Liezl Francisco, Molecular Biophysics & Biochemistry
My research in the Ivanov Lab is focused on the mechanisms of protein recruitment in the DNA damage sensing and repair. I am particularly interested in the XPF/Mus81 family of nucleases, which play essential roles in multiple DNA repair pathways. In my work I use Nuclear Magnetic Resonance, X-ray crystallography and other biophysical and biochemical techniques to identify and characterize critical macromolecular interactions involved in DNA repair. Protein networks involved in DNA damage sensing and repair are commonly altered in cancer cells because they are intricately interconnected with the pathways controlling cell cycle, cell proliferation and apoptosis. One of my research goals is to explore whether inhibitors of protein-protein interactions in DNA repair could potentially have anti-cancer activity.
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