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Merry L. Lindsey,
Assistant Professor, Ph.D., Baylor College of Medicine, 1999.
Telephone: (210) 567-4673 E-mail: lindseym@uthscsa.edu My laboratory is focused on studies
relating to cardiac extracellular matrix biology, specializing in changes
to the matrix that are the cause or effect of pathophysiological processes.
These changes include cell-matrix interactions, which both affect and react
to processes involved in tissue repair. My laboratory primarily uses the
murine model of myocardial infarction (MI). In addition to physiological
parameters, we also measure biochemical, cell biological, and proteomic
outputs. The main foci of my laboratory are: 1) the role of macrophage-derived
matrix metalloproteinases (MMPs) in left ventricular (LV) remodeling post-MI;
2) the role of the cardiac fibroblast in the remodeling process; and 3)
the influence of aging on LV remodeling.
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Jin
Y, Han HC, Lindsey ML.
ACE inhibitors to block MMP-9 activity: New functions for old inhibitors.
J Mol Cell Cardiol. 2007 Sep 12; [Epub ahead of print] No abstract
available.
PMID: 17949743
Ahuja
SS, Estrada CA, Lindsey ML.
Crosstalk between cytotoxic T-lymphocyte associated antigen-4 and interleukin-12
in cytotoxic T-lymphocyte-mediated myocarditis: adding another link to
the chain.
Circ Res. 2007 Aug 3;101(3):218-20. No abstract available.
PMID: 17673678
Lindsey
ML.
Novel strategies to delineate matrix metalloproteinase (MMP)-substrate
relationships and identify targets to block MMP activity.
Mini Rev Med Chem. 2006 Nov;6(11):1243-8. Review.
PMID: 17100635
Hinojosa-Laborde
C, Lindsey ML.
Aging modifies the cardiac response to estrogen: a new dimension to
hormone replacement therapy.
Hypertension. 2006 Oct;48(4):558-9. Epub 2006 Aug 28. No abstract
available.
PMID: 16940232
Dozier
S, Escobar GP, Lindsey ML.
Matrix metalloproteinase (MMP)-7 activates MMP-8 but not MMP-13.
Med Chem. 2006 Sep;2(5):523-6.
PMID: 17017992
Lindsey
ML, Escobar GP, Mukherjee R, Goshorn DK, Sheats NJ, Bruce JA, Mains IM,
Hendrick JK, Hewett KW, Gourdie RG, Matrisian LM, Spinale FG.
Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction,
and survival after myocardial infarction.
Circulation. 2006 Jun 27;113(25):2919-28. Epub 2006 Jun 12.
PMID: 16769909
Flack
EC, Lindsey ML, Squires CE, Kaplan BS, Stroud RE, Clark LL, Escobar PG,
Yarbrough WM, Spinale FG.
Alterations in cultured myocardial fibroblast function following the
development of left ventricular failure.
J Mol Cell Cardiol. 2006 Apr;40(4):474-83. Epub 2006 Mar 6.
PMID: 16516916
Lindsey
ML, Goshorn DK, Comte-Walters S, Hendrick JW, Hapke E, Zile MR, Schey K.
A multidimensional proteomic approach to identify hypertrophy-associated
proteins.
Proteomics. 2006 Apr;6(7):2225-35.
PMID: 16493702
Lindsey
ML, Freeman GL.
Beta-blockade in heart failure: adding SENIORS to the mix.
Eur Heart J. 2006 Mar;27(5):506-7. Epub 2006 Jan 27. No abstract
available.
PMID: 16443609
Lindsey
ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, McClister
DM Jr, Su H, Gannon J, MacGillivray C, Lee RT, Sinusas AJ, Spinale FG.
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after
myocardial infarction.
Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H232-9. Epub
2005 Aug 26.
PMID: 16126817
Squires
CE, Escobar GP, Payne JF, Leonardi RA, Goshorn DK, Sheats NJ, Mains IM,
Mingoia JT, Flack EC, Lindsey ML.
Altered fibroblast function following myocardial infarction.
J Mol Cell Cardiol. 2005 Oct;39(4):699-707.
PMID: 16111700
Ikonomidis
JS, Barbour JR, Amani Z, Stroud RE, Herron AR, McClister DM Jr, Camens
SE, Lindsey ML, Mukherjee R, Spinale FG.
Effects of deletion of the matrix metalloproteinase 9 gene on development
of murine thoracic aortic aneurysms.
Circulation. 2005 Aug 30;112(9 Suppl):I242-8.
PMID: 16159824
Lindsey
ML, Goshorn DK, Squires CE, Escobar GP, Hendrick JW, Mingoia JT, Sweterlitsch
SE, Spinale FG.
Age-dependent changes in myocardial matrix metalloproteinase/tissue
inhibitor of metalloproteinase profiles and fibroblast function.
Cardiovasc Res. 2005 May 1;66(2):410-9. Epub 2004 Dec 13.
PMID: 15820210
Stroud
RE, Deschamps AM, Lowry AS, Hardin AE, Mukherjee R, Lindsey ML, Ramamoorthy
S, Zile MR, Spencer WH, Spinale FG.
Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4
after alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
J Card Fail. 2005 Mar;11(2):124-30.
PMID: 15732032
Lindsey
ML.
MMP induction and inhibition in myocardial infarction.
Heart Fail Rev. 2004 Jan;9(1):7-19. Review.
PMID: 14739764
Lindsey
ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa
M, Libby P, Krane SM, Lee RT.
Effect of a cleavage-resistant collagen mutation on left ventricular
remodeling.
Circ Res. 2003 Aug 8;93(3):238-45. Epub 2003 Jul 10. Erratum
in: Circ Res. 2004 Aug 20;95(4):e34.
PMID: 12855673
Lindsey
ML, Mann DL, Entman ML, Spinale FG.
Extracellular matrix remodeling following myocardial injury.
Ann Med. 2003;35(5):316-26. Review.
PMID: 12952018
Lindsey
ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford
J, Black S, Libby P, Mitchell PG, Lee RT.
Selective matrix metalloproteinase inhibition reduces left ventricular
remodeling but does not inhibit angiogenesis after myocardial infarction.
Circulation. 2002 Feb 12;105(6):753-8.
PMID: 11839633
Scherrer-Crosbie
M, Ullrich R, Bloch KD, Nakajima H, Nasseri B, Aretz HT, Lindsey ML, Vançon
AC, Huang PL, Lee RT, Zapol WM, Picard MH.
Endothelial nitric oxide synthase limits left ventricular remodeling
after myocardial infarction in mice.
Circulation. 2001 Sep 11;104(11):1286-91.
PMID: 11551881
Lindsey
M, Wedin K, Brown MD, Keller C, Evans AJ, Smolen J, Burns AR, Rossen RD,
Michael L, Entman M.
Matrix-dependent mechanism of neutrophil-mediated release and activation
of matrix metalloproteinase 9 in myocardial ischemia/reperfusion.
Circulation. 2001 May 1;103(17):2181-7.
PMID: 11331260
Frangogiannis
NG, Mendoza LH, Lindsey ML, Ballantyne CM, Michael LH, Smith CW, Entman
ML.
IL-10 is induced in the reperfused myocardium and may modulate the
reaction to injury.
J Immunol. 2000 Sep 1;165(5):2798-808.
PMID: 10946312
Lindsey
M, Lee RT.
MMP inhibition as a potential therapeutic strategy for CHF.
Drug News Perspect. 2000 Aug;13(6):350-4.
PMID: 12937656
Ducharme
A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly
RA, Werb Z, Libby P, Lee RT.
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular
enlargement and collagen accumulation after experimental myocardial infarction.
J Clin Invest. 2000 Jul;106(1):55-62.
PMID: 10880048
Senzaki
H, Paolocci N, Gluzband YA, Lindsey ML, Janicki JS, Crow MT, Kass DA.
beta-blockade prevents sustained metalloproteinase activation and diastolic
stiffening induced by angiotensin II combined with evolving cardiac dysfunction.
Circ Res. 2000 Apr 14;86(7):807-15.
PMID: 10764416
Frangogiannis
NG, Youker KA, Rossen RD, Gwechenberger M, Lindsey MH, Mendoza LH, Michael
LH, Ballantyne CM, Smith CW, Entman ML.
Cytokines and the microcirculation in ischemia and reperfusion.
J Mol Cell Cardiol. 1998 Dec;30(12):2567-76. Review.
PMID: 9990529
Frangogiannis
NG, Lindsey ML, Michael LH, Youker KA, Bressler RB, Mendoza LH, Spengler
RN, Smith CW, Entman ML.
Resident cardiac mast cells degranulate and release preformed TNF-alpha,
initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion.
Circulation. 1998 Aug 18;98(7):699-710.
PMID: 9715863
Frangogiannis
NG, Perrard JL, Mendoza LH, Burns AR, Lindsey ML, Ballantyne CM, Michael
LH, Smith CW, Entman ML.
Stem cell factor induction is associated with mast cell accumulation
after canine myocardial ischemia and reperfusion.
Circulation. 1998 Aug 18;98(7):687-98.
PMID: 9715862
Dreyer
WJ, Burns AR, Phillips SC, Lindsey ML, Jackson P, Kukielka GL.
Intercellular adhesion molecule-1 regulation in the canine lung after
cardiopulmonary bypass.
J Thorac Cardiovasc Surg. 1998 Mar;115(3):689-98; discussion
698-9.
PMID: 9535458
Youker
KA, Birdsall HH, Frangogiannis NG, Kumar AG, Lindsey ML, Ballantyne CM,
Smith CW, Rossen RD, Entman ML.
Phagocytes in ischemia injury.
Ann N Y Acad Sci. 1997 Dec 15;832:243-65.
PMID: 9704052
Kumar
AG, Ballantyne CM, Michael LH, Kukielka GL, Youker KA, Lindsey ML, Hawkins
HK, Birdsall HH, MacKay CR, LaRosa GJ, Rossen RD, Smith CW, Entman ML.
Induction of monocyte chemoattractant protein-1 in the small veins
of the ischemic and reperfused canine myocardium.
Circulation. 1997 Feb 4;95(3):693-700.
PMID: 9024159