BLASTP 2.2.9 [May-01-2004]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= tem164 ter 2 ter
(325 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
1,865,463 sequences; 619,299,334 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
ref|ZP_00240821.1| thymidylate synthase [Bacillus cereus G9... 322 6e-87
ref|NP_831956.1| Thymidylate synthase [Bacillus cereus ATCC... 321 1e-86
ref|NP_978577.1| thymidylate synthase [Bacillus cereus ATCC... 320 2e-86
ref|NP_656100.1| thymidylat_synt, Thymidylate synthase [Bac... 320 2e-86
ref|NP_785417.1| thymidylate synthase [Lactobacillus planta... 319 5e-86
ref|NP_692661.1| thymidylate synthase [Oceanobacillus iheye... 317 3e-85
ref|ZP_00323475.1| COG0207: Thymidylate synthase [Pediococc... 316 4e-85
ref|NP_815293.1| thymidylate synthase [Enterococcus faecali... 313 3e-84
ref|NP_371951.1| thymidylate synthase [Staphylococcus aureu... 312 6e-84
gb|AAC45469.1| thymidylate synthase [Neisseria gonorrhoeae] 311 1e-83
sp|O33380|TYSY_NEIGO Thymidylate synthase (TS) (TSase) 311 1e-83
ref|ZP_00286217.1| COG0207: Thymidylate synthase [Enterococ... 309 4e-83
ref|NP_948831.1| thymidylate synthase [Rhodopseudomonas pal... 307 2e-82
ref|NP_773152.1| thymidylate synthase [Bradyrhizobium japon... 306 5e-82
ref|NP_274712.1| thymidylate synthase [Neisseria meningitid... 305 6e-82
ref|NP_284668.1| thymidylate synthase [Neisseria meningitid... 305 9e-82
ref|NP_390065.1| thymidylate synthase B [Bacillus subtilis]... 305 1e-81
ref|ZP_00234494.1| thymidylate synthase [Listeria monocytog... 304 1e-81
ref|NP_471322.1| similar to thymidylate synthase [Listeria ... 304 2e-81
ref|NP_465399.1| similar to thymidylate synthase [Listeria ... 304 2e-81
ref|NP_764675.1| thymidylate synthase [Staphylococcus epide... 304 2e-81
ref|NP_420927.1| thymidylate synthase [Caulobacter crescent... 302 6e-81
ref|ZP_00208952.1| COG0207: Thymidylate synthase [Magnetosp... 302 7e-81
ref|ZP_00309278.1| COG0207: Thymidylate synthase [Cytophaga... 302 7e-81
sp|P54081|TYSB_BACAM Thymidylate synthase B (TS B) (TSase B) 301 9e-81
ref|YP_014496.1| thymidylate synthase [Listeria monocytogen... 301 9e-81
pir||SYBSTB thymidylate synthase (EC 2.1.1.45) B - Bacillus... 301 1e-80
ref|NP_600073.1| thymidylate synthase [Corynebacterium glut... 301 1e-80
emb|CAA90532.1| thymidylate synthetase [Bacillus amylolique... 301 2e-80
ref|NP_969988.1| thyA [Bdellovibrio bacteriovorus HD100] >g... 299 4e-80
pir||S35239 thymidylate synthase (EC 2.1.1.45) B - Bacillus... 299 5e-80
gb|AAA25255.1| thymidylate synthase [Lactobacillus casei] 299 5e-80
ref|NP_244318.1| thymidylate synthase B [Bacillus haloduran... 299 5e-80
pdb|2TSC|A Chain A, Thymidylate Synthase (E.C.2.1.1.45) Com... 298 8e-80
ref|NP_337339.1| thymidylate synthase [Mycobacterium tuberc... 298 1e-79
ref|NP_737529.1| putative thymidylate synthase [Corynebacte... 298 1e-79
ref|NP_217280.1| thyA [Mycobacterium tuberculosis H37Rv] >g... 298 1e-79
pdb|1TLC|A Chain A, Thymidylate Synthase Complexed With Dgm... 297 2e-79
ref|NP_289379.1| thymidylate synthetase [Escherichia coli O... 297 2e-79
ref|ZP_00053813.2| COG0207: Thymidylate synthase [Magnetosp... 297 2e-79
ref|NP_708616.1| thymidylate synthetase [Shigella flexneri ... 297 2e-79
sp|Q27828|DRTS_PARTE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 297 2e-79
ref|NP_296349.1| thymidylate synthase [Deinococcus radiodur... 297 2e-79
pdb|1KCE|A Chain A, E. Coli Thymidylate Synthase Mutant E58... 297 3e-79
gb|AAB40474.1| thymidylate synthetase 296 3e-79
sp|P00469|TYSY_LACCA Thymidylate synthase (TS) (TSase) >gi|... 296 4e-79
pdb|1TDA| Thymidylate Synthase (E.C.2.1.1.45) Mutant With ... 296 4e-79
ref|ZP_00183089.1| COG0207: Thymidylate synthase [Exiguobac... 296 4e-79
pdb|1ZPR|A Chain A, E. Coli Thymidylate Synthase Mutant E58... 296 4e-79
ref|NP_404408.1| thymidylate synthase [Yersinia pestis] >gi... 296 5e-79
pdb|1F4G|A Chain A, Crystal Structure Of E. Coli Thymidylat... 296 5e-79
pdb|1BJG| D221(169)n Mutant Does Not Promote Opening Of Th... 296 6e-79
pdb|1VZB| L. Casei Thymidylate Synthase Mutant E60q Binary... 295 8e-79
pdb|1VZA| Thymidylate Synthase E60d Mutant Binary Complex ... 295 1e-78
gb|AAP31579.1| thymidylate synthase [Shigella flexneri] 295 1e-78
pdb|1FFL|A Chain A, Crystal Structure Of The Apo-Thymidylat... 295 1e-78
pdb|1TSY| Thymidylate Synthase R179k Mutant >gi|1421243|pd... 295 1e-78
pdb|1BQ2| E. Coli Thymidylate Synthase Mutant N177a >gi|51... 295 1e-78
gb|AAN41256.1| mutant thymidilate synthetase [Escherichia c... 295 1e-78
ref|NP_355015.1| AGR_C_3709p [Agrobacterium tumefaciens str... 295 1e-78
ref|NP_961803.1| ThyA [Mycobacterium avium subsp. paratuber... 294 1e-78
pdb|1TVW| Contributions Of Orientation And Hydrogen Bondin... 294 2e-78
pdb|1NCE|A Chain A, Crystal Structure Of A Ternary Complex ... 294 2e-78
pdb|1EVG|A Chain A, Crystal Structure Analysis Of Cys167 Mu... 294 2e-78
pdb|1NJD| Thymidylate Synthase, Mutation, N229d With 2'-De... 294 2e-78
ref|NP_532723.1| thymidylate synthase [Agrobacterium tumefa... 294 2e-78
pdb|1AIQ|A Chain A, Crystal Structure Of Thymidylate Syntha... 294 2e-78
pdb|1TSX| Thymidylate Synthase R179e Mutant 294 2e-78
pdb|1JMG| Contributions Of Orientation And Hydrogen Bondin... 294 2e-78
gb|AAS80323.1| thymidylate synthetase [Xenorhabdus nematoph... 294 2e-78
ref|NP_539525.1| THYMIDYLATE SYNTHASE [Brucella melitensis ... 294 2e-78
pdb|1BO8|A Chain A, Thymidylate Synthase R178t Mutant 293 2e-78
pdb|1BO7|A Chain A, Thymidylate Synthase R179t Mutant 293 2e-78
ref|NP_299611.1| thymidylate synthase [Xylella fastidiosa 9... 293 2e-78
pdb|1JG0|A Chain A, Crystal Structure Of Escherichia Coli T... 293 2e-78
pdb|1EV5|A Chain A, Crystal Structure Analysis Of Ala167 Mu... 293 3e-78
pdb|1TSV| Thymidylate Synthase R179a Mutant >gi|1421235|pd... 293 3e-78
pdb|1TVU| Contributions Of Orientation And Hydrogen Bondin... 293 3e-78
ref|NP_840652.1| Thymidylate synthase [Nitrosomonas europae... 293 3e-78
pdb|1HW4|A Chain A, Structure Of Thymidylate Synthase Sugge... 293 3e-78
pdb|1NJA| Thymidylate Synthase, Mutation, N229c With 2'-De... 293 3e-78
pdb|1BP0|A Chain A, Thymidylate Synthase R23i Mutant 293 4e-78
pdb|1KZJ|A Chain A, Crystal Structure Of Ects W80gDUMPCB371... 293 4e-78
ref|ZP_00149890.1| COG0207: Thymidylate synthase [Dechlorom... 293 4e-78
pdb|1JMH| Contributions Of Orientation And Hydrogen Bondin... 293 4e-78
ref|NP_461918.1| thymidylate synthetase [Salmonella typhimu... 292 6e-78
ref|NP_386233.1| PROBABLE THYMIDYLATE SYNTHASE PROTEIN [Sin... 292 6e-78
ref|NP_457395.1| thymidylate synthetase [Salmonella enteric... 292 7e-78
pdb|1TYS| Thymidylate Synthase (E.C.2.1.1.45) Mutant With ... 292 7e-78
sp|Q9RAM7|TYSY_METFL Thymidylate synthase (TS) (TSase) >gi|... 292 7e-78
ref|NP_302064.1| thymidylate synthase [Mycobacterium leprae... 292 8e-78
ref|NP_641194.1| thymidylate synthase [Xanthomonas axonopod... 291 9e-78
ref|ZP_00041615.1| COG0207: Thymidylate synthase [Xylella f... 291 9e-78
ref|NP_779562.1| thymidylate synthase [Xylella fastidiosa T... 291 1e-77
ref|ZP_00273289.1| COG0207: Thymidylate synthase [Ralstonia... 291 1e-77
pdb|1F4D|A Chain A, Crystal Structure Of E. Coli Thymidylat... 291 2e-77
ref|NP_001062.1| thymidylate synthetase; Thymidylate syntha... 291 2e-77
gb|AAP36499.1| Homo sapiens thymidylate synthetase [synthet... 291 2e-77
pdb|1BPJ|A Chain A, Thymidylate Synthase R178t, R179t Doubl... 291 2e-77
ref|ZP_00173943.2| COG0207: Thymidylate synthase [Methyloba... 291 2e-77
ref|NP_939189.1| thymidylate synthase [Corynebacterium diph... 290 2e-77
pdb|1QQQ|A Chain A, Crystal Structure Analysis Of Ser254 Mu... 290 2e-77
pdb|1JU6|A Chain A, Human Thymidylate Synthase Complex With... 290 2e-77
ref|ZP_00039273.1| COG0207: Thymidylate synthase [Xylella f... 290 3e-77
pdb|1BP6|A Chain A, Thymidylate Synthase R23i, R179t Double... 290 3e-77
ref|NP_900697.1| thymidylate synthase [Chromobacterium viol... 290 3e-77
ref|NP_062052.1| thymidylate synthase [Rattus norvegicus] >... 290 3e-77
pdb|1HVY|A Chain A, Human Thymidylate Synthase Complexed Wi... 290 3e-77
ref|NP_810960.1| thymidylate synthase [Bacteroides thetaiot... 290 4e-77
ref|NP_716955.1| thymidylate synthase [Shewanella oneidensi... 289 5e-77
ref|NP_067263.1| thymidylate synthase [Mus musculus] >gi|13... 289 6e-77
gb|AAH20139.1| Tyms protein [Mus musculus] 289 6e-77
ref|NP_820530.1| thymidylate synthase [Coxiella burnetii RS... 289 6e-77
pdb|1EVF|A Chain A, Crystal Structure Analysis Of Cys167 Mu... 289 7e-77
ref|NP_195183.2| bifunctional dihydrofolate reductase-thymi... 289 7e-77
pdb|1HZW|A Chain A, Crystal Structure Of Human Thymidylate ... 288 8e-77
pdb|1EV8|A Chain A, Crystal Structure Analysis Of Cys167 Mu... 288 8e-77
ref|NP_240252.1| thymidylate synthase [Buchnera aphidicola ... 288 8e-77
ref|NP_927968.1| Thymidylate synthase (TS) (TSase) [Photorh... 288 9e-77
sp|Q05763|DRT2_ARATH Bifunctional dihydrofolate reductase-t... 288 1e-76
ref|NP_636178.1| thymidylate synthase [Xanthomonas campestr... 288 1e-76
ref|NP_519068.1| PROBABLE THYMIDYLATE SYNTHASE (TRANSLATION... 287 2e-76
ref|ZP_00171069.1| COG0207: Thymidylate synthase [Ralstonia... 287 2e-76
ref|NP_326369.1| THYMIDYLATE SYNTHASE (TS) (TSASE) [Mycopla... 287 3e-76
ref|NP_477589.1| wsv067 [shrimp white spot syndrome virus] ... 286 3e-76
ref|ZP_00206347.1| COG0207: Thymidylate synthase [Bifidobac... 286 3e-76
ref|NP_110008.1| thymidylate synthase [Mycoplasma pneumonia... 286 5e-76
pdb|1HW3|A Chain A, Structure Of Human Thymidylate Synthase... 286 5e-76
ref|NP_870607.1| thymidylate synthase [Pirellula sp. 1] >gi... 286 5e-76
ref|NP_477367.1| CG3181-PA [Drosophila melanogaster] >gi|13... 285 6e-76
dbj|BAB27620.1| unnamed protein product [Mus musculus] 285 7e-76
gb|AAL88992.1| WSSV124 [shrimp white spot syndrome virus] 285 7e-76
ref|NP_696816.1| thymidylate synthase [Bifidobacterium long... 285 1e-75
gb|AAC27622.1| thymidylate synthase [Drosophila melanogaster] 284 1e-75
ref|NP_906122.1| thymidylate synthase [Porphyromonas gingiv... 284 2e-75
ref|ZP_00193117.2| COG0207: Thymidylate synthase [Mesorhizo... 283 3e-75
sp|P78029|TYSY_MYCPN Thymidylate synthase (TS) (TSase) 283 4e-75
ref|NP_571835.1| thymidylate synthase [Danio rerio] >gi|979... 283 5e-75
ref|NP_660757.1| thymidylate synthase [Buchnera aphidicola ... 283 5e-75
gb|AAH49026.1| Zgc:56465 protein [Danio rerio] 282 6e-75
sp|O81395|DRTS_MAIZE Bifunctional dihydrofolate reductase-t... 282 8e-75
sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-t... 281 1e-74
ref|NP_249033.1| thymidylate synthase [Pseudomonas aerugino... 281 1e-74
gb|AAH65845.1| Unknown (protein for MGC:77659) [Danio rerio] 281 1e-74
ref|YP_015731.1| thymidylate synthase [Mycoplasma mobile 16... 280 3e-74
emb|CAD38046.1| dihydrofolate reductase-thymidylate synthas... 280 3e-74
ref|XP_311491.1| ENSANGP00000013700 [Anopheles gambiae] >gi... 278 8e-74
ref|NP_103049.1| thymidylate synthase [Mesorhizobium loti M... 278 1e-73
ref|ZP_00318102.1| COG0207: Thymidylate synthase [Microbulb... 278 1e-73
ref|NP_048042.1| thymidylate synthase [Ateline herpesvirus ... 277 2e-73
emb|CAC84368.1| thymidylate synthase [Saimiriine herpesviru... 277 2e-73
sp|P12462|TYSY_HSVAT Thymidylate synthase (TS) (TSase) >gi|... 277 3e-73
gb|AAP57962.1| dihydrofolate reductase/thymidilate synthase... 276 3e-73
gb|AAA46174.1| thymidylate synthase 276 5e-73
ref|NP_777993.1| thymidylate synthase [Buchnera aphidicola ... 276 5e-73
ref|NP_852828.1| ThyA [Mycoplasma gallisepticum R] >gi|3386... 275 7e-73
ref|ZP_00092243.1| COG0207: Thymidylate synthase [Azotobact... 275 7e-73
ref|NP_491532.2| thymidylate synthase (35.8 kD) (1F707) [Ca... 275 8e-73
gb|AAF60422.1| Hypothetical protein Y110A7A.4 [Caenorhabdit... 275 8e-73
ref|NP_040272.1| thymidylate synthase [Saimiriine herpesvir... 275 1e-72
ref|NP_042669.1| thymidylate synthase [Equine herpesvirus 2... 275 1e-72
ref|ZP_00046564.1| COG0207: Thymidylate synthase [Lactobaci... 274 2e-72
pir||T14315 dihydrofolate reductase (EC 1.5.1.3) / thymidyl... 274 2e-72
ref|ZP_00198980.1| COG0207: Thymidylate synthase [Kineococc... 274 2e-72
gb|AAA32788.1| dihydrofolate reductase-thymidylate synthase 274 2e-72
ref|NP_965273.1| thymidylate synthase [Lactobacillus johnso... 274 2e-72
emb|CAE72941.1| Hypothetical protein CBG20269 [Caenorhabdit... 273 3e-72
sp|P45350|DRTS_DAUCA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 273 4e-72
ref|NP_040136.1| thymidylate synthase [Human herpesvirus 3]... 273 5e-72
ref|NP_179230.1| bifunctional dihydrofolate reductase-thymi... 272 6e-72
ref|NP_077428.1| thymidylate synthetase [Cercopithecine her... 272 7e-72
gb|AAD45276.1| thymidylate synthase [Mycoplasma gallisepticum] 271 1e-71
pdb|1J3I|C Chain C, Wild-Type Plasmodium Falciparum Dihydro... 271 1e-71
ref|ZP_00245378.1| COG0207: Thymidylate synthase [Rubriviva... 271 1e-71
gb|AAM88660.1| dihydrofolate reductase-thymidylate synthase... 271 1e-71
gb|AAL14421.1| thymidylate synthase [Macropodid herpesvirus 1] 271 1e-71
gb|AAA29272.1| thymidylate synthase-dihydrofolate reductase... 271 2e-71
sp|P07382|DRTS_LEIMA Bifunctional dihydrofolate reductase-t... 271 2e-71
ref|NP_702821.1| bifunctional dihydrofolate reductase-thymi... 271 2e-71
gb|AAA29586.1| dihydrofolate reductase-thymidylate synthase... 271 2e-71
ref|ZP_00147048.1| COG0207: Thymidylate synthase [Psychroba... 271 2e-71
pir||RDZQK1 dihydrofolate reductase (EC 1.5.1.3) / thymidyl... 271 2e-71
sp|P13922|DRTS_PLAFK Bifunctional dihydrofolate reductase-t... 271 2e-71
gb|AAF80470.2| thymidylate synthase [Trichinella spiralis] ... 270 2e-71
gb|AAM88659.1| dihydrofolate reductase-thymidylate synthase... 270 3e-71
sp|O02604|DRTS_PLAVI BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 269 7e-71
sp|Q27783|DRTS_TRYBB Bifunctional dihydrofolate reductase-t... 267 2e-70
ref|NP_950545.1| thymidylate synthase [Onion yellows phytop... 267 2e-70
gb|AAM18488.1| dihydrofolate reductase-thymidylate synthase... 267 2e-70
sp|Q27793|DRTS_TRYCR BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 267 2e-70
gb|AAM18487.1| dihydrofolate reductase-thymidylate synthase... 267 2e-70
gb|AAM88576.1| dhfr-ts [Leishmania donovani chagasi] 266 6e-70
gb|AAM82248.1| dihydrofolate reductase/thymidylate synthase... 265 7e-70
sp|O96650|TYSY_ASCSU Thymidylate synthase (TS) (TSase) >gi|... 265 8e-70
prf||2103303A dihydrofolate reductase/thymidylate synthase 265 1e-69
sp|P16126|DRTS_LEIAM BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 264 1e-69
gb|EAK87446.1| dihydrofolate reductase-thymidylate synthase... 264 2e-69
ref|NP_758075.1| thymidylate synthase [Mycoplasma penetrans... 264 3e-69
ref|NP_072893.1| thymidylate synthase (thyA) [Mycoplasma ge... 263 3e-69
pdb|1QZF|A Chain A, Crystal Structure Of Dhfr-Ts From Crypt... 263 4e-69
sp|P20712|DRTS_PLACH BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 263 5e-69
ref|ZP_00063209.1| COG0207: Thymidylate synthase [Leuconost... 262 6e-69
sp|Q27713|DRTS_PLABA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 262 8e-69
gb|EAA16220.1| thymidylate synthase, putative [Plasmodium y... 262 1e-68
gb|AAF59990.1| thymidylate synthetase [Macaca mulatta rhadi... 261 1e-68
ref|NP_570754.1| thymidylate synthase [Macaca mulatta rhadi... 261 1e-68
gb|AAK71186.1| dihydrofolate reductase-thymidylate syntheta... 261 2e-68
ref|NP_586629.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuni... 261 2e-68
ref|NP_597138.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuni... 260 2e-68
ref|NP_572063.1| ORF 70; thymidylate synthase TS homolog [H... 260 3e-68
ref|NP_984315.1| ADR219Cp [Eremothecium gossypii] >gi|44982... 260 4e-68
gb|AAK71144.1| dihydrofolate reductase-thymidylate syntheta... 259 4e-68
gb|AAK71166.1| dihydrofolate reductase-thymidylate syntheta... 259 4e-68
gb|AAK71159.1| dihydrofolate reductase-thymidylate syntheta... 259 4e-68
gb|AAK71177.1| dihydrofolate reductase-thymidylate syntheta... 259 4e-68
gb|AAK71184.1| dihydrofolate reductase-thymidylate syntheta... 259 5e-68
sp|P06785|TYSY_YEAST Thymidylate synthase (TS) (TSase) >gi|... 259 6e-68
sp|O62584|TYSY_ENCCU Thymidylate synthase (TS) (TSase) >gi|... 259 7e-68
pir||YXCKTA thymidylate synthase (EC 2.1.1.45) - yeast (Can... 258 9e-68
sp|P12461|TYSY_CANAL Thymidylate synthase (TS) (TSase) >gi|... 258 9e-68
gb|AAC58691.1| thymidylate synthase homolog [rhesus monkey ... 258 9e-68
gb|AAK71150.1| dihydrofolate reductase-thymidylate syntheta... 258 1e-67
gb|AAK55761.1| dihydrofolate reductase/thymidylate synthase... 255 8e-67
ref|NP_690528.1| thymidylate synthase [Heliothis zea virus ... 254 2e-66
sp|P13100|TYSY_PNECA Thymidylate synthase (TS) (TSase) >gi|... 253 3e-66
ref|ZP_00319179.1| COG0207: Thymidylate synthase [Oenococcu... 252 8e-66
sp|Q9P4T7|TYSY_AGABI Thymidylate synthase (TS) (TSase) >gi|... 249 5e-65
dbj|BAA74947.1| thymidylate synthase [Oryza sativa] 249 5e-65
gb|EAK83445.1| hypothetical protein UM02407.1 [Ustilago may... 248 2e-64
ref|NP_871323.1| thyA [Wigglesworthia glossinidia endosymbi... 247 3e-64
gb|EAA50699.1| hypothetical protein MG04458.4 [Magnaporthe ... 246 3e-64
dbj|BAB83677.1| thymidylate synthase [Homo sapiens] 246 4e-64
gb|AAC47229.1| bifunctional dihydrofolate reductase-thymidy... 246 7e-64
ref|XP_381239.1| hypothetical protein FG01063.1 [Gibberella... 245 7e-64
ref|ZP_00006113.2| COG0207: Thymidylate synthase [Rhodobact... 244 2e-63
gb|EAA61674.1| hypothetical protein AN7028.2 [Aspergillus n... 243 5e-63
sp|Q07422|DRTS_TOXGO BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 239 5e-62
ref|NP_861931.1| dTMP (thymidylate) synthase [Enterobacteri... 238 9e-62
ref|NP_594305.1| thymidylate synthase-like DNA metabolism p... 238 1e-61
ref|ZP_00303047.1| COG0207: Thymidylate synthase [Novosphin... 238 1e-61
gb|AAP80238.1| dTMP thymidylate synthase [Enterobacteria ph... 238 2e-61
sp|Q23695|DRTS_CRIFA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-T... 237 2e-61
ref|NP_149688.1| 225R [Invertebrate iridescent virus 6] >gi... 236 4e-61
ref|NP_049848.1| dTMP (thymidylate) synthase [Enterobacteri... 236 4e-61
gb|AAC12816.1| thymidylate synthase [Enterobacteria phage T4] 236 5e-61
gb|AAP86754.1| thymidylate synthase [Bacteriophage RB27] 234 3e-60
gb|AAP86755.1| thymidylate synthase [Bacteriophage RB3] 234 3e-60
gb|AAP86749.1| thymidylate synthase [Bacteriophage RB32] 233 3e-60
gb|AAP86751.1| thymidylate synthase [Bacteriophage LZ2] 233 5e-60
gb|AAP86750.1| thymidylate synthase [Bacteriophage RB14] 232 8e-60
gb|AAP86757.1| thymidylate synthase [Bacteriophage U5] 231 2e-59
gb|AAP86758.1| thymidylate synthase [Enterobacteria phage T6] 231 2e-59
ref|NP_932561.1| dTMP (thymidylate) synthase; Td [Bacteriop... 231 2e-59
gb|AAP86752.1| thymidylate synthase [Bacteriophage RB61] 231 2e-59
sp|P45351|TYSY_CRYNE Thymidylate synthase (TS) (TSase) >gi|... 230 3e-59
ref|XP_323420.1| hypothetical protein [Neurospora crassa] >... 228 2e-58
dbj|BAC40450.1| unnamed protein product [Mus musculus] 227 2e-58
ref|NP_048309.1| ORF MSV238 putative thymidylate synthase, ... 226 5e-58
dbj|BAC40165.1| unnamed protein product [Mus musculus] 226 6e-58
gb|AAP86753.1| thymidylate synthase [Bacteriophage RB23] 224 2e-57
sp|Q9Z671|TYSY_ZYMMO Thymidylate synthase (TS) (TSase) 223 5e-57
ref|YP_006920.1| putative thymidylate synthase [Bacteriopha... 222 8e-57
emb|CAA27600.1| thyA (C-terminal) [Escherichia coli] 219 5e-56
ref|NP_944201.1| dTMP synthase [Bacteriophage Aeh1] >gi|334... 209 6e-53
dbj|BAB83676.1| thymidylate synthase [Homo sapiens] 207 3e-52
ref|NP_899279.1| dTMP (thymidylate) synthase [Bacteriophage... 204 2e-51
gb|AAD01867.1| thymidylate synthase [Enterococcus faecalis] 202 1e-50
ref|NP_014717.1| Thymidylate synthase, required for de novo... 196 5e-49
gb|AAD19406.1| thymidylate synthetase [Zymomonas mobilis] 190 5e-47
ref|NP_883119.1| putative thymidylate synthase [Bordetella ... 180 5e-44
ref|NP_881719.1| putative thymidylate synthase [Bordetella ... 179 6e-44
ref|NP_747242.1| thymidylate synthase [Pseudomonas putida K... 175 9e-43
ref|ZP_00281010.1| COG0207: Thymidylate synthase [Burkholde... 171 2e-41
ref|NP_349604.1| Thymidylate synthase [Clostridium acetobut... 169 6e-41
ref|ZP_00264737.1| COG0207: Thymidylate synthase [Pseudomon... 169 7e-41
ref|NP_795013.1| thymidylate synthase [Pseudomonas syringae... 168 2e-40
ref|ZP_00126699.1| COG0207: Thymidylate synthase [Pseudomon... 165 1e-39
ref|NP_572008.1| thymidylate synthase-like protein [Rana ti... 163 5e-39
ref|NP_179750.1| bifunctional dihydrofolate reductase-thymi... 163 5e-39
ref|ZP_00222549.1| COG0207: Thymidylate synthase [Burkholde... 162 7e-39
ref|ZP_00217254.1| COG0207: Thymidylate synthase [Burkholde... 161 1e-38
ref|NP_944928.1| putative thymidylate synthase [Bacteriopha... 161 1e-38
gb|AAP86759.1| thymidylate synthase [Bacteriophage TuIa] 160 4e-38
gb|AAM75815.2| thymidylate synthase [Corallochytrium limaci... 158 1e-37
gb|AAF23264.1| thymidylate synthase [Haloferax volcanii] 150 5e-35
sp|Q59212|TYSA_BACLI Thymidylate synthase A (TS A) (TSase A... 148 2e-34
sp|P07606|TYSY_BPPHT Thymidylate synthase (TS) (TSase) >gi|... 145 1e-33
sp|Q9ANR7|TYSY_BACMO Thymidylate synthase A (TS A) (TSase A... 144 2e-33
ref|NP_891806.1| dTMP (thymidylate) synthase [Enterobacteri... 144 3e-33
ref|NP_389651.1| thymidylate synthase A [Bacillus subtilis]... 144 3e-33
pdb|1BKO|A Chain A, Thermostable Thymidylate Synthase A Fro... 141 2e-32
ref|NP_569591.1| putative thymidylate synthase [Salmonella ... 138 2e-31
gb|AAA62156.1| thymidylate synthase 135 2e-30
ref|ZP_00313679.1| COG0207: Thymidylate synthase [Clostridi... 134 3e-30
ref|ZP_00241709.1| COG0207: Thymidylate synthase [Rubriviva... 130 4e-29
sp|O30394|TYSA_BACAT Thymidylate synthase A (TS A) (TSase A... 129 7e-29
sp|O30397|TYSA_BACAM Thymidylate synthase A (TS A) (TSase A... 129 1e-28
gb|AAL54880.1| thymidylate synthase [Pasteurella multocida] 128 2e-28
gb|AAC26324.1| thymidylate synthase [Bacillus subtilis] 128 2e-28
ref|ZP_00156766.1| COG0207: Thymidylate synthase [Haemophil... 127 3e-28
ref|NP_439065.1| thymidylate synthetase [Haemophilus influe... 127 4e-28
ref|ZP_00123215.1| COG0207: Thymidylate synthase [Haemophil... 126 8e-28
ref|NP_245016.1| ThyA [Pasteurella multocida Pm70] >gi|1343... 125 1e-27
gb|AAC26325.1| thymidylate synthase [Bacillus subtilis] 125 1e-27
ref|NP_796903.1| thymidylate synthase [Vibrio parahaemolyti... 124 2e-27
ref|NP_933472.1| thymidylate synthase [Vibrio vulnificus YJ... 123 5e-27
ref|NP_759507.1| Thymidylate synthase [Vibrio vulnificus CM... 122 7e-27
ref|NP_230324.1| thymidylate synthase [Vibrio cholerae O1 b... 122 1e-26
emb|CAA07073.1| thymidylate synthetase [Vibrio cholerae] 122 1e-26
gb|AAN16904.1| mutant thymidilate synthetase [Vibrio cholerae] 118 2e-25
pir||S57628 thymidylate synthase (EC 2.1.1.45) - Staphyloco... 117 4e-25
emb|CAG19004.1| putative thymidylate synthetase (thyA) [Pho... 116 8e-25
gb|AAM75813.1| bifunctional dihydrofolate reductase-thymidy... 113 5e-24
gb|AAM75817.1| bifunctional dihydrofolate reductase-thymidy... 111 2e-23
ref|YP_003793.1| thymidylate synthase [Regina ranavirus] >g... 110 4e-23
gb|AAM75811.1| bifunctional dihydrofolate reductase-thymidy... 109 7e-23
gb|AAM75814.1| bifunctional dihydrofolate reductase-thymidy... 107 2e-22
ref|NP_873495.1| thymidylate synthase [Haemophilus ducreyi ... 107 5e-22
gb|AAC43192.1| Homologous to Swiss-Prot Accession Number P1... 100 6e-20
gb|AAM75816.1| bifunctional dihydrofolate reductase-thymidy... 100 7e-20
ref|NP_803801.1| ORF235 [Pseudomonas phage phiKZ] >gi|18996... 99 1e-19
gb|AAQ02620.1| thymidylate synthase [Hartmannella cantabrig... 97 5e-19
gb|AAK11643.1| thymidylate synthetase [Babesia bovis] 97 6e-19
gb|AAM75812.1| bifunctional dihydrofolate reductase-thymidy... 97 6e-19
ref|ZP_00185185.1| hypothetical protein Mflo086601 [Mesopla... 97 6e-19
gb|AAQ02622.1| thymidylate synthase [Hartmannella cantabrig... 97 7e-19
dbj|BAA14016.2| thymidylate synthetase [Theileria sp. Thung... 96 1e-18
gb|AAQ02616.1| thymidylate synthase [Hartmannella cantabrig... 95 2e-18
gb|AAB34157.1| thymidylate synthase; TS [Pneumocystis carinii] 93 9e-18
gb|AAQ02618.1| thymidylate synthase [Hartmannella cantabrig... 93 9e-18
ref|ZP_00185186.1| hypothetical protein Mflo086701 [Mesopla... 89 1e-16
ref|NP_345174.1| thymidylate synthase [Streptococcus pneumo... 86 2e-15
ref|NP_664405.1| putative thymidylate synthase [Streptococc... 85 2e-15
ref|NP_269081.1| putative thymidylate synthase [Streptococc... 84 5e-15
ref|NP_688313.1| thymidylate synthase [Streptococcus agalac... 84 6e-15
ref|NP_607086.1| putative thymidylate synthase [Streptococc... 84 6e-15
emb|CAC20646.1| putative thymidylate synthase [Lactobacillu... 83 9e-15
ref|NP_735822.1| thymidylate synthase [Streptococcus agalac... 83 9e-15
ref|ZP_00321969.1| COG0207: Thymidylate synthase [Haemophil... 82 1e-14
ref|NP_603147.1| Thymidylate synthase [Fusobacterium nuclea... 82 2e-14
gb|AAK91762.1| thymidylate synthase [Streptococcus thermoph... 81 3e-14
ref|ZP_00144192.1| Thymidylate synthase [Fusobacterium nucl... 80 6e-14
dbj|BAA03157.1| thymidylate synthase [Methylobacillus glyco... 77 5e-13
emb|CAA83575.1| thymidylate synthase [Mycoplasma pneumoniae] 76 1e-12
ref|NP_721343.1| thymidylate synthase [Streptococcus mutans... 72 1e-11
gb|AAF20914.1| thymidylate synthase [Equus caballus] 72 1e-11
gb|AAF66223.1| thymidylate synthase [Felis catus] 72 2e-11
ref|ZP_00278937.1| COG0207: Thymidylate synthase [Burkholde... 72 2e-11
gb|AAF66224.1| thymidylate synthase [Bos taurus] 70 9e-11
gb|AAQ02614.1| thymidylate synthase [Hartmannella cantabrig... 67 4e-10
gb|AAM75819.1| thymidylate synthase [Mastigamoeba balamuthi] 67 5e-10
emb|CAA68823.1| thymidylate synthase [Staphylococcus aureus] 64 6e-09
gb|AAF17556.1| thymidylate synthase [Canis familiaris] 63 1e-08
pir||A43797 thymidylate synthase (EC 2.1.1.45) - Lactococcu... 62 2e-08
gb|AAP42245.1| thymidylate synthase [Baboon gamma-herpesvirus] 59 2e-07
ref|NP_267697.1| thymidylate synthase [Lactococcus lactis s... 58 3e-07
pir||SZBPSP deoxyuridylate hydroxymethyltransferase (EC 2.1... 54 5e-06
sp|P31654|DUHM_BPSP1 Deoxyuridylate hydroxymethyltransferas... 54 5e-06
ref|NP_247487.1| thymidylate synthase (thyA) [Methanocaldoc... 53 7e-06
ref|ZP_00063805.1| COG0207: Thymidylate synthase [Leuconost... 53 8e-06
ref|NP_070871.1| thymidylate synthase, putative [Archaeoglo... 53 9e-06
ref|ZP_00134736.1| COG0207: Thymidylate synthase [Actinobac... 52 2e-05
ref|ZP_00297626.1| COG0207: Thymidylate synthase [Methanosa... 48 3e-04
ref|ZP_00177509.1| COG0207: Thymidylate synthase [Crocospha... 48 3e-04
emb|CAA32651.1| thymidylate synthase (exons 5-7) [Mus muscu... 48 4e-04
gb|AAN85116.1| Orf105 [Citrobacter freundii] 47 4e-04
ref|NP_619402.1| thymidylate synthase [Methanosarcina aceti... 46 0.001
sp|Q8THH4|TYSY_METAC Thymidylate synthase (TS) (TSase) 46 0.001
ref|NP_861738.1| RB69ORF048c hypothetical protein [Enteroba... 45 0.002
ref|NP_988499.1| Thymidylate synthase [Methanococcus maripa... 45 0.002
dbj|BAA00404.1| thymidylate synthase [Homo sapiens] 44 0.005
gb|AAF67636.1| thymidylate synthetase [Equus caballus] 43 0.008
ref|NP_633261.1| Thymidylate synthase [Methanosarcina mazei... 42 0.018
ref|NP_275916.1| thymidylate synthase [Methanothermobacter ... 42 0.027
sp|O26868|TYSY_METTH Thymidylate synthase (TS) (TSase) 41 0.027
sp|P80305|TYSY_METTM Thymidylate synthase (TS) (TSase) >gi|... 40 0.048
ref|ZP_00148630.1| COG0207: Thymidylate synthase [Methanoco... 40 0.052
gb|AAA35159.1| thymidylate synthase 40 0.052
ref|ZP_00134737.1| COG0207: Thymidylate synthase [Actinobac... 40 0.063
emb|CAA31422.1| thymidylate synthase [Mus musculus] 40 0.075
ref|NP_614653.1| Thymidylate synthase [Methanopyrus kandler... 35 2.2
ref|XP_314427.1| ENSANGP00000013245 [Anopheles gambiae] >gi... 35 2.4
sp|Q10751|ACE_CHICK Angiotensin-converting enzyme (Dipeptid... 34 4.8
sp|Q03202|NISC_LACLA NISIN BIOSYNTHESIS PROTEIN NISC >gi|47... 33 10.0
>ref|ZP_00240821.1| thymidylate synthase [Bacillus cereus G9241]
gb|EAL11579.1| thymidylate synthase [Bacillus cereus G9241]
Length = 318
Score = 322 bits (825), Expect = 6e-87
Identities = 155/323 (47%), Positives = 214/323 (66%), Gaps = 23/323 (7%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M H + EY NL + +M+ GT K+DRTGTGT+S+FG QM FDLSKGFPLLTTK++PFR++A
Sbjct: 1 MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVA 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV--- 127
EL WF+ GDT+++ LL N NIW + A++ +++ E + +EF
Sbjct: 61 SELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMTDFGLRSQQDEEFKVQY 120
Query: 128 ---------SAAKDTSFD-----LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDIN 173
+ +D F LG +YGKQWR+W + + + +DQL VI+ I
Sbjct: 121 DEQMELFKKNVLEDDDFSNKYGYLGDVYGKQWRAWKT------TAGETLDQLKDVIEMIK 174
Query: 174 TNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIAS 233
PDSRR IVSAWN D+ MALPPCH LFQFYV +G LSC+LYQRS D+FLG+PFNIAS
Sbjct: 175 KTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIAS 234
Query: 234 YALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIE 293
Y+LLTH+IA GL+VG+F+HT GDAHIY NH + ++ Q+ REP++ P+L + +++
Sbjct: 235 YSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRQFPELTLNPDVKSVF 294
Query: 294 DYTLEDIVLTGYDAHPTIKGKLS 316
D+ +ED+ + GYD HP IK ++
Sbjct: 295 DFEMEDLTIEGYDPHPAIKAPVA 317
>ref|NP_831956.1| Thymidylate synthase [Bacillus cereus ATCC 14579]
sp|Q81E05|TYSY_BACCR Thymidylate synthase (TS) (TSase)
gb|AAP09157.1| Thymidylate synthase [Bacillus cereus ATCC 14579]
Length = 318
Score = 321 bits (822), Expect = 1e-86
Identities = 155/323 (47%), Positives = 213/323 (65%), Gaps = 23/323 (7%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M H + EY NL + +M+ GT K+DRTGTGT+S+FG QM FDLSKGFPLLTTK++PFR++A
Sbjct: 1 MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVA 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV--- 127
EL WF+ GDT+++ LL N NIW + A++ +++ E + +EF
Sbjct: 61 SELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMTDFGLRSQQDEEFKVQY 120
Query: 128 ---------SAAKDTSFD-----LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDIN 173
+ +D F LG +YGKQWR+W + + + +DQL VI+ I
Sbjct: 121 DEQMELFKKNVLEDDEFSNKYGYLGDVYGKQWRAWKT------TAGETLDQLKDVIEMIK 174
Query: 174 TNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIAS 233
PDSRR IVSAWN D+ MALPPCH LFQFYV +G LSC+LYQRS D+FLG+PFNIAS
Sbjct: 175 KTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIAS 234
Query: 234 YALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIE 293
Y+LLTH+IA GL+VG+F+HT GDAHIY NH + ++ Q+ REP+ P+L + +++
Sbjct: 235 YSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVF 294
Query: 294 DYTLEDIVLTGYDAHPTIKGKLS 316
D+ +ED+ + GYD HP IK ++
Sbjct: 295 DFEMEDLTIEGYDPHPAIKAPVA 317
>ref|NP_978577.1| thymidylate synthase [Bacillus cereus ATCC 10987]
gb|AAS41185.1| thymidylate synthase [Bacillus cereus ATCC 10987]
Length = 318
Score = 320 bits (821), Expect = 2e-86
Identities = 155/323 (47%), Positives = 213/323 (65%), Gaps = 23/323 (7%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M H + EY NL + +M+ GT K+DRTGTGT+S+FG QM FDLSKGFPLLTTK++PFR++A
Sbjct: 1 MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVA 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV--- 127
EL WF+ GDT+++ LL N NIW + A++ +++ E + +EF
Sbjct: 61 SELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMTDFGLRSQQDEEFKVQY 120
Query: 128 ---------SAAKDTSFD-----LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDIN 173
+ +D F LG +YGKQWR+W + + + +DQL VI+ I
Sbjct: 121 DEQMELFKKNVLEDDDFSNKYGYLGDVYGKQWRAWKT------TAGETLDQLKDVIEMIK 174
Query: 174 TNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIAS 233
PDSRR IVSAWN D+ MALPPCH LFQFYV +G LSC+LYQRS D+FLG+PFNIAS
Sbjct: 175 KTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIAS 234
Query: 234 YALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIE 293
Y+LLTH+IA GL+VG+F+HT GDAHIY NH + ++ Q+ REP+ P+L + +++
Sbjct: 235 YSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVF 294
Query: 294 DYTLEDIVLTGYDAHPTIKGKLS 316
D+ +ED+ + GYD HP IK ++
Sbjct: 295 DFEMEDLTIEGYDPHPAIKAPVA 317
>ref|NP_656100.1| thymidylat_synt, Thymidylate synthase [Bacillus anthracis A2012]
ref|NP_844627.1| thymidylate synthase [Bacillus anthracis str. Ames]
ref|YP_018881.1| thymidylate synthase [Bacillus anthracis str. Ames 0581]
sp|Q81R23|TYSY_BACAA Thymidylate synthase (TS) (TSase)
gb|AAP26113.1| thymidylate synthase [Bacillus anthracis str. Ames]
gb|AAT31356.1| thymidylate synthase [Bacillus anthracis str. Ames 0581]
Length = 318
Score = 320 bits (820), Expect = 2e-86
Identities = 159/325 (48%), Positives = 218/325 (67%), Gaps = 27/325 (8%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M H + EY NL + +M+ GT K+DRTGTGT+S+FG QM FDLSKGFPLLTTK++PFR++A
Sbjct: 1 MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVA 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQ--EFV- 127
EL WF+ GDT+++ LL N NIW + A++ +++ E + G + I S+Q EF
Sbjct: 61 SELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDE--YTGPDMIDFGLRSQQDEEFKV 118
Query: 128 -----------SAAKDTSFD-----LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKD 171
+ +D F LG +YGKQWR+W + + + +DQL VI+
Sbjct: 119 QYDEQMELFKKNVLEDDEFSNKYGYLGDVYGKQWRAWKT------TAGETLDQLKDVIEM 172
Query: 172 INTNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNI 231
I PDSRR IVSAWN D+ MALPPCH LFQFYV +G LSC+LYQRS D+FLG+PFNI
Sbjct: 173 IKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNI 232
Query: 232 ASYALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHEN 291
ASY+LLTH+IA GL+VG+F+HT GDAHIY NH + ++ Q+ REP+ P+L + ++
Sbjct: 233 ASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKS 292
Query: 292 IEDYTLEDIVLTGYDAHPTIKGKLS 316
+ D+ +ED+ + GYD HP IK ++
Sbjct: 293 VFDFEMEDLTIEGYDPHPAIKAPVA 317
>ref|NP_785417.1| thymidylate synthase [Lactobacillus plantarum WCFS1]
sp|Q88W05|TYSY_LACPL Thymidylate synthase (TS) (TSase)
emb|CAD64266.1| thymidylate synthase [Lactobacillus plantarum WCFS1]
Length = 316
Score = 319 bits (818), Expect = 5e-86
Identities = 158/320 (49%), Positives = 212/320 (66%), Gaps = 23/320 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y L + I++ GT KDDRTGTGT S+FG QM FDLS+GFPLLTTKK+PF +I EL
Sbjct: 2 LEDSYLQLARTILEHGTYKDDRTGTGTYSVFGYQMRFDLSQGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEF--VSAAK 131
WF++GDT+++ LL + +IW + A++ ++ + + + L +F + A+
Sbjct: 62 LWFLHGDTNIQYLLQHHNHIWDEWAFKNWVTSADYDGPDMTNFEHRRLDDPDFAPIYQAQ 121
Query: 132 DTSFD---------------LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNP 176
+FD LG +YG QWR W + + K IDQ+ VI+ I T+P
Sbjct: 122 MQTFDDQILTDDAFAAKYGNLGDVYGAQWRHWQT------RQGKTIDQIANVIEMIKTHP 175
Query: 177 DSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYAL 236
DSRR IVSAWN D+ MALPPCH LFQFYV +G LSC+LYQRS DVFLGVPFNIASYAL
Sbjct: 176 DSRRLIVSAWNPEDVPNMALPPCHTLFQFYVADGKLSCQLYQRSGDVFLGVPFNIASYAL 235
Query: 237 LTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYT 296
LTH+IAK GL VG+F+HT GDAHIY NH++ +K+Q+ R+P+ PQL + H++I DY
Sbjct: 236 LTHLIAKETGLAVGEFVHTLGDAHIYTNHVEQVKTQLTRQPRPAPQLTLSGAHDSIFDYQ 295
Query: 297 LEDIVLTGYDAHPTIKGKLS 316
+ DI L+GYD P IK ++
Sbjct: 296 MSDIKLSGYDPAPAIKAPVA 315
>ref|NP_692661.1| thymidylate synthase [Oceanobacillus iheyensis HTE831]
sp|Q8EQG0|TYSY_OCEIH Thymidylate synthase (TS) (TSase)
dbj|BAC13696.1| thymidylate synthase [Oceanobacillus iheyensis HTE831]
Length = 317
Score = 317 bits (811), Expect = 3e-85
Identities = 164/316 (51%), Positives = 215/316 (68%), Gaps = 23/316 (7%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L K+I G + DRT TGT S+FG Q+ FDL+KGFPLLTTK++PFR++A EL WFI
Sbjct: 7 YLDLCKQIFKTGEQRGDRTNTGTHSIFGHQIRFDLNKGFPLLTTKRVPFRLVASELLWFI 66
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFE-KGWE----GLEHIAGDPLSKQ-----EFV 127
GDT+++ LL N NIW + A+ +++ + +G + GL + +KQ E
Sbjct: 67 KGDTNIRYLLKHNNNIWNEWAFEKWVNSADYQGPDMANFGLRSQKDENFNKQYQEQMELF 126
Query: 128 SAA--KDTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRR 180
+D SF DLG +YGKQWR+W + + + IDQL VI I TNP+SRR
Sbjct: 127 KTRILEDDSFADKYGDLGSVYGKQWRNWKTTQN------ETIDQLKDVIHSIKTNPNSRR 180
Query: 181 HIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHI 240
HIVSAWN DI MALPPCH LFQFYV NG LSC+LYQRSADVFLGVPFNIASYALLTH+
Sbjct: 181 HIVSAWNPEDIPTMALPPCHTLFQFYVSNGKLSCQLYQRSADVFLGVPFNIASYALLTHL 240
Query: 241 IAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDI 300
IA GL+VG F+HTFGDAHIY NH++ +++Q+ERE ++ PQL I +I + L+D+
Sbjct: 241 IAHECGLEVGDFVHTFGDAHIYSNHVEQVETQLEREIRDFPQLIINKDKNSIFEMDLDDL 300
Query: 301 VLTGYDAHPTIKGKLS 316
V+ Y+ HP+IK ++
Sbjct: 301 VIENYNPHPSIKAPIA 316
>ref|ZP_00323475.1| COG0207: Thymidylate synthase [Pediococcus pentosaceus ATCC 25745]
Length = 316
Score = 316 bits (810), Expect = 4e-85
Identities = 160/320 (50%), Positives = 211/320 (65%), Gaps = 23/320 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ +Y NL + +++ G LK DRT TGTLS FG QM FDLS+GFPLLTTK++PF +I EL
Sbjct: 2 LEEQYLNLERYVLENGHLKGDRTQTGTLSTFGYQMRFDLSEGFPLLTTKRVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK-- 131
WF+ GDT+++ LL N +IW + A++ +++ E + L+ EF K
Sbjct: 62 LWFLKGDTNIRYLLQHNNHIWDEWAFKKWVESDEYQGPDMTDFGHRSLTDPEFNELYKIE 121
Query: 132 ----------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNP 176
D +F DLG +YG QWR+W + + + IDQ+ VI I NP
Sbjct: 122 KQRFTEQILEDDTFSAKYGDLGNVYGSQWRAWKT------STGETIDQISNVIDMIKNNP 175
Query: 177 DSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYAL 236
+SRR IVSAWN D+ ALPPCH LFQFYV +G LSC+LYQRS D+FLG+PFNIASYAL
Sbjct: 176 NSRRMIVSAWNPEDVPTSALPPCHSLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYAL 235
Query: 237 LTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYT 296
LT +IAK GL+VG+FIHT GDAHIY NH+D +K Q+ER P+ P+L+ K VH++I DY
