarino LJ.
Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.
Diabetes. 2001 Nov;50(11):2572-8.
PMID: 11679436

Reasner CA, Defronzo RA.
Treatment of type 2 diabetes mellitus: a rational approach based on its pathophysiology.
Am Fam Physician. 2001 May 1;63(9):1687-8, 1691-2, 1694. No abstract available.
PMID: 11352280

Cusi KJ, Pratipanawatr T, Koval J, Printz R, Ardehali H, Granner DK, Defronzo RA, Mandarino LJ.
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Metabolism. 2001 May;50(5):602-6.
PMID: 11319725

Miyazaki Y, Mahankali A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA.
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.
Diabetes Care. 2001 Apr;24(4):710-9.
PMID: 11315836

Iozzo P, Pratipanawatr T, Pijl H, Vogt C, Kumar V, Pipek R, Matsuda M, Mandarino LJ, Cusi KJ, DeFronzo RA.
Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.
Am J Physiol Endocrinol Metab. 2001 May;280(5):E712-9.
PMID: 11287353

Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, Redondo JC.
Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes.
J Clin Endocrinol Metab. 2001 Mar;86(3):1410-7.
PMID: 11238540

Pijl H, Ohashi S, Matsuda M, Miyazaki Y, Mahankali A, Kumar V, Pipek R, Iozzo P, Lancaster JL, Cincotta AH, DeFronzo RA.
Bromocriptine: a novel approach to the treatment of type 2 diabetes.
Diabetes Care. 2000 Aug;23(8):1154-61.
PMID: 10937514

DeFronzo RA.
Pharmacologic therapy for type 2 diabetes mellitus.
Ann Intern Med. 2000 Jul 4;133(1):73-4. No abstract available.
PMID: 10877745

Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ.
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
J Clin Invest. 2000 Feb;105(3):311-20.
PMID: 10675357

Giordano M, Castellino P, Ohno A, Defronzo RA.
Differential effects of amino acid and ketoacid on protein metabolism in humans.
Nutrition. 2000 Jan;16(1):15-21.
PMID: 10674229

DeFronzo RA.
Pathogenesis of type 2 diabetes: implications for metformin.
Drugs. 1999;58 Suppl 1:29-30; discussion 75-82. No abstract available.
PMID: 10576522

Matsuda M, Liu Y, Mahankali S, Pu Y, Mahankali A, Wang J, DeFronzo RA, Fox PT, Gao JH.
Altered hypothalamic function in response to glucose ingestion in obese humans.
Diabetes. 1999 Sep;48(9):1801-6.
PMID: 10480611

Matsuda M, DeFronzo RA.
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
Diabetes Care. 1999 Sep;22(9):1462-70.
PMID: 10480510

DeFronzo RA.
Pharmacologic therapy for type 2 diabetes mellitus.
Ann Intern Med. 1999 Aug 17;131(4):281-303. Review.
PMID: 10454950

Koval JA, Maezono K, Patti ME, Pendergrass M, DeFronzo RA, Mandarino LJ.
Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle.
Med Sci Sports Exerc. 1999 Jul;31(7):998-1004.
PMID: 10416561

Kudolo GB, DeFronzo RA.
Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus.
Prostaglandins Other Lipid Mediat. 1999 May;57(2-3):87-98.
PMID: 10410380

Matsuda M, Mandarino L, DeFronzo RA.
Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats.
Metabolism. 1999 Jun;48(6):725-31.
PMID: 10381146

Castellino P, Luzi L, Giordano M, Defronzo RA.
Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients.
J Am Soc Nephrol. 1999 May;10(5):1050-8.
PMID: 10232692

Koopmans SJ, Kushwaha RS, DeFronzo RA.
Chronic physiologic hyperinsulinemia impairs suppression of plasma free fatty acids and increases de novo lipogenesis but does not cause dyslipidemia in conscious normal rats.
Metabolism. 1999 Mar;48(3):330-7.
PMID: 10094109

Diamond MP, Grainger D, Diamond MC, Sherwin RS, Defronzo RA.
Effects of methyltestosterone on insulin secretion and sensitivity in women.
J Clin Endocrinol Metab. 1998 Dec;83(12):4420-5.
PMID: 9851788

Bonadonna RC, Saccomani MP, Del Prato S, Bonora E, DeFronzo RA, Cobelli C.
Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle.
Circulation. 1998 Jul 21;98(3):234-41.
PMID: 9697823

