Shane L. Rea, Assistant Professor- Barshop Institute & Dept. Physiology
|Education:||B.Sc.(Hons.) University of Queensland |
Ph.D., University of Queensland
|Post Doctoral:||McGill University|
University of Colorado (Boulder)
|Awards and Academic Honors:||2006 Excellence In Science for Post-Doctoral Research, (sponsored by AAAS & UC Boulder)|
2001-2003 Post-doctoral Fellowship, Polis Foundation
1995-1997 Postgraduate Research Scholarship, University of Queensland
The Rea lab studies the fundamental mechanisms of aging. It makes use of various model organisms including the nematode C. elegans and the yeast S. cerevisiae. The primary focus of the group is on a class of long-lived mutants of C. elegans called the Mitochondrial (Mit) mutants. These animals contain mutations in their mitochondrial electron transport chain (ETC) that paradoxically lengthen life. Life extension following ETC disruption has also been observed in other species, including mice. Using novel GC-MS based techniques to map the exometabolism of Mit mutants, the Rea lab recently discovered that these animals uniquely generate several metabolic end products that appear to act as signaling molecules in their own right. In fact, these molecules are closely related to another group of signaling molecules in humans called oncometabolites that target enzymes belonging to the alpha-ketoglutarate-dependent hydoxylase family and are involved in the etiology of some cancers. Currently the Rea lab uses a variety of techniques that span chemistry, biochemistry and genetics, to explore how the unique metabolic profile of Mit mutants lead to their life extension.
|GC-MS Metabolomics identifies a novel alpha-ketoacid signature present in Mit mutants.
||Model depicting etiology of events leading to life extension in the C. elegans Mit mutants.|
- A metabolic signature for long-life in the C. elegans Mit mutants.
Butler JA, Mishur RJ, Bhaskaran S, Rea SL
Aging Cell: 2012-11-22; (); Epub: 2012-11-22.
PMID: 23173729   LINK:
- Profiling the anaerobic response of C. elegans using GC-MS.
Butler JA, Mishur RJ, Bokov AF, Hakala KW, Weintraub ST, Rea SL
PLoS One: 2012-09-27; 7(9); e46140 Epub: 2012-09-27.
PMID: 23029411   LINK:
- Applications of mass spectrometry to metabolomics and metabonomics: detection of biomarkers of aging and of age-related diseases.
Mishur RJ, Rea SL
Mass Spectrom Rev: 2011-04-28; 31(1); 70-95 Epub: 2011-04-28.
PMID: 21538458   LINK:
- Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.
Rea SL, Ventura N, Johnson TE
PLoS Biol: 2007-10-02; 5(10); e259
PMID: 17914900   LINK:
- A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.
Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE
Nat Genet: 2005-08-01; 37(8); 894-8 Epub: 2005-07-24.
PMID: 16041374   LINK:
Complete Publication Listing