Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, Li C, Deng C, Reyna S, Musi N, Dong LQ, DeFronzo RA, Liu F.
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.
Mol Cell Biol. 2007 Sep;27(18):6497-505. Epub 2007 Jul 9.
PMID: 17620412

Li J, Mao X, Dong LQ, Liu F, Tong L.
Crystal structures of the BAR-PH and PTB domains of human APPL1.
Structure. 2007 May;15(5):525-33.
PMID: 17502098

Lu Y, Tian Q, Liu F, Sanchez M, Wang Y.
Interactive semisupervised learning for microarray analysis.
IEEE/ACM Trans Comput Biol Bioinform. 2007 Apr-Jun;4(2):190-203.
PMID: 17473313

Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan KL, Dong LQ, Liu F.
Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1.
J Biol Chem. 2007 Mar 16;282(11):7991-6. Epub 2007 Jan 22.
PMID: 17244624

Riojas RA, Kikani CK, Wang C, Mao X, Zhou L, Langlais PR, Hu D, Roberts JL, Dong LQ, Liu F.
Fine tuning PDK1 activity by phosphorylation at Ser163.
J Biol Chem. 2006 Aug 4;281(31):21588-93. Epub 2006 Jun 2.
PMID: 16751192

Ramos FJ, Langlais PR, Hu D, Dong LQ, Liu F.
Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.
Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1262-6. Epub 2006 Jan 24.
PMID: 16434550

Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ.
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.
Nat Cell Biol. 2006 May;8(5):516-23. Epub 2006 Apr 16. Erratum in: Nat Cell Biol. 2006 Jun;8(6):642.
PMID: 16622416

Dong LQ, Liu F.
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E187-96. Review.
PMID: 16014356 [PubMed - indexed for MEDLINE]

Kikani CK, Dong LQ, Liu F.
"New"-clear functions of PDK1: Beyond a master kinase?
J Cell Biochem. 2005 Dec 15;96(6):1157-62.
PMID: 16187290 [PubMed - in process]

Langlais P, Wang C, Dong LQ, Carroll CA, Weintraub ST, Liu F.
Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.
Biochemistry. 2005 Jun 21;44(24):8890-7.
PMID: 15952796 [PubMed - indexed for MEDLINE]

Lim MA, Yang L, Zheng Y, Wu H, Dong LQ, Liu F.
Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.
Oncogene. 2004 Dec 16;23(58):9348-58.
PMID: 15531926 [PubMed - indexed for MEDLINE]

Li Y, Langlais P, Gamper N, Liu F, Shapiro MS.
Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase.
J Biol Chem. 2004 Oct 29;279(44):45399-407. Epub 2004 Aug 10.
PMID: 15304482 [PubMed - indexed for MEDLINE]

Richardson A, Liu F, Adamo ML, Van Remmen H, Nelson JF.
The role of insulin and insulin-like growth factor-I in mammalian ageing.
Best Pract Res Clin Endocrinol Metab. 2004 Sep;18(3):393-406. Review.
PMID: 15261845 [PubMed - indexed for MEDLINE]

Stratford S, Hoehn KL, Liu F, Summers SA.
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.
J Biol Chem. 2004 Aug 27;279(35):36608-15. Epub 2004 Jun 25.
PMID: 15220355 [PubMed - indexed for MEDLINE]

McClung JP, Roneker CA, Mu W, Lisk DJ, Langlais P, Liu F, Lei XG.
Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase.
Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8852-7. Epub 2004 Jun 7.
PMID: 15184668 [PubMed - indexed for MEDLINE]

Lim MA, Riedel H, Liu F.
Grb10: more than a simple adaptor protein.
Front Biosci. 2004 Jan 1;9:387-403. Review.
PMID: 14766376 [PubMed - indexed for MEDLINE]

Wick MJ, Ramos FJ, Chen H, Quon MJ, Dong LQ, Liu F.
Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop.
J Biol Chem. 2003 Oct 31;278(44):42913-9. Epub 2003 Aug 14.
PMID: 12923190 [PubMed - indexed for MEDLINE]