Pendergrass M, Fazioni E, Collins D, DeFronzo RA.
IGF-I increases forearm blood flow without increasing forearm glucose uptake.
Am J Physiol. 1998 Aug;275(2 Pt 1):E345-50.
PMID: 9688638

Koopmans SJ, Leighton B, DeFronzo RA.
Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats.
Diabetologia. 1998 Jul;41(7):813-20.
PMID: 9686923

Koopmans SJ, Frolich M, Gribnau EH, Westendorp RG, DeFronzo RA.
Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats.
Am J Physiol. 1998 Jun;274(6 Pt 1):E998-E1001.
PMID: 9611148

Koopmans SJ, Mandarino L, DeFronzo RA.
Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats.
Am J Physiol. 1998 Apr;274(4 Pt 1):E642-50.
PMID: 9575825

Pendergrass M, Koval J, Vogt C, Yki-Jarvinen H, Iozzo P, Pipek R, Ardehali H, Printz R, Granner D, DeFronzo RA, Mandarino LJ.
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Diabetes. 1998 Mar;47(3):387-94.
PMID: 9519744

Koval JA, DeFronzo RA, O'Doherty RM, Printz R, Ardehali H, Granner DK, Mandarino LJ.
Regulation of hexokinase II activity and expression in human muscle by moderate exercise.
Am J Physiol. 1998 Feb;274(2 Pt 1):E304-8.
PMID: 9486162

Kudolo GB, Bressler P, DeFronzo RA.
Plasma PAF acetylhydrolase in non-insulin dependent diabetes mellitus and obesity: effect of hyperinsulinemia and lovastatin treatment.
J Lipid Mediat Cell Signal. 1997 Nov;17(2):97-113.
PMID: 9459136

Giordano M, Castellino P, Solini A, Canessa ML, DeFronzo RA.
Na+/Li+ and Na+/H+ countertransport activity in hypertensive non-insulin-dependent diabetic patients: role of insulin resistance and antihypertensive treatment.
Metabolism. 1997 Nov;46(11):1316-23.
PMID: 9361692

Gulli G, Rossetti L, DeFronzo RA.
Hyperamylinemia is associated with hyperinsulinemia in the glucose-tolerant, insulin-resistant offspring of two Mexican-American non-insulin-dependent diabetic parents.
Metabolism. 1997 Oct;46(10):1157-61.
PMID: 9322799

Koopmans SJ, Ohman L, Haywood JR, Mandarino LJ, DeFronzo RA.
Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats.
Diabetes. 1997 Oct;46(10):1572-8.
PMID: 9313752

Solini A, Bonora E, Bonadonna R, Castellino P, DeFronzo RA.
Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue.
J Clin Endocrinol Metab. 1997 Aug;82(8):2552-8.
PMID: 9253333

Del Prato S, Matsuda M, Simonson DC, Groop LC, Sheehan P, Leonetti F, Bonadonna RC, DeFronzo RA.
Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance.
Diabetologia. 1997 Jun;40(6):687-97.
PMID: 9222649

DeFronzo RA.
Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis.
Neth J Med. 1997 May;50(5):191-7. Review.
PMID: 9175399

Kudolo GB, Koopmans SJ, Haywood JR, DeFronzo RA.
Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney.
J Lipid Mediat Cell Signal. 1997 May;16(1):23-37.
PMID: 9101420

Bahl JJ, Matsuda M, DeFronzo RA, Bressler R.
In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase.
Biochem Pharmacol. 1997 Jan 10;53(1):67-74.
PMID: 8960065

Yki-Jarvinen H, Vogt C, Iozzo P, Pipek R, Daniels MC, Virkamaki A, Makimattila S, Mandarino L, DeFronzo RA, McClain D, Gottschalk WK.
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
Diabetologia. 1997 Jan;40(1):76-81.
PMID: 9028721

Bressler P, Bailey SR, Matsuda M, DeFronzo RA.
Insulin resistance and coronary artery disease.
Diabetologia. 1996 Nov;39(11):1345-50. Erratum in: Diabetologia 1997 Mar;40(3):366.
PMID: 8933003

Cusi K, Consoli A, DeFronzo RA.
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
J Clin Endocrinol Metab. 1996 Nov;81(11):4059-67.
PMID: 8923861

DeFronzo RA, Prato SD.
Insulin resistance and diabetes mellitus.
J Diabetes Complications. 1996 Sep-Oct;10(5):243-5. Review. No abstract available.
PMID: 8887011

