Borries Demeler, PhD, Associate Professor
| Room: | 420-D |
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| Phone: | (210) 767-3332 |
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| Email: | demeler@biochem.uthscsa.edu |
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| Web Page(s): | http://www.demeler.uthscsa.edu/ |
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| Education: | 1988 B.S., Chemistry and Mathematics; University of Montana
1992 Ph.D, Biophysics; Oregon State University
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| Post Doctoral: | The University of Texas, Health Science Center, 1993-1996 |
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| Cross Appointments: | UTSA, Dept. of Computer Science |
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| Other Faculty Positions: | Director, Center for Analytical Ultracentrifugation of Macromolecular Assemblies
Director, Bioinformatics Core Facility
Co-Director, Center for Macromolecular Interactions |
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| Awards and Academic Honors: | 1994 - American Indian Science and Engineering Society: Distinguished Service Award |
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| Personal Statement: | To develop the most advanced high-resolution analysis software for analytical ultracentrifugation experiments.
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Research Interest:
Our main project involves the development of the UltraScan data analysis software package (http://www.ultrascan.uthscsa.edu). This software is used for modeling of hydrodynamic and thermodynamic properties of biological and synthetic macromolecules, and interactions and thermodynamic characteristics of macromolecular assemblies. Areas of research involve advanced numerical analysis, optimization, high-performance network computing and cluster computing. Currently we are working on the development of software for the interpretation of multiwavelength sedimentation velocity experiments, and on spectral decomposition of analytical ultracentrifugation experiments. We are also investigating rigid body modeling approaches for predicting hydrodynamic properties of macromolecules and for the interpretation of small angle X-ray scattering data.
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| A finite element modeling utility in UltraScan used for analyzing size and shape distributions obtained from AUC data. |
A 2-dimensional spectrum analysis of a sedimentation velocity experiment from a mixture of proteins heterogeneous in size and shape. |
Selected publications:
- Divergence of multimodular polyketide synthases revealed by a didomain structure.
Zheng J, Gay DC, Demeler B, White MA, Keatinge-Clay AT
Nat Chem Biol: 2012-07-01; 8(7); 615-21 Epub: 2012-05-27.
PMID: 22634636 LINK:
- A postreductionist framework for protein biochemistry.
Laue T, Demeler B
Nat Chem Biol: 2011-06-01; 7(6); 331-4
PMID: 21587250 LINK:
- Characterization of reversible associations by sedimentation velocity with UltraScan.
Demeler B, Brookes E, Wang R, Schirf V, Kim CA
Macromol Biosci: 2010-07-07; 10(7); 775-82
PMID: 20486142 LINK:
- The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: enhanced capabilities allow the reliable hydrodynamic modeling of virtually any kind of biomacromolecule.
Brookes E, Demeler B, Rosano C, Rocco M
Eur Biophys J: 2010-02-01; 39(3); 423-35 Epub: 2009-02-21.
PMID: 19234696 LINK:
- Modulation of aggregate size- and shape-distributions of the amyloid-beta peptide by a designed beta-sheet breaker.
Nagel-Steger L, Demeler B, Meyer-Zaika W, Hochdörffer K, Schrader T, Willbold D
Eur Biophys J: 2010-02-01; 39(3); 415-22 Epub: 2009-02-24.
PMID: 19238376 LINK:
Complete Publication Listing
Lab Associations:
Gary Gorbet, Senior Applications Systems Analyst
Virgil Schirf, MS, Technical Director
Post-doctoral:
Emre Brookes, PhD, Assistant Professor/Research