Sbjct: 236 LTELIAKATGLEVGEFIHTIGDAHIYSNHLDQVKEQLERTPRPAPKLKFKQVHDSIFDYE 295
Query: 297 LEDIVLTGYDAHPTIKGKLS 316
DIV+ GYD HPTIK ++
Sbjct: 296 PGDIVVEGYDPHPTIKAPVA 315
>ref|NP_815293.1| thymidylate synthase [Enterococcus faecalis V583]
gb|AAO81363.1| thymidylate synthase [Enterococcus faecalis V583]
Length = 315
Score = 313 bits (802), Expect = 3e-84
Identities = 162/322 (50%), Positives = 212/322 (65%), Gaps = 27/322 (8%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y L KKI++EG K+DRTGTGT SLFG QM FDL+KGFPLLTTK++PF +I EL
Sbjct: 1 MEEAYLALGKKILEEGHFKEDRTGTGTYSLFGYQMRFDLAKGFPLLTTKRVPFGLIKSEL 60
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLE------HIAGDPL------ 121
WF+ GDT+++ LL++N +IW + A+ Y+ + ++G + + DP
Sbjct: 61 LWFLKGDTNIRYLLERNNHIWDEWAFERYVKSAD--YQGPDMTDFGHRVLQDPAFAEQYK 118
Query: 122 -SKQEFVSAA-KDTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINT 174
Q+F A D F +LG IYG QWR W + K IDQL VI+ I T
Sbjct: 119 EEHQKFCDAILNDAEFAEKYGELGNIYGAQWRHWET------KDGSFIDQLANVIEMIKT 172
Query: 175 NPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASY 234
NPDSRR IVSAWN D+ MALPPCH +FQFYV G LSC+LYQRSADVFLGVPFNIASY
Sbjct: 173 NPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNEGKLSCQLYQRSADVFLGVPFNIASY 232
Query: 235 ALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIED 294
ALLTH+IA GL+VG+F+HT GDAH+Y NH++ ++ Q+ RE + P L + ++ D
Sbjct: 233 ALLTHLIAHETGLEVGEFVHTLGDAHLYQNHVEQMQEQLSREVRSFPTLVLNPDKASVFD 292
Query: 295 YTLEDIVLTGYDAHPTIKGKLS 316
+ +EDI + GYD HPTIK ++
Sbjct: 293 FDMEDIKVEGYDPHPTIKAPIA 314
>ref|NP_371951.1| thymidylate synthase [Staphylococcus aureus subsp. aureus Mu50]
ref|NP_374541.1| thymidylate synthase [Staphylococcus aureus subsp. aureus N315]
ref|NP_646134.1| thymidylate synthase [Staphylococcus aureus subsp. aureus MW2]
sp|Q99U61|TYSY_STAAM Thymidylate synthase (TS) (TSase)
pir||C89920 thymidylate synthase [imported] - Staphylococcus aureus (strain
N315)
dbj|BAB42520.1| thymidylate synthase [Staphylococcus aureus subsp. aureus N315]
dbj|BAB57589.1| thymidylate synthase [Staphylococcus aureus subsp. aureus Mu50]
dbj|BAB95182.1| thymidylate synthase [Staphylococcus aureus subsp. aureus MW2]
Length = 318
Score = 312 bits (800), Expect = 6e-84
Identities = 161/323 (49%), Positives = 209/323 (64%), Gaps = 24/323 (7%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
+ D Y +L +++++ G ++DRT TGT+S FG Q+ FDLSKGFPLLTTKK+ F+++A
Sbjct: 2 LNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVA 61
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAA 130
EL WFI GDT+++ LL N NIW + A+ Y+ E + LS EF
Sbjct: 62 TELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQY 121
Query: 131 K------------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDIN 173
K D +F DLG +YGKQWR W K DQL VI+ I
Sbjct: 122 KEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVD------KDGNHFDQLKTVIEQIK 175
Query: 174 TNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIAS 233
NPDSRRHIVSAWN +ID MALPPCH +FQFYV +G LSC+LYQRSAD+FLGVPFNIAS
Sbjct: 176 HNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIAS 235
Query: 234 YALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIE 293
YALLTH+IAK GL+VG+F+HTFGDAHIY NHID +++Q+ RE P L+I + ++I
Sbjct: 236 YALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINS-DKSIF 294
Query: 294 DYTLEDIVLTGYDAHPTIKGKLS 316
D ED+ + Y++HP IK ++
Sbjct: 295 DINYEDLEIVDYESHPAIKAPIA 317
>gb|AAC45469.1| thymidylate synthase [Neisseria gonorrhoeae]
Length = 267
Score = 311 bits (798), Expect = 1e-83
Identities = 153/299 (51%), Positives = 194/299 (64%), Gaps = 38/299 (12%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++D GT K DRTGTGTLS+FG QM FDL KGFPLLTTKKL R I EL WF+
Sbjct: 6 YLDLMRHVLDNGTDKSDRTGTGTLSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFL 65
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++K L D N++IW D+ W D + DL
Sbjct: 66 KGDTNIKYLKDNNVSIWDDE------------W--------------------ADENGDL 93
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWRSW P + IDQ+ V++ I NPDSRR IVSAWN +D MALP
Sbjct: 94 GPVYGYQWRSW------PAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALP 147
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GL+ G+F+HTFG
Sbjct: 148 PCHALFQFYVADGNLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFG 207
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAH+Y NH + Q+EREP+ +P ++I +++ + ED L GYD HP IK +S
Sbjct: 208 DAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVVS 266
>sp|O33380|TYSY_NEIGO Thymidylate synthase (TS) (TSase)
Length = 265
Score = 311 bits (797), Expect = 1e-83
Identities = 153/299 (51%), Positives = 194/299 (64%), Gaps = 38/299 (12%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++D GT K DRTGTGTLS+FG QM FDL KGFPLLTTKKL R I EL WF+
Sbjct: 4 YLDLMRHVLDNGTDKSDRTGTGTLSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++K L D N++IW D+ W D + DL
Sbjct: 64 KGDTNIKYLKDNNVSIWDDE------------W--------------------ADENGDL 91
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWRSW P + IDQ+ V++ I NPDSRR IVSAWN +D MALP
Sbjct: 92 GPVYGYQWRSW------PAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALP 145
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GL+ G+F+HTFG
Sbjct: 146 PCHALFQFYVADGNLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFG 205
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAH+Y NH + Q+EREP+ +P ++I +++ + ED L GYD HP IK +S
Sbjct: 206 DAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVVS 264
>ref|ZP_00286217.1| COG0207: Thymidylate synthase [Enterococcus faecium]
Length = 315
Score = 309 bits (792), Expect = 4e-83
Identities = 159/320 (49%), Positives = 206/320 (64%), Gaps = 23/320 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L +K+++EG K+DRTGTGTLSLFG QM FDL KGFPLLTTK++PF +I EL
Sbjct: 1 MEQAYLDLGRKLLEEGHRKEDRTGTGTLSLFGYQMRFDLQKGFPLLTTKRVPFGLIKSEL 60
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIA----GDPLSKQEFVSA 129
WF+ GDT+++ LL +IW + A+ Y+ + + DP +E+
Sbjct: 61 LWFLKGDTNIRYLLQNKNHIWDEWAFERYIKSPDYNGPDMTDFGHRCLTDPEFNEEYKKQ 120
Query: 130 AK--------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNP 176
+K D SF DLG IYG QWR W + K IDQ+ +VI+ I P
Sbjct: 121 SKLFCEKILTDDSFAETYGDLGHIYGYQWRHWET------KDGGFIDQIKQVIEAIKKTP 174
Query: 177 DSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYAL 236
DSRR IVSAWN D+ MALPPCH +FQFYV G LSC+LYQRS DVFLGVPFNIASYAL
Sbjct: 175 DSRRLIVSAWNPEDVPSMALPPCHTMFQFYVQEGRLSCQLYQRSGDVFLGVPFNIASYAL 234
Query: 237 LTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYT 296
LTH+IA GL VG+F+HT GDAH+YINHI+ +K Q+ RE + P L + +++ D+
Sbjct: 235 LTHLIAHETGLAVGEFVHTLGDAHLYINHIEQMKEQLSREIRAFPTLVLNQEKQSVFDFE 294
Query: 297 LEDIVLTGYDAHPTIKGKLS 316
+EDI L GYD HP IK ++
Sbjct: 295 MEDIQLEGYDPHPAIKAPIA 314
>ref|NP_948831.1| thymidylate synthase [Rhodopseudomonas palustris CGA009]
emb|CAE28934.1| thymidylate synthase [Rhodopseudomonas palustris CGA009]
Length = 264
Score = 307 bits (786), Expect = 2e-82
Identities = 147/300 (49%), Positives = 194/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+++I+ +G K DRTGTGTLS+FG QM FDL+ GFP+LTTK+LP + I EL WF
Sbjct: 3 QYQDLLERILSDGAEKHDRTGTGTLSVFGHQMRFDLAAGFPMLTTKRLPLKAIVHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++K L D + IW DE+ D + D
Sbjct: 63 LQGDTNIKYLHDHGVTIW---------DEW------------------------ADANGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P IDQ+ V++ I NPDSRR +V+AWN D++ MAL
Sbjct: 90 LGPVYGAQWRSW------PTADGGSIDQIANVVEMIKRNPDSRRLMVTAWNPADVEKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV NG LSC+LYQRSADVFLGVPFNIASYALLT ++A++ GLK G+F+HT
Sbjct: 144 PPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAQVTGLKPGEFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ + Q+ R P+ +P + I ++I + ED LTGYD HP IK +++
Sbjct: 204 GDAHLYSNHLEQARLQLTRAPRALPVMTINPAVKDIFGFRYEDFTLTGYDPHPHIKAEVA 263
>ref|NP_773152.1| thymidylate synthase [Bradyrhizobium japonicum USDA 110]
dbj|BAC51777.1| thymidylate synthase [Bradyrhizobium japonicum USDA 110]
Length = 264
Score = 306 bits (783), Expect = 5e-82
Identities = 148/300 (49%), Positives = 192/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+++I+ +G K DRTGTGTLS+FG QM F+LS GFP+LTTK+LP + I EL WF
Sbjct: 3 QYQDLLERILSDGAEKTDRTGTGTLSVFGHQMRFNLSAGFPMLTTKRLPLKAIVHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++K L D + IW DE+ D + D
Sbjct: 63 LKGDTNIKYLRDNGVTIW---------DEW------------------------ADANGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ V+ I NPDSRR IVSAWN ++D MAL
Sbjct: 90 LGPVYGHQWRSW------PAPDGRSIDQIANVVDMIKRNPDSRRLIVSAWNPAEVDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV NG LSC+LYQRSADVFLGVPFNIASYALLT ++A++ GLK G F+H+F
Sbjct: 144 PPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGDFVHSF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ K Q+ R P+ +P + I ++I + ED L GYD HP IK +++
Sbjct: 204 GDTHLYSNHLEQAKLQLTRAPRALPVMRINPDVKDIFSFRFEDFELVGYDPHPHIKAEVA 263
>ref|NP_274712.1| thymidylate synthase [Neisseria meningitidis MC58]
sp|Q9JY72|TYSY_NEIMB Thymidylate synthase (TS) (TSase)
pir||G81050 thymidylate synthase NMB1709 [imported] - Neisseria meningitidis
(strain MC58 serogroup B)
gb|AAF42056.1| thymidylate synthase [Neisseria meningitidis MC58]
Length = 264
Score = 305 bits (782), Expect = 6e-82
Identities = 151/299 (50%), Positives = 193/299 (64%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++D GT K DRTGTGT S+FG QM FDL KGFPLLTTKKL R I EL WF+
Sbjct: 4 YLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++K L D N++IW DE+ D + DL
Sbjct: 64 KGDTNIKYLKDNNVSIW---------DEW------------------------ADENGDL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWR+W P + IDQ+ V++ I NPDSRR IVSAWN +D MALP
Sbjct: 91 GPVYGYQWRNW------PAPDGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GL+ G+F+HTFG
Sbjct: 145 PCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAH+Y NH + Q+EREP+ +P ++I +++ + ED L GYD HP IK +S
Sbjct: 205 DAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFSFKFEDFELEGYDPHPHIKAAVS 263
>ref|NP_284668.1| thymidylate synthase [Neisseria meningitidis Z2491]
sp|Q9JT57|TYSY_NEIMA Thymidylate synthase (TS) (TSase)
pir||A81825 thymidylate synthase (EC 2.1.1.45) NMA1963 [imported] - Neisseria
meningitidis (strain Z2491 serogroup A)
emb|CAB85183.1| thymidylate synthase [Neisseria meningitidis Z2491]
Length = 264
Score = 305 bits (781), Expect = 9e-82
Identities = 151/299 (50%), Positives = 193/299 (64%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++D GT K DRTGTGT S+FG QM FDL KGFPLLTTKKL R I EL WF+
Sbjct: 4 YLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++K L D N++IW DE+ D + DL
Sbjct: 64 KGDTNIKYLKDNNVSIW---------DEW------------------------ADENGDL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWR+W P + IDQ+ V++ I NPDSRR IVSAWN +D MALP
Sbjct: 91 GPVYGYQWRNW------PAPDGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GL+ G+F+HTFG
Sbjct: 145 PCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAH+Y NH + Q+EREP+ +P ++I +++ + ED L GYD HP IK +S
Sbjct: 205 DAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAAVS 263
>ref|NP_390065.1| thymidylate synthase B [Bacillus subtilis]
sp|P11044|TYSB_BACSU Thymidylate synthase B (TS B) (TSase B)
gb|AAA22852.1| thymidylate synthase B (thyB)
gb|AAA96634.1| thymidylate synthase [Bacillus subtilis]
emb|CAB14100.1| thymidylate synthase B [Bacillus subtilis subsp. subtilis str. 168]
Length = 264
Score = 305 bits (780), Expect = 1e-81
Identities = 150/300 (50%), Positives = 195/300 (65%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y + + +++ G K DRTGTGT+S FG QM F+L +GFP+LTTKKL F+ IA EL WF
Sbjct: 3 QYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPMLTTKKLHFKSIAHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L + + IW + A D + +
Sbjct: 63 LKGDTNVRYLQENGVRIWNEWA---------------------------------DENGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW + IDQ+ R+I+DI TNP+SRR IVSAWNVG+ID MAL
Sbjct: 90 LGPVYGSQWRSWRG------ADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSADVFLGVPFNIASYALLT IIA + GL+ G+FIHTF
Sbjct: 144 PPCHCLFQFYVSDGKLSCQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NHI+ + Q+ER+ + +PQL ++I ++ ED ++ YD HP IKG +S
Sbjct: 204 GDVHIYQNHIEQVNLQLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVS 263
>ref|ZP_00234494.1| thymidylate synthase [Listeria monocytogenes str. 1/2a F6854]
gb|EAL05684.1| thymidylate synthase [Listeria monocytogenes str. 1/2a F6854]
Length = 314
Score = 304 bits (779), Expect = 1e-81
Identities = 157/317 (49%), Positives = 210/317 (66%), Gaps = 23/317 (7%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L K +++ GT K DRTGTGT+S FG QM FDL +GFP++TTK++PF+++ EL WF
Sbjct: 3 QYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAY-RFYLDEFEKGWEGLE---HIAGDPLSKQEFVSAAK- 131
++GDT+++ LL N NIW + A+ RF + KG + + DP K+ + + +
Sbjct: 63 LHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDPAFKEVYQAEMEK 122
Query: 132 -------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSR 179
D +F +LG IYGKQWR W + + IDQL +I+ I TNP+SR
Sbjct: 123 FKTRIIEDEAFANKYGELGNIYGKQWREWKT------SQGETIDQLADLIEMIKTNPNSR 176
Query: 180 RHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTH 239
R IVSAWN DI MALPPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH
Sbjct: 177 RLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTH 236
Query: 240 IIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLED 299
+IA+ GL VG+FIHT GDAH+Y NHI+ +K Q+ R P +P+L + I D+ + D
Sbjct: 237 LIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPATIFDFEVAD 296
Query: 300 IVLTGYDAHPTIKGKLS 316
I L GY+ P+IK +S
Sbjct: 297 ISLDGYNPDPSIKAPIS 313
>ref|NP_471322.1| similar to thymidylate synthase [Listeria innocua Clip11262]
sp|Q92AD4|TYSY_LISIN Thymidylate synthase (TS) (TSase)
pir||AB1681 thymidylate synthase homolog lin1988 [imported] - Listeria innocua
(strain Clip11262)
emb|CAC97218.1| lin1988 [Listeria innocua]
Length = 314
Score = 304 bits (779), Expect = 2e-81
Identities = 154/317 (48%), Positives = 207/317 (65%), Gaps = 23/317 (7%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L K +++ GT K DRTGTGT+S FG QM FDL +GFP++TTK++PF+++ EL WF
Sbjct: 3 QYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIA----GDPLSKQEFVSAAK- 131
++GDT+++ LL N NIW + A+ ++ + E + DP K+ + + +
Sbjct: 63 LHGDTNIRYLLQHNNNIWNEWAFERFVKSADYKGEDMTDFGLRAERDPAFKEVYQAEMEK 122
Query: 132 -------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSR 179
D +F +LG IYGKQWR W + + IDQL +I+ I TNP+SR
Sbjct: 123 FKTRILEDETFANKYGELGNIYGKQWREWKT------SQGETIDQLADLIEMIKTNPNSR 176
Query: 180 RHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTH 239
R IVSAWN DI MALPPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH
Sbjct: 177 RLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTH 236
Query: 240 IIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLED 299
+IA+ GL VG+FIHT GDAH+Y NHI+ +K Q+ R P +P+L + I D+ + D
Sbjct: 237 LIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPATIFDFEVAD 296
Query: 300 IVLTGYDAHPTIKGKLS 316
I L GY+ P IK +S
Sbjct: 297 ISLDGYNPDPAIKAPIS 313
>ref|NP_465399.1| similar to thymidylate synthase [Listeria monocytogenes EGD-e]
sp|Q8Y626|TYSY_LISMO Thymidylate synthase (TS) (TSase)
pir||AB1309 thymidylate synthase homolog lmo1874 [imported] - Listeria
monocytogenes (strain EGD-e)
emb|CAC99952.1| lmo1874 [Listeria monocytogenes]
Length = 314
Score = 304 bits (779), Expect = 2e-81
Identities = 157/317 (49%), Positives = 210/317 (66%), Gaps = 23/317 (7%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L K +++ GT K DRTGTGT+S FG QM FDL +GFP++TTK++PF+++ EL WF
Sbjct: 3 QYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAY-RFYLDEFEKGWEGLE---HIAGDPLSKQEFVSAAK- 131
++GDT+++ LL N NIW + A+ RF + KG + + DP K+ + + +
Sbjct: 63 LHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDPAFKEVYQAEMEK 122
Query: 132 -------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSR 179
D +F +LG IYGKQWR W + + IDQL +I+ I TNP+SR
Sbjct: 123 FKTRIIEDEAFATKYGELGNIYGKQWREWKT------SQGETIDQLADLIEMIKTNPNSR 176
Query: 180 RHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTH 239
R IVSAWN DI MALPPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH
Sbjct: 177 RLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTH 236
Query: 240 IIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLED 299
+IA+ GL VG+FIHT GDAH+Y NHI+ +K Q+ R P +P+L + I D+ + D
Sbjct: 237 LIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPATIFDFEVAD 296
Query: 300 IVLTGYDAHPTIKGKLS 316
I L GY+ P+IK +S
Sbjct: 297 ISLDGYNPDPSIKAPIS 313
>ref|NP_764675.1| thymidylate synthase [Staphylococcus epidermidis ATCC 12228]
ref|NP_877984.1| thymidylate synthase [Staphylococcus aureus]
ref|NP_976285.1| ThyE [Staphylococcus epidermidis]
sp|P13954|TYSY_STAEP Thymidylate synthase (TS) (TSase)
pir||YXSAT3 thymidylate synthase (EC 2.1.1.45) - Staphylococcus aureus plasmid
pSK1 transposon Tn4003
emb|CAA31648.1| unnamed protein product [Staphylococcus aureus]
gb|AAC18954.1| ThyE [Staphylococcus epidermidis]
gb|AAC63226.1| thymidylate synthetase ThyE [Staphylococcus aureus]
dbj|BAB39485.1| thymidylate synthetase [Staphylococcus epidermidis]
gb|AAO04717.1| thymidylate synthase [Staphylococcus epidermidis ATCC 12228]
gb|AAQ17128.1| thymidylate synthase [Staphylococcus aureus]
Length = 318
Score = 304 bits (778), Expect = 2e-81
Identities = 158/319 (49%), Positives = 209/319 (65%), Gaps = 24/319 (7%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELF 74
D Y L ++I++ G +DDRT TGT+S FG Q+ FDL+KGFPLLTTKK+ F+++A EL
Sbjct: 6 DEAYHGLCEEILEIGNRRDDRTHTGTISKFGHQLRFDLTKGFPLLTTKKVSFKLVATELL 65
Query: 75 WFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIA----GDPLSKQEFVSAA 130
WFI GDT+++ LL N NIW + A+ Y+ + + DP +++
Sbjct: 66 WFIKGDTNIQYLLKYNNNIWNEWAFENYVQSDDYHGPDMTDFGHRSQQDPEFNEQYKEEM 125
Query: 131 K--------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPD 177
K D +F +LG +YGKQWR W + N Y DQL VI+ I TNP+
Sbjct: 126 KKFKERILNDDAFAKKYGNLGNVYGKQWRDWEDKNGNHY------DQLKSVIQQIKTNPN 179
Query: 178 SRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALL 237
SRRHIVSAWN +ID MALPPCH +FQFYV G L+C+LYQRSAD+FLGVPFNIASYALL
Sbjct: 180 SRRHIVSAWNPTEIDSMALPPCHTMFQFYVQEGKLNCQLYQRSADIFLGVPFNIASYALL 239
Query: 238 THIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTL 297
TH++AK GL+VG+FIHTFGDAHIY NH+D + +Q+ R+ PQL+I ++I D
Sbjct: 240 THLVAKECGLEVGEFIHTFGDAHIYSNHMDAIHTQLSRDSYLPPQLKIN-TDKSIFDINY 298
Query: 298 EDIVLTGYDAHPTIKGKLS 316
ED+ L Y++HP IK ++
Sbjct: 299 EDLELINYESHPAIKAPIA 317
>ref|NP_420927.1| thymidylate synthase [Caulobacter crescentus CB15]
sp|Q9A6H0|TYSY_CAUCR Thymidylate synthase (TS) (TSase)
pir||C87512 thymidylate synthase [imported] - Caulobacter crescentus
gb|AAK24095.1| thymidylate synthase [Caulobacter crescentus CB15]
Length = 279
Score = 302 bits (774), Expect = 6e-81
Identities = 148/304 (48%), Positives = 198/304 (65%), Gaps = 40/304 (13%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y L+ I++ G + DRTGTGTL +FG Q+ FDL+KGFP+LTTKKL R I E
Sbjct: 15 HPERQYLTLLADILENGVQRGDRTGTGTLGVFGRQIRFDLAKGFPVLTTKKLHLRSIIIE 74
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WF+ GDT++ L D + IW DE+ D
Sbjct: 75 LLWFLKGDTNIAYLKDNGVRIW---------DEW------------------------AD 101
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDID 192
+ DLGP+YGKQWRSWA+ + IDQ+ +++++ NP+SRRHIV+AWN D+D
Sbjct: 102 ENGDLGPVYGKQWRSWAT------PDGRVIDQISALVENLKANPNSRRHIVTAWNPADVD 155
Query: 193 YMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKF 252
MALPPCH LFQF+V +G LSC+LYQRSADVFLGVPFNIASYALLT ++AK+ GL+ G+F
Sbjct: 156 DMALPPCHCLFQFFVADGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAKVVGLEPGEF 215
Query: 253 IHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIK 312
+HTFGDAH+Y+NH+D + Q+ REP + P ++I A ++ + ED L GY AHP IK
Sbjct: 216 VHTFGDAHLYLNHLDQAREQLTREPFDFPTMKI-ADKRDLFGFEYEDFTLEGYQAHPHIK 274
Query: 313 GKLS 316
++S
Sbjct: 275 AEVS 278
>ref|ZP_00208952.1| COG0207: Thymidylate synthase [Magnetospirillum magnetotacticum]
Length = 290
Score = 302 bits (773), Expect = 7e-81
Identities = 147/296 (49%), Positives = 191/296 (64%), Gaps = 39/296 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L+ +I+ EG KDDRTGTGTLS+FG QM FDL++GFPL+TTK+L R I EL WF+
Sbjct: 21 YHDLLDRILTEGLRKDDRTGTGTLSVFGHQMRFDLAEGFPLVTTKQLHLRSIIHELLWFL 80
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++ L + + IW DE+ D +L
Sbjct: 81 QGDTNIAYLKENGVTIW---------DEW------------------------ADADGNL 107
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YGKQWRSW + P S +DQ+ V+ +I NPDSRR IVSAWN D+D MAL
Sbjct: 108 GPVYGKQWRSW----EKP--SGGTVDQIAWVLGEIARNPDSRRLIVSAWNPADLDRMALA 161
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV +G LSC+LYQRSADVFLGVPFNIASYALLT ++A++ GL G F+HT G
Sbjct: 162 PCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTAMMAQVTGLAPGDFVHTLG 221
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
DAH+Y+NH++ + Q+ REP+ +P+L + ++ D+ EDI + GYD HP IK
Sbjct: 222 DAHLYVNHLEQARLQLSREPRALPRLRLNPEVRSLFDFRFEDIAIEGYDPHPAIKA 277
>ref|ZP_00309278.1| COG0207: Thymidylate synthase [Cytophaga hutchinsonii]
Length = 264
Score = 302 bits (773), Expect = 7e-81
Identities = 149/300 (49%), Positives = 195/300 (65%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ I+D+G K+DRTGTGT+S+FG QM F+L +GFPLLTTKKL R I EL WF
Sbjct: 3 QYHDLMQHILDQGVKKEDRTGTGTVSVFGYQMRFNLQEGFPLLTTKKLHMRSITHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++K L D N++IW DE+ D + +
Sbjct: 63 LQGDTNIKYLKDNNVSIW---------DEW------------------------ADENGN 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P K IDQ+ V+ I NPDSRR IVSAWNVG+I+ M L
Sbjct: 90 LGPVYGYQWRSW------PTPDGKHIDQITNVVNMIKNNPDSRRLIVSAWNVGEIEKMKL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH FQFYV +G LSC+LYQRSADVFLGVPFNIASYALLT ++A++ GL+ G F+HT
Sbjct: 144 PPCHAFFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVCGLQAGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ K Q+ R+ + +P ++I ++I D+ ED L GYD HP IK ++
Sbjct: 204 GDAHLYSNHLEQAKLQLSRDFRPLPAMKINPDVKSIFDFKFEDFTLEGYDPHPHIKAAVA 263
>sp|P54081|TYSB_BACAM Thymidylate synthase B (TS B) (TSase B)
Length = 264
Score = 301 bits (772), Expect = 9e-81
Identities = 147/300 (49%), Positives = 193/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L + +++ G K DRTGTGT+S FG QM F+L GFP+LTTKKL F+ IA EL WF
Sbjct: 3 QYKDLCRHVLENGEKKGDRTGTGTISTFGYQMRFNLQGGFPMLTTKKLHFKSIAHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L + + IW + A D + +
Sbjct: 63 LKGDTNVRYLQENGVRIWNEWA---------------------------------DENGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW + IDQ+ R+I DI TNP+SRR IVSAWNVG+ID MAL
Sbjct: 90 LGPVYGSQWRSWRG------ADGETIDQISRLIHDIKTNPNSRRLIVSAWNVGEIDRMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSADVFLGVPFNIASYALLT +IA + GL+ G+F+HTF
Sbjct: 144 PPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAHVTGLEPGEFVHTF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NH++ + Q+ R+ + +P+L ++I D+ ED ++ YD HP IKG +S
Sbjct: 204 GDVHIYQNHVEQVNLQLTRDVRPLPKLRFARNVDSIFDFAFEDFIIEDYDPHPHIKGAVS 263
>ref|YP_014496.1| thymidylate synthase [Listeria monocytogenes str. 4b F2365]
ref|ZP_00231029.1| thymidylate synthase [Listeria monocytogenes str. 4b H7858]
gb|AAT04673.1| thymidylate synthase [Listeria monocytogenes str. 4b F2365]
gb|EAL09150.1| thymidylate synthase [Listeria monocytogenes str. 4b H7858]
Length = 314
Score = 301 bits (772), Expect = 9e-81
Identities = 156/317 (49%), Positives = 210/317 (66%), Gaps = 23/317 (7%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L K +++ GT K DRTGTGT+S FG QM FDL +GFP++TTK++PF+++ EL WF
Sbjct: 3 QYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAY-RFYLDEFEKGWEGLE---HIAGDPLSKQEFVSAAK- 131
++GDT+++ LL N NIW + A+ RF + KG + + D K+ + + +
Sbjct: 63 LHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDSAFKEVYQAEMEK 122
Query: 132 -------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSR 179
D +F +LG IYGKQWR W + + IDQL +I+ I TNP+SR
Sbjct: 123 FKARILEDEAFANKYGELGNIYGKQWREWKT------SQGETIDQLADLIEMIKTNPNSR 176
Query: 180 RHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTH 239
R IVSAWN DI MALPPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH
Sbjct: 177 RLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTH 236
Query: 240 IIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLED 299
+IA+ GL+VG+FIHT GDAH+Y NHI+ +K Q+ R P ++P+L + I D+ + D
Sbjct: 237 LIAREVGLEVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHKLPKLVLSDKPATIFDFDVAD 296
Query: 300 IVLTGYDAHPTIKGKLS 316
I L GY+ P IK +S
Sbjct: 297 ISLDGYNPDPAIKAPIS 313
>pir||SYBSTB thymidylate synthase (EC 2.1.1.45) B - Bacillus subtilis (strain
168)
Length = 264
Score = 301 bits (772), Expect = 1e-80
Identities = 149/300 (49%), Positives = 194/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y + + +++ G K DRTGTGT+S FG QM F+L +GFP+LTTKKL F+ IA EL WF
Sbjct: 3 QYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPMLTTKKLHFKSIAHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L + + IW + A D + +
Sbjct: 63 LKGDTNVRYLQENGVRIWNEWA---------------------------------DENGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW + IDQ+ R+I+DI TNP+SRR IVSAWNVG+ID MAL
Sbjct: 90 LGPVYGSQWRSWRG------ADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH LFQFYV +G LSC+LYQRSADVFLGVPFNIASYALLT IIA + GL+ G+FIHTF
Sbjct: 144 APCHCLFQFYVSDGKLSCQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NHI+ + Q+ER+ + +PQL ++I ++ ED ++ YD HP IKG +S
Sbjct: 204 GDVHIYQNHIEQVNLQLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVS 263
>ref|NP_600073.1| thymidylate synthase [Corynebacterium glutamicum ATCC 13032]
sp|Q8NS38|TYSY_CORGL Thymidylate synthase (TS) (TSase)
dbj|BAB98237.1| Thymidylate synthase [Corynebacterium glutamicum ATCC 13032]
emb|CAF19550.1| PROBABLE THYMIDYLATE SYNTHASE [Corynebacterium glutamicum ATCC
13032]
Length = 266
Score = 301 bits (770), Expect = 1e-80
Identities = 150/303 (49%), Positives = 196/303 (64%), Gaps = 40/303 (13%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
V T Y +L++KI +EG+ KDDRTGTGT SLFG Q+ FDL++GFPLLTTKK+ F + EL
Sbjct: 3 VPTPYEDLLRKIAEEGSHKDDRTGTGTTSLFGQQIRFDLNEGFPLLTTKKVHFHSVVGEL 62
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ GD+++K L D NI IW + A D
Sbjct: 63 LWFLQGDSNVKWLQDNNIRIWNEWA---------------------------------DE 89
Query: 134 SFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
+LGP+YG QWRSW P + IDQ+ ++ + NPDSRR+IVSAWNV +++
Sbjct: 90 DGELGPVYGVQWRSW------PTPDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELEN 143
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH+LFQ YV +G LSC+LYQRSAD+FLGVPFNIASYALLTH+ A+ AGL+VG+FI
Sbjct: 144 MALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFI 203
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
T GD HIY NH + + Q+ RE + P LE+ E Y+ +DI ++GYD HP I+G
Sbjct: 204 WTGGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFE-YSFDDITVSGYDPHPLIRG 262
Query: 314 KLS 316
K++
Sbjct: 263 KVA 265
>emb|CAA90532.1| thymidylate synthetase [Bacillus amyloliquefaciens]
Length = 282
Score = 301 bits (770), Expect = 2e-80
Identities = 147/300 (49%), Positives = 193/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L + +++ G K DRTGTGT+S FG QM F+L GFP+LTTKKL F+ IA EL WF
Sbjct: 21 QYKDLCRHVLENGEKKGDRTGTGTISTFGYQMRFNLQGGFPMLTTKKLHFKSIAHELLWF 80
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L + + IW + A D + +
Sbjct: 81 LKGDTNVRYLQENGVRIWNEWA---------------------------------DENGE 107
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW + IDQ+ R+I DI TNP+SRR IVSAWNVG+ID MAL
Sbjct: 108 LGPVYGSQWRSWRG------ADGETIDQISRLIHDIKTNPNSRRLIVSAWNVGEIDRMAL 161
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSADVFLGVPFNIASYALLT +IA + GL+ G+F+HTF
Sbjct: 162 PPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAHVTGLEPGEFVHTF 221
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NH++ + Q+ R+ + +P+L ++I D+ ED ++ YD HP IKG +S
Sbjct: 222 GDVHIYQNHVEQVNLQLTRDVRPLPKLRFARNVDSIFDFAFEDFIIEDYDPHPHIKGAVS 281
>ref|NP_969988.1| thyA [Bdellovibrio bacteriovorus HD100]
emb|CAE78047.1| thyA [Bdellovibrio bacteriovorus HD100]
Length = 264
Score = 299 bits (766), Expect = 4e-80
Identities = 144/300 (48%), Positives = 198/300 (66%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+K +++ G K+DRTGTGT+S+FG QM ++L +GFPLLTTKKL R I EL WF
Sbjct: 3 QYHDLIKTVLEHGVKKEDRTGTGTISMFGYQMRYNLQEGFPLLTTKKLHTRSIFHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++K L D + IW DE+ D + +
Sbjct: 63 LKGETNIKYLHDNKVTIW---------DEW------------------------ADENGN 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWRSW + + IDQ+ V++ I NP+SRR +V A+N GD+D MAL
Sbjct: 90 LGPVYGKQWRSWET------ADGRTIDQITNVVEQIKKNPNSRRMLVVAFNPGDVDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH FQFYV NG LSC+LYQRSAD+FLGVPFNIASYALLTH+IA++ L+VG F+HT
Sbjct: 144 PPCHAFFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQVCDLEVGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y+NH++ Q+ RE + +PQL++ +++ D+T EDI + GYD HP IK +++
Sbjct: 204 GDAHLYLNHLEQANLQLTREFRPLPQLKLNPAKKDLFDFTYEDIEIIGYDPHPAIKAEVA 263
>pir||S35239 thymidylate synthase (EC 2.1.1.45) B - Bacillus subtilis (strain
ATCC 6633)
emb|CAA49350.1| thymidylate synthase B [Bacillus subtilis]
prf||1916395A thymidylate synthase B
Length = 264
Score = 299 bits (766), Expect = 5e-80
Identities = 148/300 (49%), Positives = 194/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L + +++ G K DRTGTGT+S FG QM F L +GFP+LTTKKL F+ IA EL WF
Sbjct: 3 QYKDLCRHVLEHGEKKGDRTGTGTISTFGYQMRFHLQEGFPMLTTKKLHFKSIAHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L + + IW + A D + +
Sbjct: 63 LKGDTNVRYLQENGVRIWNEWA---------------------------------DENGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW + IDQ+ R+I+DI TNP+SRR IVSAWNVG+ID MAL
Sbjct: 90 LGPVYGSQWRSWRG------ADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSADVFLGVPFNIASYALLT +IA + GL+ G+FIHTF
Sbjct: 144 PPCHCLFQFYVSDGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAHVTGLEPGEFIHTF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NHI+ + Q+ R+ + +P+L ++I ++ ED ++ YD HP IKG +S
Sbjct: 204 GDVHIYQNHIEQVNLQLTRDLRPLPKLRFAREIDSIFNFAFEDFIIEDYDPHPHIKGAVS 263
>gb|AAA25255.1| thymidylate synthase [Lactobacillus casei]
Length = 329
Score = 299 bits (766), Expect = 5e-80
Identities = 158/325 (48%), Positives = 210/325 (64%), Gaps = 25/325 (7%)
Query: 10 KMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRII 69
+ T ++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I
Sbjct: 11 EQTMLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLI 70
Query: 70 AEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA 129
EL WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 71 KSELLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAV 130
Query: 130 -----AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKD 171
AK D +F DLG +YG QWR+W + SK + IDQL VI+
Sbjct: 131 YHEEMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQ 183
Query: 172 INTNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNI 231
I T+P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNI
Sbjct: 184 IKTHPYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNI 243
Query: 232 ASYALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHEN 291
ASYALLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +
Sbjct: 244 ASYALLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHD 303
Query: 292 IEDYTLEDIVLTGYDAHPTIKGKLS 316
I D+ ++DI L YD +P IK ++
Sbjct: 304 IFDFDMKDIKLLNYDPYPAIKAPVA 328
>ref|NP_244318.1| thymidylate synthase B [Bacillus halodurans C-125]
sp|Q9K7B5|TYSY_BACHD Thymidylate synthase (TS) (TSase)
pir||C84081 thymidylate synthase B thyB [imported] - Bacillus halodurans
(strain C-125)
dbj|BAB07170.1| thymidylate synthase B [Bacillus halodurans C-125]
Length = 264
Score = 299 bits (766), Expect = 5e-80
Identities = 142/300 (47%), Positives = 195/300 (65%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L + +++ GT + DRTGTGT+S+FG QM FDL +GFP++TTKKL R I EL WF
Sbjct: 3 QYLELCRHVLEHGTERSDRTGTGTISVFGYQMRFDLQEGFPVVTTKKLHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++ L + + IW + A D + +
Sbjct: 63 LKGETNIAYLQENGVRIWNEWA---------------------------------DENGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWRSW + K +DQ+ +V++ I PDSRR IVSAWN +I+ MAL
Sbjct: 90 LGPVYGKQWRSWEG------ANGKTVDQISQVVEAIKHQPDSRRLIVSAWNAAEIEDMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT +IA++ L+ G+F+HTF
Sbjct: 144 APCHCLFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTKMIAQVCDLEEGEFVHTF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAHIY+NHI+ +K Q+ REP+ +P++ + ++ D+T +D L GYD HP IKG++S
Sbjct: 204 GDAHIYLNHIEQVKLQLTREPRPLPEMRLNPEVRSLFDFTFDDFELVGYDPHPHIKGEVS 263
>pdb|2TSC|A Chain A, Thymidylate Synthase (E.C.2.1.1.45) Complex With dUMP And
An Anti-Folate (CB3717)
pdb|2TSC|B Chain B, Thymidylate Synthase (E.C.2.1.1.45) Complex With dUMP And
An Anti-Folate (CB3717)
Length = 264
Score = 298 bits (764), Expect = 8e-80
Identities = 146/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRAPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|NP_337339.1| thymidylate synthase [Mycobacterium tuberculosis CDC1551]
gb|AAK47153.1| thymidylate synthase [Mycobacterium tuberculosis CDC1551]
Length = 266
Score = 298 bits (763), Expect = 1e-79
Identities = 153/301 (50%), Positives = 198/301 (65%), Gaps = 40/301 (13%)
Query: 16 TEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFW 75
T Y +L++ +++ GT K DRTGTGT SLFG QM +DLS GFPLLTTKK+ F+ +A EL W
Sbjct: 5 TPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLW 64
Query: 76 FINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
F+ GD+++ L + + IW DE+ A DT
Sbjct: 65 FLRGDSNIGWLHEHGVTIW---------DEW-----------------------ASDTG- 91
Query: 136 DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMA 195
+LGPIYG QWRSW P S + IDQ+ + + T+PDSRR IVSAWNVG+I+ MA
Sbjct: 92 ELGPIYGVQWRSW------PAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMA 145
Query: 196 LPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHT 255
LPPCH FQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH++A AGL VG+FI T
Sbjct: 146 LPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWT 205
Query: 256 FGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKL 315
GD HIY NH++ ++ Q+ REP+ P+L + A ++I +YT EDIV+ YD HP IK +
Sbjct: 206 GGDCHIYDNHVEQVRLQLSREPRPYPKL-LLADRDSIFEYTYEDIVVKNYDPHPAIKAPV 264
Query: 316 S 316
+
Sbjct: 265 A 265
>ref|NP_737529.1| putative thymidylate synthase [Corynebacterium efficiens YS-314]
sp|Q8FR47|TYSY_COREF Thymidylate synthase (TS) (TSase)
dbj|BAC17729.1| putative thymidylate synthase [Corynebacterium efficiens YS-314]
Length = 267
Score = 298 bits (763), Expect = 1e-79
Identities = 148/306 (48%), Positives = 195/306 (63%), Gaps = 40/306 (13%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
MT + T Y +L++ I DEG KDDRTGTGT SLFG Q+ ++L +GFPLLTTKK+ F +
Sbjct: 1 MTAIPTPYEDLLRTIRDEGAHKDDRTGTGTTSLFGQQIRYNLQEGFPLLTTKKVHFHSVV 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAA 130
EL WF+ GD++++ L D NI IW + A
Sbjct: 61 GELLWFLRGDSNVRWLQDNNIRIWNEWA-------------------------------- 88
Query: 131 KDTSFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
D +LGP+YG QWRSW P + IDQ+ R ++ + NPDSRR+IVSAWNV +
Sbjct: 89 -DEDGELGPVYGVQWRSW------PTPDGRHIDQISRALEMLKNNPDSRRNIVSAWNVSE 141
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
++ MALPPCH+LFQ YV +G LSC+LYQRSAD+FLGVPFNIASYALLTH+ A+ A L+VG
Sbjct: 142 LENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQADLEVG 201
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FI T GD HIY NH + + Q+ R + P LE+ ++ DYT EDI ++ YD HP
Sbjct: 202 EFIWTGGDCHIYDNHTEQVDEQLSRAARPYPTLELNKA-ASLFDYTFEDIAVSNYDPHPL 260
Query: 311 IKGKLS 316
I+GK++
Sbjct: 261 IRGKVA 266
>ref|NP_217280.1| thyA [Mycobacterium tuberculosis H37Rv]
ref|NP_856432.1| PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) [Mycobacterium
bovis AF2122/97]
sp|O33306|TYSY_MYCTU Thymidylate synthase (TS) (TSase)
pir||C70881 probable thyA protein - Mycobacterium tuberculosis (strain H37RV)
emb|CAA15560.1| PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) [Mycobacterium
tuberculosis H37Rv]
emb|CAD94971.1| PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) [Mycobacterium
bovis AF2122/97]
Length = 263
Score = 298 bits (762), Expect = 1e-79
Identities = 153/301 (50%), Positives = 198/301 (65%), Gaps = 40/301 (13%)
Query: 16 TEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFW 75
T Y +L++ +++ GT K DRTGTGT SLFG QM +DLS GFPLLTTKK+ F+ +A EL W
Sbjct: 2 TPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLW 61
Query: 76 FINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
F+ GD+++ L + + IW DE+ A DT
Sbjct: 62 FLRGDSNIGWLHEHGVTIW---------DEW-----------------------ASDTG- 88
Query: 136 DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMA 195
+LGPIYG QWRSW P S + IDQ+ + + T+PDSRR IVSAWNVG+I+ MA
Sbjct: 89 ELGPIYGVQWRSW------PAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMA 142
Query: 196 LPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHT 255
LPPCH FQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH++A AGL VG+FI T
Sbjct: 143 LPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWT 202
Query: 256 FGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKL 315
GD HIY NH++ ++ Q+ REP+ P+L + A ++I +YT EDIV+ YD HP IK +
Sbjct: 203 GGDCHIYDNHVEQVRLQLSREPRPYPKL-LLADRDSIFEYTYEDIVVKNYDPHPAIKAPV 261
Query: 316 S 316
+
Sbjct: 262 A 262
>pdb|1TLC|A Chain A, Thymidylate Synthase Complexed With Dgmp And Folate Analog
1843u89
pdb|1TLC|B Chain B, Thymidylate Synthase Complexed With Dgmp And Folate Analog
1843u89
pdb|1TSD|A Chain A, Thymidylate Synthase Complex With 2'-Deoxyuridine
5'-Monophosphate (Dump) And Folate Analog 1843u89
pdb|1TSD|B Chain B, Thymidylate Synthase Complex With 2'-Deoxyuridine
5'-Monophosphate (Dump) And Folate Analog 1843u89
pdb|1DDU|A Chain A, E. Coli Thymidylate Synthase In Complex With Cb3717 And
2',5'-Dideoxyuridine (Ddurd)