Raffel LJ, Robbins DC, Norris JM, Boerwinkle E, DeFronzo RA, Elbein SC, Fujimoto W, Hanis CL, Kahn SE, Permutt MA, Chiu KC, Cruz J, Ehrmann DA, Robertson RP, Rotter JI, Buse J.
The GENNID Study. A resource for mapping the genes that cause NIDDM.
Diabetes Care. 1996 Aug;19(8):864-72.
PMID: 8842605

Bonadonna RC, Del Prato S, Bonora E, Saccomani MP, Gulli G, Natali A, Frascerra S, Pecori N, Ferrannini E, Bier D, Cobelli C, DeFronzo RA.
Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM.
Diabetes. 1996 Jul;45(7):915-25.
PMID: 8666143

Reasner CA, DeFronzo RA.
Diabetic nephropathy--can it be prevented?
Endocr Pract. 1996 May-Jun;2(3):205-8. No abstract available.
PMID: 15251542

Yki-Järvinen H, Daniels MC, Virkamaki A, Makimattila S, DeFronzo RA, McClain D.
Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM.
Diabetes. 1996 Mar;45(3):302-7.
PMID: 8593934

Luzi L, Castellino P, DeFronzo RA.
Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity.
Am J Physiol. 1996 Feb;270(2 Pt 1):E273-81.
PMID: 8779949

Giordano M, Sanders LR, Castellino P, Canessa ML, DeFronzo RA.
Effect of alpha-adrenergic blockers, ACE inhibitors, and calcium channel antagonists on renal function in hypertensive non-insulin-dependent diabetic patients.
Nephron. 1996;72(3):447-53.
PMID: 8852495

Saccomani MP, Bonadonna RC, Bier DM, DeFronzo RA, Cobelli C.
A model to measure insulin effects on glucose transport and phosphorylation in muscle: a three-tracer study.
Am J Physiol. 1996 Jan;270(1 Pt 1):E170-85.
PMID: 8772490

Bonora E, Micciolo R, Ghiatas AA, Lancaster JL, Alyassin A, Muggeo M, DeFronzo RA.
Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements?
Metabolism. 1995 Dec;44(12):1617-25.
PMID: 8786733

Barzilai N, Groop PH, Groop L, DeFronzo RA.
A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin.
Acta Diabetol. 1995 Dec;32(4):273-8.
PMID: 8750768

Mandarino LJ, Printz RL, Cusi KA, Kinchington P, O'Doherty RM, Osawa H, Sewell C, Consoli A, Granner DK, DeFronzo RA.
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.
Am J Physiol. 1995 Oct;269(4 Pt 1):E701-8. Erratum in: Am J Physiol 1996 Jan;270(1 Pt 1):section E followi.
PMID: 7485484

Diamond MP, Thornton K, Connolly-Diamond M, Sherwin RS, DeFronzo RA.
Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance.
J Soc Gynecol Investig. 1995 Sep-Oct;2(5):708-15.
PMID: 9420879

DeFronzo RA, Goodman AM.
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.
N Engl J Med. 1995 Aug 31;333(9):541-9.
PMID: 7623902

Thornton KL, DeFronzo RA, Sherwin RS, Diamond MP.
Micronized estradiol and progesterone: effects on carbohydrate metabolism in reproductive-age women.
J Soc Gynecol Investig. 1995 Jul-Aug;2(4):643-52.
PMID: 9420871

Saccomani MP, Bonadonna RC, Caveggion E, DeFronzo RA, Cobelli C.
Bicarbonate kinetics in humans: identification and validation of a three-compartment model.
Am J Physiol. 1995 Jul;269(1 Pt 1):E183-92.
PMID: 7631775

Giordano M, Matsuda M, Sanders L, Canessa ML, DeFronzo RA.
Effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists, and alpha-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension.
Diabetes. 1995 Jun;44(6):665-71.
PMID: 7789631

Giordano M, Castellino P, Carroll CA, DeFronzo RA.
Comparison of the effects of human recombinant insulin-like growth factor I and insulin on plasma amino acid concentrations and leucine kinetics in humans.
Diabetologia. 1995 Jun;38(6):732-8.
PMID: 7672498

Del Prato S, Riccio A, Vigili de Kreutzenberg S, Dorella M, Tiengo A, DeFronzo RA.
Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptake.
Am J Physiol. 1995 Jun;268(6 Pt 1):E1089-95.
PMID: 7611383

Bonora E, Gulli G, Bonadonna R, Del Prato S, Solini A, DeFronzo RA.
Insulin sensitivity is not impaired in Mexican-American women without a family history of diabetes.
Diabetes Care. 1995 Jun;18(6):825-33.
PMID: 7555509

