As an additional note on paying attention to the small genes, all the green genes in SIO1 below were ignored in the initial annotation, including an obvious thioredoxin homologue. In VpV262, an interesting small gene is the one marked SSBctd. This gene is a homologue of single strand DNA binding protein. Such a gene is common in phages. However, it is missing the N terminal domain, which is the part that binds the DNA. The C terminal domain, which is present, is the part bound by many replicative or repair proteins to organize their functions on the DNA. Of course, this could just be a defective gene damaged by recombination processes and on the way to being discarded. But if one thinks in term of the coadaptive struggle between host and phage, it might make sense to make such a protein for the purpose of distracting host replicative and repair proteins and keeping them away from the viral DNA.