pdb|1DDU|B Chain B, E. Coli Thymidylate Synthase In Complex With Cb3717 And
2',5'-Dideoxyuridine (Ddurd)
pdb|1TDU|A Chain A, E. Coli Thymidylate Synthase In Complex With Cb3717 And
2'-Deoxyuridine (Durd)
pdb|1TDU|B Chain B, E. Coli Thymidylate Synthase In Complex With Cb3717 And
2'-Deoxyuridine (Durd)
pdb|1TJS| E. Coli Thymidylate Synthase
pdb|1AN5|A Chain A, E. Coli Thymidylate Synthase In Complex With Cb3717
pdb|1AN5|B Chain B, E. Coli Thymidylate Synthase In Complex With Cb3717
pdb|1AOB| E. Coli Thymidylate Synthase Complexed With Ddurd
pdb|1BDU| E. Coli Thymidylate Synthase Complexed With Durd
pdb|1BID| E. Coli Thymidylate Synthase Complexed With Dump
pdb|1TRG| E. Coli Thymidylate Synthase In Symmetric Complex With Cb3717 And
2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|1AXW|A Chain A, E. Coli Thymidylate Synthase In Complex With Methotrexate
(Mtx) And 2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|1AXW|B Chain B, E. Coli Thymidylate Synthase In Complex With Methotrexate
(Mtx) And 2'-Deoxyuridine 5'-Monophosphate (Dump)
Length = 265
Score = 297 bits (761), Expect = 2e-79
Identities = 146/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 4 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 63
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 64 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 90
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 91 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 144
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 145 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 204
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 205 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 264
>ref|NP_289379.1| thymidylate synthetase [Escherichia coli O157:H7 EDL933]
ref|NP_311711.1| thymidylate synthetase [Escherichia coli O157:H7]
ref|NP_417304.1| thymidylate synthetase [Escherichia coli K12]
ref|NP_755297.1| Thymidylate synthase [Escherichia coli CFT073]
sp|P00470|TYSY_ECOLI Thymidylate synthase (TS) (TSase)
pir||SYECT thymidylate synthase (EC 2.1.1.45) - Escherichia coli (strain
K-12)
pir||D91089 thymidylate synthetase [imported] - Escherichia coli (strain
O157:H7, substrain RIMD 0509952)
pir||F85934 thymidylate synthetase [imported] - Escherichia coli (strain
O157:H7, substrain EDL933)
pdb|3TMS| Thymidylate Synthase (E.C.2.1.1.45)
pdb|2BBQ|A Chain A, Thymidylate Synthase (E.C.2.1.1.45) Complex With D-Ump And
Polyglutamyl Cb3717
pdb|2BBQ|B Chain B, Thymidylate Synthase (E.C.2.1.1.45) Complex With D-Ump And
Polyglutamyl Cb3717
pdb|1SYN|A Chain A, E. Coli Thymidylate Synthase In Complex With Bw1843u89 And
2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|1SYN|B Chain B, E. Coli Thymidylate Synthase In Complex With Bw1843u89 And
2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|2KCE|A Chain A, Binding Of The Anticancer Drug Zd1694 To E. Coli
Thymidylate Synthase: Assessing Specificity And Affinity
pdb|2KCE|B Chain B, Binding Of The Anticancer Drug Zd1694 To E. Coli
Thymidylate Synthase: Assessing Specificity And Affinity
gb|AAA24675.1| thymidylate synthase
gb|AAC75866.1| thymidylate synthetase [Escherichia coli K12]
gb|AAG57938.1| thymidylate synthetase [Escherichia coli O157:H7 EDL933]
dbj|BAB37107.1| thymidylate synthetase [Escherichia coli O157:H7]
gb|AAN81867.1| Thymidylate synthase [Escherichia coli CFT073]
Length = 264
Score = 297 bits (761), Expect = 2e-79
Identities = 146/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|ZP_00053813.2| COG0207: Thymidylate synthase [Magnetospirillum magnetotacticum]
Length = 264
Score = 297 bits (761), Expect = 2e-79
Identities = 146/300 (48%), Positives = 193/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+++I EG K DRTGTGT S+FG QM FDLS GFPL+TTKKL R I EL WF
Sbjct: 3 QYLDLLRRIRAEGVTKTDRTGTGTTSVFGHQMRFDLSAGFPLVTTKKLHTRSIFVELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L D ++IW DE+ D D
Sbjct: 63 LRGDTNIRYLKDNKVSIW---------DEW------------------------ADADGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWRSWA + +DQ+ +V++ I +PDSRR IVSAWN DI+ MAL
Sbjct: 90 LGPVYGKQWRSWAC------PDGRTVDQITQVVEMIKKSPDSRRLIVSAWNPADIESMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV G LSC+LYQRSADVFLGVPFNIASYALLTH++A++ GL+VG F+HTF
Sbjct: 144 PPCHCLFQFYVAEGRLSCQLYQRSADVFLGVPFNIASYALLTHMMAQVTGLEVGDFVHTF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ + Q+ R P +P+LE+ +++ +T++DI + Y H I ++
Sbjct: 204 GDAHLYSNHMEQAELQLSRAPLALPRLELNPDVKDLFAFTMDDIKVVDYQCHAHISAPVA 263
>ref|NP_708616.1| thymidylate synthetase [Shigella flexneri 2a str. 301]
ref|NP_838339.1| thymidylate synthetase [Shigella flexneri 2a str. 2457T]
sp|P48464|TYSY_SHIFL Thymidylate synthase (TS) (TSase)
gb|AAN44323.1| thymidylate synthetase [Shigella flexneri 2a str. 301]
gb|AAP18149.1| thymidylate synthetase [Shigella flexneri 2a str. 2457T]
Length = 264
Score = 297 bits (760), Expect = 2e-79
Identities = 145/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP +K ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGVKAPVA 263
>sp|Q27828|DRTS_PARTE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)
[INCLUDES: DIHYDROFOLATE REDUCTASE ; THYMIDYLATE
SYNTHASE ]
pir||S65570 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - Paramecium tetraurelia
gb|AAC47025.1| dihydrofolate reductase-thymidylate synthase
Length = 462
Score = 297 bits (760), Expect = 2e-79
Identities = 152/318 (47%), Positives = 207/318 (65%), Gaps = 24/318 (7%)
Query: 1 KRTGKRGCIKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLT 60
K + ++ I H + +Y +++ KIM EG KDDRTG GT+S+FG M F+L++ FPLLT
Sbjct: 166 KNSHEQSYIDEEHQENQYLDMITKIMKEGVSKDDRTGVGTMSIFGQTMRFNLAQSFPLLT 225
Query: 61 TKKLPFRIIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDP 120
TKK+ FR + EEL WF+ G+T+ K LLDK + IW + R YLD GL+H
Sbjct: 226 TKKVFFRGVVEELLWFLRGNTNGKLLLDKGVKIWEGNGTREYLDTI-----GLQH----- 275
Query: 121 LSKQEFVSAAKDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDS 178
+QE DLGP+YG QWR + A + D S + +DQ+ +I+ + NPDS
Sbjct: 276 --RQEH---------DLGPVYGFQWRHFGAKYKDCQTDYSNQGVDQVKEIIQLLKNNPDS 324
Query: 179 RRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLT 238
RR I+SAWN D+ MALPPCHV+ QF+V NG LSC +YQRS D LG+PFNIASYALLT
Sbjct: 325 RRIILSAWNPIDLKQMALPPCHVMSQFFVANGKLSCMMYQRSCDFGLGIPFNIASYALLT 384
Query: 239 HIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLE 298
+++AK L +G+F+H GD HIY NH++ LK Q+ER P P L+IK ++++ DYT E
Sbjct: 385 YMLAKECNLNLGEFVHVLGDTHIYSNHVEALKKQIERVPYPFPLLKIKG-NKSLFDYTYE 443
Query: 299 DIVLTGYDAHPTIKGKLS 316
D L GY+AH I+ K++
Sbjct: 444 DFELVGYNAHDKIEMKMA 461
>ref|NP_296349.1| thymidylate synthase [Deinococcus radiodurans R1]
pir||E75250 thymidylate synthase - Deinococcus radiodurans (strain R1)
gb|AAF12166.1| thymidylate synthase [Deinococcus radiodurans]
Length = 387
Score = 297 bits (760), Expect = 2e-79
Identities = 144/300 (48%), Positives = 196/300 (65%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y + ++ I D GT K DRTGTGT S+FG QM FDLS+GFPL+TTK++ + I EL WF
Sbjct: 126 QYLDFLRHIRDHGTDKMDRTGTGTRSVFGYQMRFDLSEGFPLVTTKRVHLKSIIYELLWF 185
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GD++++ L + + IW DE+ + EG E
Sbjct: 186 LRGDSNVRWLQEHGVTIW---------DEWAR--EGGE---------------------- 212
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW + +IDQ+ +VI+ I TNPDSRR IVSAWNV ID MAL
Sbjct: 213 LGPVYGVQWRSWPDYGGG------QIDQISQVIEQIKTNPDSRRLIVSAWNVAQIDEMAL 266
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH+LFQFYV +G LSC+LYQRSAD FLGVPFNIASYALLT ++A++ GL+ G+FI T
Sbjct: 267 PPCHLLFQFYVADGKLSCQLYQRSADSFLGVPFNIASYALLTMMVAQVCGLEPGEFIWTG 326
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NH++ ++ Q++REP+ +P++ + +++ + ED L GYD HP IK +++
Sbjct: 327 GDCHIYSNHMEQVERQLKREPRPLPKMRLNPAVKDMFAFQYEDFTLEGYDPHPGIKAEVA 386
>pdb|1KCE|A Chain A, E. Coli Thymidylate Synthase Mutant E58q In Complex With
Cb3717 And 2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|1KCE|B Chain B, E. Coli Thymidylate Synthase Mutant E58q In Complex With
Cb3717 And 2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|1TLS|A Chain A, Thymidylate Synthase Ternary Complex With Fdump And
Methylenetetrahydrofolate
pdb|1TLS|B Chain B, Thymidylate Synthase Ternary Complex With Fdump And
Methylenetetrahydrofolate
pdb|1TSN| Thymidylate Synthase Ternary Complex With Fdump And
Methylenetetrahydrofolate
pdb|1F4B|A Chain A, Crystal Structure Of Escherichia Coli Thymidylate Synthase
pdb|1F4C|A Chain A, Crystal Structure Of E. Coli Thymidylate Synthase
Covalently Modified At C146 With
N-[tosyl-D-Prolinyl]amino- Ethanethiol
pdb|1F4C|B Chain B, Crystal Structure Of E. Coli Thymidylate Synthase
Covalently Modified At C146 With
N-[tosyl-D-Prolinyl]amino- Ethanethiol
pdb|1F4E|A Chain A, Crystal Structure Of E. Coli Thymidylate Synthase
Complexed With Tosyl-D-Proline
pdb|1F4F|A Chain A, Crystal Structure Of E. Coli Thymidylate Synthase
Complexed With Sp-722
pdb|1F4F|B Chain B, Crystal Structure Of E. Coli Thymidylate Synthase
Complexed With Sp-722
pdb|1JTQ|A Chain A, E. Coli Ts Complex With Dump And The Pyrrolo(2,3-D)
Pyrimidine-Based Antifolate Ly341770
pdb|1JTQ|B Chain B, E. Coli Ts Complex With Dump And The Pyrrolo(2,3-D)
Pyrimidine-Based Antifolate Ly341770
pdb|1JTU|A Chain A, E. Coli Thymidylate Synthase In A Complex With Dump And
Ly338913, A Polyglutamylated Pyrrolo(2,3-D)pyrimidine-
Based Antifolate
pdb|1JTU|B Chain B, E. Coli Thymidylate Synthase In A Complex With Dump And
Ly338913, A Polyglutamylated Pyrrolo(2,3-D)pyrimidine-
Based Antifolate
pdb|1JUT|A Chain A, E. Coli Thymidylate Synthase Bound To Dump And Ly338529, A
Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JUT|B Chain B, E. Coli Thymidylate Synthase Bound To Dump And Ly338529, A
Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1KZI|A Chain A, Crystal Structure Of EctsDUMPTHF COMPLEX
pdb|1KZI|B Chain B, Crystal Structure Of EctsDUMPTHF COMPLEX
Length = 264
Score = 297 bits (760), Expect = 3e-79
Identities = 146/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>gb|AAB40474.1| thymidylate synthetase
Length = 264
Score = 296 bits (759), Expect = 3e-79
Identities = 146/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVXDGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>sp|P00469|TYSY_LACCA Thymidylate synthase (TS) (TSase)
pir||SYLBT thymidylate synthase (EC 2.1.1.45) - Lactobacillus casei
pdb|4TMS| Thymidylate Synthase (E.C.2.1.1.45)
pdb|1THY| Thymidylate Synthase (E.C.2.1.1.45) Complex With 2'-Deoxyuridine
5'-Monophosphate (Ump)
pdb|1LCE| Lactobacillus Casei Thymidylate Synthase Ternary Complex With Dump
And Ch2thf
pdb|1LCB| Lactobacillus Casei Thymidylate Synthase Ternary Complex With Dtmp
And H2folate
pdb|1LCA| Lactobacillus Casei Thymidylate Synthase Ternary Complex With Dump
And Cb3717
pdb|1NJE| Thymidylate Synthase With 2'-Deoxycytidine 5'-Monophosphate (Dcmp)
pdb|2TDM| Structure Of Thymidylate Synthase
pdb|1TSL| L. Casei Thymidylate Synthase With Species Specific Inhibitor
pdb|1TSM| L. Casei Thymidylate Synthase With Species Specific Inhibitor
gb|AAA72795.1| thymidylate synthase (EC 2.1.1.45)
Length = 316
Score = 296 bits (758), Expect = 4e-79
Identities = 157/321 (48%), Positives = 208/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1TDA| Thymidylate Synthase (E.C.2.1.1.45) Mutant With Val 316 Deleted
pdb|1TDB| Thymidylate Synthase (E.C.2.1.1.45) Mutant With Val 316 Deleted
Complex With FdUMP
pdb|1TDC| Thymidylate Synthase (E.C.2.1.1.45) Mutant With Val 316 Deleted
Complex With dUMP
pdb|2TDD| Thymidylate Synthase (E.C.2.1.1.45) Mutant With Val 316 Deleted
Complex With FdUMP And 5-Hydroxymethylene
Tetrahydrofolate
Length = 315
Score = 296 bits (758), Expect = 4e-79
Identities = 157/321 (48%), Positives = 208/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>ref|ZP_00183089.1| COG0207: Thymidylate synthase [Exiguobacterium sp. 255-15]
Length = 264
Score = 296 bits (758), Expect = 4e-79
Identities = 145/297 (48%), Positives = 187/297 (62%), Gaps = 39/297 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L ++I+ G K+DRTGTGT+S+FG QM F L GFP++TTKKL + I EL WF
Sbjct: 3 QYHQLCQEILTNGVKKEDRTGTGTISIFGHQMRFSLQDGFPMVTTKKLHMKSIIHELIWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
I+G+T++ L + + IW + A D + +
Sbjct: 63 ISGETNISYLQENGVRIWNEWA---------------------------------DENGN 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRS+ P +DQL VI+ I NPDSRR IVSAWN G ++ MAL
Sbjct: 90 LGPVYGAQWRSF------PKPDGTTVDQLADVIEQIKVNPDSRRLIVSAWNPGQLEEMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH+LFQFYV +G LSC+LYQRSADVFLGVPFNIASYALLTH+IA + L+VG F+HT
Sbjct: 144 PPCHLLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTHMIAHVCKLEVGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
GD+HIY NH+D + Q+ R PK +P + E IED+T +DI++ GYD P IKG
Sbjct: 204 GDSHIYSNHLDQVNLQLSRNPKPLPTIRFAREVERIEDFTFDDIIIEGYDPDPHIKG 260
>pdb|1ZPR|A Chain A, E. Coli Thymidylate Synthase Mutant E58q In Complex With
Cb3717 And 2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|1ZPR|B Chain B, E. Coli Thymidylate Synthase Mutant E58q In Complex With
Cb3717 And 2'-Deoxyuridine 5'-Monophosphate (Dump)
Length = 264
Score = 296 bits (758), Expect = 4e-79
Identities = 145/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I +L WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHQLLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|NP_404408.1| thymidylate synthase [Yersinia pestis]
ref|NP_670470.1| thymidylate synthetase [Yersinia pestis KIM]
ref|NP_994180.1| thymidylate synthase [Yersinia pestis biovar Medievalis str. 91001]
sp|Q8ZHV1|TYSY_YERPE Thymidylate synthase (TS) (TSase)
pir||AE0096 thymidylate synthase (EC 2.1.1.45) [imported] - Yersinia pestis
(strain CO92)
emb|CAC89632.1| thymidylate synthase [Yersinia pestis CO92]
gb|AAM86721.1| thymidylate synthetase [Yersinia pestis KIM]
gb|AAS63057.1| thymidylate synthase [Yersinia pestis biovar Medievalis str. 91001]
Length = 264
Score = 296 bits (757), Expect = 5e-79
Identities = 146/300 (48%), Positives = 192/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+KK+++EGT K DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+NGDT++ L + N++IW DE+ D + D
Sbjct: 63 LNGDTNIAYLKENNVSIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGPIYGKQWR+W + ++IDQL V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPIYGKQWRAWGA------ADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NHID Q+ REP+ +P+L IK +++ DY +D + GYD HP IK ++
Sbjct: 204 GDTHLYSNHIDQAHLQLSREPRVLPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIA 263
>pdb|1F4G|A Chain A, Crystal Structure Of E. Coli Thymidylate Synthase
Complexed With Sp-876
pdb|1F4G|B Chain B, Crystal Structure Of E. Coli Thymidylate Synthase
Complexed With Sp-876
Length = 264
Score = 296 bits (757), Expect = 5e-79
Identities = 146/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H+ A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMXAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1BJG| D221(169)n Mutant Does Not Promote Opening Of The Cofactor
Imidazolidine Ring
pdb|1DNA|A Chain A, D221(169)n Mutant Does Not Promote Opening Of The Cofactor
Imidazolidine Ring
pdb|1DNA|B Chain B, D221(169)n Mutant Does Not Promote Opening Of The Cofactor
Imidazolidine Ring
Length = 264
Score = 296 bits (757), Expect = 6e-79
Identities = 145/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS +VFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCNVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1VZB| L. Casei Thymidylate Synthase Mutant E60q Binary Complex With Dump
pdb|1VZC| L. Casei Thymidylate Synthase Mutant E60q Binary Complex With Fdump
pdb|1VZD| L. Casei Thymidylate Synthase Mutant E60q Ternary Complex With
Fdump And Cb3717
pdb|1VZE| L. Casei Thymidylate Synthase Mutant E60q Ternary Complex With Dump
And Cb3717
Length = 316
Score = 295 bits (755), Expect = 8e-79
Identities = 156/321 (48%), Positives = 208/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I +L
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSQL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKAPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1VZA| Thymidylate Synthase E60d Mutant Binary Complex With
2'-Deoxyuridine 5'-Monophosphate (Dump)
Length = 316
Score = 295 bits (755), Expect = 1e-78
Identities = 156/321 (48%), Positives = 208/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I +L
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSDL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKAPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>gb|AAP31579.1| thymidylate synthase [Shigella flexneri]
Length = 264
Score = 295 bits (755), Expect = 1e-78
Identities = 144/300 (48%), Positives = 188/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW D A D + D
Sbjct: 63 LQGDTNIGYLHENNVTIWDDWA---------------------------------DENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP++GKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVFGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASY LL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYTLLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYTNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1FFL|A Chain A, Crystal Structure Of The Apo-Thymidylate Synthase R166q
Mutant
pdb|1FWM|A Chain A, Crystal Structure Of The Thymidylate Synthase R166q Mutant
pdb|1FWM|B Chain B, Crystal Structure Of The Thymidylate Synthase R166q Mutant
Length = 264
Score = 295 bits (755), Expect = 1e-78
Identities = 145/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQ+S DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQQSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1TSY| Thymidylate Synthase R179k Mutant
pdb|1TSZ| Thymidylate Synthase R179k Mutant
Length = 316
Score = 295 bits (754), Expect = 1e-78
Identities = 156/321 (48%), Positives = 208/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SR+ IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRKLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1BQ2| E. Coli Thymidylate Synthase Mutant N177a
pdb|1BQ1|A Chain A, E. Coli Thymidylate Synthase Mutant N177a In Complex With
Cb3717 And 2'-Deoxyuridine 5'-Monophosphate (Dump)
pdb|1BQ1|B Chain B, E. Coli Thymidylate Synthase Mutant N177a In Complex With
Cb3717 And 2'-Deoxyuridine 5'-Monophosphate (Dump)
Length = 264
Score = 295 bits (754), Expect = 1e-78
Identities = 145/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PF IASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFAIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>gb|AAN41256.1| mutant thymidilate synthetase [Escherichia coli]
Length = 264
Score = 295 bits (754), Expect = 1e-78
Identities = 145/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFP +TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPQVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|NP_355015.1| AGR_C_3709p [Agrobacterium tumefaciens str. C58]
pir||G97605 hypothetical protein AGR_C_3709 [imported] - Agrobacterium
tumefaciens (strain C58, Cereon)
gb|AAK87800.1| AGR_C_3709p [Agrobacterium tumefaciens str. C58]
Length = 279
Score = 295 bits (754), Expect = 1e-78
Identities = 144/300 (48%), Positives = 191/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ +M+ G+ + DRTGTGT S+FG QM FDLS+GFP+LTTKKL R I EL WF
Sbjct: 18 QYLDLLRHVMETGSDRGDRTGTGTRSVFGYQMRFDLSEGFPVLTTKKLHLRSIIHELLWF 77
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+NGDT++ L + ++IW DE+ D + D
Sbjct: 78 LNGDTNIAYLKENGVSIW---------DEW------------------------ADENGD 104
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ +I+ + TNP+SRRHIVSAWN +D MAL
Sbjct: 105 LGPVYGAQWRSW------PAPDGRHIDQIALLIEALKTNPNSRRHIVSAWNPALVDEMAL 158
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GLK G F+HT
Sbjct: 159 PPCHCLFQFYVSDGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVVGLKPGDFVHTL 218
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAHIY NH + + QM R PK +P + + +N+ + ED L Y+A +IK ++
Sbjct: 219 GDAHIYANHFEQAQLQMTRTPKALPTMRLNPDVKNLFGFKFEDFTLENYEADSSIKAPIA 278
>ref|NP_961803.1| ThyA [Mycobacterium avium subsp. paratuberculosis str. k10]
gb|AAS05186.1| ThyA [Mycobacterium avium subsp. paratuberculosis str. k10]
Length = 266
Score = 294 bits (753), Expect = 1e-78
Identities = 150/303 (49%), Positives = 195/303 (64%), Gaps = 40/303 (13%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
+ T Y +L++ ++D GT K DRTGTGT SLFG Q+ +DLS GFPL+TTKK+ + + EL
Sbjct: 3 IPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYEL 62
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ GD+++ L + IW DE+ A DT
Sbjct: 63 LWFLRGDSNVDWLHRHGVTIW---------DEW-----------------------ASDT 90
Query: 134 SFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGPIYG QWRSW P S + IDQ+ + + T+PDSRR IVSAWNVG+I
Sbjct: 91 G-DLGPIYGVQWRSW------PTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPR 143
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH FQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH++A AGL VG+F+
Sbjct: 144 MALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFV 203
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
T GD HIY NH++ ++ Q+ REP+ P+L I A ++I DYT +D+V+ YD HP IK
Sbjct: 204 WTGGDCHIYDNHVEQVRLQLSREPRPYPEL-ILAHRDSIFDYTYDDVVVHNYDPHPAIKA 262
Query: 314 KLS 316
++
Sbjct: 263 PVA 265
>pdb|1TVW| Contributions Of Orientation And Hydrogen Bonding To Catalysis In
Asn-229 Mutants Of Thymidylate Synthase
pdb|1JMI| Contributions Of Orientation And Hydrogen Bonding To Catalysis In
Asn-229 Mutants Of Thymidylate Synthase
Length = 316
Score = 294 bits (753), Expect = 2e-78
Identities = 156/321 (48%), Positives = 208/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPF+IASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFSIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1NCE|A Chain A, Crystal Structure Of A Ternary Complex Of E. Coli
Thymidylate Synthase D169c With Dump And The Antifolate
Cb3717
pdb|1NCE|B Chain B, Crystal Structure Of A Ternary Complex Of E. Coli
Thymidylate Synthase D169c With Dump And The Antifolate
Cb3717
Length = 264
Score = 294 bits (753), Expect = 2e-78
Identities = 145/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS VFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCCVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1EVG|A Chain A, Crystal Structure Analysis Of Cys167 Mutant Of Escherichia
Coli With Unmodified Catalytic Cysteine
Length = 264
Score = 294 bits (753), Expect = 2e-78
Identities = 145/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRXHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQR+ DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRTCDVFLGLPFNIASYALLVHMMAQQXDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1NJD| Thymidylate Synthase, Mutation, N229d With 2'-Deoxyuridine
5'-Monophosphate (Dump)
pdb|1NJC| Thymidylate Synthase, Mutation, N229d With 2'-Deoxycytidine
5'-Monophosphate (Dcmp)
Length = 316
Score = 294 bits (753), Expect = 2e-78
Identities = 156/321 (48%), Positives = 208/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPF+IASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFDIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>ref|NP_532723.1| thymidylate synthase [Agrobacterium tumefaciens str. C58]
sp|Q8UDS3|TYSY_AGRT5 Thymidylate synthase (TS) (TSase)
pir||AI2827 thymidylate synthase [imported] - Agrobacterium tumefaciens
(strain C58, Dupont)
gb|AAL43039.1| thymidylate synthase [Agrobacterium tumefaciens str. C58]
Length = 264
Score = 294 bits (753), Expect = 2e-78
Identities = 144/300 (48%), Positives = 191/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ +M+ G+ + DRTGTGT S+FG QM FDLS+GFP+LTTKKL R I EL WF
Sbjct: 3 QYLDLLRHVMETGSDRGDRTGTGTRSVFGYQMRFDLSEGFPVLTTKKLHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+NGDT++ L + ++IW DE+ D + D
Sbjct: 63 LNGDTNIAYLKENGVSIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ +I+ + TNP+SRRHIVSAWN +D MAL
Sbjct: 90 LGPVYGAQWRSW------PAPDGRHIDQIALLIEALKTNPNSRRHIVSAWNPALVDEMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GLK G F+HT
Sbjct: 144 PPCHCLFQFYVSDGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVVGLKPGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAHIY NH + + QM R PK +P + + +N+ + ED L Y+A +IK ++
Sbjct: 204 GDAHIYANHFEQAQLQMTRTPKALPTMRLNPDVKNLFGFKFEDFTLENYEADSSIKAPIA 263
>pdb|1AIQ|A Chain A, Crystal Structure Of Thymidylate Synthase R126e Mutant
pdb|1AIQ|B Chain B, Crystal Structure Of Thymidylate Synthase R126e Mutant
pdb|1AJM| Crystal Structure Of Thymidylate Synthase R126e Mutant
Length = 264
Score = 294 bits (752), Expect = 2e-78
Identities = 145/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDS R IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSERIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1TSX| Thymidylate Synthase R179e Mutant
Length = 316
Score = 294 bits (752), Expect = 2e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRELIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1JMG| Contributions Of Orientation And Hydrogen Bonding To Catalysis In
Asn-229 Mutants Of Thymidylate Synthase
Length = 316
Score = 294 bits (752), Expect = 2e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPF IASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFGIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>gb|AAS80323.1| thymidylate synthetase [Xenorhabdus nematophila]
Length = 264
Score = 294 bits (752), Expect = 2e-78
Identities = 144/300 (48%), Positives = 193/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+KK+++EGT KDDRTGTGT S+FG QM F+L +GFPL+TTK+ R I EL WF
Sbjct: 3 QYLDLMKKVLEEGTAKDDRTGTGTRSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+NGDT++K L D ++IW DE+ D + D
Sbjct: 63 LNGDTNIKYLHDNGVSIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W S + IDQL +V++ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAWGS------ADGRHIDQLTQVLEQLKGDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCNLDVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ Q+ REP+ +P+L IK +++ DY ED + YD +P IK ++
Sbjct: 204 GDTHLYNNHLEQTHLQLSREPRALPKLVIKRKPDSLFDYRFEDFEIVDYDPYPGIKAPVA 263
>ref|NP_539525.1| THYMIDYLATE SYNTHASE [Brucella melitensis 16M]
ref|NP_698397.1| thymidylate synthase [Brucella suis 1330]
sp|Q8YI37|TYSY_BRUME Thymidylate synthase (TS) (TSase)
pir||AB3328 thymidylate synthase (EC 2.1.1.45) [imported] - Brucella melitensis
(strain 16M)
gb|AAL51789.1| THYMIDYLATE SYNTHASE [Brucella melitensis 16M]
gb|AAN30312.1| thymidylate synthase [Brucella suis 1330]
Length = 264
Score = 294 bits (752), Expect = 2e-78
Identities = 147/299 (49%), Positives = 190/299 (63%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++D G +DDRTGTGT S+FG QM FDL +GFP+LTTKKL R I EL WF+
Sbjct: 4 YLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++ L + + IW DE+ D + DL
Sbjct: 64 KGDTNIAYLKENGVTIW---------DEW------------------------ADENGDL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWRSW P + IDQ+ ++K ++TNP SRR IVSAWN +D MALP
Sbjct: 91 GPVYGYQWRSW------PAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV NG LSC+LYQRSAD+FLGVPFNIASYALLT +IA++ GLK G+FIHT G
Sbjct: 145 PCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAHIY NH + + Q+ R PK++P + I +++ + ED L GY+A PTIK ++
Sbjct: 205 DAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIA 263
>pdb|1BO8|A Chain A, Thymidylate Synthase R178t Mutant
Length = 316
Score = 293 bits (751), Expect = 2e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P S R IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSTRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1BO7|A Chain A, Thymidylate Synthase R179t Mutant
Length = 316
Score = 293 bits (751), Expect = 2e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRTLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>ref|NP_299611.1| thymidylate synthase [Xylella fastidiosa 9a5c]
sp|Q9PB13|TYSY_XYLFA Thymidylate synthase (TS) (TSase)
pir||G82569 thymidylate synthase XF2332 [imported] - Xylella fastidiosa
(strain 9a5c)
gb|AAF85131.1| thymidylate synthase [Xylella fastidiosa 9a5c]
Length = 264
Score = 293 bits (751), Expect = 2e-78
Identities = 143/300 (47%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L+ ++ G K DRTGTGT S+FG QM FDLS+GFPL+TTKKL R I EL WF
Sbjct: 3 QYLELLNDVLVHGIQKPDRTGTGTRSVFGWQMRFDLSQGFPLVTTKKLHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++ L ++IW DE+ D + +
Sbjct: 63 LRGETNIAYLKKHQVHIW---------DEW------------------------ADATGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR WA + EIDQ+ ++++I NPDSRR ++SAWNV D+ MAL
Sbjct: 90 LGPVYGKQWRRWAGADGH------EIDQIRWLLEEIKRNPDSRRLVISAWNVADLPQMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH LFQFYV NG LSC+LYQRSAD+FLGVPFNIASYALLTH++A++ GL VG F+HT
Sbjct: 144 VPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLAVGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ Q+ER P+ P L + ++ D+T +DIV+ GYD +P IK ++
Sbjct: 204 GDAHLYANHVEQASVQLERVPRPQPVLMLNPAVTDLFDFTYDDIVIEGYDPYPAIKAPVA 263
>pdb|1JG0|A Chain A, Crystal Structure Of Escherichia Coli Thymidylate Synthase
Complexed With 2'-Deoxyuridine-5'-Monophosphate And N,O-
Didansyl-L-Tyrosine
pdb|1JG0|B Chain B, Crystal Structure Of Escherichia Coli Thymidylate Synthase
Complexed With 2'-Deoxyuridine-5'-Monophosphate And N,O-
Didansyl-L-Tyrosine
Length = 264
Score = 293 bits (751), Expect = 2e-78
Identities = 145/300 (48%), Positives = 188/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+D TGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDATGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGAHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1EV5|A Chain A, Crystal Structure Analysis Of Ala167 Mutant Of Escherichia
Coli
Length = 264
Score = 293 bits (751), Expect = 3e-78
Identities = 145/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRXHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQR+ DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRAXDVFLGLPFNIASYALLVHMMAQQXDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>pdb|1TSV| Thymidylate Synthase R179a Mutant
pdb|1TSW| Thymidylate Synthase R179a Mutant
Length = 316
Score = 293 bits (751), Expect = 3e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRALIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1TVU| Contributions Of Orientation And Hydrogen Bonding To Catalysis In
Asn-229 Mutants Of Thymidylate Synthase
pdb|1JMF| Contributions Of Orientation And Hydrogen Bonding To Catalysis In
Asn-229 Mutants Of Thymidylate Synthase
Length = 316
Score = 293 bits (751), Expect = 3e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPF IASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFAIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>ref|NP_840652.1| Thymidylate synthase [Nitrosomonas europaea ATCC 19718]
emb|CAD84479.1| Thymidylate synthase [Nitrosomonas europaea ATCC 19718]
Length = 264
Score = 293 bits (750), Expect = 3e-78
Identities = 146/300 (48%), Positives = 193/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ ++ G K DRTGTGTLS+FG QM FDL GFPL+TTKK + I EL WF
Sbjct: 3 QYLDLMRHVLQYGHKKSDRTGTGTLSVFGYQMRFDLQTGFPLVTTKKCHVKSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++ L ++IW DE+ D + D
Sbjct: 63 LRGETNIDYLKRNGVSIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGPIYG QWRSWA+ SD IDQ+ +VI+ I PDSRR IVSAWNVGD+D M L
Sbjct: 90 LGPIYGHQWRSWAA-SDGTV-----IDQISQVIQQIKETPDSRRMIVSAWNVGDLDKMKL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCHVLFQFYV +G LSC+LYQRSAD+FLGVPFNIASY+LLT +IA+ L+ G+F+HTF
Sbjct: 144 APCHVLFQFYVADGRLSCQLYQRSADIFLGVPFNIASYSLLTLMIAQCCDLQPGEFVHTF 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y+NH++ + Q+EREP+ +P +++ + NI D+ ED L YD +P IK ++
Sbjct: 204 GDAHLYLNHLEQARLQLEREPRALPAMQLNSTVRNIFDFGYEDFTLHDYDPYPPIKAPVA 263
>pdb|1HW4|A Chain A, Structure Of Thymidylate Synthase Suggests Advantages Of
Chemotherapy With Noncompetitive Inhibitors
Length = 355
Score = 293 bits (750), Expect = 3e-78
Identities = 152/308 (49%), Positives = 193/308 (62%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y ++ I+ G KDDRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 70 HGELQYLGQIQHILRXGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 129
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 130 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEG------------------ 171
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D S + +DQL RVI I TNPD RR I+ AWN
Sbjct: 172 -----DLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMXAWNP 226
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVN LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK
Sbjct: 227 RDLPLMALPPCHALXQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLK 286
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G FIHT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ ED + GY+ H
Sbjct: 287 PGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 346
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 347 PTIKMEMA 354
>pdb|1NJA| Thymidylate Synthase, Mutation, N229c With 2'-Deoxycytidine
5'-Monophosphate (Dcmp)
pdb|1NJB| Thymidylate Synthase
pdb|1TVV| Contributions Of Orientation And Hydrogen Bonding To Catalysis In
Asn-229 Mutants Of Thymidylate Synthase
Length = 316
Score = 293 bits (750), Expect = 3e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPF IASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFCIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1BP0|A Chain A, Thymidylate Synthase R23i Mutant
Length = 316
Score = 293 bits (749), Expect = 4e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K D T TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDITHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>pdb|1KZJ|A Chain A, Crystal Structure Of Ects W80gDUMPCB3717 COMPLEX
pdb|1KZJ|B Chain B, Crystal Structure Of Ects W80gDUMPCB3717 COMPLEX
pdb|1KZJ|C Chain C, Crystal Structure Of Ects W80gDUMPCB3717 COMPLEX
pdb|1KZJ|D Chain D, Crystal Structure Of Ects W80gDUMPCB3717 COMPLEX
pdb|1KZJ|E Chain E, Crystal Structure Of Ects W80gDUMPCB3717 COMPLEX
pdb|1KZJ|F Chain F, Crystal Structure Of Ects W80gDUMPCB3717 COMPLEX
Length = 264
Score = 293 bits (749), Expect = 4e-78
Identities = 145/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ I GD + D + D
Sbjct: 63 LQGDTNIAYLHENNVTI------------------------GDEWA---------DENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|ZP_00149890.1| COG0207: Thymidylate synthase [Dechloromonas aromatica RCB]
Length = 264
Score = 293 bits (749), Expect = 4e-78
Identities = 142/299 (47%), Positives = 189/299 (63%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++D G K DRTGTGT S+FG QM FDLS+GFP++TTKKL + I EL WFI
Sbjct: 4 YLDLMRHVLDNGNDKSDRTGTGTRSVFGWQMRFDLSQGFPVMTTKKLHLKSIIHELLWFI 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++K L + + IW DE+ D + DL
Sbjct: 64 QGDTNIKYLQENGVKIW---------DEW------------------------ADENGDL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YGKQWR W + + IDQ+ +++ + NPDSRRHIVSAWN GD+D MALP
Sbjct: 91 GPVYGKQWRRWET------PDGRVIDQITQLVNSLKNNPDSRRHIVSAWNPGDVDNMALP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV NG LSC+LYQRSAD+FLGVPFNIASYAL T ++A++ G + G+F+HTFG
Sbjct: 145 PCHCLFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALFTMMLAQVCGYQPGEFVHTFG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAH+Y NH + K Q+ R+ + +P + I +++ + ED L GYD HP I ++
Sbjct: 205 DAHLYSNHFEQAKLQLSRDTRPLPTMWINPEVKDLFAFRFEDFRLEGYDPHPHIPAPVA 263
>pdb|1JMH| Contributions Of Orientation And Hydrogen Bonding To Catalysis In
Asn-229 Mutants Of Thymidylate Synthase
Length = 316
Score = 293 bits (749), Expect = 4e-78
Identities = 156/321 (48%), Positives = 207/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SRR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPF IASYA
Sbjct: 175 PYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFIIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>ref|NP_461918.1| thymidylate synthetase [Salmonella typhimurium LT2]
sp|Q8ZMA9|TYSY_SALTY Thymidylate synthase (TS) (TSase)
gb|AAL21877.1| thymidylate synthetase [Salmonella typhimurium LT2]
Length = 264
Score = 292 bits (748), Expect = 6e-78
Identities = 142/300 (47%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L +GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ Q+ REP+ +P+L IK +++ DY +D + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVA 263
>ref|NP_386233.1| PROBABLE THYMIDYLATE SYNTHASE PROTEIN [Sinorhizobium meliloti 1021]
sp|Q92NQ5|TYSY_RHIME Thymidylate synthase (TS) (TSase)
emb|CAC46706.1| PROBABLE THYMIDYLATE SYNTHASE PROTEIN [Sinorhizobium meliloti]
Length = 264
Score = 292 bits (748), Expect = 6e-78
Identities = 143/300 (47%), Positives = 191/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ ++ GT + DRTGTGT S+FG QM FDLS+GFP+LTTKKL R I EL WF
Sbjct: 3 QYLDLLEHVITTGTDRGDRTGTGTRSVFGYQMRFDLSQGFPVLTTKKLHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L D ++IW DE+ D + +
Sbjct: 63 LRGDTNVAYLKDNGVSIW---------DEW------------------------ADENGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ +++ + TNP+SRRHIVSAWN +D MAL
Sbjct: 90 LGPVYGYQWRSW------PTPDGRHIDQIAALVEGLKTNPNSRRHIVSAWNPALVDEMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GL+ G F+HT
Sbjct: 144 PPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLEAGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAHIY NH + + Q+ R PK +P++EI ++I + ED L GY+A IK ++
Sbjct: 204 GDAHIYRNHFEQAQLQLTRTPKPLPKMEINPAVKDIFSFRFEDFELVGYEADSHIKAPVA 263
>ref|NP_457395.1| thymidylate synthetase [Salmonella enterica subsp. enterica serovar
Typhi str. CT18]
ref|NP_806604.1| thymidylate synthetase [Salmonella enterica subsp. enterica serovar
Typhi Ty2]
sp|Q8Z412|TYSY_SALTI Thymidylate synthase (TS) (TSase)
pir||AB0866 thymidylate synthetase [imported] - Salmonella enterica subsp.
