Donald McEwen, PhD, Assistant Professor
|Education:||Washington University School of Medicine|
(Ph.D.; David Ornitz)
|Post Doctoral:||University of North Carolina at Chapel Hill|
|Cross Appointments:||Greehey Children|
The fruitfly, Drosophila melanogaster, is a popular model system used by many labs to probe various aspects of cell biology, cell signaling, and embryonic development. It's popularity stems from a number of different intrinsic characteristics, including the fact that development occurs outside of the adult organisms, which allows one to obtain samples with out the need to sacrifice the adults; an extensively defined collection of defined mutants, and a sequenced genome. In addition, most of the key signaling pathways that play a role in regulating cell proliferation, cell differentiation, and programmed cell death are evolutionarily conserved. To this end, I use Drosophila to study various aspects of the JNK signaling pathway and how it induces programmed cell death in response to genotoxic stress.
Being trained as a developmental biologist, I am taking genetic and biochemical approaches to analyze key signaling pathways that orchestrate development, yet are co-opted during oncogenesis. As these key pathways are evolutionarily conserved, I use the fruit fly, Drosophila melanogaster, to study various aspects of the Jun N-terminal kinase (JNK) and p53 signaling pathways and how they influence the induction of programmed cell death in response to genotoxic stress.
- Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis.
McEwen DG, Peifer M
Development: 2005-09-01; 132(17); 3935-46 Epub: 2005-08-03.
PMID: 16079158   LINK:
- Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.
McCartney BM, McEwen DG, Grevengoed E, Maddox P, Bejsovec A, Peifer M
Nat Cell Biol: 2001-10-01; 3(10); 933-8
PMID: 11584277   LINK:
- A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.
Cox RT, McEwen DG, Myster DL, Duronio RJ, Loureiro J, Peifer M
Genetics: 2000-08-01; 155(4); 1725-40
PMID: 10924470   LINK:
- The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning.
McEwen DG, Cox RT, Peifer M
Development: 2000-08-01; 127(16); 3607-17
PMID: 10903184   LINK:
- Fibroblast growth factor receptor 3 gene transcription is suppressed by cyclic adenosine 3
McEwen DG, Green RP, Naski MC, Towler DA, Ornitz DM
J Biol Chem: 1999-10-22; 274(43); 30934-42
PMID: 10521488   LINK:
Complete Publication Listing