Borries Demeler, PhD photo
Borries Demeler, PhD

Borries Demeler, PhD, Associate Professor

Room:420-D
Phone:(210) 767-3332
Email:demeler@biochem.uthscsa.edu
Web Page(s):http://www.demeler.uthscsa.edu/
Education:1988 B.S., Chemistry and Mathematics; University of Montana
1992 Ph.D, Biophysics; Oregon State University
Post Doctoral:The University of Texas, Health Science Center, 1993-1996
Cross Appointments:UTSA, Dept. of Computer Science
Other Faculty Positions:Director, Center for Analytical Ultracentrifugation of Macromolecular Assemblies
Director, Bioinformatics Core Facility
Co-Director, Center for Macromolecular Interactions
Awards and Academic Honors:1994 - American Indian Science and Engineering Society: Distinguished Service Award
Personal Statement:To develop the most advanced high-resolution analysis software for analytical ultracentrifugation experiments.

Research Interest:

Our main project involves the development of the UltraScan data analysis software package (http://www.ultrascan.uthscsa.edu). This software is used for modeling of hydrodynamic and thermodynamic properties of biological and synthetic macromolecules, and interactions and thermodynamic characteristics of macromolecular assemblies. Areas of research involve advanced numerical analysis, optimization, high-performance network computing and cluster computing. Currently we are working on the development of software for the interpretation of multiwavelength sedimentation velocity experiments, and on spectral decomposition of analytical ultracentrifugation experiments. We are also investigating rigid body modeling approaches for predicting hydrodynamic properties of macromolecules and for the interpretation of small angle X-ray scattering data.

image1 image2
A finite element modeling utility in UltraScan used for analyzing size and shape distributions obtained from AUC data. A 2-dimensional spectrum analysis of a sedimentation velocity experiment from a mixture of proteins heterogeneous in size and shape.

Selected publications:

Complete Publication Listing

Lab Associations:
  Gary Gorbet, Senior Applications Systems Analyst
  Virgil Schirf, MS, Technical Director

Post-doctoral:
  Emre Brookes, PhD, Assistant Professor/Research