enterica serovar Typhi (strain CT18)
emb|CAD02826.1| thymidylate synthetase [Salmonella enterica subsp. enterica serovar
Typhi]
gb|AAO70464.1| thymidylate synthetase [Salmonella enterica subsp. enterica serovar
Typhi Ty2]
Length = 264
Score = 292 bits (748), Expect = 7e-78
Identities = 142/300 (47%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L +GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELIQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLLEGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ Q+ REP+ +P+L IK +++ DY +D + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVA 263
>pdb|1TYS| Thymidylate Synthase (E.C.2.1.1.45) Mutant With Cys 146 Replaced By
Ser (C146s)
Length = 265
Score = 292 bits (748), Expect = 7e-78
Identities = 145/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 4 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 63
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 64 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 90
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 91 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 144
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
P H FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 145 APSHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 204
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 205 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 264
>sp|Q9RAM7|TYSY_METFL Thymidylate synthase (TS) (TSase)
gb|AAF21131.1| thymidylate synthase [Methylobacillus flagellatus]
Length = 264
Score = 292 bits (747), Expect = 7e-78
Identities = 142/299 (47%), Positives = 187/299 (62%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++++G K+DRTGTGTLS+FG QM FDLS+GFPLLTTKK+ I EL WF+
Sbjct: 4 YHDLMRHVLEQGHKKEDRTGTGTLSVFGYQMRFDLSEGFPLLTTKKVHLNAIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
G T++ L + + IW DE+ D +L
Sbjct: 64 QGSTNIAYLKENGVTIW---------DEW------------------------ADAEGNL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWR+W P IDQ+ VI I +NPDSRR IVSAWNV D+D M LP
Sbjct: 91 GPVYGYQWRNW------PKPDGGHIDQISEVIAAIKSNPDSRRLIVSAWNVADVDKMELP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ L++G F+HT G
Sbjct: 145 PCHALFQFYVAEGKLSCQLYQRSADIFLGVPFNIASYALLTMMVARVCDLELGDFVHTLG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAHIY+NH++ +K Q+ REP +P + I ++I + ED L Y +HP IK ++
Sbjct: 205 DAHIYLNHLEQVKEQLSREPYPLPVMRINPEVKDIFAFRFEDFTLENYQSHPAIKAPVA 263
>ref|NP_302064.1| thymidylate synthase [Mycobacterium leprae TN]
sp|Q9CBW0|TYSY_MYCLE Thymidylate synthase (TS) (TSase)
pir||A87099 thymidylate synthase [imported] - Mycobacterium leprae
emb|CAC30470.1| thymidylate synthase [Mycobacterium leprae]
Length = 266
Score = 292 bits (747), Expect = 8e-78
Identities = 147/303 (48%), Positives = 193/303 (63%), Gaps = 40/303 (13%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
+ T Y +L++ ++D G K DRTGTGT SLFG Q+ +DLS GFPL+TTKK+ F+ + EL
Sbjct: 3 IATPYEDLLRLVLDCGVAKMDRTGTGTRSLFGQQLRYDLSVGFPLVTTKKVHFKSVVYEL 62
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ GD+++ L + +NIW DE+ +
Sbjct: 63 LWFLRGDSNVAWLHEHGVNIW---------DEW------------------------ASS 89
Query: 134 SFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
+ DLGPIYG QWRSW P S IDQ+ + + T PDSRR IVSAWNVG+I
Sbjct: 90 TGDLGPIYGVQWRSW------PTSSGDYIDQISTALDLLRTEPDSRRIIVSAWNVGEIPQ 143
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH FQFYV G LSC+LYQRSAD+FLGVPFNIASYALLTH++A +GL VG+F+
Sbjct: 144 MALPPCHAFFQFYVAQGRLSCQLYQRSADMFLGVPFNIASYALLTHMMAAQSGLLVGEFV 203
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
T GD HIY NH++ ++ Q+ REP+ P+L + A ++I DY ED+V+T YD HP IK
Sbjct: 204 WTGGDCHIYDNHVEQVQLQLSREPRAYPELFL-AQRDSIFDYVYEDVVVTNYDPHPAIKA 262
Query: 314 KLS 316
++
Sbjct: 263 PVA 265
>ref|NP_641194.1| thymidylate synthase [Xanthomonas axonopodis pv. citri str. 306]
sp|Q8PP46|TYSY_XANAC Thymidylate synthase (TS) (TSase)
gb|AAM35730.1| thymidylate synthase [Xanthomonas axonopodis pv. citri str. 306]
Length = 264
Score = 291 bits (746), Expect = 9e-78
Identities = 143/299 (47%), Positives = 184/299 (61%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y L++ ++D G K DRTGTGT S+FG QM FDL+ GFPL+TTKKL R I EL WF+
Sbjct: 4 YLELLQHVLDHGAEKSDRTGTGTRSVFGWQMRFDLNDGFPLVTTKKLHLRSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++ L D + IW DE+ D + DL
Sbjct: 64 KGDTNIGYLSDHQVRIW---------DEW------------------------ADDNGDL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YGKQWR W EIDQ+ ++ +I NPDSRR ++SAWNVG++ MAL
Sbjct: 91 GPVYGKQWRRWTG------PDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALM 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYVVNG LSC+LYQRS D+FLGVPFNIASYALLTH++A+ GL VG F+HT G
Sbjct: 145 PCHSLFQFYVVNGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAH+Y NH + + Q+ R P+ +P L + ++ + EDI + GYD HP IK ++
Sbjct: 205 DAHLYSNHFEQAREQLTRTPRALPSLRLNPEVTDLFAFRFEDIAIEGYDPHPAIKAPVA 263
>ref|ZP_00041615.1| COG0207: Thymidylate synthase [Xylella fastidiosa Ann-1]
Length = 264
Score = 291 bits (746), Expect = 9e-78
Identities = 142/300 (47%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L+ ++ G K DRTGTGT S+FG QM FDLS+GFPL+TTKKL R I EL WF
Sbjct: 3 QYLELLNDVLVHGIQKPDRTGTGTRSVFGWQMRFDLSQGFPLVTTKKLHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++ L ++IW DE+ D + +
Sbjct: 63 LRGETNIAYLKKHQVHIW---------DEW------------------------ADATGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR WA + EIDQ+ ++++I NPDSRR ++SAWNV D+ MAL
Sbjct: 90 LGPVYGKQWRRWAGADGH------EIDQIRWLVEEIKRNPDSRRLVISAWNVADLPQMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH LFQFYV NG LSC+LYQRSAD+FLGVPFNIASYALLTH++A++ GL VG F+HT
Sbjct: 144 VPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLVVGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ Q+ R P+ P L + ++ D+T +DIV+ GYD +P IK ++
Sbjct: 204 GDAHLYANHVEQASVQLGRVPRPQPVLRLNQAVTDLFDFTYDDIVIEGYDPYPAIKAPVA 263
>ref|NP_779562.1| thymidylate synthase [Xylella fastidiosa Temecula1]
sp|Q87BT4|TYSY_XYLFT Thymidylate synthase (TS) (TSase)
gb|AAO29211.1| thymidylate synthase [Xylella fastidiosa Temecula1]
Length = 264
Score = 291 bits (745), Expect = 1e-77
Identities = 142/300 (47%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L+ ++ G K DRTGTGT S+FG QM FDLS+GFPL+TTKKL R I EL WF
Sbjct: 3 QYLELLNDVLVHGIKKPDRTGTGTRSVFGWQMRFDLSQGFPLVTTKKLHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++ L ++IW DE+ D + +
Sbjct: 63 LRGETNIAYLKKHQVHIW---------DEW------------------------ADATGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR WA + EIDQ+ ++++I NPDSRR ++SAWNV D+ MAL
Sbjct: 90 LGPVYGKQWRRWAGADGH------EIDQIRWLVEEIKRNPDSRRLVISAWNVADLPQMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH LFQFYV NG LSC+LYQRSAD+FLGVPFNIASYALLTH++A++ GL VG F+HT
Sbjct: 144 VPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLVVGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ Q+ R P+ P L + ++ D+T +DIV+ GYD +P IK ++
Sbjct: 204 GDAHLYANHVEQASVQLGRVPRPQPVLRLNQAVTDLFDFTYDDIVIEGYDPYPAIKAPVA 263
>ref|ZP_00273289.1| COG0207: Thymidylate synthase [Ralstonia metallidurans CH34]
Length = 264
Score = 291 bits (745), Expect = 1e-77
Identities = 144/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y + ++ + + GT K DRTGTGT S+FG QM FDL++GFP++TTKKL + I EL WF
Sbjct: 3 QYLDFMRHVYEHGTEKSDRTGTGTRSVFGYQMRFDLNEGFPVVTTKKLHLKSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G T++K L D + IW DE+ D + +
Sbjct: 63 LQGSTNIKYLKDNGVTIW---------DEW------------------------ADANGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGPIYG QWR+W P + IDQ+ V++ I NPDSRR IVSAWNVG+I M L
Sbjct: 90 LGPIYGYQWRAW------PTPDGRHIDQITEVVQQIRDNPDSRRLIVSAWNVGEIPQMKL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH FQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH+IA+ L VG F+ T
Sbjct: 144 PPCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQQCDLGVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NH + +++Q+ REP ++P L IK ++I DY +D L GY++HP IK ++
Sbjct: 204 GDCHIYSNHFEQVETQLSREPMKLPTLRIKHRPDSIFDYKYDDFELVGYESHPAIKAPVA 263
>pdb|1F4D|A Chain A, Crystal Structure Of E. Coli Thymidylate Synthase C146s,
L143c Covalently Modified At C143 With N-[tosyl-D-
Prolinyl]amino-Ethanethiol
pdb|1F4D|B Chain B, Crystal Structure Of E. Coli Thymidylate Synthase C146s,
L143c Covalently Modified At C143 With N-[tosyl-D-
Prolinyl]amino-Ethanethiol
Length = 264
Score = 291 bits (744), Expect = 2e-77
Identities = 144/300 (48%), Positives = 188/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MA
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAC 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
P H FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APSHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|NP_001062.1| thymidylate synthetase; Thymidylate synthase [Homo sapiens]
sp|P04818|TYSY_HUMAN Thymidylate synthase (TS) (TSase) (OK/SW-cl.29)
pir||YXHUT thymidylate synthase (EC 2.1.1.45) - human
emb|CAA26178.1| unnamed protein product [Homo sapiens]
dbj|BAA00472.1| thymidylate synthase [Homo sapiens]
gb|AAH02567.1| Thymidylate synthetase [Homo sapiens]
gb|AAH13919.1| Thymidylate synthetase [Homo sapiens]
dbj|BAB93473.1| thymidylate synthetase [Homo sapiens]
gb|AAP35457.1| thymidylate synthetase [Homo sapiens]
Length = 313
Score = 291 bits (744), Expect = 2e-77
Identities = 152/308 (49%), Positives = 193/308 (62%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y ++ I+ G KDDRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEG------------------ 129
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D S + +DQL RVI I TNPD RR I+ AWN
Sbjct: 130 -----DLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNP 184
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVN LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK
Sbjct: 185 RDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLK 244
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G FIHT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ ED + GY+ H
Sbjct: 245 PGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 304
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 305 PTIKMEMA 312
>gb|AAP36499.1| Homo sapiens thymidylate synthetase [synthetic construct]
Length = 314
Score = 291 bits (744), Expect = 2e-77
Identities = 152/308 (49%), Positives = 193/308 (62%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y ++ I+ G KDDRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEG------------------ 129
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D S + +DQL RVI I TNPD RR I+ AWN
Sbjct: 130 -----DLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNP 184
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVN LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK
Sbjct: 185 RDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLK 244
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G FIHT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ ED + GY+ H
Sbjct: 245 PGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 304
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 305 PTIKMEMA 312
>pdb|1BPJ|A Chain A, Thymidylate Synthase R178t, R179t Double Mutant
Length = 316
Score = 291 bits (744), Expect = 2e-77
Identities = 155/321 (48%), Positives = 206/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K DRT TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P S IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSTTLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>ref|ZP_00173943.2| COG0207: Thymidylate synthase [Methylobacillus flagellatus KT]
Length = 264
Score = 291 bits (744), Expect = 2e-77
Identities = 142/299 (47%), Positives = 187/299 (62%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++++G K+DRTGTGTLS+FG QM FDLS+GFPLLTTKK+ + I EL WF+
Sbjct: 4 YHDLMRHVLEQGHKKEDRTGTGTLSVFGYQMRFDLSEGFPLLTTKKVHLKSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
G T++ L + + IW DE+ D +L
Sbjct: 64 QGSTNIAYLKENGVTIW---------DEW------------------------ADAEGNL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWR+W P IDQ+ VI I NPDSRR IVSAWNV D+D M LP
Sbjct: 91 GPVYGYQWRNW------PKPDGGHIDQISEVIAAIKRNPDSRRLIVSAWNVADVDKMKLP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH FQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ LK+G F+HT G
Sbjct: 145 PCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVCDLKLGDFVHTLG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAHIY+NH++ +K Q+ REP +P + I ++I + ED L Y +HP IK ++
Sbjct: 205 DAHIYLNHLEQVKEQLSREPYPLPVMRINPEVKDIFAFRFEDFTLENYQSHPAIKAPVA 263
>ref|NP_939189.1| thymidylate synthase [Corynebacterium diphtheriae NCTC 13129]
emb|CAE49341.1| thymidylate synthase [Corynebacterium diphtheriae]
Length = 270
Score = 290 bits (743), Expect = 2e-77
Identities = 141/303 (46%), Positives = 198/303 (65%), Gaps = 40/303 (13%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
+ T Y +L++ I+++G+ KDDRTGTGT SLFG QM FDL++ FPL+TTKK+ ++ + EL
Sbjct: 7 IKTPYEDLLRTILEQGSHKDDRTGTGTTSLFGQQMRFDLTEAFPLITTKKVYWKGVIGEL 66
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G ++++ L +NI+IW + W E
Sbjct: 67 LWFLQGSSNVRWLQKRNIHIWDE-------------WASEEG------------------ 95
Query: 134 SFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
+LGP+YG QWRSW P + +DQ+ + + + NPDSRR+IVSAWNV D++
Sbjct: 96 --ELGPVYGVQWRSW------PTPDGQHVDQIAQALDILKNNPDSRRNIVSAWNVADLNN 147
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH+LFQ YV +G LSC+LYQRSAD+FLGVPFNIASY+ LTH++A+ AGLKVG+FI
Sbjct: 148 MALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYSALTHMLAQQAGLKVGEFI 207
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
T GD HIY NH + + +Q+ REP+ PQL ++ +I DY +D + GYD HP I+G
Sbjct: 208 WTGGDCHIYDNHREQVLTQLSREPRPYPQLTLRKA-SSIFDYDFDDFTIEGYDPHPAIRG 266
Query: 314 KLS 316
+++
Sbjct: 267 EVA 269
>pdb|1QQQ|A Chain A, Crystal Structure Analysis Of Ser254 Mutant Of Escherichia
Coli Thymidylate Synthase
Length = 264
Score = 290 bits (743), Expect = 2e-77
Identities = 145/300 (48%), Positives = 190/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRXHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
P H FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APXHAFFQFYVADGKLSCQLYQRSXDVFLGLPFNIASYALLVHMMAQQXDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD+HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDSHPGIKAPVA 263
>pdb|1JU6|A Chain A, Human Thymidylate Synthase Complex With Dump And Ly231514,
A Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JU6|B Chain B, Human Thymidylate Synthase Complex With Dump And Ly231514,
A Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JU6|C Chain C, Human Thymidylate Synthase Complex With Dump And Ly231514,
A Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JU6|D Chain D, Human Thymidylate Synthase Complex With Dump And Ly231514,
A Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JUJ|A Chain A, Human Thymidylate Synthase Bound To Dump And Ly231514, A
Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JUJ|B Chain B, Human Thymidylate Synthase Bound To Dump And Ly231514, A
Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JUJ|C Chain C, Human Thymidylate Synthase Bound To Dump And Ly231514, A
Pyrrolo(2,3-D)pyrimidine-Based Antifolate
pdb|1JUJ|D Chain D, Human Thymidylate Synthase Bound To Dump And Ly231514, A
Pyrrolo(2,3-D)pyrimidine-Based Antifolate
Length = 313
Score = 290 bits (743), Expect = 2e-77
Identities = 152/308 (49%), Positives = 193/308 (62%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y ++ I+ G KDDRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 28 HGELQYLGQIQHILRCGVEKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEG------------------ 129
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D S + +DQL RVI I TNPD RR I+ AWN
Sbjct: 130 -----DLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNP 184
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVN LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK
Sbjct: 185 RDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLK 244
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G FIHT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ ED + GY+ H
Sbjct: 245 PGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 304
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 305 PTIKMEMA 312
>ref|ZP_00039273.1| COG0207: Thymidylate synthase [Xylella fastidiosa Dixon]
Length = 264
Score = 290 bits (742), Expect = 3e-77
Identities = 141/300 (47%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L+ ++ G K DRTGTGT S+FG QM FDLS+GFPL+TTKKL R I EL WF
Sbjct: 3 QYLELLNDVLVHGIQKPDRTGTGTRSVFGWQMRFDLSQGFPLVTTKKLHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++ L ++IW DE+ D + +
Sbjct: 63 LRGETNIAYLKKHQVHIW---------DEW------------------------ADATGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR WA + EIDQ+ ++++I NPDSRR ++SAWNV D+ MAL
Sbjct: 90 LGPVYGKQWRRWAGADGH------EIDQIRWLVEEIKRNPDSRRLVISAWNVADLPQMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH LFQFYV NG LSC+LYQRSAD+FLG+PFNIASYALLTH++A++ GL VG F+HT
Sbjct: 144 VPCHALFQFYVANGKLSCQLYQRSADIFLGLPFNIASYALLTHMLAQVTGLVVGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ Q+ R P+ P L + ++ D+T +DIV+ GYD +P IK ++
Sbjct: 204 GDAHLYANHVEQASVQLGRVPRPQPVLRLNQAVTDLFDFTYDDIVIEGYDPYPAIKAPVA 263
>pdb|1BP6|A Chain A, Thymidylate Synthase R23i, R179t Double Mutant
Length = 316
Score = 290 bits (742), Expect = 3e-77
Identities = 155/321 (48%), Positives = 206/321 (64%), Gaps = 25/321 (7%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
++ Y +L KK++DEG K D T TGT S+FG QM FDLSKGFPLLTTKK+PF +I EL
Sbjct: 2 LEQPYLDLAKKVLDEGHFKPDITHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSEL 61
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA---- 129
WF++GDT+++ LL +IW + A+ ++ E + EF +
Sbjct: 62 LWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEE 121
Query: 130 -AK-------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE-IDQLFRVIKDINTN 175
AK D +F DLG +YG QWR+W + SK + IDQL VI+ I T+
Sbjct: 122 MAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAW-------HTSKGDTIDQLGDVIEQIKTH 174
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
P SR IVSAWN D+ MALPPCH L+QFYV +G LS +LYQRSAD+FLGVPFNIASYA
Sbjct: 175 PYSRTLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYA 234
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH++A GL+VG+FIHTFGDAH+Y+NH+D +K Q+ R P+ P L++ +I D+
Sbjct: 235 LLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDF 294
Query: 296 TLEDIVLTGYDAHPTIKGKLS 316
++DI L YD +P IK ++
Sbjct: 295 DMKDIKLLNYDPYPAIKAPVA 315
>ref|NP_900697.1| thymidylate synthase [Chromobacterium violaceum ATCC 12472]
gb|AAQ58702.1| thymidylate synthase [Chromobacterium violaceum ATCC 12472]
Length = 264
Score = 290 bits (742), Expect = 3e-77
Identities = 139/300 (46%), Positives = 193/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ +++ G K DRTGTGT S+FG QM FDL+ GFPL+TTKK R I EL WF
Sbjct: 3 QYLDLMRHVLEHGHDKADRTGTGTRSVFGYQMRFDLAAGFPLVTTKKCHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
++GDT+++ L + ++IW DE+ D + D
Sbjct: 63 LSGDTNIRYLKENGVSIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ +++ I NPDSRR IVSAWN +D MAL
Sbjct: 90 LGPVYGYQWRSW------PAPDGRHIDQISQLLDMIKKNPDSRRLIVSAWNPALVDQMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV NG LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GL+ G F+HT
Sbjct: 144 PPCHSLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVCGLQPGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH++ + Q+ R+P+ +P +++ +++ +T +D L GYD HP IK +++
Sbjct: 204 GDAHLYSNHLEQARLQLTRDPRPLPTMKLNPEVKDLFAFTFDDFALEGYDPHPHIKAQVA 263
>ref|NP_062052.1| thymidylate synthase [Rattus norvegicus]
sp|P45352|TYSY_RAT Thymidylate synthase (TS) (TSase)
pir||S53715 thymidylate synthase (EC 2.1.1.45) - rat
pdb|1RTS|A Chain A, Thymidylate Synthase From Rat In Ternary Complex With Dump
And Tomudex
pdb|1RTS|B Chain B, Thymidylate Synthase From Rat In Ternary Complex With Dump
And Tomudex
pdb|2TSR|A Chain A, Thymidylate Synthase From Rat In Ternary Complex With Dump
And Tomudex
pdb|2TSR|B Chain B, Thymidylate Synthase From Rat In Ternary Complex With Dump
And Tomudex
pdb|2TSR|C Chain C, Thymidylate Synthase From Rat In Ternary Complex With Dump
And Tomudex
pdb|2TSR|D Chain D, Thymidylate Synthase From Rat In Ternary Complex With Dump
And Tomudex
gb|AAA92340.1| thymidylate synthase [Rattus norvegicus]
prf||2109225A thymidylate synthase
Length = 307
Score = 290 bits (742), Expect = 3e-77
Identities = 151/308 (49%), Positives = 196/308 (63%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y V+ IM G K+DRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 22 HGELQYLRQVEHIMRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 81
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 82 LLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEG------------------ 123
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D + S + +DQL +VI I TNPD RR I+ AWN
Sbjct: 124 -----DLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNP 178
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVNG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GL+
Sbjct: 179 KDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQ 238
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G F+HT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ +ED + GY+ H
Sbjct: 239 PGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVETIDDFKVEDFQIEGYNPH 298
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 299 PTIKMEMA 306
>pdb|1HVY|A Chain A, Human Thymidylate Synthase Complexed With Dump And
Raltitrexed, An Antifolate Drug, Is In The Closed
Conformation
pdb|1HVY|B Chain B, Human Thymidylate Synthase Complexed With Dump And
Raltitrexed, An Antifolate Drug, Is In The Closed
Conformation
pdb|1HVY|C Chain C, Human Thymidylate Synthase Complexed With Dump And
Raltitrexed, An Antifolate Drug, Is In The Closed
Conformation
pdb|1HVY|D Chain D, Human Thymidylate Synthase Complexed With Dump And
Raltitrexed, An Antifolate Drug, Is In The Closed
Conformation
Length = 288
Score = 290 bits (742), Expect = 3e-77
Identities = 152/308 (49%), Positives = 193/308 (62%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y ++ I+ G KDDRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 3 HGELQYLGQIQHILRXGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 62
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 63 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEG------------------ 104
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D S + +DQL RVI I TNPD RR I+ AWN
Sbjct: 105 -----DLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNP 159
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVN LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK
Sbjct: 160 RDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLK 219
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G FIHT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ ED + GY+ H
Sbjct: 220 PGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 279
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 280 PTIKMEMA 287
>ref|NP_810960.1| thymidylate synthase [Bacteroides thetaiotaomicron VPI-5482]
gb|AAO77154.1| thymidylate synthase [Bacteroides thetaiotaomicron VPI-5482]
Length = 264
Score = 290 bits (741), Expect = 4e-77
Identities = 145/297 (48%), Positives = 187/297 (62%), Gaps = 39/297 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+ +++ EGT K DRTGTGT+S+FG QM F+L +GFP LTTKKL + I EL WF
Sbjct: 3 QYLDLLNRVLTEGTEKSDRTGTGTISVFGHQMRFNLDEGFPCLTTKKLHLKSIIYELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+ K L + + IW + A D + D
Sbjct: 63 LQGDTNAKYLQEHGVRIWNEWA---------------------------------DENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LG IYG QWRSW + D + IDQ+ ++ I NPDSRR IVSAWNV D+ M L
Sbjct: 90 LGHIYGYQWRSWPDY-DGGF-----IDQISEAVETIKHNPDSRRIIVSAWNVADLKNMNL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH FQFYV +G LS +LYQRSAD+FLGVPFNIASYALL ++A++ GLK G+FIHT
Sbjct: 144 PPCHAFFQFYVADGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLKAGEFIHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
GDAHIY+NH+D +K Q+ REP+ +PQ++I ++I D+ ED L YD HP I G
Sbjct: 204 GDAHIYLNHLDQVKLQLSREPRALPQMKINPDVKSIYDFQFEDFELVNYDPHPHIAG 260
>ref|NP_716955.1| thymidylate synthase [Shewanella oneidensis MR-1]
sp|Q8EH94|TYSY_SHEON Thymidylate synthase (TS) (TSase)
gb|AAN54400.1| thymidylate synthase [Shewanella oneidensis MR-1]
Length = 264
Score = 289 bits (740), Expect = 5e-77
Identities = 145/300 (48%), Positives = 186/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+K I+ EG K DRTGTGT S+FG QM FDLSKGFPL+TTKK R I EL WF
Sbjct: 3 QYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L D ++IW DE+ D + D
Sbjct: 63 LKGDTNIAYLRDNKVSIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P +S + IDQ+ +VI I + PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGAQWRSW------PTQSGEAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALLT ++A+ L +G F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ Q+ REP+ +P + I +I DY +D L+ YD HP IK ++
Sbjct: 204 GDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFDDFALSNYDPHPHIKAPVA 263
>ref|NP_067263.1| thymidylate synthase [Mus musculus]
sp|P07607|TYSY_MOUSE Thymidylate synthase (TS) (TSase)
pir||YXMST thymidylate synthase (EC 2.1.1.45) - mouse
gb|AAA40439.1| thymidylate synthase (EC 2.1.1.45)
gb|AAA40444.1| thymidylate synthase
dbj|BAC29144.1| unnamed protein product [Mus musculus]
Length = 307
Score = 289 bits (739), Expect = 6e-77
Identities = 150/308 (48%), Positives = 197/308 (63%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y V+ I+ G K+DRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 22 HGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 81
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 82 LLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEG------------------ 123
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D + S + +DQL +VI I TNPD RR I+ AWN
Sbjct: 124 -----DLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNP 178
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVNG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GL+
Sbjct: 179 KDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQ 238
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G F+HT GDAHIY+NHI+ LK Q++REP+ P+L+I E I+D+ +ED + GY+ H
Sbjct: 239 PGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPH 298
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 299 PTIKMEMA 306
>gb|AAH20139.1| Tyms protein [Mus musculus]
Length = 307
Score = 289 bits (739), Expect = 6e-77
Identities = 150/308 (48%), Positives = 197/308 (63%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y V+ I+ G K+DRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 22 HGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 81
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 82 LLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEG------------------ 123
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D + S + +DQL +VI I TNPD RR I+ AWN
Sbjct: 124 -----DLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNP 178
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVNG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GL+
Sbjct: 179 KDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQ 238
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G F+HT GDAHIY+NHI+ LK Q++REP+ P+L+I E I+D+ +ED + GY+ H
Sbjct: 239 PGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPH 298
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 299 PTIKMEMA 306
>ref|NP_820530.1| thymidylate synthase [Coxiella burnetii RSA 493]
gb|AAO91044.1| thymidylate synthase [Coxiella burnetii RSA 493]
Length = 264
Score = 289 bits (739), Expect = 6e-77
Identities = 143/300 (47%), Positives = 186/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
EY N ++ I+D G K DRTG GT S+FG +M F+L +GFPL+TTKK+ + + EL WF
Sbjct: 3 EYLNFLQFILDHGVAKTDRTGIGTKSVFGYEMRFNLREGFPLVTTKKIHLKSVIYELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L D + IW DE+ D + D
Sbjct: 63 LRGDTNIQFLNDNGVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGPIYGKQWR W + +DQ+ R+I++I TNPDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPIYGKQWRRWHC------PDGRTVDQMQRLIREIKTNPDSRRLIVSAWNVGELDQMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH+LFQFYV +G LSCKL QRSAD FLGVPFNIASY+LLTH+IA+ LK G+FI +
Sbjct: 144 PPCHLLFQFYVADGFLSCKLTQRSADAFLGVPFNIASYSLLTHLIARQCNLKAGEFIWSG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY H D + +Q+ REP+ +PQL I ++ DY D + Y HP IK ++
Sbjct: 204 GDCHIYNTHQDQVSTQLSREPRALPQLIINRDPSSLYDYNFNDFSIVNYHPHPAIKAPVA 263
>pdb|1EVF|A Chain A, Crystal Structure Analysis Of Cys167 Mutant Of Escherichia
Coli
Length = 264
Score = 289 bits (739), Expect = 7e-77
Identities = 144/300 (48%), Positives = 189/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRXHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
P H FQFYV +G LSC+LYQR+ DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APXHAFFQFYVADGKLSCQLYQRTXDVFLGLPFNIASYALLVHMMAQQXDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|NP_195183.2| bifunctional dihydrofolate reductase-thymidylate synthase 2 /
DHFR-TS (THY-2) [Arabidopsis thaliana]
Length = 565
Score = 289 bits (739), Expect = 7e-77
Identities = 150/306 (49%), Positives = 195/306 (63%), Gaps = 23/306 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + Y NLVK+I+ G LKDDRTGTGTLS FG QM+F+L + FPLLTTK++ +R + EE
Sbjct: 280 HEEYLYLNLVKEIISNGNLKDDRTGTGTLSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEE 339
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K I IW +A R YLD G L+++E
Sbjct: 340 LLWFISGSTNAKVLQEKGIRIWDGNASRAYLD-------------GIGLTERE------- 379
Query: 133 TSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + A ++D + + + DQL VI I NPD RR I+SAWN D
Sbjct: 380 -EGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVINKIKNNPDDRRIIMSAWNPSD 438
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV NG LSC++YQRSAD+ LGVPFNIASY+LLT I+A + L G
Sbjct: 439 LKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIASYSLLTCILAHVCDLVPG 498
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
FIH GDAH+Y NH+ L+ Q+E PK P L+I ++I+ + +D L GYD H
Sbjct: 499 DFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKINPEKKDIDSFVADDFELIGYDPHKK 558
Query: 311 IKGKLS 316
I K++
Sbjct: 559 IDMKMA 564
>pdb|1HZW|A Chain A, Crystal Structure Of Human Thymidylate Synthase
pdb|1HZW|B Chain B, Crystal Structure Of Human Thymidylate Synthase
pdb|1I00|A Chain A, Crystal Structure Of Human Thymidylate Synthase, Ternary
Complex With Dump And Tomudex
pdb|1I00|B Chain B, Crystal Structure Of Human Thymidylate Synthase, Ternary
Complex With Dump And Tomudex
Length = 290
Score = 288 bits (738), Expect = 8e-77
Identities = 151/306 (49%), Positives = 192/306 (62%), Gaps = 27/306 (8%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELF 74
+ +Y ++ I+ G KDDRTGTGTLS+FG Q + L FPLLTTK++ ++ + EEL
Sbjct: 7 ELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELL 66
Query: 75 WFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAAKD 132
WFI G T+ K L K + IW + R +LD F EG
Sbjct: 67 WFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEG-------------------- 106
Query: 133 TSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + A + D S + +DQL RVI I TNPD RR I+ AWN D
Sbjct: 107 ---DLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRD 163
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH L QFYVVN LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK G
Sbjct: 164 LPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPG 223
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
FIHT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ ED + GY+ HPT
Sbjct: 224 DFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPT 283
Query: 311 IKGKLS 316
IK +++
Sbjct: 284 IKMEMA 289
>pdb|1EV8|A Chain A, Crystal Structure Analysis Of Cys167 Mutant Of Escherichia
Coli
Length = 264
Score = 288 bits (738), Expect = 8e-77
Identities = 144/300 (48%), Positives = 188/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L++K++DEGT K+DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRXHLRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + N+ IW DE+ D + D
Sbjct: 63 LQGDTNIAYLHENNVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W P + IDQ+ V+ + +PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAW------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
P H FQFYV +G LSC+LYQR DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APXHAFFQFYVADGKLSCQLYQRCXDVFLGLPFNIASYALLVHMMAQQXDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH+D Q+ REP+ +P+L IK E+I DY ED + GYD HP IK ++
Sbjct: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263
>ref|NP_240252.1| thymidylate synthase [Buchnera aphidicola str. APS (Acyrthosiphon
pisum)]
sp|P57515|TYSY_BUCAI Thymidylate synthase (TS) (TSase)
pir||B84981 thymidylate synthase (EC 2.1.1.45) [imported] - Buchnera sp.