Gu S, Langlais P, Liu F, Jiang JX.
Mouse system-N amino acid transporter, mNAT3, expressed in hepatocytes and regulated by insulin-activated and phosphoinositide 3-kinase-dependent signalling.
Biochem J. 2003 May 1;371(Pt 3):721-31.
PMID: 12537539 [PubMed - indexed for MEDLINE]

Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F.
Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
J Biol Chem. 2003 Mar 7;278(10):8460-7. Epub 2002 Dec 18.
PMID: 12493740 [PubMed - indexed for MEDLINE]

Langlais P, Dong LQ, Ramos FJ, Hu D, Li Y, Quon MJ, Liu F.
Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.
Mol Endocrinol. 2004 Feb;18(2):350-8. Epub 2003 Nov 13.
PMID: 14615605 [PubMed - indexed for MEDLINE]

Wick KL, Liu F.
A new molecular target of insulin action: regulating the pivotal PDK1.
Curr Drug Targets Immune Endocr Metabol Disord. 2001 Nov;1(3):209-21. Review.
PMID: 12477287 [PubMed - indexed for MEDLINE]

Dong LQ, Ramos FJ, Wick MJ, Lim MA, Guo Z, Strong R, Richardson A, Liu F.
Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.
Biochem Biophys Res Commun. 2002 May 31;294(1):136-44.
PMID: 12054753 [PubMed - indexed for MEDLINE]

Wick MJ, Wick KR, Chen H, He H, Dong LQ, Quon MJ, Liu F.
Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells.
J Biol Chem. 2002 May 10;277(19):16632-8. Epub 2002 Feb 27.
PMID: 11877406 [PubMed - indexed for MEDLINE]

Wick MJ, Dong LQ, Hu D, Langlais P, Liu F.
Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.
J Biol Chem. 2001 Nov 16;276(46):42843-50. Epub 2001 Sep 10.
PMID: 11551902 [PubMed - indexed for MEDLINE]

Wick MJ, Dong LQ, Riojas RA, Ramos FJ, Liu F.
Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1.
J Biol Chem. 2000 Dec 22;275(51):40400-6.
PMID: 11006271 [PubMed - indexed for MEDLINE]

Langlais P, Dong LQ, Hu D, Liu F.
Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family.
Oncogene. 2000 Jun 8;19(25):2895-903.
PMID: 10871840 [PubMed - indexed for MEDLINE]

Dong LQ, Landa LR, Wick MJ, Zhu L, Mukai H, Ono Y, Liu F.
Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5089-94.
PMID: 10792047 [PubMed - indexed for MEDLINE]

Dong LQ, Zhang RB, Langlais P, He H, Clark M, Zhu L, Liu F.
Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta.
J Biol Chem. 1999 Mar 19;274(12):8117-22.
PMID: 10075713 [PubMed - indexed for MEDLINE]

Dong LQ, Porter S, Hu D, Liu F.
Inhibition of hGrb10 binding to the insulin receptor by functional domain-mediated oligomerization.
J Biol Chem. 1998 Jul 10;273(28):17720-5.
PMID: 9651371 [PubMed - indexed for MEDLINE]

Liu F, Roth RA.
Binding of SH2 containing proteins to the insulin receptor: a new way for modulating insulin signalling.
Mol Cell Biochem. 1998 May;182(1-2):73-8. Review.
PMID: 9609116 [PubMed - indexed for MEDLINE]

Dong LQ, Farris S, Christal J, Liu F.
Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insulin receptor.
Mol Endocrinol. 1997 Nov;11(12):1757-65.
PMID: 9369444 [PubMed - indexed for MEDLINE]

Dong LQ, Du H, Porter SG, Kolakowski LF Jr, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J.
Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.
J Biol Chem. 1997 Nov 14;272(46):29104-12. Erratum in: J Biol Chem 1998 Feb 13;273(7):4288. Mandarino J[corrected to Mandarino LJ].
PMID: 9360986 [PubMed - indexed for MEDLINE]