Borries Demeler, PhD, Associate Professor

Room:	420-D
Phone:	(210) 767-3332
Email:	demeler@biochem.uthscsa.edu
Web Page(s):	http://www.demeler.uthscsa.edu/
Education:	1988 B.S., Chemistry and Mathematics; University of Montana 1992 Ph.D, Biophysics; Oregon State University
Post Doctoral:	The University of Texas, Health Science Center, 1993-1996
Cross Appointments:	UTSA, Dept. of Computer Science
Other Faculty Positions:	Director, Center for Analytical Ultracentrifugation of Macromolecular Assemblies Director, Bioinformatics Core Facility Co-Director, Center for Macromolecular Interactions
Awards and Academic Honors:	1994 - American Indian Science and Engineering Society: Distinguished Service Award
Personal Statement:	To develop the most advanced high-resolution analysis software for analytical ultracentrifugation experiments.

Research Interest:

Our main project involves the development of the UltraScan data analysis software package (http://www.ultrascan.uthscsa.edu). This software is used for modeling of hydrodynamic and thermodynamic properties of biological and synthetic macromolecules, and interactions and thermodynamic characteristics of macromolecular assemblies. Areas of research involve advanced numerical analysis, optimization, high-performance network computing and cluster computing. Currently we are working on the development of software for the interpretation of multiwavelength sedimentation velocity experiments, and on spectral decomposition of analytical ultracentrifugation experiments. We are also investigating rigid body modeling approaches for predicting hydrodynamic properties of macromolecules and for the interpretation of small angle X-ray scattering data.

A finite element modeling utility in UltraScan used for analyzing size and shape distributions obtained from AUC data.	A 2-dimensional spectrum analysis of a sedimentation velocity experiment from a mixture of proteins heterogeneous in size and shape.

Selected publications:

• Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
  Bhattacharya A, Alam SL, Fricke T, Zadrozny K, Sedzicki J, Taylor AB, Demeler B, Pornillos O, Ganser-Pornillos BK, Diaz-Griffero F, Ivanov DN, Yeager M
  Proc Natl Acad Sci U S A: 2014-12-30; 111(52); 18625-30     Epub: 2014-12-17.
  PMID: 25518861    LINK:
• Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres.
  Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL
  Nat Commun: 2014-08-28; 5(); 4751     Epub: 2014-08-28.
  PMID: 25163529    LINK:
• Characterization of size, anisotropy, and density heterogeneity of nanoparticles by sedimentation velocity.
  Demeler B, Nguyen TL, Gorbet GE, Schirf V, Brookes EH, Mulvaney P, El-Ballouli AO, Pan J, Bakr OM, Demeler AK, Hernandez Uribe BI, Bhattarai N, Whetten RL
  Anal Chem: 2014-08-05; 86(15); 7688-95     Epub: 2014-07-18.
  PMID: 25010012    LINK:
• A parametrically constrained optimization method for fitting sedimentation velocity experiments.
  Gorbet G, Devlin T, Hernandez Uribe BI, Demeler AK, Lindsey ZL, Ganji S, Breton S, Weise-Cross L, Lafer EM, Brookes EH, Demeler B
  Biophys J: 2014-04-15; 106(8); 1741-50
  PMID: 24739173    LINK:
• A postreductionist framework for protein biochemistry.
  Laue T, Demeler B
  Nat Chem Biol: 2011-06-01; 7(6); 331-4
  PMID: 21587250    LINK:

Complete Publication Listing

Lab Associations:
  Gary Gorbet, Senior Applications Systems Analyst
  Virgil Schirf, MS, Technical Director

Post-doctoral:
  Emre Brookes, PhD, Assistant Professor/Research