(strain APS)
dbj|BAB13138.1| thymidylate synthase [Buchnera aphidicola str. APS (Acyrthosiphon
pisum)]
Length = 264
Score = 288 bits (738), Expect = 8e-77
Identities = 147/300 (49%), Positives = 188/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y L+KKI+ G K DRTGTGTLS+FG M+FDL KGFPLLTTKK I EL WF
Sbjct: 3 QYIKLIKKIIRVGNQKKDRTGTGTLSIFGYNMKFDLKKGFPLLTTKKCHIASIIYELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + I+IW + A + S D
Sbjct: 63 LKGDTNISYLNENKISIWNNWA---------------------------------NESGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
+GPIYGKQWR+W++ EIDQ+ V+ + NPDSRR +VS+WNVGDID M L
Sbjct: 90 VGPIYGKQWRNWST------PEGHEIDQIKNVLIQLKKNPDSRRMLVSSWNVGDIDKMRL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCHVLFQFYV N TLSC+LYQRS DVFLG+PFNIASY++L H+IA+ LKVG F+ T
Sbjct: 144 PPCHVLFQFYVFNNTLSCQLYQRSCDVFLGLPFNIASYSILIHMIAQQCDLKVGDFLWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NHI+L K Q+ R P+ +P+L I +++ Y ED + GY +P IKG++S
Sbjct: 204 GDVHLYNNHIELAKKQILRIPRTLPKLTILKKPQSLFQYCFEDFKIIGYHPYPAIKGEIS 263
>ref|NP_927968.1| Thymidylate synthase (TS) (TSase) [Photorhabdus luminescens subsp.
laumondii TTO1]
emb|CAE12918.1| Thymidylate synthase (TS) (TSase) [Photorhabdus luminescens subsp.
laumondii TTO1]
Length = 264
Score = 288 bits (738), Expect = 9e-77
Identities = 141/300 (47%), Positives = 191/300 (63%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+ +++ EGT K DRTGTGTLS+FG QM F+L GFPL+TTK+ R I EL WF
Sbjct: 3 QYLDLMTRVLAEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHIRSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+NGDT++K L + + IW DE+ D + D
Sbjct: 63 LNGDTNIKYLHENGVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR+W + ++IDQL V++ + ++PDSRR IVSAWNVG++D MAL
Sbjct: 90 LGPVYGKQWRAWGT------ADGRQIDQLKTVLEQLKSDPDSRRIIVSAWNVGELDKMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH FQFYV +G LSC+LYQRS DVFLG+PFNIASYALL H++A+ L+VG F+ T
Sbjct: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ K Q+ REP+ +P+L IK ++ DY +D + YD HP IK ++
Sbjct: 204 GDTHLYSNHMEQTKLQLSREPRSLPKLVIKRKPASLFDYKFDDFEIVDYDPHPGIKAPVA 263
>sp|Q05763|DRT2_ARATH Bifunctional dihydrofolate reductase-thymidylate synthase 2
(DHFR-TS) [Includes: Dihydrofolate reductase ;
Thymidylate synthase ]
pir||T05277 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - Arabidopsis thaliana
gb|AAA32789.1| dihydrofolate reductase-thymidylate synthase
emb|CAA18836.1| dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana]
emb|CAB80174.1| dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana]
gb|AAO24591.1| At4g34570 [Arabidopsis thaliana]
Length = 518
Score = 288 bits (737), Expect = 1e-76
Identities = 150/306 (49%), Positives = 195/306 (63%), Gaps = 23/306 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + Y NLVK+I+ G LKDDRTGTGTLS FG QM+F+L + FPLLTTK++ +R + EE
Sbjct: 233 HEEYLYLNLVKEIISNGNLKDDRTGTGTLSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEE 292
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K I IW +A R YLD G L+++E
Sbjct: 293 LLWFISGSTNAKVLQEKGIRIWDGNASRAYLD-------------GIGLTERE------- 332
Query: 133 TSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + A ++D + + + DQL VI I NPD RR I+SAWN D
Sbjct: 333 -EGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVINKIKNNPDDRRIIMSAWNPSD 391
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV NG LSC++YQRSAD+ LGVPFNIASY+LLT I+A + L G
Sbjct: 392 LKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIASYSLLTCILAHVCDLVPG 451
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
FIH GDAH+Y NH+ L+ Q+E PK P L+I ++I+ + +D L GYD H
Sbjct: 452 DFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKINPEKKDIDSFVADDFELIGYDPHKK 511
Query: 311 IKGKLS 316
I K++
Sbjct: 512 IDMKMA 517
>ref|NP_636178.1| thymidylate synthase [Xanthomonas campestris pv. campestris str.
ATCC 33913]
sp|Q8PCE7|TYSY_XANCP Thymidylate synthase (TS) (TSase)
gb|AAM40102.1| thymidylate synthase [Xanthomonas campestris pv. campestris str.
ATCC 33913]
Length = 264
Score = 288 bits (737), Expect = 1e-76
Identities = 141/299 (47%), Positives = 184/299 (61%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y L++ +++ G K DRTGTGT S+FG QM FDL+ GFPL+TTKKL R I EL WF+
Sbjct: 4 YLELLQHVLEYGAEKSDRTGTGTRSVFGWQMRFDLNAGFPLVTTKKLHLRSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++ L D + IW DE+ D + DL
Sbjct: 64 QGDTNIAYLKDNQVRIW---------DEW------------------------ADANGDL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YGKQWR W EIDQ+ ++ +I NPDSRR ++SAWNVG++ MAL
Sbjct: 91 GPVYGKQWRRWTG------PDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALM 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYVV+G LSC+LYQRS D+FLGVPFNIASYALLTH++A+ GL VG F+HT G
Sbjct: 145 PCHSLFQFYVVDGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
DAH+Y NH + + Q+ R P+ +P L + ++ + EDI + GYD HP IK ++
Sbjct: 205 DAHLYSNHFEQAREQLTRTPRPLPTLRLNPDVTDLFAFRFEDIAIDGYDPHPAIKAPVA 263
>ref|NP_519068.1| PROBABLE THYMIDYLATE SYNTHASE (TRANSLATION REGULATION REPRESSOR
RNA-BINDING) PROTEIN [Ralstonia solanacearum GMI1000]
sp|Q8Y0U6|TYSY_RALSO Thymidylate synthase (TS) (TSase)
emb|CAD14649.1| PROBABLE THYMIDYLATE SYNTHASE (TRANSLATION REGULATION REPRESSOR
RNA-BINDING) PROTEIN [Ralstonia solanacearum]
Length = 264
Score = 287 bits (735), Expect = 2e-76
Identities = 144/299 (48%), Positives = 186/299 (62%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ + + GT K DRTGTGT S+FG QM FDL +GFPL+TTKK+ + I EL WF+
Sbjct: 4 YLDLMRHVHEHGTDKADRTGTGTRSVFGHQMRFDLQQGFPLVTTKKVHIKSIVYELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
G T+++ L + + IW DE+ D +L
Sbjct: 64 QGATNVRWLRENGVTIW---------DEW------------------------ADAEGEL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GPIYG QWRSW P S + IDQ+ +I I NPDSRR IVSAWNV DI M LP
Sbjct: 91 GPIYGYQWRSW------PTPSGEHIDQIAELIAQIKRNPDSRRLIVSAWNVADIPRMKLP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH FQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH+IA+ GL VG F+ T G
Sbjct: 145 PCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQQTGLDVGDFVWTGG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
D H+Y NH + +++Q+ R P +P+L IK ++I DY ED + GY++HP IK ++
Sbjct: 205 DCHLYNNHFEQVETQLARTPLPLPKLHIKRKPDSIFDYRYEDFEIVGYESHPAIKAPVA 263
>ref|ZP_00171069.1| COG0207: Thymidylate synthase [Ralstonia eutropha JMP134]
Length = 264
Score = 287 bits (734), Expect = 2e-76
Identities = 142/300 (47%), Positives = 187/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y + ++ + + GT K DRTGTGT S+FG QM FDLS+GFP++TTKKL + I EL WF
Sbjct: 3 QYLDFMRHVFEHGTEKADRTGTGTRSVFGYQMRFDLSQGFPVVTTKKLHLKSIILELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G T+++ L + ++IW DE+ D + +
Sbjct: 63 LQGSTNVRWLQENGVSIW---------DEW------------------------ADENGE 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + +DQ+ ++ I NPDSRR IVSAWNV DI M L
Sbjct: 90 LGPVYGSQWRSW------PTPDGRHVDQITDLLNQIRENPDSRRLIVSAWNVADIPRMKL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH FQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLTH+IA+ GL VG F+ T
Sbjct: 144 PPCHAFFQFYVADGRLSCQLYQRSADIFLGVPFNIASYALLTHMIAQQTGLDVGDFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD HIY NH + +++Q+ REP +P L+I ++I DY ED L GY +HP IK ++
Sbjct: 204 GDCHIYSNHYEQVQTQLSREPLPLPTLKIVRKPDSIFDYRYEDFELVGYQSHPAIKAPVA 263
>ref|NP_326369.1| THYMIDYLATE SYNTHASE (TS) (TSASE) [Mycoplasma pulmonis UAB CTIP]
sp|Q98Q31|TYSY_MYCPU Thymidylate synthase (TS) (TSase)
pir||B90579 thymidylate synthase (ts) (tsase) [imported] - Mycoplasma pulmonis
(strain UAB CTIP)
emb|CAC13711.1| THYMIDYLATE SYNTHASE (TS) (TSASE) [Mycoplasma pulmonis]
Length = 286
Score = 287 bits (734), Expect = 3e-76
Identities = 147/300 (49%), Positives = 196/300 (65%), Gaps = 17/300 (5%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y + +K ++++G K++RT T+S FG QM FDLSKGFPL+TTKK F IA EL WF
Sbjct: 3 QYLDFLKWVLEKGKHKENRTSVDTISAFGYQMRFDLSKGFPLVTTKKTNFSAIAHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
I GDT++K L+D +NIW Y Y + E L+ EF +
Sbjct: 63 IKGDTNIKYLVDNKVNIWNQWPYESYKKSQDFQSESLKEFIQKIKDDNEFAQKHGN---- 118
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YGKQWR + IDQL +VI+ I NP+SRR IVS+WN +ID M L
Sbjct: 119 LGPVYGKQWRDFLG-----------IDQLKKVIEQIKNNPNSRRLIVSSWNPSEIDTMLL 167
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV + LSC LYQRSAD FLG+PFNIASYALLT ++A+ L+VG F+H+
Sbjct: 168 PPCHTLFQFYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHSI 227
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAHIY+NH++ +K+Q++R PKE+P+L IK ++NI + EDI L Y+ P IKG+++
Sbjct: 228 GDAHIYVNHLEQVKTQLKRNPKELPKLIIK--NKNIFEINFEDIELVDYEFDPIIKGEVA 285
>ref|NP_477589.1| wsv067 [shrimp white spot syndrome virus]
gb|AAK77723.1| ORF54, putative thymidylate synthase [shrimp white spot syndrome
virus]
gb|AAL33071.1| wsv067 [shrimp white spot syndrome virus]
Length = 289
Score = 286 bits (733), Expect = 3e-76
Identities = 149/295 (50%), Positives = 187/295 (63%), Gaps = 24/295 (8%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDL-SKGFPLLTTKKLPFRIIAEELFW 75
+Y NLV++I++ G KDDRTGTGTLS+FGPQM F L P+LTTKK+ +R + EEL W
Sbjct: 6 QYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLTTKKIFWRGVVEELLW 65
Query: 76 FINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
FI G+TD K L K I+IW + R +LD GL A
Sbjct: 66 FIRGNTDAKELAKKKIHIWNANGSREFLDS-----RGLYDRA----------------EG 104
Query: 136 DLGPIYGKQWRSWASFSDNPYK--SKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGP+YG QWR + + D + K IDQL ++K + NPD RR I++AWN D+
Sbjct: 105 DLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDDRRMIMTAWNPMDLHL 164
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH+ QFYV NG LSC+LYQRS DV LGVPFNIASY+LLTH++A M GLK G+FI
Sbjct: 165 MALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVPFNIASYSLLTHLMASMVGLKPGEFI 224
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
T GDAHIY HI++LK Q+ R P+ P+L I E IED+T++ L GY H
Sbjct: 225 LTLGDAHIYNTHIEVLKKQLCRVPRPFPKLRILMAPEKIEDFTIDMFYLEGYQPH 279
>ref|ZP_00206347.1| COG0207: Thymidylate synthase [Bifidobacterium longum DJO10A]
Length = 290
Score = 286 bits (733), Expect = 3e-76
Identities = 147/305 (48%), Positives = 194/305 (63%), Gaps = 36/305 (11%)
Query: 12 THVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAE 71
T + Y +LV+KI+ EGTLK DRTGTGT+SLFG QM FDLSK FPLLTTK + F+ +A
Sbjct: 21 TDIPMPYEDLVRKILTEGTLKSDRTGTGTISLFGQQMRFDLSKYFPLLTTKTVFFKGLAY 80
Query: 72 ELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK 131
EL WF+ G +++ LL+ N++IW DE+
Sbjct: 81 ELLWFLKGSSNINWLLEHNVHIW---------DEW------------------------A 107
Query: 132 DTSFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDI 191
D + DLGP+YG QWRSW + P + IDQ+ V+ I +PDSRR IVSAWN ++
Sbjct: 108 DENGDLGPVYGVQWRSWPA--PTPEDPNRTIDQISNVLDLIKHHPDSRRMIVSAWNPAEV 165
Query: 192 DYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGK 251
+ MALPPCH LFQFYV + LSC+LYQRS D+FLGVPFNIASY+LLT ++A+ AGLK G+
Sbjct: 166 EKMALPPCHALFQFYVADDKLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLKPGE 225
Query: 252 FIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTI 311
F+ T GD H+Y NH+D Q+ R+P P +EI+ +++ DY ED + GY HPTI
Sbjct: 226 FVWTGGDCHVYDNHVDQFLEQLGRKPYPYPTIEIRKA-DSLFDYQYEDFKVVGYQHHPTI 284
Query: 312 KGKLS 316
K ++
Sbjct: 285 KAPVA 289
>ref|NP_110008.1| thymidylate synthase [Mycoplasma pneumoniae M129]
pir||S73842 thymidylate synthase (EC 2.1.1.45) - Mycoplasma pneumoniae (strain
ATCC 29342)
gb|AAB96164.1| thymidylate synthase [Mycoplasma pneumoniae M129]
Length = 328
Score = 286 bits (732), Expect = 5e-76
Identities = 145/313 (46%), Positives = 205/313 (65%), Gaps = 28/313 (8%)
Query: 10 KMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRII 69
K V +Y +L + +++ G + +RT T + +FG QM FD+SK FPLLTTKK+ ++ I
Sbjct: 37 KFRRVMQQYLDLARYVLEHGKYRPNRTDTAGIGVFGYQMHFDISKHFPLLTTKKVHWKSI 96
Query: 70 AEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSA 129
EL WFI GDT++K L+D +NIW + Y + F+K H G+ S++EF+
Sbjct: 97 VHELLWFIKGDTNIKYLVDNKVNIWNEWPY----ESFKKS----PHFNGE--SQKEFIER 146
Query: 130 AK-DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
+ D F +LGP+YGKQWR + +DQL +VI I NP SRR IV
Sbjct: 147 IRQDAKFAQQFGNLGPVYGKQWRDFNG-----------VDQLKKVIAQIKVNPFSRRLIV 195
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAK 243
S+WN ++D M LPPCH L+QFYV +G LSC+LYQRS D+FLG+PFNIASY+LL +++AK
Sbjct: 196 SSWNPNEVDQMLLPPCHSLYQFYVQDGQLSCQLYQRSGDIFLGIPFNIASYSLLVYLVAK 255
Query: 244 MAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLT 303
LK G F+HT GDAHIY NH++ +K Q+ R+PK +P++ +K+ ++I DY +DI L
Sbjct: 256 ETNLKPGSFVHTIGDAHIYENHLEQIKLQLTRQPKPLPKVVLKS-DKSIFDYQFDDIELV 314
Query: 304 GYDAHPTIKGKLS 316
YD HPTIKG+++
Sbjct: 315 DYDHHPTIKGEVA 327
>pdb|1HW3|A Chain A, Structure Of Human Thymidylate Synthase Suggests
Advantages Of Chemotherapy With Noncompetitive
Inhibitors
Length = 313
Score = 286 bits (732), Expect = 5e-76
Identities = 151/308 (49%), Positives = 192/308 (62%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y ++ I+ G KDDRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 28 HGELQYLGQIQHILRXGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEG------------------ 129
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D S + +DQL RVI I TNPD RR I+ AWN
Sbjct: 130 -----DLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMXAWNP 184
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPP H L QFYVVN LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK
Sbjct: 185 RDLPLMALPPXHALXQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLK 244
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G FIHT GDAHIY+NHI+ LK Q++REP+ P+L I E I+D+ ED + GY+ H
Sbjct: 245 PGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 304
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 305 PTIKMEMA 312
>ref|NP_870607.1| thymidylate synthase [Pirellula sp. 1]
emb|CAD77684.1| thymidylate synthase [Pirellula sp.]
Length = 264
Score = 286 bits (731), Expect = 5e-76
Identities = 141/299 (47%), Positives = 185/299 (61%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y L+ +++ +G +DDRTG GT SLFG QM FDL++GFPLLTTKKL R I EL WF+
Sbjct: 4 YLQLLDEVLHDGIDRDDRTGVGTRSLFGRQMRFDLAEGFPLLTTKKLHIRSILHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++ L + ++IW DE+ D + DL
Sbjct: 64 RGDTNIGYLKENKVSIW---------DEW------------------------ADEAGDL 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWRSW + + +DQ+ V +I TNP SRR +VSAWNV D+ MALP
Sbjct: 91 GPVYGHQWRSWEGANGD------TVDQIAWVENEIRTNPRSRRLVVSAWNVADVPKMALP 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH+LFQFYV G LSC+LYQRSAD+FLGVPFNIASYA+LT ++A + GLK G+F+HT G
Sbjct: 145 PCHLLFQFYVSGGRLSCQLYQRSADLFLGVPFNIASYAMLTSMMAHVTGLKPGEFVHTLG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
D H+Y NH D + Q+ R P+ +P IK ++ D+ +D LT YD HP IK ++
Sbjct: 205 DVHLYSNHFDQAREQLSRTPRPLPTFHIKRDVASVTDFQFDDFELTNYDPHPHIKAPVA 263
>ref|NP_477367.1| CG3181-PA [Drosophila melanogaster]
sp|O76511|TYSY_DROME Thymidylate synthase (TS) (TSase)
gb|AAF51176.1| CG3181-PA [Drosophila melanogaster]
gb|AAL90333.1| RE18955p [Drosophila melanogaster]
Length = 321
Score = 285 bits (730), Expect = 6e-76
Identities = 150/303 (49%), Positives = 191/303 (63%), Gaps = 27/303 (8%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELF 74
+ Y +L++ I+ G + DRT GTLS+FG QM FD+ FPLLTTK++ FR +AEEL
Sbjct: 36 EMHYLDLLRHIIANGEQRMDRTEVGTLSVFGSQMRFDMRNSFPLLTTKRVFFRAVAEELL 95
Query: 75 WFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTS 134
WF+ G TD K L KN++IW ++ R +LD K F A
Sbjct: 96 WFVAGKTDAKLLQAKNVHIWDGNSSREFLD------------------KMGFTGRAVG-- 135
Query: 135 FDLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDI 191
DLGP+YG QWR + + D+ Y S K IDQL +VI I NP RR I+SAWN DI
Sbjct: 136 -DLGPVYGFQWRHFGAQYGTCDDDY-SGKGIDQLRQVIDTIRNNPSDRRIIMSAWNPLDI 193
Query: 192 DYMALPPCHVLFQFYVVN--GTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
MALPPCH L QFYV G LSC+LYQRSAD+ LGVPFNIASYALLTH+IA + GLK
Sbjct: 194 PKMALPPCHCLAQFYVSEKRGELSCQLYQRSADMGLGVPFNIASYALLTHMIAHVTGLKP 253
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
G F+HT GD H+Y+NH++ LK Q+ER P+ P+L IK ++IED+ ED + Y+ HP
Sbjct: 254 GDFVHTMGDTHVYLNHVEPLKEQLERTPRPFPKLIIKRQVQDIEDFRFEDFQIVDYNPHP 313
Query: 310 TIK 312
I+
Sbjct: 314 KIQ 316
>dbj|BAB27620.1| unnamed protein product [Mus musculus]
Length = 307
Score = 285 bits (730), Expect = 7e-76
Identities = 149/308 (48%), Positives = 196/308 (63%), Gaps = 27/308 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y V+ I+ G K+DRTGTGTLS+FG Q + L FPLLTTK++ ++ + EE
Sbjct: 22 HGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 81
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G T+ K L K + IW + R +LD F EG
Sbjct: 82 LLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEG------------------ 123
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + D + S + +DQL +VI I TNPD RR I+ AWN
Sbjct: 124 -----DLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNP 178
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QFYVVNG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GL+
Sbjct: 179 KDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQ 238
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G F+HT GDAHIY+NHI+ LK Q++REP+ +L+I E I+D+ +ED + GY+ H
Sbjct: 239 PGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFQKLKILRKVETIDDFKVEDFQIEGYNPH 298
Query: 309 PTIKGKLS 316
PTIK +++
Sbjct: 299 PTIKMEMA 306
>gb|AAL88992.1| WSSV124 [shrimp white spot syndrome virus]
Length = 289
Score = 285 bits (730), Expect = 7e-76
Identities = 149/295 (50%), Positives = 187/295 (63%), Gaps = 24/295 (8%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDL-SKGFPLLTTKKLPFRIIAEELFW 75
+Y NLV++I++ G KDDRTGTGTLS+FGPQM F L P+LTTKK+ +R + EEL W
Sbjct: 6 QYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLTTKKIFWRGVVEELSW 65
Query: 76 FINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
FI G+TD K L K I+IW + R +LD GL A
Sbjct: 66 FIRGNTDAKELAKKKIHIWNANGSREFLDS-----RGLYDRA----------------EG 104
Query: 136 DLGPIYGKQWRSWASFSDNPYK--SKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGP+YG QWR + + D + K IDQL ++K + NPD RR I++AWN D+
Sbjct: 105 DLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDDRRMIMTAWNPMDLHL 164
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH+ QFYV NG LSC+LYQRS DV LGVPFNIASY+LLTH++A M GLK G+FI
Sbjct: 165 MALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVPFNIASYSLLTHLMASMVGLKPGEFI 224
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
T GDAHIY HI++LK Q+ R P+ P+L I E IED+T++ L GY H
Sbjct: 225 LTLGDAHIYNTHIEVLKKQLCRVPRPFPKLRILMAPEKIEDFTIDMFYLEGYQPH 279
>ref|NP_696816.1| thymidylate synthase [Bifidobacterium longum NCC2705]
gb|AAN25452.1| thymidylate synthase [Bifidobacterium longum NCC2705]
Length = 266
Score = 285 bits (729), Expect = 1e-75
Identities = 146/299 (48%), Positives = 192/299 (64%), Gaps = 36/299 (12%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +LV+KI+ EGTLK DRTGTGT+SLFG QM FDLSK FPLLTTK + F+ +A EL WF+
Sbjct: 3 YEDLVRKILTEGTLKSDRTGTGTISLFGQQMRFDLSKYFPLLTTKTVFFKGLAYELLWFL 62
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
G +++ LL+ N++IW DE+ D + DL
Sbjct: 63 KGSSNINWLLEHNVHIW---------DEW------------------------ADENGDL 89
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GP+YG QWRSW + P + IDQ+ V+ I +PDSRR IVSAWN +++ MALP
Sbjct: 90 GPVYGVQWRSWPA--PTPEDPNRTIDQISNVLDLIKHHPDSRRMIVSAWNPAEVEKMALP 147
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCH LFQFYV + LSC+LYQRS D+FLGVPFNIASY+LLT ++A+ AGLK G+F+ T G
Sbjct: 148 PCHALFQFYVADDKLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLKPGEFVWTGG 207
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
D H+Y NH+D Q+ R+P P +EI+ +++ DY ED + GY HPTIK ++
Sbjct: 208 DCHVYDNHVDQFLEQLGRKPYPYPTIEIRKA-DSLFDYQYEDFKVVGYQHHPTIKAPVA 265
>gb|AAC27622.1| thymidylate synthase [Drosophila melanogaster]
Length = 321
Score = 284 bits (727), Expect = 1e-75
Identities = 149/303 (49%), Positives = 191/303 (63%), Gaps = 27/303 (8%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELF 74
+ Y +L++ I+ G + DRT GTLS+FG QM FD+ FPLLTTK++ FR +AEEL
Sbjct: 36 EMHYLDLLRHIIANGEQRMDRTEVGTLSVFGSQMRFDMRNSFPLLTTKRVFFRAVAEELL 95
Query: 75 WFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTS 134
WF+ G TD K L KN++IW ++ R +LD K F A
Sbjct: 96 WFVAGKTDAKLLQAKNVHIWDGNSSREFLD------------------KMGFTGRAVG-- 135
Query: 135 FDLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDI 191
DLGP+YG QWR + + D+ Y S K IDQL +VI I NP RR I+SAWN D+
Sbjct: 136 -DLGPVYGFQWRHFGAQYGTCDDDY-SGKGIDQLRQVIDTIRNNPSDRRIIMSAWNPLDM 193
Query: 192 DYMALPPCHVLFQFYVVN--GTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
MALPPCH L QFYV G LSC+LYQRSAD+ LGVPFNIASYALLTH+IA + GLK
Sbjct: 194 PKMALPPCHCLAQFYVSEKRGELSCQLYQRSADMGLGVPFNIASYALLTHMIAHVTGLKP 253
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
G F+HT GD H+Y+NH++ LK Q+ER P+ P+L IK ++IED+ ED + Y+ HP
Sbjct: 254 GDFVHTMGDTHVYLNHVEPLKEQLERTPRPFPKLIIKRQVQDIEDFRFEDFQIVDYNPHP 313
Query: 310 TIK 312
I+
Sbjct: 314 KIQ 316
>ref|NP_906122.1| thymidylate synthase [Porphyromonas gingivalis W83]
gb|AAQ67021.1| thymidylate synthase [Porphyromonas gingivalis W83]
Length = 267
Score = 284 bits (726), Expect = 2e-75
Identities = 137/297 (46%), Positives = 184/297 (61%), Gaps = 39/297 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+++I+DEG K+DRTGTGT+S+FG QM FDL +GFPLLTTK+L + I EL WF
Sbjct: 6 QYLDLLRRILDEGVRKEDRTGTGTISVFGHQMCFDLEEGFPLLTTKRLHLKSIIYELLWF 65
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++ L + + IW + A D + D
Sbjct: 66 LRGDTNVHYLQEHGVRIWNEWA---------------------------------DENGD 92
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGPIYG QWRSW + IDQ+ V++ + PDSRR IV +WNVG + M L
Sbjct: 93 LGPIYGYQWRSWPDYRGG------HIDQMQEVLRQLREEPDSRRIIVCSWNVGQLADMHL 146
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH QFYV +G LS +LYQRSAD FLG+PFNIASYALL +IA + GLK G+F+HT
Sbjct: 147 PPCHCFMQFYVADGRLSLQLYQRSADSFLGIPFNIASYALLLQMIAHVTGLKPGRFVHTL 206
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
GDAHIY+NH++ ++ Q+ REP+ +P++ + ++ D+ ED L GYD HP I G
Sbjct: 207 GDAHIYLNHLEQVQLQLSREPRALPRMVLNPEVSDLFDFRYEDFRLEGYDPHPHIAG 263
>ref|ZP_00193117.2| COG0207: Thymidylate synthase [Mesorhizobium sp. BNC1]
Length = 264
Score = 283 bits (724), Expect = 3e-75
Identities = 140/300 (46%), Positives = 185/300 (61%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+ +++ G ++DRTGTGT +FG QM FDLS GFP+LTTKKL R I EL WF
Sbjct: 3 QYLDLLAHVLENGIDREDRTGTGTRGVFGYQMRFDLSDGFPVLTTKKLHLRSIIYELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L + + IW DE+ D + D
Sbjct: 63 LKGDTNIRYLQENGVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ ++ + NP SRRHIV+AWN +ID MAL
Sbjct: 90 LGPVYGAQWRSW------PAPDGRHIDQIANLLNGLRENPYSRRHIVTAWNPAEIDGMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQF+V G LSC+LYQRSAD+FLGVPFNIASYALLT +IA++ GLK G F+HT
Sbjct: 144 PPCHCLFQFHVAEGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH D + Q+ R PK +P + I +++ + ED L GY A PTI+ ++
Sbjct: 204 GDAHLYKNHFDQAREQLTRTPKPLPTMWINPEVDDLFAFGYEDFRLEGYVADPTIRAPIA 263
>sp|P78029|TYSY_MYCPN Thymidylate synthase (TS) (TSase)
Length = 287
Score = 283 bits (724), Expect = 4e-75
Identities = 143/306 (46%), Positives = 203/306 (66%), Gaps = 28/306 (9%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L + +++ G + +RT T + +FG QM FD+SK FPLLTTKK+ ++ I EL WF
Sbjct: 3 QYLDLARYVLEHGKYRPNRTDTAGIGVFGYQMHFDISKHFPLLTTKKVHWKSIVHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK-DTSF 135
I GDT++K L+D +NIW + Y + F+K H G+ S++EF+ + D F
Sbjct: 63 IKGDTNIKYLVDNKVNIWNEWPY----ESFKKS----PHFNGE--SQKEFIERIRQDAKF 112
Query: 136 -----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
+LGP+YGKQWR + +DQL +VI I NP SRR IVS+WN +
Sbjct: 113 AQQFGNLGPVYGKQWRDFNG-----------VDQLKKVIAQIKVNPFSRRLIVSSWNPNE 161
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+D M LPPCH L+QFYV +G LSC+LYQRS D+FLG+PFNIASY+LL +++AK LK G
Sbjct: 162 VDQMLLPPCHSLYQFYVQDGQLSCQLYQRSGDIFLGIPFNIASYSLLVYLVAKETNLKPG 221
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
F+HT GDAHIY NH++ +K Q+ R+PK +P++ +K+ ++I DY +DI L YD HPT
Sbjct: 222 SFVHTIGDAHIYENHLEQIKLQLTRQPKPLPKVVLKS-DKSIFDYQFDDIELVDYDHHPT 280
Query: 311 IKGKLS 316
IKG+++
Sbjct: 281 IKGEVA 286
>ref|NP_571835.1| thymidylate synthase [Danio rerio]
gb|AAF97476.1| thymidylate synthase [Danio rerio]
Length = 319
Score = 283 bits (723), Expect = 5e-75
Identities = 148/303 (48%), Positives = 191/303 (63%), Gaps = 27/303 (8%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +LV+ I+ G K DRTGTG +S+FG Q + L FPLLTTK++ ++ I EEL WFI
Sbjct: 39 YLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEELLWFI 98
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
G T+ K L +K + IW + R +LD+ F EG
Sbjct: 99 KGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEG----------------------- 135
Query: 136 DLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGP+YG QWR + A + D + S + +DQL +VI I +NP+ RR I+ AWN D+
Sbjct: 136 DLGPVYGFQWRHFGAEYKDMHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPL 195
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH L QFYV NG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK G F+
Sbjct: 196 MALPPCHALCQFYVSNGELSCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFV 255
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
HT GDAHIY NHI+ LK Q++REP+ P+L IK E I D+ ED + YD HPTIK
Sbjct: 256 HTLGDAHIYTNHIEPLKEQIQREPRPFPKLRIKRKVEQINDFCAEDFEIYDYDPHPTIKM 315
Query: 314 KLS 316
+++
Sbjct: 316 QMA 318
>ref|NP_660757.1| thymidylate synthase [Buchnera aphidicola str. Sg (Schizaphis
graminum)]
sp|Q8K9C3|TYSY_BUCAP Thymidylate synthase (TS) (TSase)
gb|AAM67968.1| thymidylate synthase [Buchnera aphidicola str. Sg (Schizaphis
graminum)]
Length = 264
Score = 283 bits (723), Expect = 5e-75
Identities = 144/300 (48%), Positives = 193/300 (64%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+KKI+ G K DRTGTGTLS+FG M+FDL KGFPL+TTKK I EL WF
Sbjct: 3 QYLDLIKKIIKNGNSKKDRTGTGTLSIFGHHMKFDLKKGFPLITTKKCHIPSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++K L + I+IW + A +F D
Sbjct: 63 LRGETNIKYLNENKISIWDNWADKFG---------------------------------D 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGPIYGKQWRSW + + K+IDQ+ V+K I +PDSRR +VS+WNVG+ID M+L
Sbjct: 90 LGPIYGKQWRSWDT------SNGKKIDQIKNVLKQIKEDPDSRRILVSSWNVGEIDKMSL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PCH+LFQFYV+ LSC+LYQRS DVFLG+PFNIASYA+L H+IA+ L+VG+F+ T
Sbjct: 144 APCHILFQFYVLKKKLSCQLYQRSCDVFLGLPFNIASYAILIHMIAQQCNLQVGEFLWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++L K Q+ R PK++P+L I +++ Y+ ED + GY + IKGK+S
Sbjct: 204 GDVHLYKNHVELAKKQILRIPKKLPELIILKKPQSLFQYSFEDFKIVGYKPYSLIKGKIS 263
>gb|AAH49026.1| Zgc:56465 protein [Danio rerio]
Length = 319
Score = 282 bits (722), Expect = 6e-75
Identities = 148/303 (48%), Positives = 191/303 (63%), Gaps = 27/303 (8%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +LV+ I+ G K DRTGTG +S+FG Q + L FPLLTTK++ ++ I EEL WFI
Sbjct: 39 YLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEELLWFI 98
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
G T+ K L +K + IW + R +LD+ F EG
Sbjct: 99 KGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEG----------------------- 135
Query: 136 DLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGP+YG QWR + A + D + S + +DQL +VI I +NP+ RR I+ AWN D+
Sbjct: 136 DLGPVYGFQWRHFGAEYKDMHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPL 195
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH L QFYV NG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK G F+
Sbjct: 196 MALPPCHALCQFYVSNGELSCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFV 255
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
HT GDAHIY NHI+ LK Q++REP+ P+L IK E I D+ ED + YD HPTIK
Sbjct: 256 HTLGDAHIYTNHIEPLKEQIQREPRPFPKLRIKRKVEQINDFCAEDFEIYDYDPHPTIKM 315
Query: 314 KLS 316
+++
Sbjct: 316 QMA 318
>sp|O81395|DRTS_MAIZE Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
[Includes: Dihydrofolate reductase ; Thymidylate
synthase ]
pir||T01684 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - maize
gb|AAC26003.1| bifunctional dihydrofolate reductase-thymidylate synthase [Zea
mays]
Length = 521
Score = 282 bits (721), Expect = 8e-75
Identities = 146/306 (47%), Positives = 197/306 (64%), Gaps = 23/306 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y NLV+ I+ G K+DRTGTGTLS FG QM F+L K FPLLTTK++ +R + EE
Sbjct: 236 HEEYQYLNLVEDIIRSGAQKNDRTGTGTLSKFGCQMRFNLRKNFPLLTTKRVFWRGVVEE 295
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K I+IW +A R YL+ GL H ++E
Sbjct: 296 LLWFISGSTNAKVLQEKGIHIWDGNASREYLNSV-----GLAH-------REEG------ 337
Query: 133 TSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + A ++D + + K DQL VI I +P+ RR I+SAWN D
Sbjct: 338 ---DLGPIYGFQWRHFGAEYTDMHADYTGKGFDQLMDVIDKIKNDPEDRRIILSAWNPSD 394
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV NG LSC++YQRSAD+ LGVPFNIASY+LLT++IA++ L G
Sbjct: 395 LKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTYMIAQVCDLSPG 454
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
F+H GDAH+Y NH+ L+ Q+++ PK P L+I ++I+ + D L GYD H
Sbjct: 455 DFVHVIGDAHVYRNHVRALEEQIQKMPKPFPILKINPSKKDIDSFMASDFKLVGYDPHQK 514
Query: 311 IKGKLS 316
I+ K++
Sbjct: 515 IEMKMA 520
>sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
[Includes: Dihydrofolate reductase ; Thymidylate
synthase ]
pir||S55683 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - soybean
gb|AAB34317.1| dihydrofolate reductase-thymidylate synthase; DHFR-TS [Glycine max]
prf||2111237A dihydrofolate reductase-thymidylate synthase
Length = 530
Score = 281 bits (720), Expect = 1e-74
Identities = 152/310 (49%), Positives = 192/310 (61%), Gaps = 23/310 (7%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRI 68
I H + Y LV+ I+ EGT K DRTGTGTLS FG QM F+L FPLLTTKK+ +R
Sbjct: 241 ISERHEEYLYLKLVQDIIAEGTTKGDRTGTGTLSKFGCQMRFNLRGNFPLLTTKKVFWRG 300
Query: 69 IAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVS 128
+ EEL WFI+G T+ K L +K I+IW +A R YLD G L+++E
Sbjct: 301 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD-------------GVGLTERE--- 344
Query: 129 AAKDTSFDLGPIYGKQWRSW-ASFSDNPYK-SKKEIDQLFRVIKDINTNPDSRRHIVSAW 186
DLGP+YG QWR + A ++D + S + DQL VI I NPD RR I+SAW
Sbjct: 345 -----EGDLGPVYGFQWRHFGARYTDMHHDYSGQGFDQLLDVINKIKRNPDDRRIILSAW 399
Query: 187 NVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAG 246
N D+ MALPPCH+ QFYV +G LSC++YQRSAD+ LG+PFNIASYALLT +IA +
Sbjct: 400 NPVDLKLMALPPCHMFAQFYVAHGELSCQMYQRSADMGLGIPFNIASYALLTCMIAHVCD 459
Query: 247 LKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYD 306
L G FIH GDAHIY NH+ L+ Q+ +PK P L+I ++I+ + D L GYD
Sbjct: 460 LIPGDFIHVIGDAHIYRNHVRPLQEQLHNQPKPFPTLKINPKKKDIDSFVAADFKLIGYD 519
Query: 307 AHPTIKGKLS 316
H I KLS
Sbjct: 520 PHQKIDMKLS 529
>ref|NP_249033.1| thymidylate synthase [Pseudomonas aeruginosa PA01]
ref|ZP_00140775.1| COG0207: Thymidylate synthase [Pseudomonas aeruginosa UCBPP-PA14]
sp|Q9I6F1|TYSY_PSEAE Thymidylate synthase (TS) (TSase)
pir||D83602 thymidylate synthase PA0342 [imported] - Pseudomonas aeruginosa
(strain PAO1)
gb|AAG03731.1| thymidylate synthase [Pseudomonas aeruginosa PAO1]
Length = 264
Score = 281 bits (720), Expect = 1e-74
Identities = 139/300 (46%), Positives = 187/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ + + GT K DRTGTGT S+FG QM FDL+ GFPL+TTKK + I EL WF
Sbjct: 3 QYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G T++ L + ++IW DE+ D + D
Sbjct: 63 LKGSTNIAYLKEHGVSIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ ++ + NPDSRR IVSAWN ID MAL
Sbjct: 90 LGPVYGYQWRSW------PAPDGRHIDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++AGL+ G+FI T
Sbjct: 144 PPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ Q+ REP +P +++ +++ D+ ED L GY+AHP IK ++
Sbjct: 204 GDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPVA 263
>gb|AAH65845.1| Unknown (protein for MGC:77659) [Danio rerio]
Length = 318
Score = 281 bits (719), Expect = 1e-74
Identities = 147/303 (48%), Positives = 191/303 (63%), Gaps = 27/303 (8%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +LV+ I+ G K DRTGTG +S+FG Q + L FPLLTTK++ ++ I EEL WFI
Sbjct: 38 YLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEELLWFI 97
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
G T+ K L +K + IW + R +LD+ F EG
Sbjct: 98 KGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEG----------------------- 134
Query: 136 DLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGP+YG QWR + A + D + S + +DQL +VI I +NP+ RR I+ AWN D+
Sbjct: 135 DLGPVYGFQWRHFGAEYKDMHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPL 194
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCH L QFYV NG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GLK G F+
Sbjct: 195 MALPPCHALCQFYVSNGELSCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFV 254
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
HT GDAHIY NHI+ LK Q++REP+ P+L IK E I D+ ED + Y+ HPTIK
Sbjct: 255 HTLGDAHIYTNHIEPLKEQIQREPRPFPKLRIKRKVEQINDFCAEDFEIYDYNPHPTIKM 314
Query: 314 KLS 316
+++
Sbjct: 315 QMA 317
>ref|YP_015731.1| thymidylate synthase [Mycoplasma mobile 163K]
gb|AAT27520.1| thymidylate synthase [Mycoplasma mobile 163K]
Length = 288
Score = 280 bits (717), Expect = 3e-74
Identities = 145/306 (47%), Positives = 203/306 (66%), Gaps = 27/306 (8%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L+K+I+++G K+DRT TGT+S FG Q +DLSKGFPL+TTKK+ + I EL WF
Sbjct: 3 QYLSLLKEILEKGQKKEDRTNTGTISYFGTQRRYDLSKGFPLVTTKKVHLKSIIFELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK-DTSF 135
I GDT++K L+D +NIW + Y + F+K + G+ L+ +FV K DT F
Sbjct: 63 IKGDTNIKYLVDNGVNIWNEWPY----ETFKKS----KDFNGESLA--DFVLKIKSDTLF 112
Query: 136 -----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
+LGP+YGKQWR++ DQLF I+ I NPDSRR IVSAW +
Sbjct: 113 AKKYGELGPVYGKQWRNFNG-----------TDQLFDAIETIKKNPDSRRIIVSAWAANE 161
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
I MALPPCH FQFYV N LS +LYQRS D FLGVPFNIASY++L ++A++ +VG
Sbjct: 162 ISKMALPPCHAFFQFYVNNNKLSLQLYQRSGDTFLGVPFNIASYSILLAMVAQITNYEVG 221
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIHT GD HIY+NH++ ++ Q+ R+P ++P+L + +NI+D+ EDI + Y++HP
Sbjct: 222 EFIHTIGDTHIYLNHLEQVEEQLSRKPLKLPKLVLNKKIKNIDDFKYEDIEIIDYESHPA 281
Query: 311 IKGKLS 316
IK K++
Sbjct: 282 IKAKVA 287
>emb|CAD38046.1| dihydrofolate reductase-thymidylate synthase [Pisum sativum]
Length = 530
Score = 280 bits (716), Expect = 3e-74
Identities = 144/306 (47%), Positives = 192/306 (62%), Gaps = 23/306 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + Y NLV++I+ +GT K DRTGTGTLS FG QM F+L +GFPLLTTK++ +R + EE
Sbjct: 245 HEEYMYLNLVQEIISQGTSKGDRTGTGTLSKFGCQMRFNLRRGFPLLTTKRVFWRGVVEE 304
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K I+IW D+A R +LD LS++E
Sbjct: 305 LLWFISGSTNAKVLQEKGIHIWDDNASREFLDSIG-------------LSERE------- 344
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYK--SKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + N + + + +DQL VI + NPD RR I+SAWN D
Sbjct: 345 -EGDLGPVYGFQWRHFGARYTNMHNDYAGQGVDQLLDVINKVKHNPDDRRIILSAWNPAD 403
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV NG LSC++ QRSAD+ LGVPFNIASYALLT +IA + L G
Sbjct: 404 LKLMALPPCHMSAQFYVANGELSCQMNQRSADMGLGVPFNIASYALLTCMIAHICELVPG 463
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
FIH GDAH+Y H+ L+ Q+ PK P L+I + ++I+ + D L YD H
Sbjct: 464 DFIHVLGDAHVYQTHVRPLQEQLHNLPKPFPTLKINSKKKDIDSFVATDFKLIDYDPHQK 523
Query: 311 IKGKLS 316
I+ K++
Sbjct: 524 IEMKMA 529
>ref|XP_311491.1| ENSANGP00000013700 [Anopheles gambiae]
