Christopher P. Jenkinson,  Associate Professor; Ph.D.
Telephone: (210) 567-4755 E-mail: jenkinsonc@uthscsa.edu

Research interests include: Molecular genetics of type 2 diabetes mellitus (T2DM), insulin resistance, obesity and related metabolic disorders. Search for susceptibility genes underlying T2DM and related disorders in the Mexican American population using genome-wide scanning with microsatellite markers and linkage analysis. Linkage disequilibrium mapping of high probability genomic regions using SNP detection and high-throughput screening. Analysis of differential gene expression using Affymetrix DNA microarrays.


 
 

Habib SL, Danial E, Nath S, Schneider J, Jenkinson CP, Duggirala R, Abboud HE, Thameem F.
Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis.
Cancer Biol Ther. 2007 Oct 8;7(1) [Epub ahead of print]
PMID: 17932460

Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH.
Metabolism in adipose tissue in response to citalopram and trimipramine treatment - An in situ microdialysis study.
J Psychiatr Res. 2007 Aug 8; [Epub ahead of print]
PMID: 17692337

Coletta DK, Schneider J, Stern MP, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP.
Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.
Obesity (Silver Spring). 2007 Apr;15(4):809-15.
PMID: 17426313

Colston JT, Boylston WH, Feldman MD, Jenkinson CP, de la Rosa SD, Barton A, Trevino RJ, Freeman GL, Chandrasekar B.
Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload.
Biochem Biophys Res Commun. 2007 Mar 9;354(2):552-8. Epub 2007 Jan 16.
PMID: 17250807

Sriwijitkamol A, Coletta DK, Wajcberg E, Balbontin GB, Reyna SM, Barrientes J, Eagan PA, Jenkinson CP, Cersosimo E, DeFronzo RA, Sakamoto K, Musi N.
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study.
Diabetes. 2007 Mar;56(3):836-48.
PMID: 17327455

Lehman DM, Richardson DK, Jenkinson CP, Hunt KJ, Dyer TD, Leach RJ, Arya R, Abboud HE, Blangero J, Duggirala R, Stern MP.
P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans.
Diabetes. 2007 Feb;56(2):513-7.
PMID: 17259399

Richardson DK, Schneider J, Fourcaudot MJ, Rodriguez LM, Arya R, Dyer TD, Almasy L, Blangero J, Stern MP, Defronzo RA, Duggirala R, Jenkinson CP.
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Diabetologia. 2006 Oct;49(10):2317-28. Epub 2006 Aug 29.
PMID: 16955209

Arya R, Demerath E, Jenkinson CP, Göring HH, Puppala S, Farook V, Fowler S, Schneider J, Granato R, Resendez RG, Dyer TD, Cole SA, Almasy L, Comuzzie AG, Siervogel RM, Bradshaw B, DeFronzo RA, MacCluer J, Stern MP, Towne B, Blangero J, Duggirala R.
A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies.
Hum Mol Genet. 2006 May 15;15(10):1569-79. Epub 2006 Apr 12.
PMID: 16611675

Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA.
Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study.
Diabetes. 2006 May;55(5):1430-5.
PMID: 16644701

Puppala S, Dodd GD, Fowler S, Arya R, Schneider J, Farook VS, Granato R, Dyer TD, Almasy L, Jenkinson CP, Diehl AK, Stern MP, Blangero J, Duggirala R.
A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans.
Am J Hum Genet. 2006 Mar;78(3):377-92. Epub 2006 Jan 6.
PMID: 16400619

Arya R, Dyer TD, Warren DM, Jenkinson CP, Duggirala R, Almasy L.
Effect of genotype x alcoholism interaction on linkage analysis of an alcoholism-related quantitative phenotype.
BMC Genet. 2005 Dec 30;6 Suppl 1:S120 [Epub ahead of print]
PMID: 16451578

Flechtner-Mors M, Jenkinson CP, Alt A, Biesalski HK, Adler G, Ditschuneit HH.
Studies of phosphodiesterase effects on adipose tissue metabolism in obese subjects by the microdialysis technique.
J Physiol Pharmacol. 2005 Sep;56(3):355-68.
PMID: 16204759

Richardson DK, Kashyap S, Bajaj M, Cusi K, Mandarino SJ, Finlayson J, DeFronzo RA, Jenkinson CP, Mandarino LJ.
Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.
J Biol Chem. 2005 Mar 18;280(11):10290-7. Epub 2004 Dec 14.
PMID: 15598661

Flechtner-Mors M, Biesalski HK, Jenkinson CP, Adler G, Ditschuneit HH.
Effects of moderate consumption of white wine on weight loss in overweight and obese subjects.
Int J Obes Relat Metab Disord. 2004 Nov;28(11):1420-6.
PMID: 15356671

Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E.
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Diabetologia. 2004 May;47(5):816-20. Epub 2004 Apr 23.
PMID: 15105989

Flechtner-Mors M, Jenkinson CP, Alt A, Biesalski HK, Adler G, Ditschuneit HH.
Sympathetic regulation of glucose uptake by the alpha1-adrenoceptor in human obesity.
Obes Res. 2004 Apr;12(4):612-20.
PMID: 15090628

