Semba S, Trapasso F, Fabbri M, McCorkell KA, Volinia S, Druck T, Iliopoulos D, Pekarsky Y, Ishii H, Garrison PN, Barnes LD, Croce CM, Huebner K.
Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.
Oncogene. 2006 May 11;25(20):2860-72.
PMID: 16407838

Garrison PN, Robinson AK, Pekarsky Y, Croce CM, Barnes LD.
Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms.
Biochemistry. 2005 Apr 26;44(16):6286-92.
PMID: 15835917 [PubMed - indexed for MEDLINE]

Pekarsky Y, Garrison PN, Palamarchuk A, Zanesi N, Aqeilan RI, Huebner K, Barnes LD, Croce CM.
Fhit is a physiological target of the protein kinase Src.
Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3775-9. Epub 2004 Mar 08.
PMID: 15007172 [PubMed - indexed for MEDLINE]

Hua LV, Hidaka K, Pesesse X, Barnes LD, Shears SB.
Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.
Biochem J. 2003 Jul 1;373(Pt 1):81-9.
PMID: 12689335 [PubMed - indexed for MEDLINE]

Ingram SW, Safrany ST, Barnes LD.
Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrations.
Biochem J. 2003 Feb 1;369(Pt 3):519-28.
PMID: 12387729 [PubMed - indexed for MEDLINE]

Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB.
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.
J Biol Chem. 2002 Sep 6;277(36):32730-8. Epub 2002 Jun 24.
PMID: 12105228 [PubMed - indexed for MEDLINE]

Bieganowski P, Garrison PN, Hodawadekar SC, Faye G, Barnes LD, Brenner C.
Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3.
J Biol Chem. 2002 Mar 29;277(13):10852-60. Epub 2002 Jan 22.
PMID: 11805111 [PubMed - indexed for MEDLINE]

Izbicka E, Barnes LD, Robinson AK, Davidson KK, Lawrence RA, Hannibal GT.
Alterations in DNA repair and telomere maintenance mechanism affect response to porphyrins in yeast.
Anticancer Res. 2001 May-Jun;21(3B):1899-903.
PMID: 11497275 [PubMed - indexed for MEDLINE]

Ingram SW, Barnes LD.
Disruption and overexpression of the Schizosaccharomyces pombe aph1 gene and the effects on intracellular diadenosine 5',5'''-P1, P4-tetraphosphate (Ap4A), ATP and ADP concentrations.
Biochem J. 2000 Sep 15;350 Pt 3:663-9.
PMID: 10970777 [PubMed - indexed for MEDLINE]

Chaudhuri AR, Khan IA, Prasad V, Robinson AK, Luduena RF, Barnes LD.
The tumor suppressor protein Fhit. A novel interaction with tubulin.
J Biol Chem. 1999 Aug 20;274(34):24378-82.
PMID: 10446217 [PubMed - indexed for MEDLINE]

Safrany ST, Ingram SW, Cartwright JL, Falck JR, McLennan AG, Barnes LD, Shears SB.
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.
J Biol Chem. 1999 Jul 30;274(31):21735-40.
PMID: 10419486 [PubMed - indexed for MEDLINE]

Abend A, Garrison PN, Barnes LD, Frey PA.
Stereochemical retention of the configuration in the action of Fhit on phosphorus-chiral substrates.
Biochemistry. 1999 Mar 23;38(12):3668-76.
PMID: 10090754 [PubMed - indexed for MEDLINE]

Ingram SW, Stratemann SA, Barnes LD.
Schizosaccharomyces pombe Aps1, a diadenosine 5',5' "-P1, P6-hexaphosphate hydrolase that is a member of the nudix (MutT) family of hydrolases: cloning of the gene and characterization of the purified enzyme.
Biochemistry. 1999 Mar 23;38(12):3649-55.
PMID: 10090752 [PubMed - indexed for MEDLINE]

Huebner K, Garrison PN, Barnes LD, Croce CM.
The role of the FHIT/FRA3B locus in cancer.
Annu Rev Genet. 1998;32:7-31. Review.
PMID: 9928473 [PubMed - indexed for MEDLINE]