gb|EAA07160.1| ENSANGP00000013700 [Anopheles gambiae str. PEST]
Length = 302
Score = 278 bits (712), Expect = 8e-74
Identities = 146/304 (48%), Positives = 190/304 (62%), Gaps = 28/304 (9%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGF-PLLTTKKLPFRIIAEELFWF 76
Y L++ I+++G+ + DRTG GTLS+FG QM F L G PLLTTKK+ FR +AEEL WF
Sbjct: 21 YLQLIRDIINKGSKRLDRTGVGTLSIFGAQMRFSLRDGIIPLLTTKKVFFRGVAEELLWF 80
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAAKDTS 134
I G T++K L K + IW ++ R YLD F EG
Sbjct: 81 IKGSTNVKDLQAKGVRIWDGNSTREYLDSCGFTDREEG---------------------- 118
Query: 135 FDLGPIYGKQWRSWASFSDNPYK--SKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDID 192
DLGP+YG QWR + + + + + IDQL VI I NP RR I+ AWN DI
Sbjct: 119 -DLGPVYGFQWRHFGATYKTCHDDYTGQGIDQLAEVIDKIKNNPYDRRIIMCAWNPSDIP 177
Query: 193 YMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKF 252
MALPPCH L QF+V +G LSC++YQRSADV LGVPFNIASY+LLTH+IA + GLK G+F
Sbjct: 178 NMALPPCHCLAQFFVSDGELSCQMYQRSADVGLGVPFNIASYSLLTHMIAHVTGLKAGEF 237
Query: 253 IHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIK 312
IHT GD HIY+NH+D L+ Q+ER PK+ P L K E+I+++T +D + Y+ IK
Sbjct: 238 IHTTGDTHIYLNHVDGLREQIERTPKKFPTLVFKRKVESIDNFTYDDFEILNYNPQSAIK 297
Query: 313 GKLS 316
K++
Sbjct: 298 MKMA 301
>ref|NP_103049.1| thymidylate synthase [Mesorhizobium loti MAFF303099]
sp|Q98KH9|TYSY_RHILO Thymidylate synthase (TS) (TSase)
dbj|BAB48835.1| thymidylate synthase [Mesorhizobium loti]
Length = 264
Score = 278 bits (711), Expect = 1e-73
Identities = 136/300 (45%), Positives = 186/300 (62%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ ++D G + DRTGTGT S+FG QM FDL++GFP+ TTKKL + I EL WF
Sbjct: 3 QYLDLLQHVLDNGADRSDRTGTGTRSVFGYQMRFDLARGFPVTTTKKLHLKSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT++K L D + IW DE+ D + D
Sbjct: 63 LAGDTNIKYLTDHGVTIW---------DEW------------------------ADENGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG+QWRSW P IDQ+ ++K+I NP SRR IVSAWN +++ MAL
Sbjct: 90 LGPVYGRQWRSW------PDGHGGSIDQIAGLLKEIRRNPQSRRLIVSAWNPAEVEAMAL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV G LSC+LYQRSAD+FLGVPFNIASYALLT ++A++ GLK G F+HT
Sbjct: 144 PPCHCLFQFYVSEGRLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVTGLKPGDFVHTL 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GDAH+Y NH + + Q++R P+ +P + I +++ + ED L Y A +I+ ++
Sbjct: 204 GDAHLYSNHFEQAREQLQRTPRALPTMWINPEVKDLFAFRFEDFRLENYVADASIQAPIA 263
>ref|ZP_00318102.1| COG0207: Thymidylate synthase [Microbulbifer degradans 2-40]
Length = 277
Score = 278 bits (710), Expect = 1e-73
Identities = 141/313 (45%), Positives = 190/313 (60%), Gaps = 52/313 (16%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ + D GT K+DRTGTGT+S+FG QM FDLS+GFPL+TTKK + I EL WF
Sbjct: 3 QYLDLMRHVRDTGTKKEDRTGTGTVSVFGYQMRFDLSEGFPLVTTKKCHLKSIIHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T+ + L D + IW + A E+G D
Sbjct: 63 LKGETNTQYLTDNGVRIWNEWAT-------EEG--------------------------D 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWN--------V 188
LGP+YG QWRSW P +DQ +++ I PDSRRHI+SAWN V
Sbjct: 90 LGPVYGAQWRSW------PTPDGGSLDQFALLVEQIKNKPDSRRHIISAWNPALLPDEGV 143
Query: 189 GDID-----YMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAK 243
D MALPPCH LFQFYV + LSC+LYQRSAD+FLGVPFNIASYALLT ++A+
Sbjct: 144 SPQDNVRNGKMALPPCHTLFQFYVADNKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQ 203
Query: 244 MAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLT 303
+ GL++G F+HTFGDAH+Y+NH++ +++Q+ REP +P ++I ++I + ED L
Sbjct: 204 VTGLELGDFVHTFGDAHLYLNHLEQVETQLAREPLPLPTMKINPEVKDIFSFKFEDFELV 263
Query: 304 GYDAHPTIKGKLS 316
Y AHP I +S
Sbjct: 264 DYQAHPHISAPIS 276
>ref|NP_048042.1| thymidylate synthase [Ateline herpesvirus 3]
pir||T42984 thymidylate synthase (EC 2.1.1.45) - ateline herpesvirus 3 (strain
73)
gb|AAC95595.1| thymidylate synthase [Ateline herpesvirus 3]
Length = 290
Score = 277 bits (709), Expect = 2e-73
Identities = 144/304 (47%), Positives = 188/304 (61%), Gaps = 27/304 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y + VK I++ G K DRTG GTLS+FG Q + L K FPLLTTK++ +R + EE
Sbjct: 5 HAEHQYLSQVKHILNCGNFKHDRTGVGTLSVFGMQSRYSLEKDFPLLTTKRVFWRGVVEE 64
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G TD K L ++IW + R YLD+ F EG
Sbjct: 65 LLWFIRGSTDSKELAASGVHIWDANGSRSYLDKLGFCDREEG------------------ 106
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYKSKKE-IDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + + E +DQL ++I I+TNP RR ++ AWNV
Sbjct: 107 -----DLGPVYGFQWRHFGAEYQGLKHNYGGEGVDQLKQIINTIHTNPTDRRMLMCAWNV 161
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCHVL QFYV +G LSC+LYQRSAD+ LGVPFNIASY+LLT +IA + L
Sbjct: 162 LDVPKMALPPCHVLSQFYVCDGKLSCQLYQRSADMGLGVPFNIASYSLLTCMIAHVTDLV 221
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G+FIHT GDAHIY+NHID L Q+ R P+ P L+ +I+D+ DI+L Y+ +
Sbjct: 222 PGEFIHTLGDAHIYVNHIDALTEQLTRTPRPFPTLKFARKIASIDDFKANDIILENYNPY 281
Query: 309 PTIK 312
P+IK
Sbjct: 282 PSIK 285
>emb|CAC84368.1| thymidylate synthase [Saimiriine herpesvirus 2]
Length = 294
Score = 277 bits (708), Expect = 2e-73
Identities = 145/304 (47%), Positives = 188/304 (61%), Gaps = 27/304 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y + V+ I++ G+ K+DRTGTGTLS+FG Q F L FPLLTTK++ +R + EE
Sbjct: 9 HGEHQYLSQVQHILNYGSFKNDRTGTGTLSIFGTQSRFSLENEFPLLTTKRVFWRGVVEE 68
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G TD K L ++IW + R +LD+ F EG
Sbjct: 69 LLWFIRGSTDSKELSAAGVHIWDANGSRSFLDKLGFYDRDEG------------------ 110
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYKSKKE-IDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + + K E +DQL ++I I TNP RR ++ AWNV
Sbjct: 111 -----DLGPVYGFQWRHFGAEYRGSKRDYKGEGVDQLKQLIATIKTNPTDRRMLMCAWNV 165
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
DI M LPPCHVL QFYV +G LSC+LYQRSAD+ LGVPFNIASY+LLT +IA + L
Sbjct: 166 SDIPKMVLPPCHVLSQFYVCDGKLSCQLYQRSADMGLGVPFNIASYSLLTCMIAHVTNLV 225
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G+FIHT GDAHIY++HID LK Q+ R P+ P L I+D+ +DI+L Y+ H
Sbjct: 226 PGEFIHTIGDAHIYVDHIDALKMQLTRTPRPFPTLRFARNVSCIDDFKADDIILENYNPH 285
Query: 309 PTIK 312
P IK
Sbjct: 286 PIIK 289
>sp|P12462|TYSY_HSVAT Thymidylate synthase (TS) (TSase)
pir||SYBEAT thymidylate synthase (EC 2.1.1.45) - ateline herpesvirus 2 (strain
810)
gb|AAA46170.1| thymidylate synthase
Length = 290
Score = 277 bits (708), Expect = 3e-73
Identities = 142/302 (47%), Positives = 190/302 (62%), Gaps = 23/302 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y + VK I++ G K DRTG GTLS+FG Q + L K FPLLTTK++ +R + EE
Sbjct: 5 HAEHQYLSQVKHILNCGNFKHDRTGVGTLSVFGMQSRYSLEKDFPLLTTKRVFWRGVVEE 64
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G TD K L ++IW + R YLD+ GL ++E
Sbjct: 65 LLWFIRGSTDSKELAASGVHIWDANGSRSYLDKL-----GL-------FDREEG------ 106
Query: 133 TSFDLGPIYGKQWRSW-ASFSDNPYKSKKE-IDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + A + + E +DQL ++I I+TNP RR ++ AWNV D
Sbjct: 107 ---DLGPVYGFQWRHFGAEYQGLKHNYGGEGVDQLKQIINTIHTNPTDRRMLMCAWNVLD 163
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCHVL QFYV +G LSC+LYQRSAD+ LGVPFNIASY+LLT +IA + L G
Sbjct: 164 VPKMALPPCHVLSQFYVCDGKLSCQLYQRSADMGLGVPFNIASYSLLTCMIAHVTDLVPG 223
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIHT GDAH+Y+NH+D L Q+ R P+ P L+ +I+D+ DI+L Y+ +P+
Sbjct: 224 EFIHTLGDAHVYVNHVDALTEQLTRTPRPFPTLKFARKVASIDDFKANDIILENYNPYPS 283
Query: 311 IK 312
IK
Sbjct: 284 IK 285
>gb|AAP57962.1| dihydrofolate reductase/thymidilate synthase [Babesia bovis]
Length = 511
Score = 276 bits (707), Expect = 3e-73
Identities = 141/307 (45%), Positives = 193/307 (62%), Gaps = 25/307 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y +++ ++ G LK +RTGT S FG QM FDLS+ FPLLTTKK+ R I EE
Sbjct: 226 HEEFQYLDILADVLSHGVLKPNRTGTDAYSKFGYQMRFDLSRSFPLLTTKKVALRSIIEE 285
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGW-EGLEHIAGDPLSKQEFVSAAK 131
L WFI G T+ LL KN+ IW + R +LD+ G+ E EH
Sbjct: 286 LLWFIKGSTNGNDLLAKNVRIWELNGRREFLDK--NGFTEREEH---------------- 327
Query: 132 DTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGPIYG QWR + A + D + + K IDQL +I I TNP+ RR IV +WNV
Sbjct: 328 ----DLGPIYGFQWRHFGAEYLDMHADYTGKGIDQLAEIINRIKTNPNDRRMIVCSWNVS 383
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCH FQFYV + LSC ++QRS D+ LGVPFNIASY++LT ++A++ GL +
Sbjct: 384 DLKKMALPPCHCFFQFYVSDNKLSCMMHQRSCDLGLGVPFNIASYSILTAMVAQVCGLGL 443
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
G+F+H DAHIY++H+D + +Q+ R P P+L + +NIED+T++DIV+ Y +HP
Sbjct: 444 GEFVHNLADAHIYVDHVDAVTTQIARIPYPFPRLRLNPDIKNIEDFTIDDIVVEDYVSHP 503
Query: 310 TIKGKLS 316
I +S
Sbjct: 504 AIPMAMS 510
>gb|AAA46174.1| thymidylate synthase
Length = 294
Score = 276 bits (706), Expect = 5e-73
Identities = 145/304 (47%), Positives = 188/304 (61%), Gaps = 27/304 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y + V+ I++ G+ K+DRTGTGTLS+FG Q F L FPLLTTK++ +R + EE
Sbjct: 9 HGEHQYLSQVQHILNYGSFKNDRTGTGTLSIFGTQSRFSLENEFPLLTTKRVFWRGVVEE 68
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G TD K L ++IW + R +LD+ F EG
Sbjct: 69 LLWFIRGSTDSKELSAAGVHIWDANGSRSFLDKLGFYDRDEG------------------ 110
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYKSKKE-IDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + K E +DQL ++I I TNP RR ++ AWNV
Sbjct: 111 -----DLGPVYGFQWRHFGAEYKGVGRDYKGEGVDQLKQLIDTIKTNPTDRRMLMCAWNV 165
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
DI M LPPCHVL QFYV +G LSC+LYQRSAD+ LGVPFNIASY+LLT +IA + L
Sbjct: 166 SDIPKMVLPPCHVLSQFYVCDGKLSCQLYQRSADMGLGVPFNIASYSLLTCMIAHVTNLV 225
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
+G+FIHT GDAHIY++HID LK Q+ R P+ P L I+D+ +DI+L Y+ H
Sbjct: 226 LGEFIHTIGDAHIYVDHIDALKMQLTRTPRPFPTLRFARNVSCIDDFKADDIILENYNPH 285
Query: 309 PTIK 312
P IK
Sbjct: 286 PIIK 289
>ref|NP_777993.1| thymidylate synthase [Buchnera aphidicola (Baizongia pistaciae)]
sp|P59427|TYSY_BUCBP Thymidylate synthase (TS) (TSase)
gb|AAO27098.1| thymidylate synthase [Buchnera aphidicola str. Bp (Baizongia
pistaciae)]
Length = 264
Score = 276 bits (705), Expect = 5e-73
Identities = 147/299 (49%), Positives = 184/299 (61%), Gaps = 39/299 (13%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y L+KKI+ EG+ + DRTG GTLS+FG MEF+L GFPL+TTKK F I EL WF+
Sbjct: 4 YLVLLKKILKEGSNRKDRTGIGTLSVFGYHMEFNLKLGFPLITTKKCHFPAIVHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
GDT++K L D NI+IW A E+G+ L
Sbjct: 64 KGDTNIKYLNDHNISIWNPWAD-------ERGY--------------------------L 90
Query: 138 GPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALP 197
GPIYG+QWRSW + K + IDQ+ VI I NP+SRR +VS+WNVGD+ MAL
Sbjct: 91 GPIYGEQWRSWKT------KDGRVIDQIDNVIHLIKNNPNSRRIVVSSWNVGDLHKMALL 144
Query: 198 PCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFG 257
PCHVLFQF+VV+ L C+LYQRS DVFLG+PFNIASY+LLTH+IA+ LKVG FI T G
Sbjct: 145 PCHVLFQFHVVDHVLHCQLYQRSCDVFLGLPFNIASYSLLTHMIAQQCNLKVGNFIWTGG 204
Query: 258 DAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
D H+Y NHI K Q+ R P +P+L I I +Y L+D L Y HP+I K++
Sbjct: 205 DVHLYKNHIKQAKKQILRRPYLLPKLVINRKPTQIFNYLLQDFNLLNYKYHPSIHAKIA 263
>ref|NP_852828.1| ThyA [Mycoplasma gallisepticum R]
sp|Q9XC19|TYSY_MYCGA Thymidylate synthase (TS) (TSase)
gb|AAP56396.1| ThyA [Mycoplasma gallisepticum R]
Length = 289
Score = 275 bits (704), Expect = 7e-73
Identities = 147/306 (48%), Positives = 200/306 (65%), Gaps = 28/306 (9%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++K+M +G +K DRT TGT+S FG Q +DL +GFPLLTTKK+ ++ I EL WF+
Sbjct: 4 YLDLLEKVMTKGEVKKDRTNTGTISYFGTQSRYDLREGFPLLTTKKMAWKAICHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK-DTSF- 135
GDT++K L+D N+NIW + Y + F+K G+ L Q+FV K D F
Sbjct: 64 KGDTNIKYLVDHNVNIWNEWPY----EAFKKS----NDFKGESL--QDFVEKIKTDNQFA 113
Query: 136 ----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDI 191
LGP+YGKQWR + +DQ+ VI +I TNP SRR IVSAWN G+I
Sbjct: 114 QQYGKLGPVYGKQWRDFNG-----------VDQIEWVINEIKTNPFSRRLIVSAWNPGEI 162
Query: 192 DYMALPPCHVLFQFYVVNG-TLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
MALPPCH FQF+V +S +LYQRS D+FLGVPFNIASY+LL ++A++ GLK
Sbjct: 163 KEMALPPCHSFFQFFVNEKYEISLQLYQRSGDLFLGVPFNIASYSLLLLMVAQVTGLKPA 222
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIHT GD HIY NH++ +K Q++REPK++P++ + +NI D+ EDI L Y+ H
Sbjct: 223 EFIHTIGDTHIYSNHLEQVKIQLQREPKKLPKVTLNPDIKNIFDFRFEDISLENYEHHDP 282
Query: 311 IKGKLS 316
IKGK++
Sbjct: 283 IKGKVA 288
>ref|ZP_00092243.1| COG0207: Thymidylate synthase [Azotobacter vinelandii]
Length = 264
Score = 275 bits (704), Expect = 7e-73
Identities = 136/300 (45%), Positives = 184/300 (61%), Gaps = 39/300 (13%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L++ + + GT K DRTGTGT S+FG QM FDL++GFPL+TTKK + I EL WF
Sbjct: 3 QYLDLMRLVREHGTFKSDRTGTGTFSVFGHQMRFDLAEGFPLVTTKKCHLKSIVHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ GDT+++ L + ++IW DE+ G + D
Sbjct: 63 LKGDTNIRYLKENGVSIW---------DEWADG------------------------NGD 89
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG QWRSW P + IDQ+ V+ I NPDSRR IVSAWN ID M L
Sbjct: 90 LGPVYGYQWRSW------PAPDGRHIDQIANVVNMIRDNPDSRRLIVSAWNPALIDEMKL 143
Query: 197 PPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTF 256
PPCH LFQFYV +G LSC+LYQRSAD+FLGVPFNIASYALL ++A++ GL G+F+ T
Sbjct: 144 PPCHALFQFYVADGRLSCQLYQRSADIFLGVPFNIASYALLILMMAQVTGLAPGEFVWTG 203
Query: 257 GDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
GD H+Y NH++ Q+ REP +P +++ +++ + ED L GY +HP IK ++
Sbjct: 204 GDCHLYANHLEQADLQLSREPLPLPTMQLDPDVKDLFAFRFEDFELVGYQSHPHIKAPVA 263
>ref|NP_491532.2| thymidylate synthase (35.8 kD) (1F707) [Caenorhabditis elegans]
pir||T52178 thymidylate synthase - Caenorhabditis elegans
gb|AAC97508.1| thymidylate synthase; TS [Caenorhabditis elegans]
Length = 315
Score = 275 bits (704), Expect = 8e-73
Identities = 143/308 (46%), Positives = 192/308 (62%), Gaps = 28/308 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ + + +Y V++I+ EGT +DDRTGTGT+S+FG Q ++ L G PLLTTK++ ++
Sbjct: 25 VHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVYWK 84
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQE 125
+ EEL WFI+G TD K L++KN+ IW + R +LD F EG
Sbjct: 85 GVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEG------------- 131
Query: 126 FVSAAKDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
DLGP+YG QWR + A + D + S + +DQL VI+ I PDSRR I+
Sbjct: 132 ----------DLGPVYGFQWRHFGAKYVDCHTDYSGQGVDQLAEVIRQIKEQPDSRRIIM 181
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAK 243
SAWN D+ M LPPCH + QFYV NG LSC+LYQRS D+ LGVPFN+ASY LLTH+IAK
Sbjct: 182 SAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAK 241
Query: 244 MAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLT 303
+ GLK G +HT GDAH+Y NH+D LK Q++REP P++ +I+D+T + I L
Sbjct: 242 VCGLKPGTLVHTLGDAHVYSNHVDALKIQLDREPYAFPKIRFTRDVASIDDFTSDMIALD 301
Query: 304 GYDAHPTI 311
Y HP I
Sbjct: 302 DYKCHPKI 309
>gb|AAF60422.1| Hypothetical protein Y110A7A.4 [Caenorhabditis elegans]
Length = 312
Score = 275 bits (704), Expect = 8e-73
Identities = 143/308 (46%), Positives = 192/308 (62%), Gaps = 28/308 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ + + +Y V++I+ EGT +DDRTGTGT+S+FG Q ++ L G PLLTTK++ ++
Sbjct: 22 VHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVYWK 81
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQE 125
+ EEL WFI+G TD K L++KN+ IW + R +LD F EG
Sbjct: 82 GVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEG------------- 128
Query: 126 FVSAAKDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
DLGP+YG QWR + A + D + S + +DQL VI+ I PDSRR I+
Sbjct: 129 ----------DLGPVYGFQWRHFGAKYVDCHTDYSGQGVDQLAEVIRQIKEQPDSRRIIM 178
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAK 243
SAWN D+ M LPPCH + QFYV NG LSC+LYQRS D+ LGVPFN+ASY LLTH+IAK
Sbjct: 179 SAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAK 238
Query: 244 MAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLT 303
+ GLK G +HT GDAH+Y NH+D LK Q++REP P++ +I+D+T + I L
Sbjct: 239 VCGLKPGTLVHTLGDAHVYSNHVDALKIQLDREPYAFPKIRFTRDVASIDDFTSDMIALD 298
Query: 304 GYDAHPTI 311
Y HP I
Sbjct: 299 DYKCHPKI 306
>ref|NP_040272.1| thymidylate synthase [Saimiriine herpesvirus 2]
sp|P06854|TYSY_SHV21 Thymidylate synthase (TS) (TSase)
pir||SYBEHS thymidylate synthase (EC 2.1.1.45) - saimiriine herpesvirus 1
emb|CAA45693.1| thymidylate synthase [Saimiriine herpesvirus 2]
gb|AAA46146.1| thymidylate synthase
gb|AAA46175.1| dTMP synthase
Length = 294
Score = 275 bits (702), Expect = 1e-72
Identities = 145/304 (47%), Positives = 187/304 (61%), Gaps = 27/304 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y + V+ I++ G+ K+DRTGTGTLS+FG Q F L FPLLTTK++ +R + EE
Sbjct: 9 HGEHQYLSQVQHILNYGSFKNDRTGTGTLSIFGTQSRFSLENEFPLLTTKRVFWRGVVEE 68
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAA 130
L WFI G TD K L ++IW + R +LD+ F EG
Sbjct: 69 LLWFIRGSTDSKELSAAGVHIWDANGSRSFLDKLGFYDRDEG------------------ 110
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYKSKKE-IDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A + K E +DQL ++I I TNP RR ++ AWNV
Sbjct: 111 -----DLGPVYGFQWRHFGAEYKGVGRDYKGEGVDQLKQLIDTIKTNPTDRRMLMCAWNV 165
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
DI M LPPCHVL QFYV +G LSC+LYQRSAD+ LGVPFNIASY+LLT +IA + L
Sbjct: 166 SDIPKMVLPPCHVLSQFYVCDGKLSCQLYQRSADMGLGVPFNIASYSLLTCMIAHVTNLV 225
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G+FIHT GDAHIY++HID LK Q+ R P+ P L I+D+ +DI+L Y+ H
Sbjct: 226 PGEFIHTIGDAHIYVDHIDALKMQLTRTPRPFPTLRFARNVSCIDDFKADDIILENYNPH 285
Query: 309 PTIK 312
P IK
Sbjct: 286 PIIK 289
>ref|NP_042669.1| thymidylate synthase [Equine herpesvirus 2]
sp|Q89940|TYSY_EHV2 Thymidylate synthase (TS) (TSase)
pir||S55667 thymidylate synthase 70 - equine herpesvirus 2
gb|AAC13860.1| thymidylate synthase
Length = 289
Score = 275 bits (702), Expect = 1e-72
Identities = 136/308 (44%), Positives = 191/308 (62%), Gaps = 23/308 (7%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
+TH + +Y N V++I+ G + DRTG GTLS+FG Q ++ L FPLLTTK++ +R +
Sbjct: 2 VTHCEHQYLNTVREILANGVRRGDRTGVGTLSVFGDQAKYSLRGQFPLLTTKRVFWRGVL 61
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAA 130
EEL WFI G TD L + + IW + R +L GL H
Sbjct: 62 EELLWFIRGSTDSNELSARGVKIWDANGSRDFLAR-----AGLGH--------------- 101
Query: 131 KDTSFDLGPIYGKQWRSW-ASFSDNPYKSKKE-IDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + A++ D+ + + +DQL +I +I NP+SRR +++AWN
Sbjct: 102 -REPGDLGPVYGFQWRHFGAAYVDSKTDYRGQGVDQLRDLIGEIKRNPESRRLVLTAWNP 160
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH+L QFYV G LSC+LYQRS D+ LGVPFNIASY+LLT+++A + GL+
Sbjct: 161 ADLPAMALPPCHLLCQFYVAGGELSCQLYQRSGDMGLGVPFNIASYSLLTYMVAHLTGLE 220
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G FIH GDAH+Y+NH++ LK Q+ R P+ P+L I E+I+D+ ED L GY H
Sbjct: 221 PGDFIHVLGDAHVYLNHVEPLKLQLTRSPRPFPRLRILRRVEDIDDFRAEDFALEGYHPH 280
Query: 309 PTIKGKLS 316
I +++
Sbjct: 281 AAIPMEMA 288
>ref|ZP_00046564.1| COG0207: Thymidylate synthase [Lactobacillus gasseri]
Length = 318
Score = 274 bits (701), Expect = 2e-72
Identities = 151/326 (46%), Positives = 205/326 (62%), Gaps = 29/326 (8%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M ++ Y +L+ KIM EG K+DRTGTGT S+FG QM F+LS+GFP+LTTK++PF +I
Sbjct: 1 MATLEQPYLDLLNKIMIEGHDKEDRTGTGTRSIFGAQMRFNLSEGFPILTTKRVPFGLIK 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYL--DEFEK------GWEGLEHIAGDPLS 122
EL WF+ GDT+++ LL+ N +IW + A++ ++ DE+ G E +
Sbjct: 61 SELLWFLRGDTNIRFLLEHNNHIWDEWAFKNWVESDEYHGPDMTNFGLRSQEDAKFKQVY 120
Query: 123 KQEF------VSAAKDTSF---DLGPIYGKQWRSWASFSDNPYKSKKE---IDQLFRVIK 170
++E + A +D + +LG +YG QWR W K+E IDQ+ VI
Sbjct: 121 QEEMKKFDERILADRDFAVKFGNLGDVYGAQWRHW---------QKREGGFIDQIQNVID 171
Query: 171 DINTNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFN 230
I P SRR IVSAWN D+ ALPPCHVLFQFYV +G LS +LYQRS D+FLGVPFN
Sbjct: 172 QIKKTPYSRRLIVSAWNPEDVPNSALPPCHVLFQFYVNDGRLSVQLYQRSGDMFLGVPFN 231
Query: 231 IASYALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHE 290
IASY+LL ++IA+ GLK G+FIHT GDAHIY NH D +K + R+P + P+L + +
Sbjct: 232 IASYSLLVNLIAQETGLKPGEFIHTLGDAHIYRNHFDQVKELLTRKPYDSPKLWLNPDKK 291
Query: 291 NIEDYTLEDIVLTGYDAHPTIKGKLS 316
IED+ + DI L Y H TIK ++
Sbjct: 292 KIEDFEMSDIKLVDYKHHGTIKAPVA 317
>pir||T14315 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - carrot
emb|CAA05895.1| dihydrofolate reductase-thymidylate synthetase precursor [Daucus
carota]
Length = 577
Score = 274 bits (700), Expect = 2e-72
Identities = 144/307 (46%), Positives = 189/307 (61%), Gaps = 24/307 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + Y LV+ I+ G K+DRT TGT+S+FG QM F+L K FPLLTTKK+ +R + EE
Sbjct: 291 HEEYLYLGLVENIISNGVTKNDRTRTGTVSIFGCQMRFNLRKSFPLLTTKKVFWRGVVEE 350
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K +NIW + R YLD L+ +E
Sbjct: 351 LLWFISGSTNAKILKEKGVNIWEGNGSREYLDSIG-------------LTDRE------- 390
Query: 133 TSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + A ++D + S + DQL VI I NPD RR I SAWN D
Sbjct: 391 -EGDLGPIYGFQWRHFGARYTDMHADYSGQGFDQLLDVISKIKNNPDDRRIIQSAWNPSD 449
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV NG LSC++YQRSAD+ LGVPFNIA+YALLT +IA + L G
Sbjct: 450 LRLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIAAYALLTCMIAHVCDLVPG 509
Query: 251 KFIHTFGDAHIYINHI-DLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
F+H+ GDAH+Y NH+ DL ++ PK P L+I + ++I+ + D L GYD H
Sbjct: 510 DFVHSIGDAHVYSNHLSDLFETSFRMLPKTFPVLKINSGEKDIDSFEAADFKLIGYDPHQ 569
Query: 310 TIKGKLS 316
I+ K++
Sbjct: 570 KIEMKMA 576
>ref|ZP_00198980.1| COG0207: Thymidylate synthase [Kineococcus radiotolerans SRS30216]
Length = 268
Score = 274 bits (700), Expect = 2e-72
Identities = 133/303 (43%), Positives = 189/303 (62%), Gaps = 41/303 (13%)
Query: 14 VDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEEL 73
+DT+Y +L++ ++ GT K DRTGTGT S+FG Q+ +DLS GFPL+TTK++ F+ IA EL
Sbjct: 6 IDTQYEDLLRHVLATGTPKSDRTGTGTRSVFGHQLRYDLSAGFPLVTTKRVHFKSIALEL 65
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ GD +++ L ++ + IW DE+ D
Sbjct: 66 LWFLRGDGNVRWLQERGVTIW---------DEW------------------------ADE 92
Query: 134 SFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
+ DLGP+YG QWRSW P + +DQ+ +V+ + T+PDSRR +VSAWNV ++D
Sbjct: 93 NGDLGPVYGVQWRSW------PTPDGRHVDQIAQVLHTLRTDPDSRRMVVSAWNVAELDR 146
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MAL PCH FQF+V +G LSC+LYQRSAD+FLGVPFNIASYALLTH++A GL+VG F+
Sbjct: 147 MALAPCHAFFQFHVADGKLSCQLYQRSADLFLGVPFNIASYALLTHLVAAEVGLEVGDFV 206
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
T GD H+Y NH++ + Q+ R P P+L ++ + ++ ED + Y HP IK
Sbjct: 207 WTGGDVHVYDNHVEQVTEQLTRTPYPFPRLAVRPA--GLFEHEYEDFEVLDYRHHPAIKA 264
Query: 314 KLS 316
++
Sbjct: 265 PVA 267
>gb|AAA32788.1| dihydrofolate reductase-thymidylate synthase
Length = 519
Score = 274 bits (700), Expect = 2e-72
Identities = 143/306 (46%), Positives = 192/306 (62%), Gaps = 23/306 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + Y N+V+ I+ G +K+DRTGTGTLS FG QM+F+L + FPLLTTK++ +R + EE
Sbjct: 234 HEEFLYLNMVEDIISNGNVKNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEE 293
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K I+IW +A R YLD G L+++E
Sbjct: 294 LLWFISGSTNAKVLQEKGIHIWDGNASREYLD-------------GIGLTERE------- 333
Query: 133 TSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + A ++D + + + DQL VI I NPD RR I+SAWN D
Sbjct: 334 -EGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSD 392
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV G LSC++YQRSAD+ LGVPFNIASY+LLT ++A + L G
Sbjct: 393 LKLMALPPCHMFAQFYVAEGELSCQMYQRSADMGLGVPFNIASYSLLTCMLAHVCDLVPG 452
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
FIH GDAH+Y H+ L+ Q+ PK P L+I + I+ + D LTGYD H
Sbjct: 453 DFIHVLGDAHVYKTHVRPLQEQLLNPPKPFPVLKINPEKKQIDSFVASDFDLTGYDPHKK 512
Query: 311 IKGKLS 316
I+ K++
Sbjct: 513 IEMKMA 518
>ref|NP_965273.1| thymidylate synthase [Lactobacillus johnsonii NCC 533]
gb|AAS09239.1| thymidylate synthase [Lactobacillus johnsonii NCC 533]
Length = 318
Score = 274 bits (700), Expect = 2e-72
Identities = 149/326 (45%), Positives = 201/326 (61%), Gaps = 29/326 (8%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M ++ Y +L+ KIM EG K+DRTGTGT SLFG QM FDL+ GFP+LTTKK+PF +I
Sbjct: 1 MATLEQPYLDLLSKIMSEGHDKEDRTGTGTRSLFGAQMRFDLNDGFPILTTKKIPFGLIK 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIA----GDPLSKQEF 126
EL WF+ GDT+++ LL+ N +IW + A++ +++ E + + DP K+ +
Sbjct: 61 SELLWFLRGDTNIRFLLEHNNHIWDEWAFKNWVESNEYQGPDMTNFGLRSQQDPEFKRIY 120
Query: 127 VSAAK--------DTSF-----DLGPIYGKQWRSWASFSDNPYKSKKE---IDQLFRVIK 170
K D +F +LG +YG QWR W K+E IDQ+ VI
Sbjct: 121 QEEMKKFDQKVLEDQTFAEKYGNLGDVYGAQWRHW---------QKREGGFIDQIQNVID 171
Query: 171 DINTNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFN 230
I P SRR IVSAWN D+ ALPPCHVLFQFYV +G LS +LYQRS D+FLGVPFN
Sbjct: 172 QIKKTPYSRRLIVSAWNPEDVPTSALPPCHVLFQFYVNDGCLSLQLYQRSGDMFLGVPFN 231
Query: 231 IASYALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHE 290
IASYALL +++A+ GLK G+FIHT GDAHIY NH + +K + R + P L + +
Sbjct: 232 IASYALLVNLVARETGLKPGEFIHTLGDAHIYKNHFNQVKELLNRSAYDAPMLWLNPDKK 291
Query: 291 NIEDYTLEDIVLTGYDAHPTIKGKLS 316
++D+ ++DI L Y H TIK ++
Sbjct: 292 LVQDFEMKDIKLINYRHHGTIKAPVA 317
>emb|CAE72941.1| Hypothetical protein CBG20269 [Caenorhabditis briggsae]
Length = 315
Score = 273 bits (699), Expect = 3e-72
Identities = 144/316 (45%), Positives = 196/316 (62%), Gaps = 28/316 (8%)
Query: 1 KRTGKRGCIKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDL-SKGFPLL 59
+++GK + + +Y V++I+ EG+ +DDRTGTGT+S+FG Q ++ L + PLL
Sbjct: 17 EKSGKEIAQHVNQDEFKYLKQVEQILQEGSRRDDRTGTGTISIFGMQSKYSLRNDTIPLL 76
Query: 60 TTKKLPFRIIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIA 117
TTK++ ++ + EEL WFI+G TD K L+ KN+ IW + R +LD F EG
Sbjct: 77 TTKRVYWKGVLEELLWFISGSTDGKLLMAKNVKIWEKNGDRAFLDNLGFTSREEG----- 131
Query: 118 GDPLSKQEFVSAAKDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTN 175
DLGP+YG QWR + A + D + + + IDQL VI+ I
Sbjct: 132 ------------------DLGPVYGFQWRHFGAKYVDCHTDYTGQGIDQLAEVIRQIKEE 173
Query: 176 PDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYA 235
PDSRR I+SAWN ++ M LPPCH + QFYV NG LSC+LYQRS D+ LGVPFN+ASY
Sbjct: 174 PDSRRIILSAWNPSELGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMGLGVPFNLASYG 233
Query: 236 LLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
LLTH+IAK+ GLK G +HT GDAH+Y NH+D LK+QMEREP P++ +I+D+
Sbjct: 234 LLTHMIAKVCGLKAGTLVHTLGDAHVYSNHVDALKTQMEREPYAFPKIRFTRDVSSIDDF 293
Query: 296 TLEDIVLTGYDAHPTI 311
T + IVL Y H I
Sbjct: 294 TSDMIVLEDYKCHGKI 309
>sp|P45350|DRTS_DAUCA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)
[INCLUDES: DIHYDROFOLATE REDUCTASE ; THYMIDYLATE
SYNTHASE ]
pir||S35272 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - carrot
emb|CAA78954.1| dihydrofolate reductase-thymidylate synthetase [Daucus carota]
Length = 528
Score = 273 bits (697), Expect = 4e-72
Identities = 144/307 (46%), Positives = 189/307 (61%), Gaps = 24/307 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + Y LV+ I+ G K+DRT TGT+S+FG QM F+L K FPLLTTKK+ +R + EE
Sbjct: 242 HEEYLYLGLVENIISNGVTKNDRTRTGTVSIFGCQMRFNLRKSFPLLTTKKVFWRGVVEE 301
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K +NIW + R YLD L+ +E
Sbjct: 302 LLWFISGSTNAKILKEKGVNIWEGNGSREYLDSIG-------------LTDRE------- 341
Query: 133 TSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + A ++D + S + DQL VI I NPD RR I SAWN D
Sbjct: 342 -EGDLGPIYGFQWRHFGARYTDMHADYSGQGFDQLLDVISKIKNNPDDRRIIQSAWNPSD 400
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV NG LSC++YQRSAD+ LGVPFNIA+YALLT +IA + L G
Sbjct: 401 LRLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIAAYALLTCMIAHVCDLVPG 460
Query: 251 KFIHTFGDAHIYINHI-DLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
F+H+ GDAH+Y NH+ DL ++ PK P L+I + ++I+ + D L GYD H
Sbjct: 461 DFVHSIGDAHVYSNHLSDLFETSFRMLPKTFPVLKINSGEKDIDSFEAADFKLIGYDPHQ 520
Query: 310 TIKGKLS 316
I+ K++
Sbjct: 521 KIEMKMA 527
>ref|NP_040136.1| thymidylate synthase [Human herpesvirus 3]
sp|P09249|TYSY_VZVD Thymidylate synthase (TS) (TSase)
pir||SYBE13 thymidylate synthase (EC 2.1.1.45) - human herpesvirus 3
emb|CAA27896.1| unnamed protein product [Human herpesvirus 3]
gb|AAT07695.1| thymidylate synthase [Human herpesvirus 3]
gb|AAT07771.1| thymidylate synthase [Human herpesvirus 3]
Length = 301
Score = 273 bits (697), Expect = 5e-72
Identities = 148/304 (48%), Positives = 187/304 (61%), Gaps = 23/304 (7%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELF 74
+ +Y V I+ G K DRTG GTLSLFG Q ++L FPLLTTK++ +R + EEL
Sbjct: 18 ELQYLKQVDDILRYGVRKRDRTGIGTLSLFGMQARYNLRNEFPLLTTKRVFWRAVVEELL 77
Query: 75 WFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTS 134
WFI G TD K L K+I+IW D Y + L++ F K +
Sbjct: 78 WFIRGSTDSKELAAKDIHIW--DIYG----------------SSKFLNRNGF---HKRHT 116
Query: 135 FDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDID 192
DLGPIYG QWR + A + D ++ IDQL VI I TNP+SRR I+S+WN DI
Sbjct: 117 GDLGPIYGFQWRHFGAEYKDCQSNYLQQGIDQLQTVIDTIKTNPESRRMIISSWNPKDIP 176
Query: 193 YMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKF 252
M LPPCH L QFYV NG LSC++YQRS D+ LGVPFNIA YALLT+I+A + GLK G
Sbjct: 177 LMVLPPCHTLCQFYVANGELSCQVYQRSGDMGLGVPFNIAGYALLTYIVAHVTGLKTGDL 236
Query: 253 IHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIK 312
IHT GDAHIY+NHID LK Q+ R PK P L+I +I D+ +D L GY+ HP +K
Sbjct: 237 IHTMGDAHIYLNHIDALKVQLARSPKPFPCLKIIRNVTDINDFKWDDFQLDGYNPHPPLK 296
Query: 313 GKLS 316
+++
Sbjct: 297 MEMA 300
>ref|NP_179230.1| bifunctional dihydrofolate reductase-thymidylate synthase 1 /
DHFR-TS (THY-1) [Arabidopsis thaliana]
sp|Q05762|DRT1_ARATH Bifunctional dihydrofolate reductase-thymidylate synthase 1
(DHFR-TS) [Includes: Dihydrofolate reductase ;
Thymidylate synthase ]
pir||E84539 dihydrofolate reductase-thymidylate synthase [imported] -
Arabidopsis thaliana
gb|AAD22302.1| dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana]
gb|AAL36324.1| putative dihydrofolate reductase-thymidylate synthase [Arabidopsis
thaliana]
gb|AAM45080.1| putative dihydrofolate reductase-thymidylate synthase [Arabidopsis
thaliana]
Length = 519
Score = 272 bits (696), Expect = 6e-72
Identities = 142/306 (46%), Positives = 192/306 (62%), Gaps = 23/306 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + Y N+V+ I+ G +K+DRTGTGTLS FG QM+F+L + FPLLTTK++ +R + EE
Sbjct: 234 HEEFLYLNMVEDIISNGNVKNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEE 293
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI+G T+ K L +K I+IW +A R YLD G L+++E
Sbjct: 294 LLWFISGSTNAKVLQEKGIHIWDGNASREYLD-------------GIGLTERE------- 333
Query: 133 TSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + A ++D + + + DQL VI I NPD RR I+SAWN D
Sbjct: 334 -EGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSD 392
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+ QFYV G LSC++YQRSAD+ LGVPFNIASY+LLT ++A + L G
Sbjct: 393 LKLMALPPCHMFAQFYVAEGELSCQMYQRSADMGLGVPFNIASYSLLTCMLAHVCDLVPG 452
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
FIH GDAH+Y H+ L+ Q+ PK P ++I + I+ + D LTGYD H
Sbjct: 453 DFIHVLGDAHVYKTHVRPLQEQLLNLPKPFPVMKINPEKKQIDSFVASDFDLTGYDPHKK 512
Query: 311 IKGKLS 316
I+ K++
Sbjct: 513 IEMKMA 518
>ref|NP_077428.1| thymidylate synthetase [Cercopithecine herpesvirus 7]
gb|AAG27186.1| thymidylate synthetase [Cercopithecine herpesvirus 7]
Length = 295
Score = 272 bits (696), Expect = 7e-72
Identities = 141/310 (45%), Positives = 191/310 (61%), Gaps = 27/310 (8%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
+ H + +Y V I+ G K DRTGTGTLS+FG Q ++L FPLLTTK++ ++ +
Sbjct: 8 IKHSEYQYLEQVNFILHNGVQKTDRTGTGTLSVFGMQSRYNLRNEFPLLTTKRVFWKGVV 67
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYL--DEFEKGWEGLEHIAGDPLSKQEFVS 128
EEL WFI G T+ L++K + IW+ + +L + F+ EG
Sbjct: 68 EELLWFIKGSTNSTELVEKGVKIWSAHGSKQFLHSNGFDNRQEG---------------- 111
Query: 129 AAKDTSFDLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAW 186
DLGP+YG QWR + A + D N + +DQL VI I TNP+ RR I+ AW
Sbjct: 112 -------DLGPVYGFQWRHFGAEYVDMNTNYFGQGVDQLQNVINLIKTNPNDRRIILCAW 164
Query: 187 NVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAG 246
N D+ MALPPCH+L QFYV N LSC++YQRSAD+ LGVPFNIASYALLT++IA +
Sbjct: 165 NAKDVPLMALPPCHMLCQFYVANNELSCQMYQRSADMGLGVPFNIASYALLTYMIAHVTD 224
Query: 247 LKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYD 306
LK G +HT GDAHIY+NHI+ LK Q+ R+PK+ P L I ++I D+ +D VL GY+
Sbjct: 225 LKTGDLVHTIGDAHIYLNHIEPLKLQLTRQPKQFPTLRITRTVKDINDFKADDFVLEGYN 284
Query: 307 AHPTIKGKLS 316
H +I ++S
Sbjct: 285 PHNSIPMEMS 294
>gb|AAD45276.1| thymidylate synthase [Mycoplasma gallisepticum]
Length = 289
Score = 271 bits (694), Expect = 1e-71
Identities = 146/306 (47%), Positives = 199/306 (65%), Gaps = 28/306 (9%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++K+M +G +K DRT TGT+S FG Q +DL +GFPLLTTKK+ ++ I EL WF+
Sbjct: 4 YLDLLEKVMTKGEVKKDRTNTGTISYFGTQSRYDLREGFPLLTTKKMAWKAICHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK-DTSF- 135
GDT++K L+D N+NIW + Y + F+K G+ L Q+FV K D F
Sbjct: 64 KGDTNMKYLVDHNVNIWNEWPY----EAFKKS----NDFKGESL--QDFVEKIKTDNQFA 113
Query: 136 ----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDI 191
LGP+YGKQWR + +DQ+ VI +I TNP SRR IVSAWN G+I
Sbjct: 114 QQYGKLGPVYGKQWRDFNG-----------VDQIEWVINEIKTNPFSRRLIVSAWNPGEI 162
Query: 192 DYMALPPCHVLFQFYVVNG-TLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
MALPPCH FQF+V +S +LYQRS D+FLGVPFNIASY+LL ++A++ LK
Sbjct: 163 KEMALPPCHSFFQFFVNEKYEISLQLYQRSGDLFLGVPFNIASYSLLLLMVAQVTWLKPA 222
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIHT GD HIY NH++ +K Q++REPK++P++ + +NI D+ EDI L Y+ H
Sbjct: 223 EFIHTIGDTHIYSNHLEQVKIQLQREPKKLPKVTLNPDIKNIFDFRFEDISLENYEHHDP 282
Query: 311 IKGKLS 316
IKGK++
Sbjct: 283 IKGKVA 288
>pdb|1J3I|C Chain C, Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-
Thymidylate Synthase (Pfdhfr-Ts) Complexed With Wr99210,
Nadph, And Dump
pdb|1J3I|D Chain D, Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-
Thymidylate Synthase (Pfdhfr-Ts) Complexed With Wr99210,
Nadph, And Dump
pdb|1J3J|C Chain C, Double Mutant (C59r+s108n) Plasmodium Falciparum
Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts)
Complexed With Pyrimethamine, Nadph, And Dump
pdb|1J3J|D Chain D, Double Mutant (C59r+s108n) Plasmodium Falciparum
Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts)
Complexed With Pyrimethamine, Nadph, And Dump
pdb|1J3K|C Chain C, Quadruple Mutant (N51i+c59r+s108n+i164l) Plasmodium
Falciparum Dihydrofolate Reductase-Thymidylate Synthase
(Pfdhfr-Ts) Complexed With Wr99210, Nadph, And Dump
pdb|1J3K|D Chain D, Quadruple Mutant (N51i+c59r+s108n+i164l) Plasmodium
Falciparum Dihydrofolate Reductase-Thymidylate Synthase
(Pfdhfr-Ts) Complexed With Wr99210, Nadph, And Dump
Length = 328
Score = 271 bits (694), Expect = 1e-71
Identities = 141/301 (46%), Positives = 186/301 (61%), Gaps = 23/301 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ IM G + DRTG G LS FG M+FDLS+ FPLLTTKKL R I EE
Sbjct: 43 HPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEE 102
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 103 LLWFIRGETNGNTLLNKNVRIWEANGTREFLD-----------------NRKLFHREVN- 144
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + + N Y + K +DQL +I I +P SRR ++ AWNV D
Sbjct: 145 ---DLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKD 201
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ TH+IA++ L+
Sbjct: 202 LDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPA 261
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIH G+AH+Y NHID LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 262 QFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 321