Arya R, Duggirala R, Jenkinson CP, Almasy L, Blangero J, O'Connell P, Stern MP.
Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans.
Am J Hum Genet. 2004 Feb;74(2):272-82. Epub 2004 Jan 20. Erratum in: Am J Hum Genet. 2004 May;74(5):1080.
PMID: 14740316

Duggirala R, Almasy L, Blangero J, Jenkinson CP, Arya R, DeFronzo RA, Stern MP, O'Connell P; American Diabetes Association GENNID Study Group.
Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q.
Genet Epidemiol. 2003 Apr;24(3):240-2. No abstract available.
PMID: 12652528

Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH.
In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects.
J Pharmacol Exp Ther. 2002 Apr;301(1):229-33.
PMID: 11907178

Pratipanawatr W, Pratipanawatr T, Cusi K, Berria R, Adams JM, Jenkinson CP, Maezono K, DeFronzo RA, Mandarino LJ.
Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.
Diabetes. 2001 Nov;50(11):2572-8.
PMID: 11679436

Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH.
Effects of acipimox on the lipolysis rate in subcutaneous adipose tissue of obese subjects.
Diabetes Metab Res Rev. 2001 Sep-Oct;17(5):387-90.
PMID: 11747144

Flechtner-Mors M, Alt A, Adler G, Ditschuneit HH, Jenkinson CP.
Norepinephrine-induced glycerol release from adipose tissue: influence of age and body mass index in obese people.
Nutrition. 2001 Sep;17(9):729-31. No abstract available.
PMID: 11527660

Jenkinson CP, Hanson R, Cray K, Wiedrich C, Knowler WC, Bogardus C, Baier L.
Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians.
Int J Obes Relat Metab Disord. 2000 Oct;24(10):1233-8.
PMID: 11093282

Jenkinson CP, Cray K, Walder K, Herzog H, Hanson, Ravussin E.
Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians.
Int J Obes Relat Metab Disord. 2000 May;24(5):580-4.
PMID: 10849579

Flechtner-Mors M, Ditschuneit HH, Jenkinson CP, Alt A, Adler G.
Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study.
Diabet Med. 1999 Dec;16(12):1000-6.
PMID: 10656228

Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Silver MH, Shuldiner AR, Solanes G, Lowell BB, Chung WK, Leibel RL, Pratley R, Ravussin E.
Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.
Hum Mol Genet. 1998 Sep;7(9):1431-5.
PMID: 9700198

Que LG, Kantrow SP, Jenkinson CP, Piantadosi CA, Huang YC.
Induction of arginase isoforms in the lung during hyperoxia.
Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102.
PMID: 9688940

Carraway MS, Piantadosi CA, Jenkinson CP, Huang YC.
Differential expression of arginase and iNOS in the lung in sepsis.
Exp Lung Res. 1998 May-Jun;24(3):253-68.
PMID: 9635249

Iyer RK, Bando JM, Jenkinson CP, Vockley JG, Kim PS, Kern RM, Cederbaum SD, Grody WW.
Cloning and characterization of the mouse and rat type II arginase genes.
Mol Genet Metab. 1998 Mar;63(3):168-75.
PMID: 9608538

Iyer R, Jenkinson CP, Vockley JG, Kern RM, Grody WW, Cederbaum S.
The human arginases and arginase deficiency.
J Inherit Metab Dis. 1998;21 Suppl 1:86-100. Review.
PMID: 9686347

Robinson MF, Thomson CD, Jenkinson CP, Luzhen G, Whanger PD.
Long-term supplementation with selenate and selenomethionine: urinary excretion by New Zealand women.
Br J Nutr. 1997 Apr;77(4):551-63.
PMID: 9155505

Vockley JG, Jenkinson CP, Shukla H, Kern RM, Grody WW, Cederbaum SD.
Cloning and characterization of the human type II arginase gene.
Genomics. 1996 Dec 1;38(2):118-23.
PMID: 8954792

Buga GM, Singh R, Pervin S, Rogers NE, Schmitz DA, Jenkinson CP, Cederbaum SD, Ignarro LJ.
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production.
Am J Physiol. 1996 Nov;271(5 Pt 2):H1988-98.
PMID: 8945918

Vockley JG, Goodman BK, Tabor DE, Kern RM, Jenkinson CP, Grody WW, Cederbaum SD.
Loss of function mutations in conserved regions of the human arginase I gene.
Biochem Mol Med. 1996 Oct;59(1):44-51.
PMID: 8902193

Jenkinson CP, Grody WW, Cederbaum SD.
Comparative properties of arginases.
Comp Biochem Physiol B Biochem Mol Biol. 1996 May;114(1):107-32. Review.
PMID: 8759304

Wang WW, Jenkinson CP, Griscavage JM, Kern RM, Arabolos NS, Byrns RE, Cederbaum SD, Ignarro LJ.
Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide.
Biochem Biophys Res Commun. 1995 May 25;210(3):1009-16.
PMID: 7539253

Spector EB, Jenkinson CP, Grigor MR, Kern RM, Cederbaum SD.
Subcellular location and differential antibody specificity of arginase in tissue culture and whole animals.
Int J Dev Neurosci. 1994 Jun;12(4):337-42. Review.
PMID: 7976488

Jenkinson CP, Grigor MR.
Rat mammary arginase: isolation and characterization.
Biochem Med Metab Biol. 1994 Apr;51(2):156-65.
PMID: 8043299