Xiaoli Gao, PhD photo
Xiaoli Gao, PhD

Xiaoli Gao, PhD, Technical Director

Phone:210-562-4067 (Office); 210-562-4066 (Lab)
Web Page(s):
Education:Ph.D. Michigan State University
Post Doctoral:Pacific Northwest National Laboratory

Research Interest:

I am the Technical Director of the Metabolomics Core in the UTHSCSA Institutional Mass Spectrometry Laboratory. I have extensive experience in mass spectrometry (MS) based small molecule qualitative and quantitative analyses, with particular emphasis on identification and quantification of lipids and polar metabolites in complex biological matrices. My research interests have focused on global and targeted metabolomic profiling in biological samples for studying human health and diseases such as cancer.

Selected from 39 peer-reviewed publications:
33. Hamilton R, Walsh M, Singh R, Rodriguez K, Gao X, Rahman MM, Chaudhuri A, Bhattacharya A. Oxidative damage to myelin proteins accompanies peripheral nerve motor dysfunction in aging C57BL/6 male mice. J Neurol Sci. 2016 Nov 15;370:47-52.
32. Parrott JM, Redus L, Santana-Coelho D, Morales J, Gao X, O'Connor JC. Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. Transl Psychiatry. 2016 Oct 18;6(10):e918.
31. Kar A, Beam H, Borror MB, Luckow M, Gao X, Rea SL. CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System. PLoS One. 2016 Sep 7;11(9):e0162165.
30. Wali S, Gupta R, Yu JJ, Mfuh A, Gao X, Guentzel, MN, Chambers JP, Sazaly AB, Zhong G, Arulanandam BP. Guinea Pig Genital Tract Lipidome Reveals In vivo and In vitro Regulation of Phosphotidylcholine 16:0/18:1 and contribution to Chlamydia trachomatis Serovar D Infectivity. Metabolomics, 2016 12:74.
29. Green D, Ruparel S, Gao X, Ruparel N, Patil M, Akopian A, Hargreaves K. EXPRESS: Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. Mol Pain. 2016 Jul 12;12.
28. Jiang J, Zhou J, Riquelme M, Gu S, Kar R, Gao X, Sun L. Osteocytic connexin hemichannels suppress breast cancer growth and bone metastasis. Oncogene. 2016 Apr 4.
27. Muralimanoharan S, Gao X, Weintraub S, Myatt L, Maloyan A. Sexual Dimorphism in Activation of Placental Autophagy in Obese Women with Evidence for Fetal Programming from a Placenta-Specific Mouse Model. Autophagy. 2016 Mar 17:0.
26. Edmunds LR, Sharma L, Wang H, Kang A, dSouza S, Lu J, McLaughlin M, Dolezal JM, Gao X, Weintraub ST, Ding Y, Zeng X, Yates N, Prochownik EV. c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function. PLoS One. 2015 Jul 31;10(7):e0134049.
25. Lin AP, Abbas S, Kim SW, Ortega M, Bouamar H, Escobedo Y, Varadarajan P, Qin Y, Sudderth J, Schulz E, Deutsch A, Mohan S, Ulz P, Neumeister P, Rakheja D, Gao X, Hinck A, Weintraub ST, DeBerardinis RJ, Sill H, Dahia PL, Aguiar RC. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Nature Commun. 2015 Jul 16;6:7768.
24. Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. p53 and rapamycin are additive. Oncotarget. 2015 Jun 23.
23. Robertson CL, Srivastava J, Siddiq A, Gredler R, Emdad L, Rajasekaran D, Akiel M, Shen XN, Corwin F, Sundaresan G, Zweit J, Croniger C, Gao X, Ghosh S, Hylemon PB, Subler MA, Windle JJ, Fisher PB, Sarkar D. Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis. J Biol Chem. 2015 Jul 17;290(29):18227-36.
22. Lin AL, Zhang W, Gao X, Watts L. Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain. Neurobiol Aging. 2015 Jul;36(7):2296-303.
21. Eskander MA, Ruparel S, Green DP, Chen PB, Por ED, Jeske NA, Gao X, Flores ER, Hargreaves KM. Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms. J Neurosci. 2015 Jun 3;35(22):8593-603.
20. Zhou JZ, Riquelme MA, Gao X, Ellies LG, Sun LZ, Jiang JX. Differential Impact of Adenosine Nucleotides Released by Osteocytes on Breast Cancer Growth and Bone Metastasis. Oncogene. 2015 Apr 2;34(14):1831-42.