Query: 311 I 311
I
Sbjct: 322 I 322
>ref|ZP_00245378.1| COG0207: Thymidylate synthase [Rubrivivax gelatinosus PM1]
Length = 261
Score = 271 bits (693), Expect = 1e-71
Identities = 142/297 (47%), Positives = 177/297 (59%), Gaps = 46/297 (15%)
Query: 27 DEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFINGDTDLKTL 86
D G +K DRTGTGT S+FG QM FDL +GFPL+TTKK+ + I EL WF+ GD + L
Sbjct: 3 DHGVVKADRTGTGTTSVFGHQMRFDLREGFPLVTTKKVHLKSIVLELLWFLRGDGNATWL 62
Query: 87 LDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDLGPIYGKQWR 146
++ + IW DE+ AA D DLGP+YG QWR
Sbjct: 63 QERGVTIW---------DEW----------------------AAPDG--DLGPVYGVQWR 89
Query: 147 SWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFY 206
SW P +DQ+ V+K + TNPDSRR IVSAWNV D+ MAL PCH FQFY
Sbjct: 90 SW------PTPDGGHVDQIAEVVKQLKTNPDSRRIIVSAWNVADLPKMALMPCHAFFQFY 143
Query: 207 VV-------NGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHTFGDA 259
V G LSC+LYQRSAD+FLGVPFNIASYALLTH++A+ L+VG F+ T GD
Sbjct: 144 VAPGDSPSARGRLSCQLYQRSADIFLGVPFNIASYALLTHMLAQQCDLEVGDFVWTGGDC 203
Query: 260 HIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKLS 316
HIY NH + ++ Q+ R P+ P L+IK +I DY ED + GYD HP IK ++
Sbjct: 204 HIYSNHREQVELQLSRAPRPYPTLQIKRRPPSIFDYAYEDFEIIGYDPHPAIKAPVA 260
>gb|AAM88660.1| dihydrofolate reductase-thymidylate synthase [Leishmania tropica]
Length = 520
Score = 271 bits (693), Expect = 1e-71
Identities = 140/315 (44%), Positives = 192/315 (60%), Gaps = 30/315 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ H + +Y L+ +IM G +K+DRTG GT+SLFG QM F L PLLTTK++ +R
Sbjct: 228 VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRGNRLPLLTTKRVFWR 287
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV 127
+ EEL WF+ G+T+ + L DK+I+IW + R +LD GL
Sbjct: 288 GVCEELLWFLRGETNARLLADKDIHIWDGNGSREFLDS-----RGL-------------- 328
Query: 128 SAAKDTSFDLGPIYGKQWRSWAS----FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
++ DLGP+YG QWR + + F N + +DQ+ +++ I NP+ RR +V
Sbjct: 329 --TENKEMDLGPVYGFQWRHFGADYKGFEAN--YDGEGVDQIRFIVETIKANPNDRRLLV 384
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGT--LSCKLYQRSADVFLGVPFNIASYALLTHII 241
+AWN + MALPPCH+L QFYV T LSC LYQRS D+ LGVPFNIASYALLT +I
Sbjct: 385 TAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILI 444
Query: 242 AKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIV 301
AK GL+ G+ +HT GDAH+Y NH+D LK+Q+ER P P L KA + +EDY L D+
Sbjct: 445 AKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKAERQFLEDYELTDME 504
Query: 302 LTGYDAHPTIKGKLS 316
+ Y HP IK +++
Sbjct: 505 VIDYVPHPPIKMEMA 519
>gb|AAL14421.1| thymidylate synthase [Macropodid herpesvirus 1]
Length = 316
Score = 271 bits (693), Expect = 1e-71
Identities = 143/307 (46%), Positives = 192/307 (62%), Gaps = 25/307 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y V +I+ EG K DRTGTGTLS+FG Q ++L FPLLTTK++ ++ + EE
Sbjct: 31 HGEWQYLYQVARILREGYRKGDRTGTGTLSVFGTQARYNLRGEFPLLTTKRVYWKGVVEE 90
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WF+ G T+ K L + + IW R +LD+ G P S++E
Sbjct: 91 LLWFVRGATNTKELSSRGVKIWDAHGSRDFLDK-----------RGFP-SREEG------ 132
Query: 133 TSFDLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGP+YG QWR + + S+ Y S + DQL VI + NPD RR ++ AWN
Sbjct: 133 ---DLGPVYGFQWRHFGAEYRGSEADY-SGQGADQLQYVIDTLKRNPDDRRIVMCAWNPK 188
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCH L QFYV NG LSC+LYQRS D+ LGVPFNIASYALLT++IA + GL
Sbjct: 189 DLPLMALPPCHTLCQFYVANGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHVVGLVP 248
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
G+ +HT GDAHIY+NHI+ L+ Q++REP+ PQL+I +I+ + ED VL GY H
Sbjct: 249 GELVHTLGDAHIYLNHIERLRIQLQREPRPFPQLKIIRAVTSIDYFRSEDFVLEGYRPHS 308
Query: 310 TIKGKLS 316
+K +L+
Sbjct: 309 ALKMELA 315
>gb|AAA29272.1| thymidylate synthase-dihydrofolate reductase (EC 2.1.1.45; EC
1.5.1.3)
Length = 520
Score = 271 bits (693), Expect = 2e-71
Identities = 139/315 (44%), Positives = 191/315 (60%), Gaps = 30/315 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ H + +Y L+ +IM G +K+DRTG GT+SLFG QM F L PLLTTK++ +R
Sbjct: 228 VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWR 287
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV 127
+ EEL WF+ G+T + L DK+I+IW + R +LD GL
Sbjct: 288 GVCEELLWFLRGETSAQLLTDKDIHIWDGNGSREFLDS-----RGL-------------- 328
Query: 128 SAAKDTSFDLGPIYGKQWRSWAS----FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
++ DLGP+YG QWR + + F N + +DQ+ +++ I TNP+ RR +V
Sbjct: 329 --TENKEMDLGPVYGFQWRHFGADYKGFEAN--YDGEGVDQIKLIVETIKTNPNDRRLLV 384
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGT--LSCKLYQRSADVFLGVPFNIASYALLTHII 241
+AWN + MA+PPCH+L QFYV T LSC LYQRS D+ LGVPFNIASYALLT +I
Sbjct: 385 TAWNPCALQKMAVPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILI 444
Query: 242 AKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIV 301
AK GL+ G+ +HT GDAH+Y NH+D LK+Q+ER P P L K + +EDY L D+
Sbjct: 445 AKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQYLEDYELTDME 504
Query: 302 LTGYDAHPTIKGKLS 316
+ Y HP IK +++
Sbjct: 505 VIDYVPHPAIKMEMA 519
>sp|P07382|DRTS_LEIMA Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
[Includes: Dihydrofolate reductase ; Thymidylate
synthase ]
pir||RDLNTS dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - Leishmania major
emb|CAA36019.1| unnamed protein product [Leishmania major]
gb|AAA29232.1| dihydrofolate reductase-thymidylate synthase (EC 1.5.1.3 and EC
2.1.1.45)
Length = 520
Score = 271 bits (693), Expect = 2e-71
Identities = 140/315 (44%), Positives = 191/315 (60%), Gaps = 30/315 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ H + +Y L+ +IM G +K+DRTG GT+SLFG QM F L PLLTTK++ +R
Sbjct: 228 VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWR 287
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV 127
+ EEL WF+ G+T + L DK+I+IW + R +LD GL
Sbjct: 288 GVCEELLWFLRGETSAQLLADKDIHIWDGNGSREFLDS-----RGL-------------- 328
Query: 128 SAAKDTSFDLGPIYGKQWRSWAS----FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
++ DLGP+YG QWR + + F N + +DQ+ +++ I TNP+ RR +V
Sbjct: 329 --TENKEMDLGPVYGFQWRHFGADYKGFEAN--YDGEGVDQIKLIVETIKTNPNDRRLLV 384
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGT--LSCKLYQRSADVFLGVPFNIASYALLTHII 241
+AWN + MALPPCH+L QFYV T LSC LYQRS D+ LGVPFNIASYALLT +I
Sbjct: 385 TAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILI 444
Query: 242 AKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIV 301
AK GL+ G+ +HT GDAH+Y NH+D LK+Q+ER P P L K + +EDY L D+
Sbjct: 445 AKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQYLEDYELTDME 504
Query: 302 LTGYDAHPTIKGKLS 316
+ Y HP IK +++
Sbjct: 505 VIDYVPHPAIKMEMA 519
>ref|NP_702821.1| bifunctional dihydrofolate reductase-thymidylate synthase
[Plasmodium falciparum 3D7]
gb|AAC53680.1| dihydrofolate reductase-thymidylate synthase [synthetic construct]
emb|CAD49208.1| bifunctional dihydrofolate reductase-thymidylate synthase
[Plasmodium falciparum 3D7]
Length = 608
Score = 271 bits (692), Expect = 2e-71
Identities = 141/301 (46%), Positives = 186/301 (61%), Gaps = 23/301 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ IM G + DRTG G LS FG M+FDLS+ FPLLTTKKL R I EE
Sbjct: 323 HPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEE 382
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 383 LLWFIRGETNGNTLLNKNVRIWEANGTREFLD-----------------NRKLFHREVN- 424
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + + N Y + K +DQL +I I +P SRR ++ AWNV D
Sbjct: 425 ---DLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKD 481
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ TH+IA++ L+
Sbjct: 482 LDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPA 541
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIH G+AH+Y NHID LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 542 QFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601
Query: 311 I 311
I
Sbjct: 602 I 602
>gb|AAA29586.1| dihydrofolate reductase-thymidylate synthase (EC 1.5.1.3) (EC
2.1.1.45)
Length = 608
Score = 271 bits (692), Expect = 2e-71
Identities = 141/301 (46%), Positives = 186/301 (61%), Gaps = 23/301 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ IM G + DRTG G LS FG M+FDLS+ FPLLTTKKL R I EE
Sbjct: 323 HPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEE 382
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 383 LLWFIRGETNGNTLLNKNVRIWEANGTREFLD-----------------NRKLFHREVN- 424
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + + N Y + K +DQL +I I +P SRR ++ AWNV D
Sbjct: 425 ---DLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKD 481
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ TH+IA++ L+
Sbjct: 482 LDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPA 541
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIH G+AH+Y NHID LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 542 QFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601
Query: 311 I 311
I
Sbjct: 602 I 602
>ref|ZP_00147048.1| COG0207: Thymidylate synthase [Psychrobacter sp. 273-4]
Length = 300
Score = 271 bits (692), Expect = 2e-71
Identities = 137/301 (45%), Positives = 191/301 (63%), Gaps = 27/301 (8%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L++ ++ EGT K DRTGTGT+S FG Q+ FDL+ GFPLLTTKK+ F+ I EL WF+
Sbjct: 24 YLDLLRLVLSEGTEKGDRTGTGTVSHFGAQLRFDLADGFPLLTTKKVHFKSIIYELLWFL 83
Query: 78 NGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFDL 137
+G T + L + IW + W E A K + DL
Sbjct: 84 SGSTHVDYLQQNGVRIWNE-------------WATAEQTA-----------RFKRLAGDL 119
Query: 138 GPIYGKQWRSWAS--FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMA 195
GPIYG QWR++ + D Y + DQ+ +VI+ I TNP+SRR IVS WN G+ + +A
Sbjct: 120 GPIYGHQWRNYGATKVEDGSYDNDG-FDQISQVIEQIKTNPNSRRLIVSGWNPGEAEQVA 178
Query: 196 LPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHT 255
LPPCH +FQF+V + LSC+LYQRSAD+FLGVPFNIASYALLTH++A++ L+VG+FI T
Sbjct: 179 LPPCHTMFQFFVADNKLSCQLYQRSADLFLGVPFNIASYALLTHMVAQVCDLEVGEFIWT 238
Query: 256 FGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKL 315
GD HIY NH + ++ Q+ RE +P L + ++I + +DI + GY++HP IK ++
Sbjct: 239 GGDCHIYQNHREQVELQLTRELYTLPTLTLNPDVQDIFAFNYDDISVNGYESHPAIKAQV 298
Query: 316 S 316
+
Sbjct: 299 A 299
>pir||RDZQK1 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - malaria parasite (Plasmodium falciparum)
gb|AAA29585.1| dihydrofolate reductase-thymidylate synthase
gb|AAB59212.1| dihydrofolate reductase-thymidylate synthase
Length = 608
Score = 271 bits (692), Expect = 2e-71
Identities = 141/301 (46%), Positives = 186/301 (61%), Gaps = 23/301 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ IM G + DRTG G LS FG M+FDLS+ FPLLTTKKL R I EE
Sbjct: 323 HPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEE 382
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 383 LLWFIRGETNGNTLLNKNVRIWEANGTREFLD-----------------NRKLFHREVN- 424
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + + N Y + K +DQL +I I +P SRR ++ AWNV D
Sbjct: 425 ---DLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKD 481
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ TH+IA++ L+
Sbjct: 482 LDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPA 541
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIH G+AH+Y NHID LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 542 QFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601
Query: 311 I 311
I
Sbjct: 602 I 602
>sp|P13922|DRTS_PLAFK Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
[Includes: Dihydrofolate reductase ; Thymidylate
synthase ]
gb|AAA29580.1| dihydrofolate reductase-thymidylate synthetase
Length = 608
Score = 271 bits (692), Expect = 2e-71
Identities = 141/301 (46%), Positives = 186/301 (61%), Gaps = 23/301 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ IM G + DRTG G LS FG M+FDLS+ FPLLTTKKL R I EE
Sbjct: 323 HPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEE 382
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 383 LLWFIRGETNGNTLLNKNVRIWEANGTREFLD-----------------NRKLFHREVN- 424
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + + N Y + K +DQL +I I +P SRR ++ AWNV D
Sbjct: 425 ---DLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKD 481
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ TH+IA++ L+
Sbjct: 482 LDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPA 541
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIH G+AH+Y NHID LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 542 QFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601
Query: 311 I 311
I
Sbjct: 602 I 602
>gb|AAF80470.2| thymidylate synthase [Trichinella spiralis]
gb|AAK96220.1| thymidylate synthase [Trichinella spiralis]
Length = 307
Score = 270 bits (691), Expect = 2e-71
Identities = 144/309 (46%), Positives = 188/309 (60%), Gaps = 42/309 (13%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ Y N +K I+D G K+DRTG GTLS FG Q + L FPLLTTK++ +R + EEL
Sbjct: 23 ELNYLNQLKDIIDHGVRKNDRTGIGTLSTFGTQSRYCLRDDIFPLLTTKRVFWRGVVEEL 82
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDE-----FEKGWEGLEHIAGDPLSKQEFVS 128
WFI+G T+ K L +KN+NIW ++ R +LD +E+G
Sbjct: 83 LWFISGSTNAKQLSEKNVNIWDGNSSREFLDSRGLYNYEEG------------------- 123
Query: 129 AAKDTSFDLGPIYGKQWRSWASFSDNPYKSK------KEIDQLFRVIKDINTNPDSRRHI 182
DLGP+YG QWR + PY S K DQL + IK I P+SRR I
Sbjct: 124 -------DLGPVYGFQWRHFGC----PYSSMTADYKGKGYDQLQQCIKMIREEPESRRII 172
Query: 183 VSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIA 242
++AWN D++ +ALPPCH QFYV +G LSC++YQRSAD+ LGVPFNIASY+LLT +IA
Sbjct: 173 MTAWNPCDLEKVALPPCHCFVQFYVADGELSCQMYQRSADMGLGVPFNIASYSLLTRMIA 232
Query: 243 KMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVL 302
+ LK G FIHT GDAH+Y+ H+D LK QMER+P+ P+L+I ENI+D+ ED L
Sbjct: 233 HITSLKPGFFIHTIGDAHVYLTHVDALKVQMERKPRPFPKLKILRNVENIDDFRAEDFEL 292
Query: 303 TGYDAHPTI 311
Y +P I
Sbjct: 293 INYKPYPKI 301
>gb|AAM88659.1| dihydrofolate reductase-thymidylate synthase [Leishmania tropica]
Length = 520
Score = 270 bits (690), Expect = 3e-71
Identities = 140/315 (44%), Positives = 191/315 (60%), Gaps = 30/315 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ H + +Y L+ +IM G +K+DRTG GT+SLFG QM F L PLLTTK++ +R
Sbjct: 228 VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRGNRLPLLTTKRVFWR 287
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV 127
+ EEL WF+ G+T+ L DK+I+IW + R +LD GL
Sbjct: 288 GVCEELLWFLRGETNAXLLADKDIHIWDGNGSREFLDS-----RGL-------------- 328
Query: 128 SAAKDTSFDLGPIYGKQWRSWAS----FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
++ DLGP+YG QWR + + F N + +DQ+ +++ I NP+ RR +V
Sbjct: 329 --TENKEMDLGPVYGFQWRHFGADYKGFEAN--YDGEGVDQIRFIVETIKANPNDRRLLV 384
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGT--LSCKLYQRSADVFLGVPFNIASYALLTHII 241
+AWN + MALPPCH+L QFYV T LSC LYQRS D+ LGVPFNIASYALLT +I
Sbjct: 385 TAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILI 444
Query: 242 AKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIV 301
AK GL+ G+ +HT GDAH+Y NH+D LK+Q+ER P P L KA + +EDY L D+
Sbjct: 445 AKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKAERQFLEDYELTDME 504
Query: 302 LTGYDAHPTIKGKLS 316
+ Y HP IK +++
Sbjct: 505 VIDYVPHPPIKMEMA 519
>sp|O02604|DRTS_PLAVI BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)
[INCLUDES: DIHYDROFOLATE REDUCTASE ; THYMIDYLATE
SYNTHASE ]
pir||JC6568 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - Plasmodium vivax
emb|CAA66805.1| dihydrofolate reductase-thymidylate synthetase [Plasmodium vivax]
Length = 623
Score = 269 bits (687), Expect = 7e-71
Identities = 138/308 (44%), Positives = 188/308 (61%), Gaps = 23/308 (7%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M H + +Y ++ I+ G + DRTG G +S FG M+F+LS+ FPLLTTKKL R I
Sbjct: 336 MQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGII 395
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAA 130
EEL WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 396 EELLWFIRGETNGNTLLNKNVRIWEANGTREFLD-----------------NRKLFHREV 438
Query: 131 KDTSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGPIYG QWR + + N + + K +DQL VI I P SRR I+ AWNV
Sbjct: 439 N----DLGPIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNV 494
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ TH+IA++ L+
Sbjct: 495 KDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQ 554
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
+FIH G+AH+Y NH+D LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 555 PAQFIHILGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHH 614
Query: 309 PTIKGKLS 316
I +++
Sbjct: 615 DKITMEMA 622
>sp|Q27783|DRTS_TRYBB Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
[Includes: Dihydrofolate reductase ; Thymidylate
synthase ]
gb|AAA91362.1| dihydrofolate reductase-thymidylate synthase
Length = 527
Score = 267 bits (683), Expect = 2e-70
Identities = 134/305 (43%), Positives = 185/305 (60%), Gaps = 24/305 (7%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y NLV +I+DEG K DRTG GT SLFG QM F L PLLTTK++ +R + EEL
Sbjct: 243 EEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 302
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T+ K L DK I+IW + R +LD +G + +
Sbjct: 303 LWFLRGETNAKLLSDKGIHIWDGNGSRAFLDS--RGLTDYDEM----------------- 343
Query: 134 SFDLGPIYGKQWRSWAS--FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDI 191
DLGP+YG QWR + + S K +DQ+ ++K + NPD RR I +AWN +
Sbjct: 344 --DLGPVYGFQWRHFGADYISCKVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAAL 401
Query: 192 DYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGK 251
MALPPCH++ QFYV NG LSC LYQRS D+ LGVPFNIASYALLT ++AK +GL+ G+
Sbjct: 402 PRMALPPCHMMAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGE 461
Query: 252 FIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTI 311
+HT GDAH+Y NH++ + Q++R P+ P + K E +ED+ DI + Y +P I
Sbjct: 462 LVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVI 521
Query: 312 KGKLS 316
+++
Sbjct: 522 SMEMA 526
>ref|NP_950545.1| thymidylate synthase [Onion yellows phytoplasma OY-M]
dbj|BAD04378.1| thymidylate synthase [Onion yellows phytoplasma]
Length = 288
Score = 267 bits (683), Expect = 2e-70
Identities = 138/305 (45%), Positives = 196/305 (64%), Gaps = 27/305 (8%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWFI 77
Y +L + I+ +G+ ++DRT TGT S+FG QM F+L +GFPLLTTKK+ R I EL WF+
Sbjct: 4 YLDLCRFILQKGSFRNDRTNTGTKSVFGYQMRFNLEEGFPLLTTKKMNLRSIIHELLWFL 63
Query: 78 NGDTDLKTLLDKNINIWTDDAYR------FYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK 131
GDT++ L+ N+NIW + Y+ F+ +E K E LE I DPL A K
Sbjct: 64 KGDTNICYLVQNNVNIWNEWPYQKYQQSAFFQNETLK--EFLEKIKNDPLF------AIK 115
Query: 132 DTSFDLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDI 191
+LGP+YGKQWR + +DQ+ +I +I TNP+SRR I+++WN +
Sbjct: 116 HG--NLGPVYGKQWRDFNG-----------VDQIKFLISEIKTNPNSRRLILNSWNPPLL 162
Query: 192 DYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGK 251
+ MALPPCHVL QFYV G LS +LYQRS DVFLG+PFNIASY+LL ++A++ L+ +
Sbjct: 163 NQMALPPCHVLIQFYVHQGKLSLQLYQRSGDVFLGIPFNIASYSLLLMMVAQVTNLQPYE 222
Query: 252 FIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTI 311
FIHT GDAHIY NH+ +++Q++R PK++PQ+ + +NI+D+ D L Y +
Sbjct: 223 FIHTLGDAHIYSNHLAQVQTQIQRTPKKLPQMILNPDIKNIDDFKFSDFTLQNYQCDGIL 282
Query: 312 KGKLS 316
KG ++
Sbjct: 283 KGDIA 287
>gb|AAM18488.1| dihydrofolate reductase-thymidylate synthase [Trypanosoma cruzi]
Length = 521
Score = 267 bits (683), Expect = 2e-70
Identities = 135/306 (44%), Positives = 186/306 (60%), Gaps = 26/306 (8%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 237 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 296
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 297 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 337
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 338 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 394
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 395 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 454
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY D+ + Y +P
Sbjct: 455 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPP 514
Query: 311 IKGKLS 316
I K++
Sbjct: 515 ISMKMA 520
>sp|Q27793|DRTS_TRYCR BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)
[INCLUDES: DIHYDROFOLATE REDUCTASE ; THYMIDYLATE
SYNTHASE ]
gb|AAB49898.1| dihydrofolate reductase-thymidylate synthase [Trypanosoma cruzi]
Length = 521
Score = 267 bits (682), Expect = 2e-70
Identities = 135/306 (44%), Positives = 186/306 (60%), Gaps = 26/306 (8%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 237 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 296
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 297 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 337
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 338 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 394
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 395 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 454
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY D+ + Y +P
Sbjct: 455 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPP 514
Query: 311 IKGKLS 316
I K++
Sbjct: 515 ISMKMA 520
>gb|AAM18487.1| dihydrofolate reductase-thymidylate synthase [Trypanosoma cruzi]
Length = 521
Score = 267 bits (682), Expect = 2e-70
Identities = 135/306 (44%), Positives = 186/306 (60%), Gaps = 26/306 (8%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 237 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 296
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 297 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 337
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 338 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 394
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 395 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 454
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY D+ + Y +P
Sbjct: 455 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPP 514
Query: 311 IKGKLS 316
I K++
Sbjct: 515 ISMKMA 520
>gb|AAM88576.1| dhfr-ts [Leishmania donovani chagasi]
Length = 520
Score = 266 bits (679), Expect = 6e-70
Identities = 138/315 (43%), Positives = 189/315 (60%), Gaps = 30/315 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ H + +Y L+ +IM G +K+DRTG GT+SLFG QM F L PLLTTK++ +R
Sbjct: 228 VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWR 287
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV 127
+ EEL WF+ G+T+ + L DK+I+IW + R +LD GL
Sbjct: 288 GVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDS-----RGL-------------- 328
Query: 128 SAAKDTSFDLGPIYGKQWRSWAS----FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
++ DLGP+YG QWR + + F N + +DQ+ +++ I NP+ RR +
Sbjct: 329 --TENKEMDLGPVYGFQWRHFGADYKGFEAN--YDGEGVDQIRSIVETIKANPNDRRLLF 384
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGT--LSCKLYQRSADVFLGVPFNIASYALLTHII 241
+AWN + MALPPCH+L QFYV T LSC LYQRS D+ LGVPFNIASYALLT +I
Sbjct: 385 TAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILI 444
Query: 242 AKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIV 301
AK GL+ G+ +HT GDAH+Y NH+ LKSQ+ER P P L K + +EDY L D+
Sbjct: 445 AKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDME 504
Query: 302 LTGYDAHPTIKGKLS 316
+ Y HP IK +++
Sbjct: 505 VIDYVPHPPIKMEMA 519
>gb|AAM82248.1| dihydrofolate reductase/thymidylate synthase [Leishmania infantum]
Length = 520
Score = 265 bits (678), Expect = 7e-70
Identities = 138/315 (43%), Positives = 189/315 (60%), Gaps = 30/315 (9%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ H + +Y L+ +IM G +K+DRTG GT+SLFG QM F L PLLTTK++ +R
Sbjct: 228 VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWR 287
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV 127
+ EEL WF+ G+T+ + L DK+I+IW + R +LD GL
Sbjct: 288 GVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDS-----RGL-------------- 328
Query: 128 SAAKDTSFDLGPIYGKQWRSWAS----FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIV 183
++ DLGP+YG QWR + + F N + +DQ+ +++ I NP+ RR +
Sbjct: 329 --TENKEMDLGPVYGFQWRHFGADYKGFEAN--YDGEGVDQIRSIVETIKANPNDRRLLF 384
Query: 184 SAWNVGDIDYMALPPCHVLFQFYVVNGT--LSCKLYQRSADVFLGVPFNIASYALLTHII 241
+AWN + MALPPCH+L QFYV T LSC LYQRS D+ LGVPFNIASYALLT +I
Sbjct: 385 TAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILI 444
Query: 242 AKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIV 301
AK GL+ G+ +HT GDAH+Y NH+ LKSQ+ER P P L K + +EDY L D+
Sbjct: 445 AKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDME 504
Query: 302 LTGYDAHPTIKGKLS 316
+ Y HP IK +++
Sbjct: 505 VIDYVPHPPIKMEMA 519
>sp|O96650|TYSY_ASCSU Thymidylate synthase (TS) (TSase)
gb|AAC97507.1| thymidylate synthase; TS [Ascaris suum]
Length = 294
Score = 265 bits (678), Expect = 8e-70
Identities = 142/304 (46%), Positives = 184/304 (60%), Gaps = 30/304 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +K I+DEG DRTG GTLSLFG + L G PLLTTK++ ++ + EEL
Sbjct: 10 ERKYLRQIKHIIDEGDKVIDRTGVGTLSLFGLHSTYSLRNGVIPLLTTKRVYWKGVVEEL 69
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDE--FEKGWEGLEHIAGDPLSKQEFVSAAK 131
WFI GDTD K L K + IW + R +LD F+ EG
Sbjct: 70 LWFIKGDTDAKRLSAKGVKIWDANGSREFLDSQGFKDRPEG------------------- 110
Query: 132 DTSFDLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGPIYG QWR + + +D YK + +DQL VI+ I NP+SRR I++AWNV
Sbjct: 111 ----DLGPIYGFQWRHFGAEYHGTDADYKGQG-VDQLADVIEQIKNNPNSRRIILNAWNV 165
Query: 189 GDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLK 248
D+ MALPPCH L QF V NG LSC+LYQRS D+ LGVPFN+ASY LLTH+IA + LK
Sbjct: 166 KDLHQMALPPCHTLAQFAVKNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCALK 225
Query: 249 VGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAH 308
G H GDAH+Y+NHID LK Q+ R+P+ P + + ++I+D+T E I+L GY+
Sbjct: 226 TGFLHHVLGDAHVYLNHIDALKEQLSRDPRPFPTVHFEGRIDSIDDFTAESIILNGYNPM 285
Query: 309 PTIK 312
IK
Sbjct: 286 APIK 289
>prf||2103303A dihydrofolate reductase/thymidylate synthase
Length = 521
Score = 265 bits (676), Expect = 1e-69
Identities = 134/306 (43%), Positives = 185/306 (60%), Gaps = 26/306 (8%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 237 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 296
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 297 LWFLRGETYAKKLSDKGVHIWDDNGSRRFLDS--RGLTEYEEM----------------- 337
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 338 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 394
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ L VPFNIASYALLT +IAK GL+ G
Sbjct: 395 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLAVPFNIASYALLTILIAKATGLRPG 454
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY D+ + Y +P
Sbjct: 455 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPP 514
Query: 311 IKGKLS 316
I K++
Sbjct: 515 ISMKMA 520
>sp|P16126|DRTS_LEIAM BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)
[INCLUDES: DIHYDROFOLATE REDUCTASE ; THYMIDYLATE
SYNTHASE ]
pir||RDLNTZ dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - Leishmania mexicana amazonensis
emb|CAA36020.1| unnamed protein product [Leishmania amazonensis]
Length = 520
Score = 264 bits (675), Expect = 1e-69
Identities = 139/313 (44%), Positives = 188/313 (60%), Gaps = 26/313 (8%)
Query: 9 IKMTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFR 67
+ H + +Y L+ +IM G K+DRTG GTLSLFG QM F L PLLTTK++ +R
Sbjct: 228 VPRNHEERQYLELIDRIMKTGIAKEDRTGVGTLSLFGAQMRFSLRDNRLPLLTTKRVFWR 287
Query: 68 IIAEELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFV 127
+ EEL WF+ G+T+ + L DK+I+IW + R +LD GL
Sbjct: 288 GVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDS-----RGL-------------- 328
Query: 128 SAAKDTSFDLGPIYGKQWRSW-ASFSDNPYKSKKE-IDQLFRVIKDINTNPDSRRHIVSA 185
++T DLGP+YG QWR + A + E +DQ+ +++ I NP+ RR + +A
Sbjct: 329 --TENTEMDLGPVYGFQWRHFGAEYRGLEANYDGEGVDQIKFIVETIKANPNDRRLLFTA 386
Query: 186 WNVGDIDYMALPPCHVLFQFYV--VNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAK 243
WN + MALPPCH+L QFYV LSC LYQRS D+ LGVPFNIASYALLT +IAK
Sbjct: 387 WNPCALHKMALPPCHLLAQFYVNTEKSELSCMLYQRSCDMGLGVPFNIASYALLTILIAK 446
Query: 244 MAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLT 303
GL+ G+ +HT GDAH+Y +HID LK+Q+ER P P L K + +EDY L D+ +
Sbjct: 447 ATGLRPGELVHTLGDAHVYRSHIDALKAQLERVPHAFPTLVFKEERQFLEDYELMDMEVI 506
Query: 304 GYDAHPTIKGKLS 316
Y HP IK +++
Sbjct: 507 DYVPHPPIKMEMA 519
>gb|EAK87446.1| dihydrofolate reductase-thymidylate synthase [Cryptosporidium
parvum]
Length = 531
Score = 264 bits (674), Expect = 2e-69
Identities = 137/311 (44%), Positives = 192/311 (61%), Gaps = 32/311 (10%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y +L+ ++++ G +++RTG T S+FG M FD+ + FPLLTTKK+ R I EE
Sbjct: 245 HYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEE 304
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI GDT+ L++K + IW+ + + YL+ GL H ++E
Sbjct: 305 LIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERI-----GLGH-------REEN------ 346
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKSKKE------IDQLFRVIKDINTNPDSRRHIVSAW 186
DLGPIYG QWR + + YK+ + +DQL ++I+ + NP RRHI++AW
Sbjct: 347 ---DLGPIYGFQWRHY----NGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAW 399
Query: 187 NVGDIDYMALPPCHVLFQFYVVN-GTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMA 245
N + MALPPCHVL Q+YV N LSC LYQRS D+ LG PFNIASYA+LT ++A++
Sbjct: 400 NPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVC 459
Query: 246 GLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGY 305
G + G+ GDAHIY NH+ LK Q+ R P+ PQL+ K ENIED+ EDI L GY
Sbjct: 460 GYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGY 519
Query: 306 DAHPTIKGKLS 316
+PTIK +++
Sbjct: 520 YPYPTIKMEMA 530
>ref|NP_758075.1| thymidylate synthase [Mycoplasma penetrans HF-2]
sp|Q8EV81|TYSY_MYCPE Thymidylate synthase (TS) (TSase)
dbj|BAC44479.1| thymidylate synthase [Mycoplasma penetrans HF-2]
Length = 289
Score = 264 bits (674), Expect = 3e-69
Identities = 136/301 (45%), Positives = 195/301 (64%), Gaps = 16/301 (5%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
EY +L+K ++D G ++++RT T ++ FG Q +DL+KGFPLLTTKK+ ++ I EL WF
Sbjct: 3 EYKDLLKLVLDNGIMQENRTDTDAIAYFGTQSRYDLTKGFPLLTTKKMAYKAIFHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
+ G+T++K L+D N+ IW + Y Y E ++ L +E S AK +
Sbjct: 63 LKGETNIKYLVDNNVKIWNEWPYENYKKSPYFKNESIDEFI---LKIKEDDSFAKQFG-E 118
Query: 137 LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDYMAL 196
LGP+YG+QWR++ +DQ+ +I++I N SRR IVS WN +I M L
Sbjct: 119 LGPVYGRQWRNFNG-----------VDQITNLIEEIKKNKYSRRLIVSVWNPSEIKNMLL 167
Query: 197 PPCHVLFQFYV-VNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFIHT 255
PPCH LFQF+V LSC+LYQRSAD+FLGVPFNIASY+LLT++IA++ +F+HT
Sbjct: 168 PPCHCLFQFFVNSKNELSCQLYQRSADLFLGVPFNIASYSLLTYMIAQVTNTTAKEFVHT 227
Query: 256 FGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKGKL 315
G AHIY NHID +K Q+ REP ++P L + +NI D+ +EDI + Y++HP IKGK+
Sbjct: 228 IGVAHIYNNHIDQVKEQLTREPLQLPTLVLNKNIKNIFDFKIEDIEIKDYNSHPAIKGKV 287
Query: 316 S 316
+
Sbjct: 288 A 288
>ref|NP_072893.1| thymidylate synthase (thyA) [Mycoplasma genitalium G-37]
sp|P47469|TYSY_MYCGE Thymidylate synthase (TS) (TSase)
pir||A64225 thymidylate synthase (EC 2.1.1.45) - Mycoplasma genitalium
gb|AAC71448.1| thymidylate synthase (thyA) [Mycoplasma genitalium G-37]
Length = 287
Score = 263 bits (673), Expect = 3e-69
Identities = 143/306 (46%), Positives = 196/306 (64%), Gaps = 28/306 (9%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y +L ++ G + +RT T TLS+FG QM+FDL+ FPLLTTKK+ ++ I EL WF
Sbjct: 3 QYLDLASYVLANGKKRKNRTDTDTLSVFGYQMKFDLTNSFPLLTTKKVNWKAIVHELLWF 62
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK-DTSF 135
I GDT++K L+D +NIW + Y + F+K + L QEF+ K D F
Sbjct: 63 IKGDTNIKYLVDNGVNIWNEWPY----ENFKKS----PSFQNETL--QEFILKVKTDNEF 112
Query: 136 -----DLGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YGKQWR++ +DQL +VI++I NP+SRR IVS+WN +
Sbjct: 113 AKQFADLGPVYGKQWRNFNG-----------VDQLKKVIQEIKENPNSRRLIVSSWNPSE 161
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
++ MAL PCH LFQFYV LS +LYQRS D+FLGVPFNIASYALL +++A LK G
Sbjct: 162 LEKMALAPCHSLFQFYVEEDKLSLQLYQRSGDIFLGVPFNIASYALLVYLVAHETKLKPG 221
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
FIHT GDAHIY NHI+ +K Q+ R + PQ+ +K+ ++I Y+ +DI L GY+ HP
Sbjct: 222 YFIHTLGDAHIYENHIEQIKLQLTRTTLDPPQVVLKS-DKSIFAYSFDDIELVGYNYHPF 280
Query: 311 IKGKLS 316
I G+++
Sbjct: 281 IYGRVA 286
>pdb|1QZF|A Chain A, Crystal Structure Of Dhfr-Ts From Cryptosporidium Hominis
pdb|1QZF|B Chain B, Crystal Structure Of Dhfr-Ts From Cryptosporidium Hominis
pdb|1QZF|C Chain C, Crystal Structure Of Dhfr-Ts From Cryptosporidium Hominis
pdb|1QZF|D Chain D, Crystal Structure Of Dhfr-Ts From Cryptosporidium Hominis
pdb|1QZF|E Chain E, Crystal Structure Of Dhfr-Ts From Cryptosporidium Hominis
gb|AAC47230.1| bifunctional dihydrofolate reductase-thymidylate synthase
Length = 521
Score = 263 bits (672), Expect = 4e-69
Identities = 137/307 (44%), Positives = 189/307 (61%), Gaps = 32/307 (10%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y +L+ ++++ G +++RTG T S+FG M FD+ + FPLLTTKK+ R I EE
Sbjct: 235 HYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEE 294
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI GDT+ L++K + IW+ + + YL+ GL H ++E
Sbjct: 295 LIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERI-----GLGH-------REEN------ 336
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKSKKE------IDQLFRVIKDINTNPDSRRHIVSAW 186
DLGPIYG QWR + + YK+ + +DQL ++I+ + NP RRHI++AW
Sbjct: 337 ---DLGPIYGFQWRHY----NGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAW 389
Query: 187 NVGDIDYMALPPCHVLFQFYVVN-GTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMA 245
N + MALPPCHVL Q+YV N LSC LYQRS D+ LG PFNIASYA+LT ++A++
Sbjct: 390 NPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVC 449
Query: 246 GLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGY 305
G + G+ GDAHIY NH+ LK Q+ R P+ PQL+ K ENIED+ EDI L GY
Sbjct: 450 GYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGY 509
Query: 306 DAHPTIK 312
+PTIK
Sbjct: 510 YPYPTIK 516
>sp|P20712|DRTS_PLACH BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)
[INCLUDES: DIHYDROFOLATE REDUCTASE ; THYMIDYLATE
SYNTHASE ]
pir||RDZQTB dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC
2.1.1.45) - Plasmodium chabaudi
gb|AAA29587.1| dihydrofolate reductase/thymidylate synthase
Length = 583
Score = 263 bits (671), Expect = 5e-69
Identities = 139/302 (46%), Positives = 188/302 (62%), Gaps = 25/302 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ I+ G +DDRTG G LS FG M+F+LS+ FPLLTTKKL R I EE
Sbjct: 298 HPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLSEYFPLLTTKKLFVRGIIEE 357
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 358 LLWFIRGETNGNTLLEKNVRIWEANGTREFLD-----------------NRKLFHREVN- 399
Query: 133 TSFDLGPIYGKQWRSW-ASFSD--NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGPIYG QWR + A ++D YK K +DQL +I I +P RR I+ AWNV
Sbjct: 400 ---DLGPIYGFQWRHFGAEYTDMHADYKDKG-VDQLKNIINLIKNDPTCRRIILCAWNVK 455
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ T++IA++ L+
Sbjct: 456 DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQP 515
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
+FIH G+AH+Y NH++ LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 516 AEFIHVLGNAHVYNNHVESLKVQLNRTPYPFPTLKLNPEIKNIEDFTISDFTVQNYVHHD 575
Query: 310 TI 311
I
Sbjct: 576 KI 577
>ref|ZP_00063209.1| COG0207: Thymidylate synthase [Leuconostoc mesenteroides subsp.