Shank ML, Del Prato S, DeFronzo RA.
Bedtime insulin/daytime glipizide. Effective therapy for sulfonylurea failures in NIDDM.
Diabetes. 1995 Feb;44(2):165-72.
PMID: 7859936

Giordano M, DeFronzo RA.
Acute effect of human recombinant insulin-like growth factor I on renal function in humans.
Nephron. 1995;71(1):10-5.
PMID: 8538827

Giordano M, Castellino P, McConnell EL, DeFronzo RA.
Effect of amino acid infusion on renal hemodynamics in humans: a dose-response study.
Am J Physiol. 1994 Nov;267(5 Pt 2):F703-8.
PMID: 7977774

Mari A, Wahren J, DeFronzo RA, Ferrannini E.
Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods.
Metabolism. 1994 Nov;43(11):1419-25.
PMID: 7968597

DeFronzo RA, Reasner C.
The Diabetes Control and Complications Trial Study: implications for the diabetic foot.
J Foot Ankle Surg. 1994 Nov-Dec;33(6):551-6. Review.
PMID: 7894400

Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA.
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man.
Diabetologia. 1994 Oct;37(10):1025-35.
PMID: 7851681

Petrides AS, Luzi L, DeFronzo RA.
Time-dependent regulation by insulin of leucine metabolism in young healthy adults.
Am J Physiol. 1994 Sep;267(3 Pt 1):E361-8.
PMID: 7943216

Bonadonna RC, Groop LC, Simonson DC, DeFronzo RA.
Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle.
Am J Physiol. 1994 Mar;266(3 Pt 1):E501-9.
PMID: 8166272

Barrett EJ, Bevilacqua S, DeFronzo RA, Ferrannini E.
Glycogen turnover during refeeding in the postabsorptive dog: implications for the estimation of glycogen formation using tracer methods.
Metabolism. 1994 Mar;43(3):285-92.
PMID: 8139475

Castellino P, Tuttle KR, DeFronzo RA.
Diabetic nephropathy.
Curr Ther Endocrinol Metab. 1994;5:426-36. No abstract available.
PMID: 7704768

Bonadonna RC, del Prato S, Bonora E, Gulli G, Solini A, DeFronzo RA.
Effects of physiological hyperinsulinemia on the intracellular metabolic partition of plasma glucose.
Am J Physiol. 1993 Dec;265(6 Pt 1):E943-53.
PMID: 8279550

Bonadonna RC, Del Prato S, Saccomani MP, Bonora E, Gulli G, Ferrannini E, Bier D, Cobelli C, DeFronzo RA.
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.
J Clin Invest. 1993 Jul;92(1):486-94.
PMID: 8326013

Diamond MP, Jacob R, Connolly-Diamond M, DeFronzo RA.
Glucose metabolism during the menstrual cycle. Assessment with the euglycemic, hyperinsulinemic clamp.
J Reprod Med. 1993 Jun;38(6):417-21.
PMID: 8331618

Bonora E, Bonadonna RC, Del Prato S, Gulli G, Solini A, Matsuda M, DeFronzo RA.
In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension.
Diabetes. 1993 May;42(5):764-72.
PMID: 8482434

Saloranta C, Koivisto V, Widén E, Falholt K, DeFronzo RA, Härkönen M, Groop L.
Contribution of muscle and liver to glucose-fatty acid cycle in humans.
Am J Physiol. 1993 Apr;264(4 Pt 1):E599-605.
PMID: 8476039

Bonadonna RC, Saccomani MP, Cobelli C, DeFronzo RA.
Effect of insulin on system A amino acid transport in human skeletal muscle.
J Clin Invest. 1993 Feb;91(2):514-21.
PMID: 8432860

Del Prato S, Bonadonna RC, Bonora E, Gulli G, Solini A, Shank M, DeFronzo RA.
Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.
J Clin Invest. 1993 Feb;91(2):484-94.
PMID: 8432857

Bonadonna RC, Saccomani MP, Seely L, Zych KS, Ferrannini E, Cobelli C, DeFronzo RA.
Glucose transport in human skeletal muscle. The in vivo response to insulin.
Diabetes. 1993 Jan;42(1):191-8.
PMID: 8093605

Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo RA.
The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents.
Diabetes. 1992 Dec;41(12):1575-86.
PMID: 1446799