Guranowski A, Starzynska E, Barnes LD, Robinson AK, Liu S.
Adenosine 5'-tetraphosphate phosphohydrolase activity is an inherent property of soluble exopolyphosphatase from yeast Saccharomyces cerevisiae.
Biochim Biophys Acta. 1998 Apr 10;1380(2):232-8.
PMID: 9565693 [PubMed - indexed for MEDLINE]

Brenner C, Pace HC, Garrison PN, Robinson AK, Rosler A, Liu XH, Blackburn GM, Croce CM, Huebner K, Barnes LD.
Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.
Protein Eng. 1997 Dec;10(12):1461-3.
PMID: 9543008 [PubMed - indexed for MEDLINE]

Pace HC, Garrison PN, Robinson AK, Barnes LD, Draganescu A, Rosler A, Blackburn GM, Siprashvili Z, Croce CM, Huebner K, Brenner C.
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5484-9.
PMID: 9576908 [PubMed - indexed for MEDLINE]

Siprashvili Z, Sozzi G, Barnes LD, McCue P, Robinson AK, Eryomin V, Sard L, Tagliabue E, Greco A, Fusetti L, Schwartz G, Pierotti MA, Croce CM, Huebner K.
Replacement of Fhit in cancer cells suppresses tumorigenicity.
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13771-6.
PMID: 9391102 [PubMed - indexed for MEDLINE]

Barnes LD, Garrison PN, Siprashvili Z, Guranowski A, Robinson AK, Ingram SW, Croce CM, Ohta M, Huebner K.
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.
Biochemistry. 1996 Sep 10;35(36):11529-35.
PMID: 8794732 [PubMed - indexed for MEDLINE]

Huang Y, Garrison PN, Barnes LD.
Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) asymmetrical hydrolase: sequence similarity with the histidine triad (HIT) protein family.
Biochem J. 1995 Dec 15;312 ( Pt 3):925-32.
PMID: 8554540 [PubMed - indexed for MEDLINE]

Garrison PN, de la Pena CE, Barnes LD.
Synthesis and use of a chromogenic substrate analog for Ap4A catabolic enzymes.
Anal Biochem. 1993 May 1;210(2):226-30.
PMID: 7685562 [PubMed - indexed for MEDLINE]

Robinson AK, de la Pena CE, Barnes LD.
Isolation and characterization of diadenosine tetraphosphate (Ap4A) hydrolase from Schizosaccharomyces pombe.
Biochim Biophys Acta. 1993 Feb 13;1161(2-3):139-48.
PMID: 8381667 [PubMed - indexed for MEDLINE]

Garrison PN, Koob M, Barnes LD.
Physical mapping of the Saccharomyces cerevisiae Ap4A phosphorylase I-encoding gene by the Achilles' cleavage method.
Gene. 1992 Feb 1;111(1):131-4.
PMID: 1312500 [PubMed - indexed for MEDLINE]

Avila DM, Robinson AK, Kaushal V, Barnes LD.
A paradoxical increase of a metabolite upon increased expression of its catabolic enzyme: the case of diadenosine tetraphosphate (Ap4A) and Ap4A phosphorylase I in Saccharomyces cerevisiae.
J Bacteriol. 1991 Dec;173(24):7875-80.
PMID: 1660456 [PubMed - indexed for MEDLINE]

Robinson AK, Barnes LD.
Chemical modification of a functional arginine residue in diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) phosphorylase I from Saccharomyces cerevisiae.
Biochem J. 1991 Oct 1;279 ( Pt 1):135-9.
PMID: 1656937 [PubMed - indexed for MEDLINE]

Kaushal V, Avila DM, Hardies SC, Barnes LD.
Sequencing and enhanced expression of the gene encoding diadenosine 5',5'''-P1, P4-tetraphosphate (Ap4A) phosphorylase in Saccharomyces cerevisiae.
Gene. 1990 Oct 30;95(1):79-84.
PMID: 2174812 [PubMed - indexed for MEDLINE]