mesenteroides ATCC 8293]
Length = 322
Score = 262 bits (670), Expect = 6e-69
Identities = 134/323 (41%), Positives = 199/323 (61%), Gaps = 19/323 (5%)
Query: 11 MTHVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIA 70
M+ + +Y +L +KI+DEG+ K DRTGTGT SLFG QM F+L++GFPLLTTKK+ F +I
Sbjct: 1 MSQNEQQYLDLAQKILDEGSHKGDRTGTGTRSLFGTQMRFNLAEGFPLLTTKKVFFGLIK 60
Query: 71 EELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAA 130
EL WF+ GD +++ LL+ N +IW + A++ +++ + + + + + F
Sbjct: 61 SELLWFLRGDNNIRFLLEHNNHIWDEWAFKKWIESDKYTGPDMTNFGLRSQTDENFAKIY 120
Query: 131 K------------DTSFD-----LGPIYGKQWRSWASFSDNPYKSKKEIDQLFRVIKDIN 173
K D F +G +YGK WRSW + ++ + +DQ+ R+I I
Sbjct: 121 KEQKDIFVNNILNDDEFKEEFGYIGNVYGKLWRSWET--NSLTAGDETVDQVARLIDQIK 178
Query: 174 TNPDSRRHIVSAWNVGDIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIAS 233
P+SRR I++AWN LP CHVL QFYV +G LS ++YQRS D FLGVPFNIAS
Sbjct: 179 ETPNSRRLILTAWNAETTPQAPLPSCHVLSQFYVADGKLSLQMYQRSGDFFLGVPFNIAS 238
Query: 234 YALLTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIE 293
Y+LL H++A G +VG+FIHT GD HIY NH+D + Q+ R ++P+L + +++
Sbjct: 239 YSLLLHMVAAQTGYEVGEFIHTIGDTHIYNNHVDQITEQLSRPMHKLPKLWLNPEVKSLF 298
Query: 294 DYTLEDIVLTGYDAHPTIKGKLS 316
DYT++DI + YD+ P IK ++
Sbjct: 299 DYTMDDIKILDYDSEPAIKAPVA 321
>sp|Q27713|DRTS_PLABA BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)
[INCLUDES: DIHYDROFOLATE REDUCTASE ; THYMIDYLATE
SYNTHASE ]
gb|AAB60237.1| dihydrofolate reductase thymidylate synthase
Length = 587
Score = 262 bits (669), Expect = 8e-69
Identities = 138/302 (45%), Positives = 189/302 (62%), Gaps = 25/302 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ I+ G +DDRTG G LS FG M+F+L++ FPLLTTKKL R I EE
Sbjct: 302 HPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLNEYFPLLTTKKLFIRGIIEE 361
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 362 LLWFIRGETNGNTLLEKNVRIWEANGTREFLD-----------------NRKLFHREVN- 403
Query: 133 TSFDLGPIYGKQWRSW-ASFSD--NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGPIYG QWR + A ++D + YK K +DQL +I I +P RR I+ AWNV
Sbjct: 404 ---DLGPIYGFQWRHFGAEYTDMHDNYKDKG-VDQLKNIINLIKNDPTCRRIILCAWNVK 459
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
++D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ T++IA++ L+
Sbjct: 460 NLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQA 519
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
+FIH G+AH+Y NHI+ LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 520 AEFIHVLGNAHVYNNHIESLKIQLNRTPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHD 579
Query: 310 TI 311
I
Sbjct: 580 KI 581
>gb|EAA16220.1| thymidylate synthase, putative [Plasmodium yoelii yoelii]
Length = 588
Score = 262 bits (669), Expect = 1e-68
Identities = 139/302 (46%), Positives = 189/302 (62%), Gaps = 25/302 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ I+ G +DDRTG G LS FG M+F+L++ FPLLTTKKL R I EE
Sbjct: 303 HPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLNQYFPLLTTKKLFVRGIIEE 362
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD +++ F
Sbjct: 363 LLWFIRGETNGNTLLEKNVRIWEANGTREFLD-----------------NRKLFHREVN- 404
Query: 133 TSFDLGPIYGKQWRSW-ASFSD--NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGPIYG QWR + A ++D + YK K +DQL +I I +P RR I+ AWNV
Sbjct: 405 ---DLGPIYGFQWRHFGAEYTDMHDNYKDKG-VDQLKNIINLIKNDPTCRRIILCAWNVK 460
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+D MALPPCH+L QFYV +G LSC +YQRS D+ LGVPFNIASY++ T++IA++ L+
Sbjct: 461 DLDKMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQP 520
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
+FIH G+AH+Y NHI+ LK Q+ R P P L++ +NIED+T+ D + Y H
Sbjct: 521 AEFIHVLGNAHVYNNHIESLKIQLNRTPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHD 580
Query: 310 TI 311
I
Sbjct: 581 KI 582
>gb|AAF59990.1| thymidylate synthetase [Macaca mulatta rhadinovirus 26-95]
Length = 333
Score = 261 bits (667), Expect = 1e-68
Identities = 135/307 (43%), Positives = 182/307 (59%), Gaps = 25/307 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y + I+ G ++DRTG GT S+FG Q ++L FPLLTTK++ +R + EE
Sbjct: 48 HGELQYLAHLDLIIKHGVQREDRTGVGTRSVFGLQARYNLRDEFPLLTTKRVFWRGVVEE 107
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G TD L + + IW R +L + Q F
Sbjct: 108 LLWFIRGSTDSTELSRRGVKIWDAHGSRAFL------------------AAQGF---GDR 146
Query: 133 TSFDLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGP+YG QWR + + +D Y+ + +DQL V+ IN P RR ++ AWN
Sbjct: 147 REGDLGPVYGFQWRHFGAEYRGADANYEGQG-VDQLRYVVDLINRRPHDRRIVMCAWNPA 205
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCHVL QFYV G LSC+LYQRSAD+ LGVPFNIASYALLT++IA + GL
Sbjct: 206 DLARMALPPCHVLCQFYVARGELSCQLYQRSADMGLGVPFNIASYALLTYLIAHVTGLTP 265
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
G F+HT GDAH+Y NH+D L Q+ R P+ P+L+I +ED+T D+ L GYD HP
Sbjct: 266 GDFVHTLGDAHVYNNHVDPLLLQLRRTPRPFPRLKILRKVARLEDFTRADLSLEGYDPHP 325
Query: 310 TIKGKLS 316
I+ +++
Sbjct: 326 HIEMEMA 332
>ref|NP_570754.1| thymidylate synthase [Macaca mulatta rhadinovirus]
gb|AAD21340.1| thymidylate synthase [Macaca mulatta rhadinovirus 17577]
gb|AAD53009.1| thymidylate synthase [Cercopithecine herpesvirus 17]
Length = 333
Score = 261 bits (667), Expect = 1e-68
Identities = 135/307 (43%), Positives = 182/307 (59%), Gaps = 25/307 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y + I+ G ++DRTG GT S+FG Q ++L FPLLTTK++ +R + EE
Sbjct: 48 HGELQYLAHLDLIIKHGVQREDRTGVGTRSVFGLQARYNLRDEFPLLTTKRVFWRGVVEE 107
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G TD L + + IW R +L + Q F
Sbjct: 108 LLWFIRGSTDSTELSRRGVKIWDAHGSRAFL------------------AAQGF---GDR 146
Query: 133 TSFDLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGP+YG QWR + + +D Y+ + +DQL V+ IN P RR ++ AWN
Sbjct: 147 REGDLGPVYGFQWRHFGAEYRGADANYEGQG-VDQLRYVVDLINRRPHDRRIVMCAWNPA 205
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCHVL QFYV G LSC+LYQRSAD+ LGVPFNIASYALLT++IA + GL
Sbjct: 206 DLARMALPPCHVLCQFYVARGELSCQLYQRSADMGLGVPFNIASYALLTYLIAHVTGLTP 265
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
G F+HT GDAH+Y NH+D L Q+ R P+ P+L+I +ED+T D+ L GYD HP
Sbjct: 266 GDFVHTLGDAHVYNNHVDPLLLQLRRTPRPFPRLKILRKVARLEDFTRADLSLEGYDPHP 325
Query: 310 TIKGKLS 316
I+ +++
Sbjct: 326 HIEMEMA 332
>gb|AAK71186.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma
vespertilionis]
Length = 491
Score = 261 bits (667), Expect = 2e-68
Identities = 131/285 (45%), Positives = 177/285 (62%), Gaps = 26/285 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 227 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 286
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 287 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 327
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 328 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 384
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 385 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 444
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
+ +HT GDAH+Y NH++ K Q++R P+ P L + E +EDY
Sbjct: 445 ELVHTLGDAHVYSNHVEPCKEQLKRVPRAFPYLVFRREREFLEDY 489
>ref|NP_586629.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuniculi]
ref|NP_586757.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuniculi]
emb|CAD24888.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuniculi]
emb|CAD25016.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuniculi]
Length = 294
Score = 261 bits (666), Expect = 2e-68
Identities = 137/309 (44%), Positives = 187/309 (60%), Gaps = 27/309 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAE 71
H + +Y +LVK I++ G + DRTGTGTLS+FG M F L FPLLTT+++ +R + E
Sbjct: 7 HPEHQYLDLVKHILENGARRMDRTGTGTLSVFGATMRFSLEDNTFPLLTTRRVFYRGVVE 66
Query: 72 ELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK 131
EL +F+ G+TD K L K + IW + + +L G++ GD
Sbjct: 67 ELLFFLRGETDSKVLEKKGVRIWEKNGAKQFLQSV-----GIDREEGD------------ 109
Query: 132 DTSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
LGPIYG QWR + + + S K +DQ+ I I NP SRR +VSAWN
Sbjct: 110 -----LGPIYGFQWRHFGARYETSASSYEGKGVDQIASAIAAIRANPASRRIVVSAWNPT 164
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCHVLFQF V +G LSC +YQRS D+ LGVPFNIASY+LLT ++A + GL+
Sbjct: 165 DLGSMALPPCHVLFQFNVTDGKLSCAMYQRSGDMGLGVPFNIASYSLLTILVAHLTGLQP 224
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEI--KAVHENIEDYTLEDIVLTGYDA 307
G+F+H GDAH+Y++H+D L+ Q++R P+ P+L + K E + ED L GYD
Sbjct: 225 GEFVHFLGDAHVYLDHVDSLRQQIQRPPRAFPKLFVSPKGPRTEPEHFQYEDFELVGYDP 284
Query: 308 HPTIKGKLS 316
HP IK +S
Sbjct: 285 HPAIKMNMS 293
>ref|NP_597138.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuniculi]
emb|CAD26314.1| THYMIDYLATE SYNTHASE [Encephalitozoon cuniculi]
Length = 294
Score = 260 bits (665), Expect = 2e-68
Identities = 137/309 (44%), Positives = 187/309 (60%), Gaps = 27/309 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAE 71
H + +Y +LVK I++ G + DRTGTGTLS+FG M F L FPLLTT+++ +R + E
Sbjct: 7 HPEHQYLDLVKHILENGARRMDRTGTGTLSVFGATMRFSLEDNTFPLLTTRRVFYRGVVE 66
Query: 72 ELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK 131
EL +F+ G+TD K L K + IW + + +L G++ GD
Sbjct: 67 ELLFFLRGETDSKVLEKKGVRIWEKNGAKQFLQSV-----GIDREEGD------------ 109
Query: 132 DTSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
LGPIYG QWR + + + S K +DQ+ I I NP SRR +VSAWN
Sbjct: 110 -----LGPIYGFQWRHFGARYETSASSYEGKGVDQIASAIAAIRANPASRRIVVSAWNPT 164
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCHVLFQF V +G LSC +YQRS D+ LGVPFNIASY+LLT ++A + GL+
Sbjct: 165 DLGSMALPPCHVLFQFNVTDGKLSCAMYQRSGDMGLGVPFNIASYSLLTILVAHLTGLQP 224
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEI--KAVHENIEDYTLEDIVLTGYDA 307
G+F+H GDAH+Y++H+D L+ Q++R P+ P+L + K E + ED L GYD
Sbjct: 225 GEFVHFLGDAHVYLDHVDSLRQQVQRPPRAFPKLFVSPKGPRTEPEHFQYEDFELVGYDP 284
Query: 308 HPTIKGKLS 316
HP IK +S
Sbjct: 285 HPAIKMNMS 293
>ref|NP_572063.1| ORF 70; thymidylate synthase TS homolog [Human herpesvirus 8]
sp|P90463|TYSY_HHV8 Thymidylate synthase (TS) (TSase)
gb|AAC57092.1| ORF 70; thymidylate synthase TS homolog [Human herpesvirus 8]
gb|AAC56948.1| thymidylate synthase homolog [Human herpesvirus 8]
gb|AAB62673.1| ORF 70, thymidylate synthase (TS) homolog [Human herpesvirus 8]
gb|AAC34940.1| thymidylate synthase [Human herpesvirus 8]
Length = 337
Score = 260 bits (664), Expect = 3e-68
Identities = 135/307 (43%), Positives = 190/307 (61%), Gaps = 25/307 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y +++I+ G+ + DRTG GTLSLFG Q + L FPLLTTK++ +R + +E
Sbjct: 52 HEELQYLRQLREILCRGSDRLDRTGIGTLSLFGMQARYSLRDHFPLLTTKRVFWRGVVQE 111
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WF+ G TD + L + IW + R EF G GL H ++E
Sbjct: 112 LLWFLKGSTDSRELSRTGVKIWDKNGSR----EFLAG-RGLAH-------RREG------ 153
Query: 133 TSFDLGPIYGKQWRSWASF---SDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGP+YG QWR + + +D Y + + DQL ++ I NP RR I+ AWN
Sbjct: 154 ---DLGPVYGFQWRHFGAAYVDADADY-TGQGFDQLSYIVDLIKNNPHDRRIIMCAWNPA 209
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCH+L QFYV +G LSC+LYQRS D+ LGVPFNIASY+LLT+++A + GL+
Sbjct: 210 DLSLMALPPCHLLCQFYVADGELSCQLYQRSGDMGLGVPFNIASYSLLTYMLAHVTGLRP 269
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHP 309
G+FIHT GDAHIY HI+ L+ Q+ R P+ P+LEI ++E++T +D L Y HP
Sbjct: 270 GEFIHTLGDAHIYKTHIEPLRLQLTRTPRPFPRLEILRSVSSMEEFTPDDFRLVDYCPHP 329
Query: 310 TIKGKLS 316
TI+ +++
Sbjct: 330 TIRMEMA 336
>ref|NP_984315.1| ADR219Cp [Eremothecium gossypii]
gb|AAS52139.1| ADR219Cp [Eremothecium gossypii]
Length = 340
Score = 260 bits (664), Expect = 4e-68
Identities = 149/313 (47%), Positives = 190/313 (60%), Gaps = 33/313 (10%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGP-QMEFDLS-KGFPLLTTKKLPFRIIAEE 72
+ +Y +L K+I++ G + DRTGTGT SLF P Q+ FDLS FPLLTTKK+ R I E
Sbjct: 49 EQQYLDLCKRIIEHGEFRPDRTGTGTYSLFAPPQLRFDLSGDKFPLLTTKKVFTRGIILE 108
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G TD K L ++ + IW + R YLD GL ++E
Sbjct: 109 LLWFIAGCTDGKKLSEQGVKIWEGNGSREYLDGL-----GLH-------DRREG------ 150
Query: 133 TSFDLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
DLGP+YG QWR + + D+ Y + K +DQL +I I P RR I+SAWN
Sbjct: 151 ---DLGPVYGFQWRHFGAEYGTCDDDY-TGKGVDQLRELIDKIKNKPYDRRIILSAWNPA 206
Query: 190 DIDYMALPPCHVLFQFYVVNG------TLSCKLYQRSADVFLGVPFNIASYALLTHIIAK 243
D MALPPCHVL QFYV G LSC+LYQRS D+ LGVPFNIASYALLT +IA
Sbjct: 207 DFPKMALPPCHVLSQFYVSFGPEGSRPKLSCQLYQRSCDMGLGVPFNIASYALLTKMIAM 266
Query: 244 MAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLT 303
+ + G+FIHT GDAH+Y +HI LK Q+ER P+E P L IK +I+D+TL+D +T
Sbjct: 267 VCDMDAGEFIHTMGDAHVYSDHIAALKEQIERVPREFPNLRIKRKVTDIDDFTLDDFEIT 326
Query: 304 GYDAHPTIKGKLS 316
Y+ HP I+ +S
Sbjct: 327 DYNPHPRIQMNMS 339
>gb|AAK71144.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71145.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71146.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71147.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71148.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71149.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71151.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71152.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71153.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71155.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71156.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71157.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71158.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71160.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
Length = 491
Score = 259 bits (663), Expect = 4e-68
Identities = 130/285 (45%), Positives = 176/285 (61%), Gaps = 26/285 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 227 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 286
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 287 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 327
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 328 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 384
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 385 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 444
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY
Sbjct: 445 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489
>gb|AAK71166.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71167.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71168.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71169.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71170.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71171.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71172.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71173.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71175.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71179.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71181.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71183.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
Length = 491
Score = 259 bits (663), Expect = 4e-68
Identities = 130/285 (45%), Positives = 176/285 (61%), Gaps = 26/285 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 227 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 286
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 287 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 327
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 328 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 384
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 385 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 444
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY
Sbjct: 445 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489
>gb|AAK71159.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71161.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71162.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71163.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71164.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71165.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71174.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71176.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71178.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71180.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71182.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
Length = 491
Score = 259 bits (663), Expect = 4e-68
Identities = 130/285 (45%), Positives = 176/285 (61%), Gaps = 26/285 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 227 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 286
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 287 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 327
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 328 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 384
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 385 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 444
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY
Sbjct: 445 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489
>gb|AAK71177.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
Length = 491
Score = 259 bits (663), Expect = 4e-68
Identities = 130/285 (45%), Positives = 176/285 (61%), Gaps = 26/285 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 227 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 286
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 287 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 327
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 328 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 384
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 385 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 444
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY
Sbjct: 445 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489
>gb|AAK71184.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi
marinkellei]
gb|AAK71185.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi
marinkellei]
Length = 491
Score = 259 bits (662), Expect = 5e-68
Identities = 131/285 (45%), Positives = 176/285 (61%), Gaps = 26/285 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 227 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 286
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 287 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 327
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 328 --DLGPVYGFQWRHFGADYTHHDANYDGQG-VDQIKTIVETLKTNPDDRRMLFTAWNPSA 384
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYALLT +IAK GL+ G
Sbjct: 385 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPG 444
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
+ +HT GDAH+Y NH++ K Q++R P+ P L E +EDY
Sbjct: 445 ELVHTLGDAHVYSNHVEPCKEQLKRVPRAFPYLVFHREREFLEDY 489
>sp|P06785|TYSY_YEAST Thymidylate synthase (TS) (TSase)
gb|AAA60940.1| thymidylate synthase [Saccharomyces cerevisiae]
emb|CAA94559.1| YOR29-25 [Saccharomyces cerevisiae]
Length = 304
Score = 259 bits (662), Expect = 6e-68
Identities = 147/317 (46%), Positives = 191/317 (60%), Gaps = 38/317 (11%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGP-QMEFDL-SKGFPLLTTKKLPFRIIAEE 72
+ +Y +L K+I+DEG + DRTGTGTLSLF P Q+ F L FPLLTTKK+ R I E
Sbjct: 10 EEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIILE 69
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WF+ GDTD L ++ + IW + R YLD+ KD
Sbjct: 70 LLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKM----------------------GFKD 107
Query: 133 TSF-DLGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNV 188
DLGP+YG QWR + + D+ Y + + IDQL +VI + TNP RR I+SAWN
Sbjct: 108 RKVGDLGPVYGFQWRHFGAKYKTCDDDY-TGQGIDQLKQVIHKLKTNPYDRRIIMSAWNP 166
Query: 189 GDIDYMALPPCHVLFQFYVV---------NGTLSCKLYQRSADVFLGVPFNIASYALLTH 239
D D MALPPCH+ QFYV LSC LYQRS D+ LGVPFNIASYALLT
Sbjct: 167 ADFDKMALPPCHIFSQFYVSFPKEGEGSGKPRLSCLLYQRSCDMGLGVPFNIASYALLTR 226
Query: 240 IIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLED 299
+IAK+ ++ G+FIHT GDAH+Y +HID LK Q+ R P+ P+L+IK ++I+D+ L D
Sbjct: 227 MIAKVVDMEPGEFIHTLGDAHVYKDHIDALKEQITRNPRPFPKLKIKRDVKDIDDFKLTD 286
Query: 300 IVLTGYDAHPTIKGKLS 316
+ Y+ HP I+ K+S
Sbjct: 287 FEIEDYNPHPRIQMKMS 303
>sp|O62584|TYSY_ENCCU Thymidylate synthase (TS) (TSase)
emb|CAA06648.1| thymidylate synthase [Encephalitozoon cuniculi]
Length = 294
Score = 259 bits (661), Expect = 7e-68
Identities = 136/309 (44%), Positives = 186/309 (60%), Gaps = 27/309 (8%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAE 71
H + +Y +LVK I++ G + DRTGTG LS+FG M F L FPLLTT+++ +R + E
Sbjct: 7 HPEHQYLDLVKHILENGARRMDRTGTGALSVFGATMRFSLEDNTFPLLTTRRVFYRGVVE 66
Query: 72 ELFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAK 131
EL +F+ G+TD K L K + IW + + +L G++ GD
Sbjct: 67 ELLFFLRGETDSKVLEKKGVRIWEKNGAKQFLQSV-----GIDREEGD------------ 109
Query: 132 DTSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVG 189
LGPIYG QWR + + + S K +DQ+ I I NP SRR +VSAWN
Sbjct: 110 -----LGPIYGFQWRHFGARYETSASSYEGKGVDQIASAIAAIRANPASRRIVVSAWNPT 164
Query: 190 DIDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKV 249
D+ MALPPCHVLFQF V +G LSC +YQRS D+ LGVPFNIASY+LLT ++A + GL+
Sbjct: 165 DLGSMALPPCHVLFQFNVTDGKLSCAMYQRSGDMGLGVPFNIASYSLLTILVAHLTGLQP 224
Query: 250 GKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEI--KAVHENIEDYTLEDIVLTGYDA 307
G+F+H GDAH+Y++H+D L+ Q++R P+ P+L + K E + ED L GYD
Sbjct: 225 GEFVHFLGDAHVYLDHVDSLRQQIQRPPRAFPKLFVSPKGPRTEPEHFQYEDFELVGYDP 284
Query: 308 HPTIKGKLS 316
HP IK +S
Sbjct: 285 HPAIKMNMS 293
>pir||YXCKTA thymidylate synthase (EC 2.1.1.45) - yeast (Candida albicans)
Length = 315
Score = 258 bits (660), Expect = 9e-68
Identities = 152/324 (46%), Positives = 192/324 (59%), Gaps = 46/324 (14%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGP-QMEFDLSKG-FPLLTTKKLPFRIIAEELFW 75
Y +L K+I+DEG + DRTGTGT SLF P Q+ FDLS FPLLTTKK+ + I EL W
Sbjct: 12 YLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHELLW 71
Query: 76 FINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
F+ G TD K L +K + IW + R +LD+ GL H ++E
Sbjct: 72 FVAGSTDAKILSEKGVKIWEGNGSREFLDKL-----GLTH-------RREG--------- 110
Query: 136 DLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGP+YG QWR + A + D + + + DQL VIK + TNP RR I+SAWN D
Sbjct: 111 DLGPVYGFQWRHFGAEYKDCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAWNPPDFAK 170
Query: 194 MALPPCHVLFQFYV-----------------VNGTLSCKLYQRSADVFLGVPFNIASYAL 236
MALPPCHV QFYV LSC LYQRS D+ LGVPFNIASYAL
Sbjct: 171 MALPPCHVFCQFYVNFPTSLPDPNNPKQAKTAKPKLSCLLYQRSCDMGLGVPFNIASYAL 230
Query: 237 LTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHEN----I 292
LT +IA + + G+FIHT GDAH+Y++HID LK Q ER PK+ P+L IK +N I
Sbjct: 231 LTKMIAHVVDMDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIKEERKNEIKSI 290
Query: 293 EDYTLEDIVLTGYDAHPTIKGKLS 316
+D+ ED + GY+ +P IK K+S
Sbjct: 291 DDFKFEDFEIVGYEPYPPIKMKMS 314
>sp|P12461|TYSY_CANAL Thymidylate synthase (TS) (TSase)
gb|AAA34374.2| thymidylate synthase precursor [Candida albicans]
gb|EAK95868.1| hypothetical protein CaO19.3549 [Candida albicans SC5314]
gb|EAK95932.1| hypothetical protein CaO19.11033 [Candida albicans SC5314]
Length = 315
Score = 258 bits (660), Expect = 9e-68
Identities = 152/324 (46%), Positives = 192/324 (59%), Gaps = 46/324 (14%)
Query: 18 YFNLVKKIMDEGTLKDDRTGTGTLSLFGP-QMEFDLSKG-FPLLTTKKLPFRIIAEELFW 75
Y +L K+I+DEG + DRTGTGT SLF P Q+ FDLS FPLLTTKK+ + I EL W
Sbjct: 12 YLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHELLW 71
Query: 76 FINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSF 135
F+ G TD K L +K + IW + R +LD+ GL H ++E
Sbjct: 72 FVAGSTDAKILSEKGVKIWEGNGSREFLDKL-----GLTH-------RREG--------- 110
Query: 136 DLGPIYGKQWRSW-ASFSD-NPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
DLGP+YG QWR + A + D + + + DQL VIK + TNP RR I+SAWN D
Sbjct: 111 DLGPVYGFQWRHFGAEYKDCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAWNPPDFAK 170
Query: 194 MALPPCHVLFQFYV-----------------VNGTLSCKLYQRSADVFLGVPFNIASYAL 236
MALPPCHV QFYV LSC LYQRS D+ LGVPFNIASYAL
Sbjct: 171 MALPPCHVFCQFYVNFPTSSPDPNNPKQAKTAKPKLSCLLYQRSCDMGLGVPFNIASYAL 230
Query: 237 LTHIIAKMAGLKVGKFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHEN----I 292
LT +IA + + G+FIHT GDAH+Y++HID LK Q ER PK+ P+L IK +N I
Sbjct: 231 LTKMIAHVVDMDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIKEERKNEIKSI 290
Query: 293 EDYTLEDIVLTGYDAHPTIKGKLS 316
+D+ ED + GY+ +P IK K+S
Sbjct: 291 DDFKFEDFEIVGYEPYPPIKMKMS 314
>gb|AAC58691.1| thymidylate synthase homolog [rhesus monkey rhadinovirus H26-95]
Length = 282
Score = 258 bits (660), Expect = 9e-68
Identities = 134/303 (44%), Positives = 180/303 (59%), Gaps = 25/303 (8%)
Query: 17 EYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEELFWF 76
+Y + I+ G ++DRTG GT S+FG Q ++L FPLLTTK++ +R + EEL WF
Sbjct: 1 QYLAHLDLIIKHGVQREDRTGVGTRSVFGLQARYNLRDEFPLLTTKRVFWRGVVEELLWF 60
Query: 77 INGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDTSFD 136
I G TD L + + IW R +L + Q F D
Sbjct: 61 IRGSTDSTELSRRGVKIWDAHGSRAFL------------------AAQGF---GDRREGD 99
Query: 137 LGPIYGKQWRSWAS---FSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGDIDY 193
LGP+YG QWR + + +D Y+ + +DQL V+ IN P RR ++ AWN D+
Sbjct: 100 LGPVYGFQWRHFGAEYRGADANYEGQG-VDQLRYVVDLINRRPHDRRIVMCAWNPADLAR 158
Query: 194 MALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVGKFI 253
MALPPCHVL QFYV G LSC+LYQRSAD+ LGVPFNIASYALLT++IA + GL G F+
Sbjct: 159 MALPPCHVLCQFYVARGELSCQLYQRSADMGLGVPFNIASYALLTYLIAHVTGLTPGDFV 218
Query: 254 HTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPTIKG 313
HT GDAH+Y NH+D L Q+ R P+ P+L+I +ED+T D+ L GYD HP I+
Sbjct: 219 HTLGDAHVYNNHVDPLLLQLRRTPRPFPRLKILRKVARLEDFTRADLSLEGYDPHPHIEM 278
Query: 314 KLS 316
+++
Sbjct: 279 EMA 281
>gb|AAK71150.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
gb|AAK71154.1| dihydrofolate reductase-thymidylate synthetase [Trypanosoma cruzi]
Length = 491
Score = 258 bits (659), Expect = 1e-67
Identities = 129/285 (45%), Positives = 175/285 (61%), Gaps = 26/285 (9%)
Query: 15 DTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKG-FPLLTTKKLPFRIIAEEL 73
+ +Y +LV +I+ EG +K DRTG GTLS+FG QM F L PLLTTK++ +R + EEL
Sbjct: 227 EEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEEL 286
Query: 74 FWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKDT 133
WF+ G+T K L DK ++IW D+ R +LD +G E +
Sbjct: 287 LWFLRGETYAKKLSDKGVHIWDDNGSRAFLDS--RGLTEYEEM----------------- 327
Query: 134 SFDLGPIYGKQWRSWA---SFSDNPYKSKKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGP+YG QWR + + D Y + +DQ+ +++ + TNPD RR + +AWN
Sbjct: 328 --DLGPVYGFQWRHFGAAYTHHDANYDGQG-VDQIKAIVETLKTNPDDRRMLFTAWNPSA 384
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+ MALPPCH+L QFYV NG LSC LYQRS D+ LGVPFNIASYA LT +IAK GL+ G
Sbjct: 385 LPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYAFLTILIAKATGLRPG 444
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDY 295
+ +HT GDAH+Y NH++ Q++R P+ P L + E +EDY
Sbjct: 445 ELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489
>gb|AAK55761.1| dihydrofolate reductase/thymidylate synthase [Plasmodium
gallinaceum]
Length = 589
Score = 255 bits (652), Expect = 8e-67
Identities = 133/301 (44%), Positives = 183/301 (60%), Gaps = 23/301 (7%)
Query: 13 HVDTEYFNLVKKIMDEGTLKDDRTGTGTLSLFGPQMEFDLSKGFPLLTTKKLPFRIIAEE 72
H + +Y N++ ++ G + DRTG G +S FG M+F+L++ FPLLTTKKL R I EE
Sbjct: 304 HPEYQYLNIIYDVIMNGNKQGDRTGVGVVSKFGYMMKFNLNQYFPLLTTKKLFIRGIIEE 363
Query: 73 LFWFINGDTDLKTLLDKNINIWTDDAYRFYLDEFEKGWEGLEHIAGDPLSKQEFVSAAKD 132
L WFI G+T+ TLL+KN+ IW + R +LD K++ +
Sbjct: 364 LLWFIRGETNGNTLLNKNVRIWEANGTREFLD------------------KRKLFDREVN 405
Query: 133 TSFDLGPIYGKQWRSWASFSDNPYKS--KKEIDQLFRVIKDINTNPDSRRHIVSAWNVGD 190
DLGPIYG QWR + + N + + K +DQL +I I P SRR I+ AWNV D
Sbjct: 406 ---DLGPIYGFQWRHFGAEYTNMHDNYENKGVDQLKNIINLIKNEPTSRRIILCAWNVKD 462
Query: 191 IDYMALPPCHVLFQFYVVNGTLSCKLYQRSADVFLGVPFNIASYALLTHIIAKMAGLKVG 250
+D MALPPCH+L QFYV + LSC +YQRS D+ LGVPFNIASY++ T++IA++ L+
Sbjct: 463 LDKMALPPCHILCQFYVFDNKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQPA 522
Query: 251 KFIHTFGDAHIYINHIDLLKSQMEREPKEMPQLEIKAVHENIEDYTLEDIVLTGYDAHPT 310
+FIH G+AH+Y NHID LK Q+ R P P L++ +NIED+ + D