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Christopher P. Jenkinson,
Associate Professor; Ph.D.
Telephone: (210) 567-4755 E-mail: jenkinsonc@uthscsa.edu Research interests include: Molecular genetics of type 2 diabetes mellitus (T2DM), insulin resistance, obesity and related metabolic disorders. Search for susceptibility genes underlying T2DM and related disorders in the Mexican American population using genome-wide scanning with microsatellite markers and linkage analysis. Linkage disequilibrium mapping of high probability genomic regions using SNP detection and high-throughput screening. Analysis of differential gene expression using Affymetrix DNA microarrays. |
Habib
SL, Danial E, Nath S, Schneider J, Jenkinson CP, Duggirala R, Abboud HE,
Thameem F.
Genetic polymorphisms in OGG1 and their association with angiomyolipoma,
a benign kidney tumor in patients with tuberous sclerosis.
Cancer Biol Ther. 2007 Oct 8;7(1) [Epub ahead of print]
PMID: 17932460
Flechtner-Mors
M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH.
Metabolism in adipose tissue in response to citalopram and trimipramine
treatment - An in situ microdialysis study.
J Psychiatr Res. 2007 Aug 8; [Epub ahead of print]
PMID: 17692337
Coletta
DK, Schneider J, Stern MP, Blangero J, DeFronzo RA, Duggirala R, Jenkinson
CP.
Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia
in Mexican Americans.
Obesity (Silver Spring). 2007 Apr;15(4):809-15.
PMID: 17426313
Colston
JT, Boylston WH, Feldman MD, Jenkinson CP, de la Rosa SD, Barton A, Trevino
RJ, Freeman GL, Chandrasekar B.
Interleukin-18 knockout mice display maladaptive cardiac hypertrophy
in response to pressure overload.
Biochem Biophys Res Commun. 2007 Mar 9;354(2):552-8. Epub 2007
Jan 16.
PMID: 17250807
Sriwijitkamol
A, Coletta DK, Wajcberg E, Balbontin GB, Reyna SM, Barrientes J, Eagan
PA, Jenkinson CP, Cersosimo E, DeFronzo RA, Sakamoto K, Musi N.
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects
with type 2 diabetes: a time-course and dose-response study.
Diabetes. 2007 Mar;56(3):836-48.
PMID: 17327455
Lehman
DM, Richardson DK, Jenkinson CP, Hunt KJ, Dyer TD, Leach RJ, Arya R, Abboud
HE, Blangero J, Duggirala R, Stern MP.
P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are
associated with type 2 diabetes in Mexican Americans.
Diabetes. 2007 Feb;56(2):513-7.
PMID: 17259399
Richardson
DK, Schneider J, Fourcaudot MJ, Rodriguez LM, Arya R, Dyer TD, Almasy L,
Blangero J, Stern MP, Defronzo RA, Duggirala R, Jenkinson CP.
Association between variants in the genes for adiponectin and its receptors
with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Diabetologia. 2006 Oct;49(10):2317-28. Epub 2006 Aug 29.
PMID: 16955209
Arya
R, Demerath E, Jenkinson CP, Göring HH, Puppala S, Farook
V, Fowler S, Schneider J, Granato R, Resendez RG, Dyer TD, Cole SA, Almasy
L, Comuzzie AG, Siervogel RM, Bradshaw B, DeFronzo RA, MacCluer J, Stern
MP, Towne B, Blangero J, Duggirala R.
A quantitative trait locus (QTL) on chromosome 6q influences birth
weight in two independent family studies.
Hum Mol Genet. 2006 May 15;15(10):1569-79. Epub 2006 Apr 12.
PMID: 16611675
Abdul-Ghani
MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA.
Insulin secretion and action in subjects with impaired fasting glucose
and impaired glucose tolerance: results from the Veterans Administration
Genetic Epidemiology Study.
Diabetes. 2006 May;55(5):1430-5.
PMID: 16644701
Puppala
S, Dodd GD, Fowler S, Arya R, Schneider J, Farook VS, Granato R, Dyer TD,
Almasy L, Jenkinson CP, Diehl AK, Stern MP, Blangero J, Duggirala R.
A genomewide search finds major susceptibility loci for gallbladder
disease on chromosome 1 in Mexican Americans.