Avila DM, Kaushal V, Barnes LD.
Immunoaffinity chromatography of diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase from Saccharomyces cerevisiae.
Biotechnol Appl Biochem. 1990 Jun;12(3):276-83.
PMID: 2163260 [PubMed - indexed for MEDLINE]

Floyd LJ, Barnes LD, Williams RF.
Photoaffinity labeling of tubulin with (2-nitro-4-azidophenyl)deacetylcolchicine: direct evidence for two colchicine binding sites.
Biochemistry. 1989 Oct 17;28(21):8515-25.
PMID: 2605201 [PubMed - indexed for MEDLINE]

Garrison PN, Mathis SA, Barnes LD.
Changes in diadenosine tetraphosphate levels in Physarum polycephalum with different oxygen concentrations.
J Bacteriol. 1989 Mar;171(3):1506-12.
PMID: 2921243 [PubMed - indexed for MEDLINE]

Banerjee A, Barnes LD, Luduena RF.
The role of the B-ring of colchicine in the stability of the colchicine-tubulin complex.
Biochim Biophys Acta. 1987 Jun 17;913(2):138-44.
PMID: 3593734 [PubMed - indexed for MEDLINE]

Kaushal V, Barnes LD.
Effect of zwitterionic buffers on measurement of small masses of protein with bicinchoninic acid.
Anal Biochem. 1986 Sep;157(2):291-4.
PMID: 3777432 [PubMed - indexed for MEDLINE]

Robinson AK, Barnes LD.
Three diadenosine 5',5''-P1,P4-tetraphosphate hydrolytic enzymes from Physarum polycephalum with differential effects by calcium: a specific dinucleoside polyphosphate pyrophosphohydrolase, a nucleotide pyrophosphatase, and a phosphodiesterase.
Arch Biochem Biophys. 1986 Aug 1;248(2):502-15.
PMID: 3017212 [PubMed - indexed for MEDLINE]

Garrison PN, Mathis SA, Barnes LD.
In vivo levels of diadenosine tetraphosphate and adenosine tetraphospho-guanosine in Physarum polycephalum during the cell cycle and oxidative stress.
Mol Cell Biol. 1986 Apr;6(4):1179-86.
PMID: 3785160 [PubMed - indexed for MEDLINE]

Williams RF, Mumford CL, Williams GA, Floyd LJ, Aivaliotis MJ, Martinez RA, Robinson AK, Barnes LD.
A photoaffinity derivative of colchicine: 6'-(4'-azido-2'-nitrophenylamino)hexanoyldeacetylcolchicine. Photolabeling and location of the colchicine-binding site on the alpha-subunit of tubulin.
J Biol Chem. 1985 Nov 5;260(25):13794-802.
PMID: 4055757 [PubMed - indexed for MEDLINE]

Barnes LD, Robinson AK, Mumford CH, Garrison PN.
Assay of diadenosine tetraphosphate hydrolytic enzymes by boronate chromatography.
Anal Biochem. 1985 Jan;144(1):296-304.
PMID: 2984957 [PubMed - indexed for MEDLINE]

Horowitz PM, Lee JC, Williams GA, Williams RF, Barnes LD.
Electrophoresis of proteins and nucleic acids on acrylamide-agarose gels lacking covalent crosslinking.
Anal Biochem. 1984 Dec;143(2):333-40.
PMID: 6085222 [PubMed - indexed for MEDLINE]

Garrison PN, Barnes LD.
Assay of adenosine 5'-P1-tetraphospho-P4-5"'-adenosine and adenosine 5'-P1-tetraphospho-P4-5"'-guanosine in Physarum polycephalum and other eukaryotes. An isocratic high-pressure liquid-chromatography method.
Biochem J. 1984 Feb 1;217(3):805-11.
PMID: 6370234 [PubMed - indexed for MEDLINE]

Barnes LD, Robinson AK, Williams RF, Horowitz PM.
Binding of colchicine to renal tubulin at 5 degrees C.
Biochem Biophys Res Commun. 1983 Nov 15;116(3):866-72.
PMID: 6651851 [PubMed - indexed for MEDLINE]