Groop LC, Bonadonna RC, Simonson DC, Petrides AS, Shank M, DeFronzo RA.
Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.
Am J Physiol. 1992 Jul;263(1 Pt 1):E79-84.
PMID: 1636701

DeFronzo RA.
Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview.
Diabetologia. 1992 Apr;35(4):389-97. Review. No abstract available.
PMID: 1516769

DeFronzo RA, Bonadonna RC, Ferrannini E.
Pathogenesis of NIDDM. A balanced overview.
Diabetes Care. 1992 Mar;15(3):318-68.
PMID: 1532777

Castellino P, Solini A, Luzi L, Barr JG, Smith DJ, Petrides A, Giordano M, Carroll C, DeFronzo RA.
Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids.
Am J Physiol. 1992 Feb;262(2 Pt 2):F168-76.
PMID: 1539681

Frontoni S, Ohman L, Haywood JR, DeFronzo RA, Rossetti L.
In vivo insulin action in genetic models of hypertension.
Am J Physiol. 1992 Feb;262(2 Pt 1):E191-6.
PMID: 1539644

Mak RH, DeFronzo RA.
Glucose and insulin metabolism in uremia.
Nephron. 1992;61(4):377-82. Review. No abstract available.
PMID: 1501732

Petrides AS, Strohmeyer G, DeFronzo RA.
Insulin resistance in liver disease and portal hypertension.
Prog Liver Dis. 1992;10:311-28. Review. No abstract available.
PMID: 1296234

DeFronzo RA.
Insulin resistance, hyperinsulinemia, and coronary artery disease: a complex metabolic web.
J Cardiovasc Pharmacol. 1992;20 Suppl 11:S1-16. Review.
PMID: 1284137

DeFronzo RA, Barzilai N, Simonson DC.
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.
J Clin Endocrinol Metab. 1991 Dec;73(6):1294-301.
PMID: 1955512

Petrides AS, Luzi L, Reuben A, Riely C, DeFronzo RA.
Effect of insulin and plasma amino acid concentration on leucine metabolism in cirrhosis.
Hepatology. 1991 Sep;14(3):432-41.
PMID: 1874488

Groop LC, Barzilai N, Ratheiser K, Luzi L, WÃ¥hlin-Boll E, Melander A, DeFronzo RA.
Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans.
Diabetes Care. 1991 Aug;14(8):724-7.
PMID: 1954808

Petrides AS, Groop LC, Riely CA, DeFronzo RA.
Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis.
J Clin Invest. 1991 Aug;88(2):561-70.
PMID: 1864966

Tuttle KR, Bruton JL, Perusek MC, Lancaster JL, Kopp DT, DeFronzo RA.
Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus.
N Engl J Med. 1991 Jun 6;324(23):1626-32. Erratum in: N Engl J Med 1991 Dec 5;325(23):1666.
PMID: 2030719

Shulman GI, DeFronzo RA, Rossetti L.
Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion.
Am J Physiol. 1991 May;260(5 Pt 1):E731-5.
PMID: 2035629

Lancaster JL, Ghiatas AA, Alyassin A, Kilcoyne RF, Bonora E, DeFronzo RA.
Measurement of abdominal fat with T1-weighted MR images.
J Magn Reson Imaging. 1991 May-Jun;1(3):363-9.
PMID: 1802150

Rossetti L, Frontoni S, Dimarchi R, DeFronzo RA, Giaccari A.
Metabolic effects of IGF-I in diabetic rats.
Diabetes. 1991 Apr;40(4):444-8.
PMID: 2010044

Diamond MP, Grainger DA, Laudano AJ, Starick-Zych K, DeFronzo RA.
Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women.
J Clin Endocrinol Metab. 1991 Apr;72(4):883-7.
PMID: 1826009

DeFronzo RA, Ferrannini E.
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.
Diabetes Care. 1991 Mar;14(3):173-94. Review.
PMID: 2044434

Tuttle KR, DeFronzo RA, Stein JH.
Treatment of diabetic nephropathy: a rational approach based on its pathophysiology.
Semin Nephrol. 1991 Mar;11(2):220-35. Review. No abstract available.
PMID: 1674623

Kahn BB, Shulman GI, DeFronzo RA, Cushman SW, Rossetti L.
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.
J Clin Invest. 1991 Feb;87(2):561-70.
PMID: 1991839

Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA.
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus.
J Clin Endocrinol Metab. 1991 Jan;72(1):96-107.
PMID: 1986032

Groop LC, Bonadonna RC, Shank M, Petrides AS, DeFronzo RA.
Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man.
J Clin Invest. 1991 Jan;87(1):83-9.
PMID: 1985114

