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Andrew P. Hinck,
Professor; Ph.D., University of Wisconsin, Madison, 1993.
Telephone: (210) 567-8780 E-mail: hinck@uthscsa.edu www: http://hincklab.uthscsa.edu Solution NMR spectroscopy of proteins and nucleic acids; transforming growth factor b and its interaction with the ligand binding domain of the TGF-b type I and type II receptors; protein-RNA interactions. |
Chang
SL, Hinck AP, Ishima R.
Model-free analysis for large proteins at high magnetic field strengths.
J Biomol NMR. 2007 Aug;38(4):315-24. Epub 2007 Jun 26.
PMID: 17593525
De
Crescenzo G, Hinck CS, Shu Z, Zuniga J, Yang J, Tang Y, Baardsnes J, Mendoza
V, Sun L, Lopez-Casillas F, O'Connor-McCourt M, Hinck AP.
Three key residues underlie the differential affinity of the TGFbeta
isoforms for the TGFbeta type II receptor.
J Mol Biol. 2006 Jan 6;355(1):47-62. Epub 2005 Nov 2. Erratum
in: J Mol Biol. 2006 Jun 2;359(2):508.
PMID: 16300789
Zuniga
JE, Groppe JC, Cui Y, Hinck CS, Contreras-Shannon V, Pakhomova ON, Yang
J, Tang Y, Mendoza V, López-Casillas F, Sun L, Hinck AP.
Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with
receptor extracellular domains is cooperative and isoform-dependent.
J Mol Biol. 2005 Dec 16;354(5):1052-68. Epub 2005 Oct 27.
PMID: 16289576
Yin
H, Ilangovan U, Hinck AP, Lee JC.
Sequential resonance assignment of the human BMP type II receptor extracellular
domain.
J Biomol NMR. 2005 Aug;32(4):336. No abstract available.
PMID: 16211489
Ilangovan
U, Ding W, Zhong Y, Wilson CL, Groppe JC, Trbovich JT, Zuniga J, Demeler
B, Tang Q, Gao G, Mulder KM, Hinck AP.
Structure and dynamics of the homodimeric dynein light chain km23.
J Mol Biol. 2005 Sep 16;352(2):338-54.
PMID: 16083906 [PubMed - indexed for MEDLINE]
Yin
J, Huang Q, Pakhomova ON, Hinck AP, Zwieb C.
The conserved adenosine in helix 6 of Archaeoglobus fulgidus signal
recognition particle RNA initiates SRP assembly.
Archaea. 2004 Oct;1(4):269-75.
PMID: 15810437 [PubMed - indexed for MEDLINE]
Borges
CR, Qi J, Wu W, Torng E, Hinck AP, Watson JT.
Algorithm-assisted elucidation of disulfide structure: application
of the negative signature mass algorithm to mass-mapping the disulfide
structure of the 12-cysteine transforming growth factor beta type II receptor
extracellular domain.
Anal Biochem. 2004 Jun 1;329(1):91-103. Erratum in: Anal Biochem.
2005 Jun 15;341(2):388.
PMID: 15136171 [PubMed - indexed for MEDLINE]
Ilangovan
U, Deep S, Hinck CS, Hinck AP.
Sequential resonance assignments of the extracellular domain of the
human TGFbeta type II receptor in complex with monomeric TGFbeta3.
J Biomol NMR. 2004 May;29(1):103-4. No abstract available.
PMID: 15017149 [PubMed - indexed for MEDLINE]
Deep
S, Walker KP 3rd, Shu Z, Hinck AP.
Solution structure and backbone dynamics of the TGFbeta type II receptor
extracellular domain.
Biochemistry. 2003 Sep 2;42(34):10126-39.
PMID: 12939140 [PubMed - indexed for MEDLINE]
Pakhomova
ON, Deep S, Huang Q, Zwieb C, Hinck AP.
Solution structure of protein SRP19 of Archaeoglobus fulgidus signal
recognition particle.
J Mol Biol. 2002 Mar 15;317(1):145-58.
PMID: 11916385 [PubMed - indexed for MEDLINE]
Benavides-Garcia
MG, Rivera EV, Ramos W, Hinck AP, Nall BT.
Backbone sequential resonance assignments of yeast iso-2 cytochrome
c, reduced and oxidized forms.
J Biomol NMR. 2002 Jan;22(1):93-4. No abstract available.
PMID: 11885986 [PubMed - indexed for MEDLINE]
Hart
PJ, Deep S, Taylor AB, Shu Z, Hinck CS, Hinck AP.
Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.
Nat Struct Biol. 2002 Mar;9(3):203-8.
PMID: 11850637 [PubMed - indexed for MEDLINE]
Miller
RT, Hinck AP.
Characterization of hydride transfer to flavin adenine dinucleotide
in neuronal nitric oxide synthase reductase domain: geometric relationship
between the nicotinamide and isoalloxazine rings.
Arch Biochem Biophys. 2001 Nov 1;395(1):129-35.
PMID: 11673874 [PubMed - indexed for MEDLINE]
Pakhomova
ON, Cui Y, Zwieb C, Hinck AP.
Sequence-specific 1H, 13C and 15N signal assignments and secondary
structure of archaeoglobusfulgidus SRP19.
J Biomol NMR. 2001 Jun;20(2):187-8. No abstract available.
PMID: 11495253 [PubMed - indexed for MEDLINE]
Bhuiyan
SH, Pakhomova ON, Hinck AP, Zwieb C.
Complexes with truncated RNAs from the large domain of Archaeoglobus
fulgidus signal recognition particle.
