Shane L. Rea photo
Shane L. Rea

Shane L. Rea, Assistant Professor- Barshop Institute & Dept. Physiology

Room:STCBM 2.200.04
Web Page(s):
Education:B.Sc.(Hons.) University of Queensland
Ph.D., University of Queensland
Post Doctoral:McGill University
University of Colorado (Boulder)
Awards and Academic Honors:2006 Excellence In Science for Post-Doctoral Research, (sponsored by AAAS & UC Boulder)
2001-2003 Post-doctoral Fellowship, Polis Foundation
1995-1997 Postgraduate Research Scholarship, University of Queensland

Research Interest:

The Rea lab studies the fundamental mechanisms of aging. It makes use of various model organisms including the nematode C. elegans and the yeast S. cerevisiae. The primary focus of the group is on a class of long-lived mutants of C. elegans called the Mitochondrial (Mit) mutants. These animals contain mutations in their mitochondrial electron transport chain (ETC) that paradoxically lengthen life. Life extension following ETC disruption has also been observed in other species, including mice. Using novel GC-MS based techniques to map the exometabolism of Mit mutants, the Rea lab recently discovered that these animals uniquely generate several metabolic end products that appear to act as signaling molecules in their own right. In fact, these molecules are closely related to another group of signaling molecules in humans called oncometabolites that target enzymes belonging to the alpha-ketoglutarate-dependent hydoxylase family and are involved in the etiology of some cancers. Currently the Rea lab uses a variety of techniques that span chemistry, biochemistry and genetics, to explore how the unique metabolic profile of Mit mutants lead to their life extension.

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GC-MS Metabolomics identifies a novel alpha-ketoacid signature present in Mit mutants. Model depicting etiology of events leading to life extension in the C. elegans Mit mutants.

Selected publications:

Complete Publication Listing