Am J Hum Genet. 2006 Mar;78(3):377-92. Epub 2006 Jan 6.
PMID: 16400619
Arya
R, Dyer TD, Warren DM, Jenkinson CP, Duggirala R, Almasy L.
Effect of genotype x alcoholism interaction on linkage analysis of
an alcoholism-related quantitative phenotype.
BMC Genet. 2005 Dec 30;6 Suppl 1:S120 [Epub ahead of print]
PMID: 16451578
Flechtner-Mors
M, Jenkinson CP, Alt A, Biesalski HK, Adler G, Ditschuneit HH.
Studies of phosphodiesterase effects on adipose tissue metabolism in
obese subjects by the microdialysis technique.
J Physiol Pharmacol. 2005 Sep;56(3):355-68.
PMID: 16204759
Richardson
DK, Kashyap S, Bajaj M, Cusi K, Mandarino SJ, Finlayson J, DeFronzo RA,
Jenkinson CP, Mandarino LJ.
Lipid infusion decreases the expression of nuclear encoded mitochondrial
genes and increases the expression of extracellular matrix genes in human
skeletal muscle.
J Biol Chem. 2005 Mar 18;280(11):10290-7. Epub 2004 Dec 14.
PMID: 15598661
Flechtner-Mors
M, Biesalski HK, Jenkinson CP, Adler G, Ditschuneit HH.
Effects of moderate consumption of white wine on weight loss in overweight
and obese subjects.
Int J Obes Relat Metab Disord. 2004 Nov;28(11):1420-6.
PMID: 15356671
Civitarese
AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort
R, DeFronzo RA, Mandarino LJ, Ravussin E.
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic
Mexican Americans with or without a family history of Type 2 diabetes.
Diabetologia. 2004 May;47(5):816-20. Epub 2004 Apr 23.
PMID: 15105989
Flechtner-Mors
M, Jenkinson CP, Alt A, Biesalski HK, Adler G, Ditschuneit HH.
Sympathetic regulation of glucose uptake by the alpha1-adrenoceptor
in human obesity.
Obes Res. 2004 Apr;12(4):612-20.
PMID: 15090628
Arya
R, Duggirala R, Jenkinson CP, Almasy L, Blangero J, O'Connell P, Stern
MP.
Evidence of a novel quantitative-trait locus for obesity on chromosome
4p in Mexican Americans.
Am J Hum Genet. 2004 Feb;74(2):272-82. Epub 2004 Jan 20. Erratum
in: Am J Hum Genet. 2004 May;74(5):1080.
PMID: 14740316
Duggirala
R, Almasy L, Blangero J, Jenkinson CP, Arya R, DeFronzo RA, Stern MP, O'Connell
P; American Diabetes Association GENNID Study Group.
Further evidence for a type 2 diabetes susceptibility locus on chromosome
11q.
Genet Epidemiol. 2003 Apr;24(3):240-2. No abstract available.
PMID: 12652528
Flechtner-Mors
M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH.
In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose
tissue of obese subjects.
J Pharmacol Exp Ther. 2002 Apr;301(1):229-33.
PMID: 11907178
Pratipanawatr
W, Pratipanawatr T, Cusi K, Berria R, Adams JM, Jenkinson CP, Maezono K,
DeFronzo RA, Mandarino LJ.
Skeletal muscle insulin resistance in normoglycemic subjects with a
strong family history of type 2 diabetes is associated with decreased insulin-stimulated
insulin receptor substrate-1 tyrosine phosphorylation.
Diabetes. 2001 Nov;50(11):2572-8.
PMID: 11679436
Flechtner-Mors
M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH.
Effects of acipimox on the lipolysis rate in subcutaneous adipose tissue
of obese subjects.
Diabetes Metab Res Rev. 2001 Sep-Oct;17(5):387-90.
PMID: 11747144
Flechtner-Mors
M, Alt A, Adler G, Ditschuneit HH, Jenkinson CP.
Norepinephrine-induced glycerol release from adipose tissue: influence
of age and body mass index in obese people.
Nutrition. 2001 Sep;17(9):729-31. No abstract available.
PMID: 11527660
Jenkinson
CP, Hanson R, Cray K, Wiedrich C, Knowler WC, Bogardus C, Baier L.
Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA
with obesity or type 2 diabetes mellitus in Pima Indians.
Int J Obes Relat Metab Disord. 2000 Oct;24(10):1233-8.
PMID: 11093282
Jenkinson
CP, Cray K, Walder K, Herzog H, Hanson, Ravussin E.
Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with
obesity in Pima Indians.
Int J Obes Relat Metab Disord. 2000 May;24(5):580-4.
PMID: 10849579
Flechtner-Mors
M, Ditschuneit HH, Jenkinson CP, Alt A, Adler G.
Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic,
hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis
study.
Diabet Med. 1999 Dec;16(12):1000-6.
PMID: 10656228
Walder
K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick
J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Silver MH, Shuldiner
AR, Solanes G, Lowell BB, Chung WK, Leibel RL, Pratley R, Ravussin E.
Association between uncoupling protein polymorphisms (UCP2-UCP3) and
energy metabolism/obesity in Pima indians.
Hum Mol Genet. 1998 Sep;7(9):1431-5.
PMID: 9700198
Que
LG, Kantrow SP, Jenkinson CP, Piantadosi CA, Huang YC.
Induction of arginase isoforms in the lung during hyperoxia.
Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102.
PMID: 9688940
Carraway
MS, Piantadosi CA, Jenkinson CP, Huang YC.
Differential expression of arginase and iNOS in the lung in sepsis.
Exp Lung Res. 1998 May-Jun;24(3):253-68.
PMID: 9635249
Iyer
RK, Bando JM, Jenkinson CP, Vockley JG, Kim PS, Kern RM, Cederbaum SD,
Grody WW.
Cloning and characterization of the mouse and rat type II arginase
genes.
Mol Genet Metab. 1998 Mar;63(3):168-75.
PMID: 9608538
Iyer
R, Jenkinson CP, Vockley JG, Kern RM, Grody WW, Cederbaum S.
The human arginases and arginase deficiency.
J Inherit Metab Dis. 1998;21 Suppl 1:86-100. Review.
PMID: 9686347
Robinson
MF, Thomson CD, Jenkinson CP, Luzhen G, Whanger PD.
Long-term supplementation with selenate and selenomethionine: urinary
excretion by New Zealand women.
Br J Nutr. 1997 Apr;77(4):551-63.
PMID: 9155505
Vockley
JG, Jenkinson CP, Shukla H, Kern RM, Grody WW, Cederbaum SD.
Cloning and characterization of the human type II arginase gene.
Genomics. 1996 Dec 1;38(2):118-23.
PMID: 8954792
Buga
GM, Singh R, Pervin S, Rogers NE, Schmitz DA, Jenkinson CP, Cederbaum SD,
Ignarro LJ.
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine
during high-output NO production.
Am J Physiol. 1996 Nov;271(5 Pt 2):H1988-98.
PMID: 8945918
Vockley
JG, Goodman BK, Tabor DE, Kern RM, Jenkinson CP, Grody WW, Cederbaum SD.
Loss of function mutations in conserved regions of the human arginase
I gene.
Biochem Mol Med. 1996 Oct;59(1):44-51.
PMID: 8902193
Jenkinson
CP, Grody WW, Cederbaum SD.
Comparative properties of arginases.
Comp Biochem Physiol B Biochem Mol Biol. 1996 May;114(1):107-32.
Review.
PMID: 8759304
Wang
WW, Jenkinson CP, Griscavage JM, Kern RM, Arabolos NS, Byrns RE, Cederbaum
SD, Ignarro LJ.
Co-induction of arginase and nitric oxide synthase in murine macrophages
activated by lipopolysaccharide.
Biochem Biophys Res Commun. 1995 May 25;210(3):1009-16.
PMID: 7539253
Spector
EB, Jenkinson CP, Grigor MR, Kern RM, Cederbaum SD.
Subcellular location and differential antibody specificity of arginase
in tissue culture and whole animals.
Int J Dev Neurosci. 1994 Jun;12(4):337-42. Review.
PMID: 7976488
Jenkinson
CP, Grigor MR.
Rat mammary arginase: isolation and characterization.
Biochem Med Metab Biol. 1994 Apr;51(2):156-65.
PMID: 8043299