Williams RF, Aivaliotis MJ, Barnes LD, Robinson AK.
High-performance liquid chromatographic application of the Hummel and Dreyer method for the determination of colchicine-tubulin binding parameters.
J Chromatogr. 1983 Aug 26;266:141-50.
PMID: 6630344 [PubMed - indexed for MEDLINE]

Horowitz PM, Barnes LD.
A simple, inexpensive, and precise microcell for the exchange dialysis and equilibrium dialysis of small samples.
Anal Biochem. 1983 Feb 1;128(2):478-80. No abstract available.
PMID: 6846825 [PubMed - indexed for MEDLINE]

Garrison PN, Roberson GM, Culver CA, Barnes LD.
Diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum. Substrate specificity.
Biochemistry. 1982 Nov 23;21(24):6129-33.
PMID: 6295457 [PubMed - indexed for MEDLINE]

Barnes LD, Culver CA.
Isolation and characterization of diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum.
Biochemistry. 1982 Nov 23;21(24):6123-8.
PMID: 6295456 [PubMed - indexed for MEDLINE]

Barnes LD, Guy MN, Roberson GM, Osgood RW.
Synthesis, characterization, and biological activity of N alpha-(N-fluoresceinthiocarbamoyl)-(Asp1, Ile5)-angiotensin II.
Arch Biochem Biophys. 1982 Mar;214(1):239-47. No abstract available.
PMID: 7081999 [PubMed - indexed for MEDLINE]

Guy MN, Roberson GM, Barnes LD.
Analysis of angiotensins I, II, III, and iodinated derivatives by high-performance liquid chromatography.
Anal Biochem. 1981 Apr;112(2):272-7. No abstract available.
PMID: 7258642 [PubMed - indexed for MEDLINE]

Garrison PN, Barnes LD.
Cyclic AMP in the cell cycle of Physarum polycephalum.
Biochim Biophys Acta. 1980 Nov 17;633(1):114-21.
PMID: 6256004 [PubMed - indexed for MEDLINE]

Barnes LD, Roberson GM.
Tubulin and microtubules from bovine kidney: purification, properties, and characterization of ligand binding.
Arch Biochem Biophys. 1979 Sep;196(2):511-24. No abstract available.
PMID: 485163 [PubMed - indexed for MEDLINE]

Roberson GM, Barnes LD.
Separation of cyclic AMP and cyclic GMP from thymidine, electrolytes and polyvalent nucleotides in tissue samples.
Biochim Biophys Acta. 1978 Nov 15;544(1):20-8.
PMID: 214147 [PubMed - indexed for MEDLINE]

Dousa TP, Hui YS, Barnes LD.
Microtubule assembly in renal medullary slices: effects of vasopressin, vinblastine, and lithium.
J Lab Clin Med. 1978 Aug;92(2):252-61.
PMID: 681812 [PubMed - indexed for MEDLINE]

Stein JH, Lifschitz MD, Barnes LD.
Current concepts on the pathophysiology of acute renal failure.
Am J Physiol. 1978 Mar;234(3):F171-81. Review.
PMID: 343602 [PubMed - indexed for MEDLINE]

Kim JK, Frohnert PP, Hui YS, Barnes LD, Farrow GM, Dousa TP.
Enzymes of cyclic 3',5'-nucleotide metabolism in human renal cortex and renal adenocarcinoma.
Kidney Int. 1977 Sep;12(3):172-83. No abstract available.
PMID: 21991 [PubMed - indexed for MEDLINE]

Dousa TP, Barnes LD, Ong SH, Steiner AL.
Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic GMP in rat renal cortex: effect of parathyroid hormone.
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3569-73. No abstract available.
PMID: 198790 [PubMed - indexed for MEDLINE]

Hall DA, Barnes LD, Dousa TP.
Cyclic AMP in action of antidiuretic hormone: effects of exogenous cyclic AMP and its new analogue.
Am J Physiol. 1977 Apr;232(4):F368-76.
PMID: 192088 [PubMed - indexed for MEDLINE]

