VIEW RESEARCH STAFF

Xiaoli Gao, PhD photo
Xiaoli Gao, PhD

Xiaoli Gao, PhD, Technical Director

Room:256/STRF
Phone:210-562-4067 (Office); 210-562-4066 (Lab)
Email:gaox@uthscsa.edu
Web Page(s):
Education:Ph.D. Michigan State University
Post Doctoral:Pacific Northwest National Laboratory

Research Interest:

I am the Technical Director of the Metabolomics Core in the UTHSCSA Institutional Mass Spectrometry Laboratory. I have extensive experience in mass spectrometry (MS) based small molecule qualitative and quantitative analyses, with particular emphasis on identification and quantification of lipids and polar metabolites in complex biological matrices. My research interests have focused on global and targeted metabolomic profiling in biological samples.

Selected from 30 peer-reviewed publications:
21. Eskander MA, Ruparel S, Green DP, Chen PB, Por ED, Jeske NA, Gao X, Flores ER, Hargreaves KM. Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms. J Neurosci. 2015 Jun 3;35(22):8593-603.
20. Lin AL, Zhang W, Gao X, Watts L. Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain. Neurobiol Aging. 2015 Jul;36(7):2296-303.
19. Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014 Apr 10;7(1):79-85.
18. Meng D, Zhang Q, Gao X, Wu S, Lin G. LipidMiner: a software for automated identification and quantification of lipids from multiple liquid chromatography-mass spectrometry data files. Rapid Commun Mass Spectrom. Apr 30;28(8):981-5. 2014.
17. Zhou J, Riquelme MA, Gao X, Ellies LG, Sun L and Jiang J. Differential Impact of Adenosine Nucleotides Released by Osteocytes on Breast Cancer Growth and Bone Metastasis. Oncogene. May 19. doi: 10.1038/onc.2014.113.
16. Aye IL, Gao X, Weintraub ST, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis. Molecular Endocrinology. Apr;28(4):512-24. 2014.
15. Paredes R, Marballi K, Quinones M, Gao X, Valdez C, Ahuja S, Velligan D, Walss-Bass C. Metabolomic profiling of schizophrenia patients at risk for metabolic syndrome. The International Journal of Neuropsychopharmacology. Feb 25:1-10. 2014.
14. Bao J, Gao X, Jones AD. Unusual negative charge-directed fragmentation: collision-induced dissociation of cyclopentenone oxylipins in negative ion mode. Rapid Commun Mass Spectrom. Mar 15;28(5):457-64. 2014.
13. Gao X, Zhang Q, Meng D, Isaac G, Zhao R, Fillmore TL, Chu RK, Zhou J, Tang K, Hu Z, Moore RJ, Smith RD, Katze MG, Metz TO. A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling. Anal Bioanal Chem. 402, 2923-2933, 2012
12. Hu ZP, Kim YM, Sowa MB, Robinson RJ, Gao X, Metz TO, Morgan WF, Zhang Q. Metabolomic response of human skin tissue to low dose ionizing radiation. Mol Biosyst. 8, 1979-1986, 2012
11. Zhou JY, Dann GP, Shi T, Wang L, Gao X, Su D, Nicora CD, Shukla AK, Moore RJ, Liu T, Camp Ii DG, Smith RD, Qian WJ. Simple Sodium Dodecyl Sulfate-Assisted Sample Preparation Method for LC-MS-Based Proteomics Applications. Anal Chem. 84, 2862-2867, 2012
10. Xu Y, Gao X, Wang SH, Liu H, Williams PA, Zhou NY. MhbT is a Specific Transporter for 3-Hydroxybenzoate Uptake by Gram-Negative Bacteria. Appl Environ Microbiol. 2012 Jun 22.
9. Rasmussen AL, Diamond DL, McDermott JE, Gao X, Metz TO, Matzke MM, Carter VS, Belisle SE, Korth MJ, Waters KM, Smith RD, Katze MG. Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis. J Virol. 85, 11646-11654, 2011
8. Zeng W, Brutus A, Kremer JM, Withers JC, Gao X, Jones AD, He SY. A genetic screen reveals Arabidopsis stomatal and/or apoplastic defenses against Pseudomonas syringae pv. tomato DC3000. PLoS Pathog. 7, e1002291, 2011
7. Koo AJ, Gao X, Jones AD, Howe GA. A rapid wound signal activates the systemic synthesis of bioactive jasmonates in Arabidopsis. Plant J. 59, 974-986, 2009
6. Zhang Y, Gao X. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of L-lactate dehydrogenase and its H171C mutant from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):63-5.
5. Zhang Y, Gao X, Zheng Y, Garavito RM. Identification of succinic semialdehyde reductases from Geobacter: expression, purification, crystallization, preliminary functional, and crystallographic analysis. Acta Biochim Biophys Sin. 2011 Dec;43(12):996-1002.
4. Zhang Y, Gao X, Garavito RM. Biochemical characterization of human dynamin-like protein 1. J Biochem. 2011 Dec;150(6):627-33.
3. Zhang Y, Gao X, Michael Garavito R. Structural analysis of the intracellular domain of (pro)renin receptor fused to maltose-binding protein. Biochem Biophys Res Commun. 2011 Apr 22;407(4):674-9.
2. Zhang Y, Gao X, Qin L, Buchko GW, Robinson H, Varnum SM. High-level expression, purification, crystallization and preliminary X-ray crystallographic studies of the receptor-binding domain of botulinum neurotoxin serotype D. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1610-3.
1. Gao X, Tan CL, Yeo CC, and Poh CL. Molecular and biochemical characterization of the xlnD-encoded 3-hydroxybenzoate 6-hydroxylase involved in the degradation of 2,5-xylenol via the gentisate pathway in Pseudomonas alcaligenes NCIMB 9867. J Bacteriology, 2005. 187(22): 7696-7702.

 

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