FEMS Microbiol Lett. 2001 May 1;198(2):105-10.
PMID: 11430398 [PubMed - indexed for MEDLINE]
Hinck
AP, Walker KP 3rd, Martin NR, Deep S, Hinck CS, Freedberg DI.
Sequential resonance assignments of the extracellular ligand binding
domain of the human TGF-beta type II receptor.
J Biomol NMR. 2000 Dec;18(4):369-70. No abstract available.
PMID: 11200535 [PubMed - indexed for MEDLINE]
Hinck
AP, Markus MA, Huang S, Grzesiek S, Kustonovich I, Draper DE, Torchia DA.
The RNA binding domain of ribosomal protein L11: three-dimensional
structure of the RNA-bound form of the protein and its interaction with
23 S rRNA.
J Mol Biol. 1997 Nov 21;274(1):101-13.
PMID: 9398519 [PubMed - indexed for MEDLINE]
Markus
MA, Hinck AP, Huang S, Draper DE, Torchia DA.
High resolution solution structure of ribosomal protein L11-C76, a
helical protein with a flexible loop that becomes structured upon binding
to RNA.
Nat Struct Biol. 1997 Jan;4(1):70-7.
PMID: 8989327 [PubMed - indexed for MEDLINE]
Qian
SW, Burmester JK, Tsang ML, Weatherbee JA, Hinck AP, Ohlsen DJ, Sporn MB,
Roberts AB.
Binding affinity of transforming growth factor-beta for its type II
receptor is determined by the C-terminal region of the molecule.
J Biol Chem. 1996 Nov 29;271(48):30656-62.
PMID: 8940041 [PubMed - indexed for MEDLINE]
Hinck
AP, Truckses DM, Markley JL.
Engineered disulfide bonds in staphylococcal nuclease: effects on the
stability and conformation of the folded protein.
Biochemistry. 1996 Aug 13;35(32):10328-38.
PMID: 8756688 [PubMed - indexed for MEDLINE]
Hinck
AP, Archer SJ, Qian SW, Roberts AB, Sporn MB, Weatherbee JA, Tsang ML,
Lucas R, Zhang BL, Wenker J, Torchia DA.
Transforming growth factor beta 1: three-dimensional structure in solution
and comparison with the X-ray structure of transforming growth factor beta
2.
Biochemistry. 1996 Jul 2;35(26):8517-34.
PMID: 8679613 [PubMed - indexed for MEDLINE]
Yamazaki
T, Hinck AP, Wang YX, Nicholson LK, Torchia DA, Wingfield P, Stahl SJ,
Kaufman JD, Chang CH, Domaille PJ, Lam PY.
Three-dimensional solution structure of the HIV-1 protease complexed
with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear
magnetic resonance spectroscopy.
Protein Sci. 1996 Mar;5(3):495-506.
PMID: 8868486 [PubMed - indexed for MEDLINE]
Hinck
AP, Eberhardt ES, Markley JL.
NMR strategy for determining Xaa-Pro peptide bond configurations in
proteins: mutants of staphylococcal nuclease with altered configuration
at proline-117.
Biochemistry. 1993 Nov 9;32(44):11810-8.
PMID: 8218252 [PubMed - indexed for MEDLINE]
Royer
CA, Hinck AP, Loh SN, Prehoda KE, Peng X, Jonas J, Markley JL.
Effects of amino acid substitutions on the pressure denaturation of
staphylococcal nuclease as monitored by fluorescence and nuclear magnetic
resonance spectroscopy.
Biochemistry. 1993 May 18;32(19):5222-32.
PMID: 8494899 [PubMed - indexed for MEDLINE]
Hinck
AP, Walkenhorst WF, Westler WM, Choe S, Markley JL.
Overexpression and purification of avian ovomucoid third domains in
Escherichia coli.
Protein Eng. 1993 Feb;6(2):221-7.
PMID: 8475048 [PubMed - indexed for MEDLINE]
Wang
JF, Hinck AP, Loh SN, LeMaster DM, Markley JL.
Solution studies of staphylococcal nuclease H124L. 2. 1H, 13C, and
15N chemical shift assignments for the unligated enzyme and analysis of
chemical shift changes that accompany formation of the nuclease-thymidine
3',5'-bisphosphate-calcium ternary complex.
Biochemistry. 1992 Jan 28;31(3):921-36.
PMID: 1731949 [PubMed - indexed for MEDLINE]
Alexandrescu
AT, Hinck AP, Markley JL.
Coupling between local structure and global stability of a protein:
mutants of staphylococcal nuclease.
Biochemistry. 1990 May 15;29(19):4516-25.
PMID: 2372535 [PubMed - indexed for MEDLINE]
Wang
JF, Hinck AP, Loh SN, Markley JL.
Two-dimensional NMR studies of staphylococcal nuclease: evidence for
conformational heterogeneity from hydrogen-1, carbon-13, and nitrogen-15
spin system assignments of the aromatic amino acids in the nuclease H124L-thymidine
3',5'-bisphosphate-Ca2+ ternary complex.
Biochemistry. 1990 May 1;29(17):4242-53.
PMID: 2361141 [PubMed - indexed for MEDLINE]
Wang
JF, Hinck AP, Loh SN, Markley JL.
Two-dimensional NMR studies of staphylococcal nuclease. 2. Sequence-specific
assignments of carbon-13 and nitrogen-15 signals from the nuclease H124L-thymidine
3',5'-bisphosphate-Ca2+ ternary complex.
Biochemistry. 1990 Jan 9;29(1):102-13.
PMID: 2322533 [PubMed - indexed for MEDLINE]
