Borries Demeler, PhD, Associate Professor
|Education:||1988 B.S., Chemistry and Mathematics; University of Montana|
1992 Ph.D, Biophysics; Oregon State University
|Post Doctoral:||The University of Texas, Health Science Center, 1993-1996|
|Cross Appointments:||UTSA, Dept. of Computer Science|
|Other Faculty Positions:||Director, Center for Analytical Ultracentrifugation of Macromolecular Assemblies|
Director, Bioinformatics Core Facility
Co-Director, Center for Macromolecular Interactions
|Awards and Academic Honors:||1994 - American Indian Science and Engineering Society: Distinguished Service Award|
|Personal Statement:||To develop the most advanced high-resolution analysis software for analytical ultracentrifugation experiments.
Our main project involves the development of the UltraScan data analysis software package (http://www.ultrascan.uthscsa.edu). This software is used for modeling of hydrodynamic and thermodynamic properties of biological and synthetic macromolecules, and interactions and thermodynamic characteristics of macromolecular assemblies. Areas of research involve advanced numerical analysis, optimization, high-performance network computing and cluster computing. Currently we are working on the development of software for the interpretation of multiwavelength sedimentation velocity experiments, and on spectral decomposition of analytical ultracentrifugation experiments. We are also investigating rigid body modeling approaches for predicting hydrodynamic properties of macromolecules and for the interpretation of small angle X-ray scattering data.
|A finite element modeling utility in UltraScan used for analyzing size and shape distributions obtained from AUC data.
||A 2-dimensional spectrum analysis of a sedimentation velocity experiment from a mixture of proteins heterogeneous in size and shape.|
- Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Bhattacharya A, Alam SL, Fricke T, Zadrozny K, Sedzicki J, Taylor AB, Demeler B, Pornillos O, Ganser-Pornillos BK, Diaz-Griffero F, Ivanov DN, Yeager M
Proc Natl Acad Sci U S A: 2014-12-30; 111(52); 18625-30 Epub: 2014-12-17.
PMID: 25518861   LINK:
- Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres.
Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL
Nat Commun: 2014-08-28; 5(); 4751 Epub: 2014-08-28.
PMID: 25163529   LINK:
- Characterization of size, anisotropy, and density heterogeneity of nanoparticles by sedimentation velocity.
Demeler B, Nguyen TL, Gorbet GE, Schirf V, Brookes EH, Mulvaney P, El-Ballouli AO, Pan J, Bakr OM, Demeler AK, Hernandez Uribe BI, Bhattarai N, Whetten RL
Anal Chem: 2014-08-05; 86(15); 7688-95 Epub: 2014-07-18.
PMID: 25010012   LINK:
- A parametrically constrained optimization method for fitting sedimentation velocity experiments.
Gorbet G, Devlin T, Hernandez Uribe BI, Demeler AK, Lindsey ZL, Ganji S, Breton S, Weise-Cross L, Lafer EM, Brookes EH, Demeler B
Biophys J: 2014-04-15; 106(8); 1741-50
PMID: 24739173   LINK:
- A postreductionist framework for protein biochemistry.
Laue T, Demeler B
Nat Chem Biol: 2011-06-01; 7(6); 331-4
PMID: 21587250   LINK:
Complete Publication Listing
Gary Gorbet, Senior Applications Systems Analyst
Virgil Schirf, MS, Technical Director
Emre Brookes, PhD, Assistant Professor/Research