Petrides AS, Riely CA, DeFronzo RA.
Insulin resistance in noncirrhotic idiopathic portal hypertension.
Gastroenterology. 1991 Jan;100(1):245-51.
PMID: 1983828

Groop LC, Ratheiser K, Luzi L, Melander A, Simonson DC, Petrides A, Bonadonna RC, Widen E, DeFronzo RA.
Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: a dose-response study.
Acta Diabetol. 1991;28(2):162-8.
PMID: 1777653

Bonadonna RC, Groop LC, Zych K, Shank M, DeFronzo RA.
Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans.
Am J Physiol. 1990 Nov;259(5 Pt 1):E736-50.
PMID: 2240211

Ferrannini E, Katz LD, Glickman MG, Defronzo RA.
Influence of combined intravenous and oral glucose administration on splanchnic glucose uptake in man.
Clin Physiol. 1990 Nov;10(6):527-38.
PMID: 2083480

Castellino P, DeFronzo RA.
Glucose metabolism and the kidney.
Semin Nephrol. 1990 Sep;10(5):458-63. Review.
PMID: 2236987

Groop LC, Bonadonna R, DelPrato S, Ratheiser K, DeFronzo RA.
Effect of prolonged overnight fasting on energy metabolism in non-insulin-dependent diabetic and non-diabetic subjects.
Acta Endocrinol (Copenh). 1990 Jul;123(1):30-6.
PMID: 2202174

Rossetti L, Giaccari A, DeFronzo RA.
Glucose toxicity.
Diabetes Care. 1990 Jun;13(6):610-30. Review.
PMID: 2192847

Castellino P, Shohat J, DeFronzo RA.
Hyperfiltration and diabetic nephropathy: is it the beginning? Or is it the end?
Semin Nephrol. 1990 May;10(3):228-41. Review.
PMID: 2190280

Tuttle KR, Stein JH, DeFronzo RA.
The natural history of diabetic nephropathy.
Semin Nephrol. 1990 May;10(3):184-93. Review.
PMID: 2190276

Bonadonna RC, Groop L, Kraemer N, Ferrannini E, Del Prato S, DeFronzo RA.
Obesity and insulin resistance in humans: a dose-response study.
Metabolism. 1990 May;39(5):452-9.
PMID: 2186255

Del Prato S, DeFronzo RA, Castellino P, Wahren J, Alvestrand A.
Regulation of amino acid metabolism by epinephrine.
Am J Physiol. 1990 May;258(5 Pt 1):E878-87.
PMID: 1970711

Castellino P, Levin R, Shohat J, DeFronzo RA.
Effect of specific amino acid groups on renal hemodynamics in humans.
Am J Physiol. 1990 Apr;258(4 Pt 2):F992-7.
PMID: 2330990

Rossetti L, DeFronzo RA, Gherzi R, Stein P, Andraghetti G, Falzetti G, Shulman GI, Klein-Robbenhaar E, Cordera R.
Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations.
Metabolism. 1990 Apr;39(4):425-35.
PMID: 2157941

Cordera R, Andraghetti G, DeFronzo RA, Rossetti L.
Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats.
Endocrinology. 1990 Apr;126(4):2177-83.
PMID: 2156685

Groop L, Makipernaa A, Stenman S, DeFronzo RA, Teppo AM.
Urinary excretion of kappa light chains in patients with diabetes mellitus.
Kidney Int. 1990 Apr;37(4):1120-5.
PMID: 2111417

Simonson DC, DeFronzo RA.
Indirect calorimetry: methodological and interpretative problems.
Am J Physiol. 1990 Mar;258(3 Pt 1):E399-412. Review.
PMID: 2180312

Castellino P, Bia MJ, DeFronzo RA.
Adrenergic modulation of potassium metabolism in uremia.
Kidney Int. 1990 Feb;37(2):793-8.
PMID: 2308263

Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG.
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.
N Engl J Med. 1990 Jan 25;322(4):223-8.
PMID: 2403659

Luzi L, Castellino P, Simonson DC, Petrides AS, DeFronzo RA.
Leucine metabolism in IDDM. Role of insulin and substrate availability.
Diabetes. 1990 Jan;39(1):38-48.
PMID: 2210059

Castellino P, Luzi L, Del Prato S, DeFronzo RA.
Dissociation of the effects of epinephrine and insulin on glucose and protein metabolism.
Am J Physiol. 1990 Jan;258(1 Pt 1):E117-25.
PMID: 2105656