John C. Lee, PhD photo
John C. Lee, PhD

John C. Lee, PhD, Adjunct Professor (Retired, UT Health San Antonio)

Web Page(s):
Education:Ph.D. (Purdue University)
Post Doctoral:Massachusetts Institute of Technology

Research Interest:

Our major research interest focuses on elucidation of the molecular mechanism of action of Bone Morphogenetic Protein -7 (BMP-7, also called Osteogenic Protein-1 (OP-1). BMP-7 is a member of the BMP family of proteins, consisting of about 20 structurally related proteins. BMPs belong to the transforming growth factor-beta (TGF-������¯���¯���¿���½������¢) superfamily. Most BMPs exhibit multiple functions in various tissues during embryogenesis and development. For example, BMP-7 induces differentiation, growth, and repair of bone, cartilage, and tendon/ligament cells. Clinical studies show that implantation of BMP-7 into fracture or wound sites in adults results in improved repair/healing. BMP-7 is essential in the development of the eye, the kidney, and the nerve system and in the repair of these tissues in adults. Recent projects in the laboratory include (1) structural analysis of the interactions between BMP-7 and its receptors (using a combination of biochemical and biophysical methodologies, such as NMR spectroscopy, fluorescence spectroscopy, computational analysis, and molecular genetics) in order to understand the specificity of the ligand-receptor interaction, (2) analysis of the genes that are activated or inactivated by BMP-7 (using different molecular approaches, including DNA microarray analysis) and their mode of regulation, as well as (3) analysis of the functional relationships between BMP-7 and other proteins and signaling molecules, such as IGF-I.

Selected publications:

Complete Publication Listing

Lab Associations:
  Lee-Chuan Caroline Yeh, PhD, Assistant Professor/Research