19. Renthal R, Li AY, Gao X, Adalberto A. Perez De Leon. Surface Polar Lipids Differ in Male and Female Phlebotomus papatasi (Diptera: Psychodidae). J Med Entomol. 2014 Nov 1;51(6):1237-1241.
18. Paredes R, Marballi K, Quinones M, Gao X, Valdez C, Ahuja S, Velligan D, Walss-Bass C. Metabolomic profiling of schizophrenia patients at risk for metabolic syndrome. Int J Neuropsychopharmacol. 2014 Aug;17(8):1139-48.
17. Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014 Apr 10;7(1):79-85.
16. Meng D, Zhang Q, Gao X, Wu S, Lin G. LipidMiner: a software for automated identification and quantification of lipids from multiple liquid chromatography-mass spectrometry data files. Rapid Commun Mass Spectrom. 2014 Apr 30;28(8):981-5.
15. Aye IL, Gao X, Weintraub ST, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis. Mol Endocrinol. 2014 Apr;28(4):512-24.
14. Bao J, Gao X, Jones AD. Unusual negative charge-directed fragmentation: collision-induced dissociation of cyclopentenone oxylipins in negative ion mode. Rapid Commun Mass Spectrom. 2014 Mar 15;28(5):457-64.
13. Xu Y, Gao X, Wang SH, Liu H, Williams PA, Zhou NY. MhbT is a Specific Transporter for 3-Hydroxybenzoate Uptake by Gram-Negative Bacteria. Appl Environ Microbiol. 2012 Sep;78(17):6113-20.
12. Hu ZP, Kim YM, Sowa MB, Robinson RJ, Gao X, Metz TO, Morgan WF, Zhang Q. Metabolomic response of human skin tissue to low dose ionizing radiation. Mol Biosyst. 2012 Jul 6;8(7):1979-86.
11. Gao X, Zhang Q, Meng D, Isaac G, Zhao R, Fillmore TL, Chu RK, Zhou J, Tang K, Hu Z, Moore RJ, Smith RD, Katze MG, Metz TO. A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling. Anal Bioanal Chem. 2012 Mar;402(9):2923-33.
10. Zhou JY, Dann GP, Shi T, Wang L, Gao X, Su D, Nicora CD, Shukla AK, Moore RJ, Liu T, Camp Ii DG, Smith RD, Qian WJ. Simple Sodium Dodecyl Sulfate-Assisted Sample Preparation Method for LC-MS-Based Proteomics Applications. Anal Chem. 2012 Mar 20;84(6):2862-7.
9. Zhang Y, Gao X. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of L-lactate dehydrogenase and its H171C mutant from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):63-5.
8. Zhang Y, Gao X, Zheng Y, Garavito RM. Identification of succinic semialdehyde reductases from Geobacter: expression, purification, crystallization, preliminary functional, and crystallographic analysis. Acta Biochim Biophys Sin. 2011 Dec;43(12):996-1002.
7. Zhang Y, Gao X, Garavito RM. Biochemical characterization of human dynamin-like protein 1. J Biochem. 2011 Dec;150(6):627-33.
6. Rasmussen AL, Diamond DL, McDermott JE, Gao X, Metz TO, Matzke MM, Carter VS, Belisle SE, Korth MJ, Waters KM, Smith RD, Katze MG. Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis. J Virol. 2011 Nov;85(22):11646-54.
5. Zeng W, Brutus A, Kremer JM, Withers JC, Gao X, Jones AD, He SY. A genetic screen reveals Arabidopsis stomatal and/or apoplastic defenses against Pseudomonas syringae pv. tomato DC3000. PLoS Pathog. 2011 Oct;7(10):e1002291.
4. Zhang Y, Gao X, Michael Garavito R. Structural analysis of the intracellular domain of (pro)renin receptor fused to maltose-binding protein. Biochem Biophys Res Commun. 2011 Apr 22;407(4):674-9.
3. Zhang Y, Gao X, Qin L, Buchko GW, Robinson H, Varnum SM. High-level expression, purification, crystallization and preliminary X-ray crystallographic studies of the receptor-binding domain of botulinum neurotoxin serotype D. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1610-3.
2. Koo AJ, Gao X, Jones AD, Howe GA. A rapid wound signal activates the systemic synthesis of bioactive jasmonates in Arabidopsis. Plant J. 2009 Sep;59(6):974-86.
1. Gao X, Tan CL, Yeo CC, and Poh CL. Molecular and biochemical characterization of the xlnD-encoded 3-hydroxybenzoate 6-hydroxylase involved in the degradation of 2,5-xylenol via the gentisate pathway in Pseudomonas alcaligenes NCIMB 9867. J Bacteriology, 2005. 187(22): 7696-7702.


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