Dousa TP, Barnes LD.
Regulation of protein kinase by vasopressin in renal medulla in situ.
Am J Physiol. 1977 Jan;232(1):F50-7.
PMID: 189620 [PubMed - indexed for MEDLINE]

Dousa TP, Barnes LD.
Lithium-induced diuretic effect of antidiuretic hormone in rats.
Am J Physiol. 1976 Dec;231(6):1754-9.
PMID: 188342 [PubMed - indexed for MEDLINE]

Mulvehill JB, Hui YS, Barnes LD, Palumbo PJ, Dousa TP.
Glucagon-sensitive adenylate cyclase in human renal medulla.
J Clin Endocrinol Metab. 1976 Feb;42(2):380-4.
PMID: 4466 [PubMed - indexed for MEDLINE]

Stellwagen E, Barnes LD.
Analysis of the thermostability of enolases.
Experientia Suppl. 1976;26:223-7. No abstract available.
PMID: 939273 [PubMed - indexed for MEDLINE]

Barnes LD, Engel AG, Dousa TP.
Studies on in vitro polymerization of tubulin from renal medullary extracts.
Biochim Biophys Acta. 1975 Oct 20;405(2):422-33.
PMID: 1180965 [PubMed - indexed for MEDLINE]

Wollin A, Barnes LD, Hui YS, Dousa TP.
Activation of protein kinase in the guinea pig fundic gastric mucosa by histamine.
Life Sci. 1975 Oct 15;17(8):1303-6. No abstract available.
PMID: 172756 [PubMed - indexed for MEDLINE]

Dousa TP, Hui YF, Barnes LD.
Renal medullary adenylate cyclase in rats with hypothalamic diabetes insipidus.
Endocrinology. 1975 Oct;97(4):802-7.
PMID: 172317 [PubMed - indexed for MEDLINE]

Barnes LD, Hui YS, Dousa TP.
Interaction of ethacrynic acid and cysteine with renal medullary adenylate cyclase.
Life Sci. 1975 Jan 15;16(2):255-62. No abstract available.
PMID: 1110603 [PubMed - indexed for MEDLINE]

Barnes LD, Hui YS, Frohnert PP, Dousa TP.
Subcellular distribution of the enzymes related to the cellular action of vasopressin in renal medulla.
Endocrinology. 1975 Jan;96(1):119-28.
PMID: 162875 [PubMed - indexed for MEDLINE]

Dousa TP, Barnes LD.
Effects of colchicine and vinblastine on the cellular action of vasopressin in mammalian kidney. A possible role of microtubules.
J Clin Invest. 1974 Aug;54(2):252-62. No abstract available.
PMID: 4367887 [PubMed - indexed for MEDLINE]

Stellwagen E, Cronlund MM, Barnes LD.
A thermostable enolase from the extreme thermophile Thermus aquaticus YT-1.
Biochemistry. 1973 Apr 10;12(8):1552-9. No abstract available.
PMID: 4699989 [PubMed - indexed for MEDLINE]

Barnes LD, Stellwagen E.
Enolase from the thermophile Thermus X-1.
Biochemistry. 1973 Apr 10;12(8):1559-65. No abstract available.
PMID: 4573199 [PubMed - indexed for MEDLINE]

Barnes LD, McGuire JJ, Atkinson DE.
Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase.
Regulation of activity and unidirectional catalysis. Biochemistry. 1972 Nov 7;11(23):4322-9. No abstract available.
PMID: 4342903 [PubMed - indexed for MEDLINE]

Kuehn GD, Barnes LD, Atkinson DE.
Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase. Binding of ligands.
Biochemistry. 1971 Oct 12;10(21):3945-51. No abstract available.
PMID: 4334284 [PubMed - indexed for MEDLINE]

Barnes LD, Kuehn GD, Atkinson DE.
Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase.
Purification and some properties. Biochemistry. 1971 Oct 12;10(21):3939-44. No abstract available.
PMID: 4334283 [PubMed - indexed for MEDLINE]